SG80028A1 - Active hedgehog protein conjugate, process for its production and use - Google Patents

Active hedgehog protein conjugate, process for its production and use

Info

Publication number
SG80028A1
SG80028A1 SG9902117A SG1999002117A SG80028A1 SG 80028 A1 SG80028 A1 SG 80028A1 SG 9902117 A SG9902117 A SG 9902117A SG 1999002117 A SG1999002117 A SG 1999002117A SG 80028 A1 SG80028 A1 SG 80028A1
Authority
SG
Singapore
Prior art keywords
hedgehog protein
production
hydrophobic
protein conjugate
amino acids
Prior art date
Application number
SG9902117A
Other languages
English (en)
Inventor
Angelika Esswein
Kurt Lang
Petra Rueger
Tilmann Seytter
Original Assignee
Roche Diagnostics Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98107911A external-priority patent/EP0953575A1/de
Application filed by Roche Diagnostics Gmbh filed Critical Roche Diagnostics Gmbh
Publication of SG80028A1 publication Critical patent/SG80028A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG9902117A 1998-04-30 1999-04-28 Active hedgehog protein conjugate, process for its production and use SG80028A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98107911A EP0953575A1 (de) 1998-04-30 1998-04-30 Aktives Hedgehog-Protein-Konjugat, Verfahren zur Herstellung und Verwendung
EP98116733 1998-09-03

Publications (1)

Publication Number Publication Date
SG80028A1 true SG80028A1 (en) 2001-04-17

Family

ID=26149214

Family Applications (1)

Application Number Title Priority Date Filing Date
SG9902117A SG80028A1 (en) 1998-04-30 1999-04-28 Active hedgehog protein conjugate, process for its production and use

Country Status (18)

Country Link
US (4) US6468978B1 (el)
EP (2) EP0953576B1 (el)
JP (1) JP3433136B2 (el)
KR (1) KR19990083621A (el)
CN (1) CN1233616A (el)
AT (1) ATE308563T1 (el)
AU (1) AU719797B2 (el)
CA (1) CA2269221A1 (el)
CY (1) CY1105683T1 (el)
DE (1) DE69928040T2 (el)
DK (1) DK0953576T3 (el)
ES (1) ES2252886T3 (el)
HU (1) HUP9901411A2 (el)
IL (1) IL129620A (el)
MA (1) MA26625A1 (el)
NO (1) NO992090L (el)
NZ (1) NZ335385A (el)
SG (1) SG80028A1 (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1034269A1 (en) * 1997-11-28 2000-09-13 Roche Diagnostics GmbH An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EP0953576B1 (en) * 1998-04-30 2005-11-02 Curis, Inc. Active hedgehog protein conjugate, process for its production and use
DK0978285T3 (da) 1998-08-07 2006-03-27 Curis Inc Stabilt farmaceutisk præparat af hedgehogproteiner og anvendelse deraf
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
DE69931390T2 (de) * 1998-12-03 2007-06-06 Curis, Inc., Cambridge Verfahren und Zusammensetzungen zur Behandlung von Krankheiten bei denen Excitotoxizität beteiligt ist
EP1025861A1 (de) * 1999-02-04 2000-08-09 Roche Diagnostics GmbH Pharmazeutische Zusammensetzung von hydrophob modifizierten Hedgehog-Proteinen und deren Verwendung
CA2375700A1 (en) * 1999-06-01 2000-12-07 Biogen, Inc. Polymer conjugates of hedgehog proteins and uses
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro
US7573637B2 (en) * 2004-08-03 2009-08-11 Seiko Epson Corporation Intrinsic polarizer and method of manufacturing an intrinsic polarizer
US8669418B2 (en) * 2005-12-22 2014-03-11 Vib Vzw Means and methods for mediating protein interference
WO2009108868A2 (en) * 2008-02-27 2009-09-03 Radiomedix Inc. Radiolabeled hedgehog derivatives for imaging and therapy
US20100172889A1 (en) * 2008-12-05 2010-07-08 Catchmark Jeffrey M Degradable biomolecule compositions
US20110086236A1 (en) * 2009-10-13 2011-04-14 The Penn State Research Foundation Composites containing polypeptides attached to polysaccharides and molecules
TWI535455B (zh) * 2011-06-06 2016-06-01 奇尼塔一有限責任公司 以ｓｈｋ為主之醫藥組合物及其製備方法及用途
EP3024887B1 (en) 2013-07-26 2023-11-22 The Penn State Research Foundation Method for preparation of polymer compositions and coatings
KR20170065016A (ko) * 2015-12-02 2017-06-12 한미약품 주식회사 지방산 유도체를 이용한 단백질 결합체 및 이의 제조방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5844079A (en) * 1993-12-30 1998-12-01 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins, and uses related thereto

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5364839A (en) * 1990-06-18 1994-11-15 Genetics Institute, Inc. Osteoinductive pharmaceutical formulations
AU651421B2 (en) * 1990-11-30 1994-07-21 Celtrix Pharmaceuticals, Inc. Use of a bone morphogenetic protein in synergistic combination with TGF-beta for bone repair
CA2179029C (en) * 1993-12-30 2009-02-24 Philip W. Ingham Vertebrate embryonic pattern-inducing hedgehog-like proteins
US6281332B1 (en) * 1994-12-02 2001-08-28 The Johns Hopkins University School Of Medicine Hedgehog-derived polypeptides
US5700774A (en) * 1996-03-26 1997-12-23 Genetics Institute, Inc. Compositions comprising bone morphogenic proteins and truncated parathyroid hormone related peptide, and methods of inducing cartilage by administration of same
GB9614871D0 (en) 1996-07-15 1996-09-04 Smithkline Beecham Plc Compounds
EP0966478A4 (en) * 1996-10-07 2002-08-21 Univ Johns Hopkins Med NOVEL POLYPEPTIDES DERIVED FROM A HERISSON PROTEIN
EP1034269A1 (en) * 1997-11-28 2000-09-13 Roche Diagnostics GmbH An active hedgehog-protein-mutant, a process for its preparation and its use for pharmaceutical purposes
US6897297B1 (en) * 1997-12-03 2005-05-24 Curis, Inc. Hydrophobically-modified protein compositions and methods
EA003739B1 (ru) * 1997-12-03 2003-08-28 Байоджен, Инк. Гидрофобно-модифицированные белки, способы их получения и их применение
EP0953576B1 (en) * 1998-04-30 2005-11-02 Curis, Inc. Active hedgehog protein conjugate, process for its production and use
DK0978285T3 (da) * 1998-08-07 2006-03-27 Curis Inc Stabilt farmaceutisk præparat af hedgehogproteiner og anvendelse deraf
AU2001255767A1 (en) * 2000-04-28 2001-11-12 Curis, Inc. Methods and reagents for tissue engineering of cartilage in vitro

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5844079A (en) * 1993-12-30 1998-12-01 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins, and uses related thereto

Also Published As

Publication number Publication date
CY1105683T1 (el) 2010-12-22
IL129620A0 (en) 2000-02-29
DK0953576T3 (da) 2006-03-20
AU719797B2 (en) 2000-05-18
KR19990083621A (ko) 1999-11-25
EP1557427A3 (en) 2005-10-19
US20070191274A1 (en) 2007-08-16
US20050148510A1 (en) 2005-07-07
ATE308563T1 (de) 2005-11-15
CA2269221A1 (en) 1999-10-30
EP0953576B1 (en) 2005-11-02
DE69928040T2 (de) 2006-07-27
IL129620A (en) 2009-06-15
US20030139574A1 (en) 2003-07-24
US6818623B2 (en) 2004-11-16
JP2000053699A (ja) 2000-02-22
US7153836B2 (en) 2006-12-26
NO992090D0 (no) 1999-04-29
JP3433136B2 (ja) 2003-08-04
NZ335385A (en) 2000-09-29
EP0953576A1 (en) 1999-11-03
HUP9901411A2 (hu) 1999-12-28
DE69928040D1 (de) 2005-12-08
EP1557427A2 (en) 2005-07-27
CN1233616A (zh) 1999-11-03
AU2500999A (en) 1999-11-11
HU9901411D0 (en) 1999-07-28
ES2252886T3 (es) 2006-05-16
MA26625A1 (fr) 2004-12-20
US6468978B1 (en) 2002-10-22
NO992090L (no) 1999-11-01

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