SG72692A1 - Prodrugs of paclitaxel derivatives - Google Patents

Prodrugs of paclitaxel derivatives

Info

Publication number
SG72692A1
SG72692A1 SG1996009989A SG1996009989A SG72692A1 SG 72692 A1 SG72692 A1 SG 72692A1 SG 1996009989 A SG1996009989 A SG 1996009989A SG 1996009989 A SG1996009989 A SG 1996009989A SG 72692 A1 SG72692 A1 SG 72692A1
Authority
SG
Singapore
Prior art keywords
prodrugs
paclitaxel derivatives
paclitaxel
derivatives
Prior art date
Application number
SG1996009989A
Other languages
English (en)
Inventor
Paul M Scola
John F Kadow
Dolatrai M Vyas
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of SG72692A1 publication Critical patent/SG72692A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Epoxy Compounds (AREA)
SG1996009989A 1995-06-06 1996-06-06 Prodrugs of paclitaxel derivatives SG72692A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US46924795A 1995-06-06 1995-06-06

Publications (1)

Publication Number Publication Date
SG72692A1 true SG72692A1 (en) 2000-05-23

Family

ID=23863053

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996009989A SG72692A1 (en) 1995-06-06 1996-06-06 Prodrugs of paclitaxel derivatives

Country Status (23)

Country Link
EP (1) EP0747385B1 (fr)
JP (1) JPH08337589A (fr)
KR (1) KR100375956B1 (fr)
CN (1) CN1066151C (fr)
AR (1) AR002756A1 (fr)
AT (1) ATE222259T1 (fr)
AU (1) AU695959B2 (fr)
CA (1) CA2176191A1 (fr)
CZ (1) CZ291516B6 (fr)
DE (1) DE69622933T2 (fr)
DK (1) DK0747385T3 (fr)
ES (1) ES2181824T3 (fr)
HU (1) HUP9601524A3 (fr)
IL (1) IL118526A (fr)
MX (1) MX9601994A (fr)
NO (1) NO315233B1 (fr)
NZ (1) NZ286723A (fr)
PL (1) PL187883B1 (fr)
PT (1) PT747385E (fr)
RU (1) RU2162082C2 (fr)
SG (1) SG72692A1 (fr)
TW (1) TW354293B (fr)
ZA (1) ZA964261B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395770B1 (en) * 1995-10-26 2002-05-28 Baker Norton Pharmaceuticals, Inc. Method and compositions for administering taxanes orally to human patients
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
US6515016B2 (en) 1996-12-02 2003-02-04 Angiotech Pharmaceuticals, Inc. Composition and methods of paclitaxel for treating psoriasis
CN1550231A (zh) * 1997-05-27 2004-12-01 �Ϳˡ�ŵ��ҩ�����޹�˾ 给予病人口服紫杉烷类药物的方法和组合物
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6538038B1 (en) * 1999-02-18 2003-03-25 Oxigene, Inc. Compositions and methods for use in targeting vascular destruction
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
AU776122B2 (en) 2000-02-02 2004-08-26 Florida State University Research Foundation, Inc. C7 carbonate substituted taxanes as antitumor agents
CO5280224A1 (es) 2000-02-02 2003-05-30 Univ Florida State Res Found Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen
US6916942B2 (en) 2000-02-03 2005-07-12 Bristol-Myers Squibb Company Process for the preparation of C-4 carbonate taxanes
US6750246B1 (en) 2000-02-03 2004-06-15 Bristol-Myers Squibb Company C-4 carbonate taxanes
US7063977B2 (en) 2001-08-21 2006-06-20 Bristol-Myers Squibb Company Enzymatic resolution of t-butyl taxane derivatives
KR20030049023A (ko) * 2001-12-13 2003-06-25 주식회사 코오롱 방사선 감작제용 파클리탁셀 유도체
CN1960721A (zh) 2004-03-05 2007-05-09 佛罗里达州立大学研究基金有限公司 C7乳酰氧基取代的紫杉烷类
EP3345632A1 (fr) * 2005-02-18 2018-07-11 Abraxis BioScience, LLC Médicaments à hydrophobie améliorée destinés à être incorporés dans des dispositifs médicaux
AU2014235462C1 (en) 2013-03-15 2018-11-01 Concert Pharmaceuticals, Inc. Deuterated palbociclib
WO2015009889A1 (fr) 2013-07-18 2015-01-22 Concert Pharmaceuticals, Inc. Dérivés deutériés d'intédanib et leur utilisation pour le traitement de troubles prolifératifs
JP7110094B2 (ja) * 2015-11-19 2022-08-01 バイオヘイブン・ファーマシューティカル・ホールディング・カンパニー・リミテッド 医薬化合物のアミンプロドラッグ

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO310238B1 (no) * 1992-12-24 2001-06-11 Bristol Myers Squibb Co Kjemiske forbindelser og farmasöytisk preparat samt anvendelse av slike preparater
CA2129288C (fr) * 1993-08-17 2000-05-16 Jerzy Golik Esters phosphonooxymethyliques de derives de taxane

Also Published As

Publication number Publication date
MX9601994A (es) 1997-08-30
DE69622933D1 (de) 2002-09-19
PT747385E (pt) 2002-11-29
CZ291516B6 (cs) 2003-03-12
PL314637A1 (en) 1996-12-09
KR100375956B1 (ko) 2003-04-21
RU2162082C2 (ru) 2001-01-20
IL118526A0 (en) 1996-10-16
HUP9601524A3 (en) 2000-03-28
CZ156396A3 (en) 1996-12-11
HU9601524D0 (en) 1996-07-29
DK0747385T3 (da) 2002-12-16
NZ286723A (en) 1998-03-25
NO315233B1 (no) 2003-08-04
HUP9601524A2 (en) 1997-05-28
AU695959B2 (en) 1998-08-27
IL118526A (en) 2001-05-20
CA2176191A1 (fr) 1996-12-07
JPH08337589A (ja) 1996-12-24
AR002756A1 (es) 1998-04-29
NO962231L (no) 1996-12-09
CN1066151C (zh) 2001-05-23
ATE222259T1 (de) 2002-08-15
ZA964261B (en) 1997-11-27
PL187883B1 (pl) 2004-10-29
ES2181824T3 (es) 2003-03-01
NO962231D0 (no) 1996-05-31
CN1144805A (zh) 1997-03-12
AU5471896A (en) 1996-12-19
KR970000222A (ko) 1997-01-21
EP0747385A1 (fr) 1996-12-11
TW354293B (en) 1999-03-11
EP0747385B1 (fr) 2002-08-14
DE69622933T2 (de) 2003-04-24

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