SG47583A1 - 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines - Google Patents

4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines

Info

Publication number
SG47583A1
SG47583A1 SG1996002948A SG1996002948A SG47583A1 SG 47583 A1 SG47583 A1 SG 47583A1 SG 1996002948 A SG1996002948 A SG 1996002948A SG 1996002948 A SG1996002948 A SG 1996002948A SG 47583 A1 SG47583 A1 SG 47583A1
Authority
SG
Singapore
Prior art keywords
substituted
pyrimidinamines
phenyl
disclosure describes
describes novel
Prior art date
Application number
SG1996002948A
Other languages
English (en)
Inventor
Lawrence W Torley
Bernard B Johnson
John Paul Dusza
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25224278&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG47583(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SG47583A1 publication Critical patent/SG47583A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Photoreceptors In Electrophotography (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Dental Preparations (AREA)
SG1996002948A 1986-01-13 1987-01-12 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines SG47583A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81795186A 1986-01-13 1986-01-13

Publications (1)

Publication Number Publication Date
SG47583A1 true SG47583A1 (en) 1998-04-17

Family

ID=25224278

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996002948A SG47583A1 (en) 1986-01-13 1987-01-12 4,5,6-Substituted-n- (substituted-phenyl) -2- pyrimidinamines

Country Status (18)

Country Link
EP (1) EP0233461B2 (fr)
JP (1) JPH0780857B2 (fr)
KR (1) KR900004693B1 (fr)
AT (1) ATE135699T1 (fr)
AU (2) AU591223B2 (fr)
BR (1) BR1100989A (fr)
CA (1) CA1320201C (fr)
DE (1) DE3751742T3 (fr)
DK (1) DK171251B1 (fr)
ES (1) ES2087056T3 (fr)
FI (1) FI91150C (fr)
GR (1) GR3019455T3 (fr)
HU (1) HU198708B (fr)
IE (1) IE74202B1 (fr)
NZ (1) NZ218924A (fr)
PH (1) PH25056A (fr)
SG (1) SG47583A1 (fr)
ZA (1) ZA87219B (fr)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966622A (en) * 1988-04-12 1990-10-30 Ciba-Geigy Corporation N-phenyl-N-pyrimidin-2-ylureas
FR2632521B1 (fr) * 1988-06-10 1990-09-14 Rhone Poulenc Sante Nouveaux derives de la phenothiazine, leur preparation et les compositions pharmaceutiques qui les contiennent
IE62023B1 (en) * 1989-01-02 1994-12-14 Boots Co Plc Therapeutic agents
GB8903592D0 (en) * 1989-02-16 1989-04-05 Boots Co Plc Therapeutic agents
IN172842B (fr) * 1990-05-17 1993-12-11 Boots Pharmaceuticals Limited
CN1037346C (zh) * 1990-06-29 1998-02-11 布茨公司 降血糖的脒类和胍类的制备方法
US5270319A (en) * 1991-09-09 1993-12-14 Warner-Lambert Company 5-hydroxy-2-pyrimidinylmethylene derivatives useful as antiinflammatory agents
US5162328A (en) * 1991-12-31 1992-11-10 American Cyanamid Company N-[3-[2-(1H-imidazol-1-yl)ethoxy]phenyl]-4-(2-thienyl)-2-pyrimidinamine and pharmacologically acceptable salts
US5196431A (en) * 1992-02-24 1993-03-23 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5220025A (en) * 1992-02-24 1993-06-15 Warner-Lambert Company 2-substituted amino-4, 6-di-tertiary-butyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
US5521184A (en) * 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
TW225528B (fr) * 1992-04-03 1994-06-21 Ciba Geigy Ag
GB9212673D0 (en) * 1992-06-15 1992-07-29 Celltech Ltd Chemical compounds
US5516775A (en) * 1992-08-31 1996-05-14 Ciba-Geigy Corporation Further use of pyrimidine derivatives
GB9222253D0 (en) * 1992-10-23 1992-12-09 Celltech Ltd Chemical compounds
GB9304920D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
GB9304919D0 (en) * 1993-03-10 1993-04-28 Celltech Ltd Chemical compounds
PL179417B1 (en) * 1993-10-01 2000-09-29 Novartis Ag Pharmacologically active derivatives of pyridine and methods of obtaining them
US5612340A (en) * 1993-10-01 1997-03-18 Ciba-Geigy Corporation Pyrimidineamine derivatives and processes for the preparation thereof
PT672042E (pt) * 1993-10-01 2006-08-31 Novartis Ag Derivados de pirimidinoamina farmacologicamente activos e processos para a sua preparacao
US5543520A (en) * 1993-10-01 1996-08-06 Ciba-Geigy Corporation Pyrimidine derivatives
GB9326699D0 (en) * 1993-12-22 1994-03-02 Celltech Ltd Chemical compounds
EP0738268B1 (fr) * 1993-12-22 2004-03-03 Celltech R&D Limited Derives de phenyle trisubstitues, leurs procedes de preparation et leur utilisation sous forme d'inhibiteurs de la phosphodiesterase (type iv)
US6245774B1 (en) 1994-06-21 2001-06-12 Celltech Therapeutics Limited Tri-substituted phenyl or pyridine derivatives
US5786354A (en) * 1994-06-21 1998-07-28 Celltech Therapeutics, Limited Tri-substituted phenyl derivatives and processes for their preparation
GB9412571D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412573D0 (en) * 1994-06-22 1994-08-10 Celltech Ltd Chemical compounds
GB9412672D0 (en) * 1994-06-23 1994-08-10 Celltech Ltd Chemical compounds
GB9523675D0 (en) 1995-11-20 1996-01-24 Celltech Therapeutics Ltd Chemical compounds
GB9526246D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526245D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
GB9526243D0 (en) * 1995-12-21 1996-02-21 Celltech Therapeutics Ltd Chemical compounds
ZA9610687B (en) * 1995-12-22 1997-09-29 Smithkline Beecham Corp Novel synthesis.
JP2000506532A (ja) * 1996-03-13 2000-05-30 スミスクライン・ビーチャム・コーポレイション サイトカイン介在疾患の治療にて有用な新規ピリミジン化合物
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
GB9619284D0 (en) * 1996-09-16 1996-10-30 Celltech Therapeutics Ltd Chemical compounds
GB9622363D0 (en) * 1996-10-28 1997-01-08 Celltech Therapeutics Ltd Chemical compounds
GB9625184D0 (en) * 1996-12-04 1997-01-22 Celltech Therapeutics Ltd Chemical compounds
AU5330698A (en) 1996-12-23 1998-07-17 Celltech Therapeutics Limited Fused polycyclic 2-aminopyrimidine derivatives, their preparation and their use as protein tyrosine kinase inhibitors
GB9705361D0 (en) 1997-03-14 1997-04-30 Celltech Therapeutics Ltd Chemical compounds
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
WO2000025780A1 (fr) * 1998-10-29 2000-05-11 Bristol-Myers Squibb Company Composes derives d'un noyau amine inhibiteurs de l'enzyme impdh
US6239279B1 (en) 1998-12-16 2001-05-29 Smithkline Beecham Corporation Synthesis for 4-aryl-5-pyrimidine imidazole substituted derivatives
GB9914258D0 (en) 1999-06-18 1999-08-18 Celltech Therapeutics Ltd Chemical compounds
CA2376951A1 (fr) 1999-06-30 2001-01-04 Peter J. Sinclair Composes inhibiteurs de la kinase src
JP2003503351A (ja) 1999-06-30 2003-01-28 メルク エンド カムパニー インコーポレーテッド Ｓｒｃキナーゼ阻害化合物
ATE253915T1 (de) * 1999-06-30 2003-11-15 Merck & Co Inc Src-kinase hemmende verbindungen
GB9924862D0 (en) 1999-10-20 1999-12-22 Celltech Therapeutics Ltd Chemical compounds
HUP0301117A3 (en) * 2000-02-17 2004-01-28 Amgen Inc Thousand Oaks Imidazole derivatives kinase inhibitors, their use, process for their preparation and pharmaceutical compositions containing them
CN100355751C (zh) * 2000-03-29 2007-12-19 西克拉塞尔有限公司 2－取代的4－杂芳基－嘧啶、其组合物及其用途
US7429599B2 (en) * 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
US7122544B2 (en) * 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
IL156784A0 (en) * 2001-02-20 2004-02-08 Astrazeneca Ab 2-arylamino-pyrimidines for the treatment of gsk3-related disorders
GB0107901D0 (en) * 2001-03-29 2001-05-23 Cyclacel Ltd Anti-cancer compounds
CA2460909A1 (fr) 2001-09-28 2003-04-10 Cyclacel Limited N-(4-(4-methylthiazol-5-yl) pyrimidine-2-yl) -n-phenylamines comme composes a action antiproliferante
EA007063B1 (ru) * 2001-11-01 2006-06-30 Янссен Фармацевтика Н.В. ПРОИЗВОДНЫЕ АМИНОБЕНЗАМИДОВ В КАЧЕСТВЕ ИНГИБИТОРОВ ГЛИКОГЕНСИНТАЗА-КИНАЗЫ 3β;
CA2463822A1 (fr) 2001-11-01 2003-05-08 Janssen Pharmaceutica N.V. Heteroaryl amines utiles comme inhibiteurs de glycogene synthase kinase 3beta (inhibiteurs de gsk3)
AR038368A1 (es) 2002-02-01 2005-01-12 Novartis Ag Compuestos n-pirimidin-2-il-aminas sustituidas como inhibidores de ige, una composicion farmaceutica y el uso de dichos compuestos para la preparacion de un medicamento
GB0222514D0 (en) 2002-09-27 2002-11-06 Novartis Ag Organic compounds
GB0229581D0 (en) * 2002-12-19 2003-01-22 Cyclacel Ltd Use
ES2403558T3 (es) 2004-08-27 2013-05-20 Cyclacel Limited Inhibidores purínicos y pirimidínicos de CDK y su uso para el tratamiento de enfermedades autoinmunitarias
US7786132B2 (en) 2004-12-17 2010-08-31 Amgen Inc. Aminopyrimidine compounds and methods of use
GB0500492D0 (en) * 2005-01-11 2005-02-16 Cyclacel Ltd Compound
GB0520958D0 (en) 2005-10-14 2005-11-23 Cyclacel Ltd Compound
JP2009519218A (ja) * 2005-11-03 2009-05-14 エスジーエックス ファーマシューティカルズ、インコーポレイテッド ピリミジニル−チオフェンキナーゼモジュレータ
AU2007336933A1 (en) * 2006-12-22 2008-07-03 Novartis Ag Heteroaryl-heteroaryl compounds as CDK inhibitors for the treatment of cancer, inflammation and viral infections
PT2200436E (pt) 2007-09-04 2015-04-29 Scripps Research Inst Pirimidinilaminas substituídas como inibidoras da proteína quinase
US7923450B2 (en) 2008-01-11 2011-04-12 Hoffmann-La Roche Inc. Modulators for amyloid beta
WO2009103652A1 (fr) * 2008-02-22 2009-08-27 F. Hoffmann-La Roche Ag Modulateurs de la bêta-amyloïde
KR101324414B1 (ko) 2008-10-09 2013-11-01 에프. 호프만-라 로슈 아게 아밀로이드 베타의 조절자
CN102209537A (zh) 2008-11-10 2011-10-05 弗·哈夫曼-拉罗切有限公司 杂环γ分泌酶调节剂
WO2010068863A2 (fr) 2008-12-12 2010-06-17 Cystic Fibrosis Foundation Therapeutics, Inc. Composés de pyrimidine et leurs procédés de fabrication et d'utilisation
US8486967B2 (en) 2010-02-17 2013-07-16 Hoffmann-La Roche Inc. Heteroaryl substituted piperidines
US8334292B1 (en) 2010-06-14 2012-12-18 Cystic Fibrosis Foundation Therapeutics, Inc. Pyrimidine compounds and methods of making and using same
WO2013035102A1 (fr) 2011-09-05 2013-03-14 Natco Pharma Limited Procédés pour la préparation d'imatinib sous forme de base et leurs intermédiaires
RU2486180C1 (ru) * 2011-11-02 2013-06-27 Общество с ограниченной ответственностью "ТехноХим" (ООО "ТехноХим") Способ получения 2-ариламино-4-гетарилпиримидинов
WO2014055972A2 (fr) * 2012-10-05 2014-04-10 The Regents Of The University Of California Nouvelle entité chimique utile dans le traitement de diverses maladies
CN114181199B (zh) * 2020-09-15 2023-09-26 成都赜灵生物医药科技有限公司 2，4-二取代嘧啶衍生物及其制备方法和用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB735702A (en) * 1952-03-18 1955-08-24 Wellcome Found Improvements in and relating to 2,4-diaminopyrimidines and methods of making the same
US4512993A (en) * 1983-07-25 1985-04-23 Sterling Drug Inc. 4(Or 5)-(pyridinyl)-2-pyrimidinamines and cardiotonic use thereof
US4504482A (en) * 1983-07-28 1985-03-12 Sterling Drug Inc. [5(or 4)-(Pyridinyl)-2-pyrimidinyl]ureas and cardiotonic use thereof
GB8412184D0 (en) * 1984-05-12 1984-06-20 Fisons Plc Biologically active nitrogen heterocycles
EP0164204A1 (fr) † 1984-05-12 1985-12-11 FISONS plc Pyrimidines utiles dans des préparations pharmaceutiques
US4725600A (en) † 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPS62501632A (ja) * 1985-02-05 1987-07-02 ジ・アップジョン・カンパニ− ４−置換−６−アリ−ルピリミジン化合物
US4711888A (en) * 1985-07-24 1987-12-08 Pfizer Inc. Hydroxy and alkoxy pyrimidines

Also Published As

Publication number Publication date
KR870007154A (ko) 1987-08-17
HUT43582A (en) 1987-11-30
DK171251B1 (da) 1996-08-12
JPS62223177A (ja) 1987-10-01
EP0233461A3 (en) 1988-05-25
DE3751742T3 (de) 2002-11-21
GR3019455T3 (en) 1996-06-30
BR1100989A (pt) 1999-11-09
DE3751742D1 (de) 1996-04-25
ZA87219B (en) 1987-08-26
CA1320201C (fr) 1993-07-13
DE3751742T2 (de) 1996-11-21
HU198708B (en) 1989-11-28
JPH0780857B2 (ja) 1995-08-30
FI870113A (fi) 1987-07-14
PH25056A (en) 1991-01-28
NZ218924A (en) 1990-04-26
DK15187A (da) 1987-07-14
ATE135699T1 (de) 1996-04-15
AU6751887A (en) 1987-07-16
AU621461B2 (en) 1992-03-12
DK15187D0 (da) 1987-01-13
FI91150B (fi) 1994-02-15
KR900004693B1 (ko) 1990-07-02
FI870113A0 (fi) 1987-01-13
AU5057890A (en) 1990-07-26
EP0233461A2 (fr) 1987-08-26
FI91150C (fi) 1994-05-25
AU591223B2 (en) 1989-11-30
ES2087056T3 (es) 1996-07-16
IE870074L (en) 1987-07-13
EP0233461B1 (fr) 1996-03-20
IE74202B1 (en) 1997-07-16
EP0233461B2 (fr) 2002-05-29

Similar Documents

Publication Publication Date Title
EP0233461A3 (en) 4,5,6-substituted-2-pyrimidinamines
DE3784147D1 (en) 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-en-2-carbonsaeure-derivate.
GR3006319T3 (fr)
GR3004959T3 (fr)
DE3761977D1 (en) 2-phosphonobutan-1,2,4-tricarbonsaeurederivate als emulgatoren.
EP0429060A3 (en) Benzothiazepines
DE3775837D1 (en) 1,7-substituierte heptin-2-one.
ZA87428B (en) Novel 2,4-diamino-6-haloalkylpyrimidines
ZA874093B (en) Certain 2-phenylacetyl-1,3,5-cyclohexanetriones
CS594886A1 (en) Sposob vyroby derivatov 2,1,3 benzotiadiazin 4 on 2,2 dioxidu
CS1003186A1 (en) Zpusob vyroby 1,6 disubstituovanych n ( 8alfa ergolinyl .p n, n, diethylmocovin
CS698486A1 (en) Zpusob pripravy 1 amino 8 naftol 3,6 disulfonove kyseliny
CS393386A1 (en) Sposob pripravy 2,2 dibenztiazolyldisulfidu
IE870340L (en) 1,4-benzoxazine hypotensives.
CS632786A1 (en) N (2,6 dichlorfenyl) benziminofenylether
IE870825L (en) 1,4-diazepines.
CS241986A1 (en) Zvaraci prasok pre elektrotroskove zvaranie hlinika 22, 04 04 86
IL100160A0 (en) Substituted 1,2,3-thiadiazole-4-thiolates
IE862861L (en) Substituted 1,1,2-triphenylbut-1-enes
IE860757L (en) Substituted 1,8-naphthyridinones
CS829086A1 (en) Zpusob pipravy noveho fluorovaneho 10 piperazino10,11 dihydrodibenzo(b,f) thiepinu
CS857186A1 (en) Zpusob pripravy 1 tricyklo (3,3,1,13,7) dekankarboxylove kyseliny
CS361486A1 (en) Zpusob rafinacni kondenzace 9,10 antrachinonu
CS232186A1 (en) Zpusob pripravy 2,5 dijod 4 hydroxybenzonitrilu
CS368686A1 (en) Zpusob pripravy 2,2,6,6 tetrametyl 4 piperidonoximu