SG81972A1 - Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity - Google Patents

Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Info

Publication number
SG81972A1
SG81972A1 SG9901555A SG1999001555A SG81972A1 SG 81972 A1 SG81972 A1 SG 81972A1 SG 9901555 A SG9901555 A SG 9901555A SG 1999001555 A SG1999001555 A SG 1999001555A SG 81972 A1 SG81972 A1 SG 81972A1
Authority
SG
Singapore
Prior art keywords
phenoxymethyl
tetrazole
derivatives
acetic acid
antitumor activity
Prior art date
Application number
SG9901555A
Other languages
English (en)
Inventor
Di Domenico Roberto
Silke Hansen
Brigitte Kaluza
Ernesto Menta
Ralf Schumacher
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG81972A1 publication Critical patent/SG81972A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/62—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by hydrogenation of carbon-to-carbon double or triple bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
    • C07C45/74—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups combined with dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/83—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/82—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups
    • C07C49/835—Ketones containing a keto group bound to a six-membered aromatic ring containing hydroxy groups having unsaturation outside an aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708—Ethers
    • C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG9901555A 1998-03-30 1999-03-27 Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity SG81972A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98105726A EP0947511A1 (en) 1998-03-30 1998-03-30 Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Publications (1)

Publication Number Publication Date
SG81972A1 true SG81972A1 (en) 2001-07-24

Family

ID=8231677

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9901555A SG81972A1 (en) 1998-03-30 1999-03-27 Derivatives of phenoxy acetic acid and of phenoxymethyl tetrazole having antitumor activity

Country Status (20)

Country Link
EP (1) EP0947511A1 (xx)
JP (1) JP2000063340A (xx)
KR (1) KR19990078366A (xx)
CN (1) CN1232028A (xx)
AR (1) AR018170A1 (xx)
AU (1) AU2250299A (xx)
BR (1) BR9901208A (xx)
CA (1) CA2267047A1 (xx)
HR (1) HRP990093A2 (xx)
HU (1) HUP9900804A3 (xx)
ID (1) ID22335A (xx)
IL (1) IL129191A0 (xx)
MA (1) MA26616A1 (xx)
NO (1) NO991526L (xx)
NZ (1) NZ334874A (xx)
PE (1) PE20000341A1 (xx)
PL (1) PL332273A1 (xx)
SG (1) SG81972A1 (xx)
TR (1) TR199900719A2 (xx)
ZA (1) ZA992407B (xx)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2841900B1 (fr) 2002-07-08 2007-03-02 Genfit S A Nouveaux derives de 1,3-diphenylprop-2-en-1-one substitues, preparation et utilisations
FR2841784B1 (fr) 2002-07-08 2007-03-02 Composition a base de derives de 1,3-diphenylprop-2en-1-one substitues, preparation et utilisations
FR2857361B1 (fr) * 2003-07-08 2005-09-09 Genfit S A PREPARATION DE DERIVES DE 1,3-DIPHENYPROP-2-¼n-1-one
WO2005063774A1 (en) * 2003-12-22 2005-07-14 Johns Hopkins University Boronic acid aryl analogs
JP2007297283A (ja) * 2004-07-28 2007-11-15 Santen Pharmaceut Co Ltd 新規桂皮酸関連化合物
ES2425965T3 (es) * 2006-08-30 2013-10-18 The Regents Of The University Of Michigan Nuevos inhibidores de moléculas pequeñas de MDM2 y usos de los mismos
JP2010504298A (ja) * 2006-09-21 2010-02-12 エフ．ホフマン−ラ ロシュ アーゲー オキシンドール誘導体
US7638548B2 (en) * 2006-11-09 2009-12-29 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US7553833B2 (en) * 2007-05-17 2009-06-30 Hoffmann-La Roche Inc. 3,3-spiroindolinone derivatives
US7928233B2 (en) 2009-02-10 2011-04-19 Hoffmann-La Roche Inc. Spiroindolinone pyridine derivatives
US8217051B2 (en) 2009-02-17 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone derivatives
US8076482B2 (en) 2009-04-23 2011-12-13 Hoffmann-La Roche Inc. 3,3′-spiroindolinone derivatives
US8017607B2 (en) 2009-10-14 2011-09-13 Hoffmann-La Roche Inc. N-substituted-pyrrolidines as inhibitors of MDM2-P-53 interactions
US8088815B2 (en) 2009-12-02 2012-01-03 Hoffman-La Roche Inc. Spiroindolinone pyrrolidines
US8288431B2 (en) 2010-02-17 2012-10-16 Hoffmann-La Roche Inc. Substituted spiroindolinones
US8217044B2 (en) 2010-04-28 2012-07-10 Hoffmann-La Roche Inc. Spiroindolinone pyrrolidines

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3251064A (en) * 1962-11-13 1966-05-10 Everett M Schultz beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids
US3255241A (en) * 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
JPH0624975A (ja) * 1992-05-12 1994-02-01 Dainippon Ink & Chem Inc 制癌活性増強剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL300456A (xx) * 1962-11-13
US3994955A (en) * 1975-01-20 1976-11-30 G. D. Searle & Co. Substituted phenoxydialkylacetic acids and esters
US4904697A (en) * 1987-04-09 1990-02-27 Merrell Dow Pharmaceuticals Inc. Controlling the growth of certain tumor tissue with chalcone derivatives
DE4327365A1 (de) * 1993-08-14 1995-02-16 Boehringer Mannheim Gmbh Verwendung von Phenolen und Phenolderivaten als Arzneimittel mit fibrinogensenkender Wirkung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3255241A (en) * 1961-01-19 1966-06-07 Merck & Co Inc (2-alkylidene acyl)phenoxy-and (2-alkylidene acyl)phenylmercaptocarboxylic acids
US3251064A (en) * 1962-11-13 1966-05-10 Everett M Schultz beta-aminoacylphenoxy-and beta-aminoacylphenylmercapto-derivatives of monocarboxylicacids
JPH0624975A (ja) * 1992-05-12 1994-02-01 Dainippon Ink & Chem Inc 制癌活性増強剤

Also Published As

Publication number Publication date
BR9901208A (pt) 2000-04-25
NO991526L (no) 1999-10-01
NO991526D0 (no) 1999-03-29
IL129191A0 (en) 2000-02-17
CN1232028A (zh) 1999-10-20
HUP9900804A2 (hu) 1999-11-29
EP0947511A1 (en) 1999-10-06
HU9900804D0 (en) 1999-05-28
KR19990078366A (ko) 1999-10-25
JP2000063340A (ja) 2000-02-29
NZ334874A (en) 2000-08-25
AR018170A1 (es) 2001-10-31
ID22335A (id) 1999-09-30
HUP9900804A3 (en) 2001-08-28
PE20000341A1 (es) 2000-05-08
HRP990093A2 (en) 2000-02-29
TR199900719A2 (xx) 1999-10-21
ZA992407B (en) 1999-09-30
PL332273A1 (en) 1999-10-11
MA26616A1 (fr) 2004-12-20
AU2250299A (en) 1999-10-14
CA2267047A1 (en) 1999-09-30

Similar Documents

Publication Publication Date Title
HU9900804D0 (en) Derivatives of phenoxy acetic acid and phenoxymethyl tetrazole having antitumor activity
HUP0002224A3 (en) Benzimidazole derivatives of antivirus activity
AU7051000A (en) Method of activity based costing
PL338633A1 (en) Derivatives of aryloxyarylsuphonylamino hydroxamic acid
AU1630501A (en) Compositions and methods for detecting protein modification and enzymatic activity
PL335027A1 (en) Derivatives of arylsulphonylamino hydroxamic acid
HUP0202477A3 (en) Use of phthalazine derivatives
IL135673A0 (en) Therapeutic uses of quinoline derivatives
HU9701299D0 (en) Insuline derivatives of enhanced zinc-binding activity
AU7710300A (en) Methods for diagnosis and therapy of hematological and virus-associated malignancies
AU5668499A (en) Veneer tape and method of use
PL340461A1 (en) Derivatives of isothiazocarboxylic acid
AU3522999A (en) Purification of human acid alpha-glucosidase
PL351986A1 (en) Method of reducing il-5 activity
AU3669200A (en) Detection of smooth muscle motor activity
HU9904659D0 (en) Aryl carboxylic acid and tetrazole derivatives
HU9800373D0 (en) Steroide compounds of anticeptive and antiosteoporosive activity
PL335601A1 (en) Derivatives of 2-substituted benzoylcycloalkyl carboxylic acid
AU6500600A (en) Methods and compositions for determining enzymatic activity
AU7608100A (en) 1-cyclohexene-1-carboxylic acid and 1-cyclohexene-1-carboxylates as neuraminidase inhibitors
HUP0102073A3 (en) Hydroxamic and carboxylic acid derivatives and medicaments containing them
AU3755700A (en) Mixed-element stitching and noise reduction system
AU5530800A (en) Method and composition for enhancing the activity of an enzyme
AU1143601A (en) Method and composition for enhancing the activity of an enzyme
PL354481A1 (en) Thienoisoxazole phenoxy unsubstituted ethyl and propyl derivatives useful as d4