SG48889A1 - Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agents - Google Patents
Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agentsInfo
- Publication number
- SG48889A1 SG48889A1 SG1996003475A SG1996003475A SG48889A1 SG 48889 A1 SG48889 A1 SG 48889A1 SG 1996003475 A SG1996003475 A SG 1996003475A SG 1996003475 A SG1996003475 A SG 1996003475A SG 48889 A1 SG48889 A1 SG 48889A1
- Authority
- SG
- Singapore
- Prior art keywords
- contrast agents
- polyamacrocyclocarboxylic
- bicycle
- acid complexes
- complexes
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80527091A | 1991-12-10 | 1991-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG48889A1 true SG48889A1 (en) | 1998-05-18 |
Family
ID=25191100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996003475A SG48889A1 (en) | 1991-12-10 | 1992-12-10 | Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agents |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP0579802B1 (fr) |
| JP (1) | JPH07502277A (fr) |
| AT (1) | ATE192047T1 (fr) |
| AU (1) | AU3415493A (fr) |
| CA (1) | CA2103554C (fr) |
| DE (1) | DE69230970T2 (fr) |
| ES (1) | ES2145041T3 (fr) |
| HU (1) | HUT67602A (fr) |
| IL (1) | IL104059A0 (fr) |
| MX (1) | MX9207164A (fr) |
| SG (1) | SG48889A1 (fr) |
| WO (1) | WO1993011800A1 (fr) |
| ZA (1) | ZA929575B (fr) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334371A (en) * | 1988-07-20 | 1994-08-02 | Schering Aktiengesellschaft | Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI |
| US5385893A (en) * | 1993-05-06 | 1995-01-31 | The Dow Chemical Company | Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents |
| CN1225631A (zh) * | 1996-03-13 | 1999-08-11 | 孟山都公司 | 有歧化过氧化物催化剂效果的含氮大环配位体锰或铁配合物的生物缀合物 |
| US6214817B1 (en) | 1997-06-20 | 2001-04-10 | Monsanto Company | Substituted pyridino pentaazamacrocyle complexes having superoxide dismutase activity |
| ES2240101T3 (es) | 1999-05-27 | 2005-10-16 | Monsanto Company | Biomateriales modificados con mimeticos de superoxido dismutasa. |
| FR2794744B1 (fr) | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
| CA2419629A1 (fr) * | 2000-09-25 | 2002-04-04 | The Procter & Gamble Company | Compositions ameliorant les images irm |
| FR2883562B1 (fr) | 2005-03-24 | 2009-02-27 | Guerbet Sa | Chelates lipophiles et leur utilisation en imagerie |
| FR2891830B1 (fr) | 2005-10-07 | 2011-06-24 | Guerbet Sa | Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale |
| NO331773B1 (no) * | 2009-12-18 | 2012-03-26 | Ge Healthcare As | Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR) |
| ES2626582T5 (es) | 2013-04-26 | 2022-10-07 | Guerbet Sa | Formulación de producto de contraste y su procedimiento de preparación asociado |
| GB201610738D0 (en) | 2016-06-20 | 2016-08-03 | Ge Healthcare As | Chelate compounds |
| JP7034160B2 (ja) | 2016-11-28 | 2022-03-11 | バイエル・ファルマ・アクティエンゲゼルシャフト | 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物 |
| PE20211471A1 (es) | 2018-11-23 | 2021-08-05 | Bayer Ag | Formulacion de medios de contraste y proceso para prepararlos |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957939A (en) * | 1981-07-24 | 1990-09-18 | Schering Aktiengesellschaft | Sterile pharmaceutical compositions of gadolinium chelates useful enhancing NMR imaging |
| SE8502573D0 (sv) * | 1985-05-23 | 1985-05-23 | Jouko Kanakre | Fluorescent lanthanide chelates useful as labels of physiologically active materials |
| US4933441A (en) * | 1987-01-27 | 1990-06-12 | Gibby Wendell A | Contrast enhancing agents for magnetic resonance images |
| SE8702824L (sv) * | 1987-07-10 | 1989-01-11 | Wallac Oy | Metall-kelaterande 2,6-disubstituerade pyridinfoereningar och deras anvaendning |
| DE4001655A1 (de) * | 1990-01-18 | 1991-07-25 | Schering Ag | 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE3825040A1 (de) * | 1988-07-20 | 1990-01-25 | Schering Ag, 13353 Berlin | 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| FR2644785B1 (fr) * | 1989-03-24 | 1991-07-05 | Guerbet Sa | Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant |
| GB9001245D0 (en) * | 1990-01-19 | 1990-03-21 | Salutar Inc | Compounds |
-
1992
- 1992-12-10 HU HU9302309A patent/HUT67602A/hu unknown
- 1992-12-10 DE DE69230970T patent/DE69230970T2/de not_active Expired - Fee Related
- 1992-12-10 WO PCT/US1992/011003 patent/WO1993011800A1/fr active IP Right Grant
- 1992-12-10 JP JP51119493A patent/JPH07502277A/ja active Pending
- 1992-12-10 AU AU34154/93A patent/AU3415493A/en not_active Abandoned
- 1992-12-10 ZA ZA929575A patent/ZA929575B/xx unknown
- 1992-12-10 CA CA002103554A patent/CA2103554C/fr not_active Expired - Fee Related
- 1992-12-10 ES ES93902658T patent/ES2145041T3/es not_active Expired - Lifetime
- 1992-12-10 IL IL104059A patent/IL104059A0/xx unknown
- 1992-12-10 MX MX9207164A patent/MX9207164A/es not_active IP Right Cessation
- 1992-12-10 AT AT93902658T patent/ATE192047T1/de not_active IP Right Cessation
- 1992-12-10 EP EP93902658A patent/EP0579802B1/fr not_active Expired - Lifetime
- 1992-12-10 SG SG1996003475A patent/SG48889A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0579802A1 (fr) | 1994-01-26 |
| IL104059A0 (en) | 1993-05-13 |
| AU3415493A (en) | 1993-07-19 |
| WO1993011800A1 (fr) | 1993-06-24 |
| ZA929575B (en) | 1994-06-10 |
| MX9207164A (es) | 1993-07-01 |
| CA2103554C (fr) | 2002-07-30 |
| CA2103554A1 (fr) | 1993-06-11 |
| EP0579802A4 (en) | 1994-07-06 |
| ES2145041T3 (es) | 2000-07-01 |
| HU9302309D0 (en) | 1993-12-28 |
| EP0579802B1 (fr) | 2000-04-26 |
| HUT67602A (en) | 1995-04-28 |
| DE69230970T2 (de) | 2001-01-04 |
| DE69230970D1 (de) | 2000-05-31 |
| ATE192047T1 (de) | 2000-05-15 |
| JPH07502277A (ja) | 1995-03-09 |
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