SG87053A1 - High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide - Google Patents
High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamideInfo
- Publication number
- SG87053A1 SG87053A1 SG9904601A SG1999004601A SG87053A1 SG 87053 A1 SG87053 A1 SG 87053A1 SG 9904601 A SG9904601 A SG 9904601A SG 1999004601 A SG1999004601 A SG 1999004601A SG 87053 A1 SG87053 A1 SG 87053A1
- Authority
- SG
- Singapore
- Prior art keywords
- polymorth
- isoxazolyl
- sulfonamide
- oxazolyl
- biphenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1197496P | 1996-02-20 | 1996-02-20 | |
US08/786,523 US5856507A (en) | 1997-01-21 | 1997-01-21 | Methods for the preparation of biphenyl isoxazole sulfonamides |
Publications (1)
Publication Number | Publication Date |
---|---|
SG87053A1 true SG87053A1 (en) | 2002-03-19 |
Family
ID=26682999
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904595A SG87052A1 (en) | 1996-02-20 | 1997-02-19 | Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
SG9904601A SG87053A1 (en) | 1996-02-20 | 1997-02-19 | High melt polymorth of the compound n-(3,4-dimethyl-5-isoxazolyl)-4'- (2-oxazolyl) [1,1'-biphenyl]-2-sulfonamide |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG9904595A SG87052A1 (en) | 1996-02-20 | 1997-02-19 | Pinacol ester intermediates useful for the preparation of biphenyl isoxazole sulfonamides |
SG9904589A SG87051A1 (en) | 1996-02-20 | 1997-02-19 | Process for preparing biphenyl isoxazole sulfonamide intermediates |
Country Status (15)
Country | Link |
---|---|
US (1) | US6515136B1 (no) |
EP (1) | EP0904077A4 (no) |
JP (1) | JP2001523218A (no) |
KR (1) | KR19990087063A (no) |
CN (1) | CN1211183A (no) |
AU (1) | AU717230B2 (no) |
BR (1) | BR9708151A (no) |
CZ (1) | CZ263098A3 (no) |
HU (1) | HUP0002351A3 (no) |
IL (1) | IL124542A (no) |
NO (1) | NO311430B1 (no) |
NZ (1) | NZ330464A (no) |
PL (1) | PL328571A1 (no) |
SG (3) | SG87052A1 (no) |
WO (1) | WO1997029747A1 (no) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
CN1100047C (zh) * | 1998-04-28 | 2003-01-29 | 中国人民解放军空军总医院 | N3-(5-甲基异噁唑)基-3,4-二羟基肉桂酰胺及其制法 |
AU767456B2 (en) | 1998-07-06 | 2003-11-13 | Bristol-Myers Squibb Company | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
DE19858593A1 (de) * | 1998-12-18 | 2000-06-21 | Merck Patent Gmbh | Sulfonyloxazolamine als therapeutische Wirkstoffe |
HUP0201320A2 (en) | 1999-03-19 | 2002-08-28 | Bristol Myers Squibb Co | Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates thereof |
US6639082B2 (en) * | 2000-10-17 | 2003-10-28 | Bristol-Myers Squibb Company | Methods for the preparation of biphenyl isoxazole sulfonamides |
EP1475103A4 (en) * | 2002-01-25 | 2007-11-07 | Taisho Pharmaceutical Co Ltd | MEANS FOR THE TREATMENT OF CHRONIC KIDNEY DISEASES |
CN114262279B (zh) * | 2021-12-30 | 2022-12-16 | 上海汇禾医疗科技有限公司 | 一种x射线可显影分子、栓塞微球及其制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Family Cites Families (43)
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---|---|---|---|---|
GB804036A (en) | 1956-03-02 | 1958-11-05 | Hoffmann La Roche | A process for the manufacture of a sulphanilamide of the isoxazole series |
DE1059459B (de) | 1956-09-04 | 1959-06-18 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wertvollen 3-Sulfanilamido-5-methylisoxazols |
CH364506A (de) | 1956-09-04 | 1962-09-30 | Shionogi & Co | Verfahren zur Herstellung des therapeutisch wirksamen 3-Sulfanilamido-5-methyl-isoxazols |
GB897440A (en) | 1960-02-08 | 1962-05-30 | Shionogi & Co | Improvements in or relating to sulfonamides |
GB1473433A (no) | 1975-10-09 | 1977-05-11 | Banyu Pharmaceutical Co Ltd Hi | |
DE3276313D1 (en) | 1981-09-24 | 1987-06-19 | Beecham Wuelfing Gmbh & Co Kg | Sulphonamides |
EP0194548A3 (de) | 1985-03-12 | 1988-08-17 | Dr. Karl Thomae GmbH | Neue Sulfonylaminoäthylverbindungen, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5464853A (en) | 1993-05-20 | 1995-11-07 | Immunopharmaceutics, Inc. | N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
US5514691A (en) | 1993-05-20 | 1996-05-07 | Immunopharmaceutics, Inc. | N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5571821A (en) | 1993-05-20 | 1996-11-05 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5594021A (en) | 1993-05-20 | 1997-01-14 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin |
US5591761A (en) | 1993-05-20 | 1997-01-07 | Texas Biotechnology Corporation | Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
CA2005741C (en) | 1988-12-26 | 1998-06-02 | Hiroyoshi Hidaka | Quinoline sulfonoamino compounds having vessel smooth muscle relaxation activity |
US5082838A (en) | 1989-06-21 | 1992-01-21 | Takeda Chemical Industries, Ltd. | Sulfur-containing fused pyrimidine derivatives, their production and use |
PH30484A (en) | 1990-02-19 | 1997-05-28 | Ciba Geigy | Acy compounds pharmaceutical composition containing said compound and method of use thereof |
WO1991015479A1 (en) | 1990-03-30 | 1991-10-17 | Merck & Co., Inc. | Substituted pyrazoles, isoxazoles and isothiazoles |
US5236928A (en) | 1991-03-19 | 1993-08-17 | Merck & Co., Inc. | Imidazole derivatives bearing acidic functional groups at the 5-position, their compositions and methods of use as angiotensin II antagonists |
TW270116B (no) | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
RU2086544C1 (ru) | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
WO1993008799A1 (en) | 1991-11-05 | 1993-05-13 | Smithkline Beecham Corporation | Endothelin receptor antagonists |
SE9103397D0 (sv) | 1991-11-18 | 1991-11-18 | Kabi Pharmacia Ab | Nya substituerade salicylsyror |
TW224462B (no) | 1992-02-24 | 1994-06-01 | Squibb & Sons Inc | |
US5378715A (en) | 1992-02-24 | 1995-01-03 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
TW215434B (no) | 1992-03-07 | 1993-11-01 | Hoechst Ag | |
US5514696A (en) * | 1992-05-06 | 1996-05-07 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
AU4376893A (en) | 1992-05-19 | 1993-12-13 | Immunopharmaceutics, Inc. | Compounds that modulate endothelin activity |
TW287160B (no) | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
ES2141197T3 (es) | 1993-03-19 | 2000-03-16 | Merck & Co Inc | Derivados del acido fenoxifenilacetico. |
EP0626174A3 (en) | 1993-04-21 | 1996-01-03 | Takeda Chemical Industries Ltd | Method and composition for the prophylaxis and / or treatment of underactive organs. |
TW394761B (en) | 1993-06-28 | 2000-06-21 | Hoffmann La Roche | Novel Sulfonylamino Pyrimidines |
DK0634175T3 (da) | 1993-07-15 | 2001-04-30 | Hoffmann La Roche | Farmaceutisk kombination, der indeholder en hæmmer af renin-angiotensin-systemet og en endothelin-antagonist |
US5965732A (en) | 1993-08-30 | 1999-10-12 | Bristol-Myers Squibb Co. | Sulfonamide endothelin antagonists |
GB9504854D0 (en) | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
GB9409618D0 (en) | 1994-05-13 | 1994-07-06 | Zeneca Ltd | Pyridine derivatives |
US5612359A (en) * | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
CA2168154A1 (en) * | 1995-02-06 | 1996-08-07 | Natesan Murugesan | Substituted biphenyl sulfonamide endothelin antagonists |
DE19509950A1 (de) | 1995-03-18 | 1996-09-19 | Merck Patent Gmbh | Endothelin-Rezeptor-Antagonisten |
EE9700251A (et) | 1995-04-04 | 1998-04-15 | Texas Biotechnology Corporation | Tienüül-, furüül-, pürrolüül- ja bifenüülsulfoonamiidid ning nende derivaadid, mis moduleerivad endoteliini aktiivsust |
UA58494C2 (uk) | 1995-06-07 | 2003-08-15 | Зенека Лімітед | Похідні n-гетероарилпіридинсульфонаміду, фармацевтична композиція, спосіб одержання та спосіб протидії впливам ендотеліну |
GB9512697D0 (en) | 1995-06-22 | 1995-08-23 | Zeneca Ltd | Heterocyclic compounds |
US5846990A (en) * | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
US5580894A (en) * | 1996-01-11 | 1996-12-03 | Howard University | Isoxazolyl enaminones |
-
1997
- 1997-02-19 SG SG9904595A patent/SG87052A1/en unknown
- 1997-02-19 SG SG9904589A patent/SG87051A1/en unknown
- 1997-02-19 NZ NZ330464A patent/NZ330464A/xx unknown
- 1997-02-19 BR BR9708151A patent/BR9708151A/pt not_active IP Right Cessation
- 1997-02-19 CN CN97192338A patent/CN1211183A/zh active Pending
- 1997-02-19 AU AU19737/97A patent/AU717230B2/en not_active Ceased
- 1997-02-19 IL IL12454297A patent/IL124542A/xx not_active IP Right Cessation
- 1997-02-19 WO PCT/US1997/002917 patent/WO1997029747A1/en not_active Application Discontinuation
- 1997-02-19 CZ CZ982630A patent/CZ263098A3/cs unknown
- 1997-02-19 PL PL97328571A patent/PL328571A1/xx unknown
- 1997-02-19 HU HU0002351A patent/HUP0002351A3/hu unknown
- 1997-02-19 EP EP97907841A patent/EP0904077A4/en not_active Withdrawn
- 1997-02-19 SG SG9904601A patent/SG87053A1/en unknown
- 1997-02-19 KR KR1019980706449A patent/KR19990087063A/ko not_active Application Discontinuation
- 1997-02-19 JP JP52960897A patent/JP2001523218A/ja active Pending
-
1998
- 1998-08-19 NO NO19983784A patent/NO311430B1/no not_active IP Right Cessation
- 1998-08-27 US US09/141,402 patent/US6515136B1/en not_active Expired - Fee Related
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2888455A (en) * | 1956-09-04 | 1959-05-26 | Shionogi & Co | New sulfonamide and process for producing the same |
US4415496A (en) * | 1981-03-23 | 1983-11-15 | Merck & Co., Inc. | Bicyclic lactams |
US4661479A (en) * | 1982-02-19 | 1987-04-28 | Merck And Co., Inc. | Bicyclic lactams as antihypertensives |
Also Published As
Publication number | Publication date |
---|---|
SG87052A1 (en) | 2002-03-19 |
NO983784D0 (no) | 1998-08-19 |
NO311430B1 (no) | 2001-11-26 |
WO1997029747A1 (en) | 1997-08-21 |
EP0904077A4 (en) | 1999-12-22 |
IL124542A0 (en) | 1998-12-06 |
EP0904077A2 (en) | 1999-03-31 |
IL124542A (en) | 2003-07-06 |
AU717230B2 (en) | 2000-03-23 |
SG87051A1 (en) | 2002-03-19 |
CN1211183A (zh) | 1999-03-17 |
NZ330464A (en) | 2000-04-28 |
CZ263098A3 (cs) | 1999-05-12 |
BR9708151A (pt) | 1999-07-27 |
JP2001523218A (ja) | 2001-11-20 |
KR19990087063A (ko) | 1999-12-15 |
US6515136B1 (en) | 2003-02-04 |
HUP0002351A3 (en) | 2001-10-29 |
NO983784L (no) | 1998-08-19 |
HUP0002351A2 (hu) | 2001-09-28 |
AU1973797A (en) | 1997-09-02 |
PL328571A1 (en) | 1999-02-01 |
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