SG19895G - Novel indole derivatives - Google Patents

Novel indole derivatives

Info

Publication number
SG19895G
SG19895G SG19895A SG19895A SG19895G SG 19895 G SG19895 G SG 19895G SG 19895 A SG19895 A SG 19895A SG 19895 A SG19895 A SG 19895A SG 19895 G SG19895 G SG 19895G
Authority
SG
Singapore
Prior art keywords
hydrogen
alkyl
substituted
hydroxy
optionally
Prior art date
Application number
SG19895A
Other languages
English (en)
Inventor
Jens Kristian Perregaard
Henrik Pedersen
Kim Andersen
Klaus Peter Boegesoe
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DK158590A priority Critical patent/DK158590D0/da
Priority to IE200091A priority patent/IE65339B1/en
Priority to IL9849591A priority patent/IL98495A/en
Priority to NO912301A priority patent/NO178191C/no
Priority to DE69105839T priority patent/DE69105839T2/de
Priority to AT91610055T priority patent/ATE115576T1/de
Priority to ES91610055T priority patent/ES2064973T3/es
Priority to EP91610055A priority patent/EP0465398B1/en
Priority to DK91610055.5T priority patent/DK0465398T3/da
Priority to KR1019910010711A priority patent/KR950010163B1/ko
Priority to US07/722,081 priority patent/US5216001A/en
Priority to NZ238757A priority patent/NZ238757A/xx
Priority to CA002045955A priority patent/CA2045955C/en
Priority to JP3160289A priority patent/JP3057109B2/ja
Priority to PT98168A priority patent/PT98168B/pt
Priority to FI913194A priority patent/FI101223B1/fi
Priority to ZA915110A priority patent/ZA915110B/xx
Priority to AU80144/91A priority patent/AU644186B2/en
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Priority to SG19895A priority patent/SG19895G/en
Priority to GR950400464T priority patent/GR3015286T3/el
Priority to HK52195A priority patent/HK52195A/xx
Publication of SG19895G publication Critical patent/SG19895G/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Paints Or Removers (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG19895A 1990-07-02 1995-02-07 Novel indole derivatives SG19895G (en)

Priority Applications (21)

Application Number Priority Date Filing Date Title
DK158590A DK158590D0 (da) 1990-07-02 1990-07-02 Indolderivater
IE200091A IE65339B1 (en) 1990-07-02 1991-06-12 Novel indole derivatives
IL9849591A IL98495A (en) 1990-07-02 1991-06-13 History of indole, the process for their preparation and the pharmaceutical preparations containing them
NO912301A NO178191C (no) 1990-07-02 1991-06-14 Analogifremgangsmåte ved fremstilling av terapeutisk aktive indolderivater
AT91610055T ATE115576T1 (de) 1990-07-02 1991-06-24 Neue indolderivate.
ES91610055T ES2064973T3 (es) 1990-07-02 1991-06-24 Nuevos derivados de indol.
EP91610055A EP0465398B1 (en) 1990-07-02 1991-06-24 Novel indole derivatives
DK91610055.5T DK0465398T3 (da) 1990-07-02 1991-06-24 Indolforbindelser
DE69105839T DE69105839T2 (de) 1990-07-02 1991-06-24 Neue Indolderivate.
KR1019910010711A KR950010163B1 (ko) 1990-07-02 1991-06-26 신규 인돌 유도체
US07/722,081 US5216001A (en) 1990-07-02 1991-06-27 Indole derivatives
NZ238757A NZ238757A (en) 1990-07-02 1991-06-27 Optionally heterocyclically-substituted 3-(piperidyl or piperazinyl)-indole derivatives and pharmaceutical compositions
CA002045955A CA2045955C (en) 1990-07-02 1991-06-28 Indole derivatives
PT98168A PT98168B (pt) 1990-07-02 1991-07-01 Processo para a preparacao de novos derivados do indole e de composicoes farmaceuticas que os contem
FI913194A FI101223B1 (fi) 1990-07-02 1991-07-01 Menetelmä uusien terapeuttisesti käyttökelpoisten 6-substituoitujen tai 2-alkyylisubstituoitujen indoli- tai 2,3-dihydroindolijohdannaisten valmistamiseksi
JP3160289A JP3057109B2 (ja) 1990-07-02 1991-07-01 新規インドール誘導体
ZA915110A ZA915110B (en) 1990-07-02 1991-07-02 Indole derivatives
AU80144/91A AU644186B2 (en) 1990-07-02 1991-07-02 Novel indole derivatives
SG19895A SG19895G (en) 1990-07-02 1995-02-07 Novel indole derivatives
GR950400464T GR3015286T3 (en) 1990-07-02 1995-03-03 Novel indole derivatives.
HK52195A HK52195A (en) 1990-07-02 1995-04-06 Novel indole derivatives.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK158590A DK158590D0 (da) 1990-07-02 1990-07-02 Indolderivater
SG19895A SG19895G (en) 1990-07-02 1995-02-07 Novel indole derivatives

Publications (1)

Publication Number Publication Date
SG19895G true SG19895G (en) 1995-08-18

Family

ID=26065925

Family Applications (1)

Application Number Title Priority Date Filing Date
SG19895A SG19895G (en) 1990-07-02 1995-02-07 Novel indole derivatives

Country Status (20)

Country Link
US (1) US5216001A (no)
EP (1) EP0465398B1 (no)
JP (1) JP3057109B2 (no)
KR (1) KR950010163B1 (no)
AT (1) ATE115576T1 (no)
AU (1) AU644186B2 (no)
CA (1) CA2045955C (no)
DE (1) DE69105839T2 (no)
DK (2) DK158590D0 (no)
ES (1) ES2064973T3 (no)
FI (1) FI101223B1 (no)
GR (1) GR3015286T3 (no)
HK (1) HK52195A (no)
IE (1) IE65339B1 (no)
IL (1) IL98495A (no)
NO (1) NO178191C (no)
NZ (1) NZ238757A (no)
PT (1) PT98168B (no)
SG (1) SG19895G (no)
ZA (1) ZA915110B (no)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK152090D0 (da) * 1990-06-22 1990-06-22 Lundbaek A S H Piperidylsubstituerede indolderivater
US5545644A (en) * 1990-10-15 1996-08-13 Pfizer Inc. Indole derivatives
US5607951A (en) * 1990-10-15 1997-03-04 Pfizer Inc Indole derivatives
US5559246A (en) * 1990-10-15 1996-09-24 Pfizer Inc. Indole derivatives
US5578612A (en) * 1990-10-15 1996-11-26 Pfizer Inc. Indole derivatives
US5559129A (en) * 1990-10-15 1996-09-24 Pfizer Inc Indole derivatives
US5643784A (en) * 1990-12-04 1997-07-01 H, Lundbeck A/S Indan derivatives
DK36291D0 (da) * 1991-03-01 1991-03-01 Lundbeck & Co As H Anvendelse af piperidylsubstituerede indolderivater til behandling af kognitive lidelser
NZ243065A (en) * 1991-06-13 1995-07-26 Lundbeck & Co As H Piperidine derivatives and pharmaceutical compositions
DK206591D0 (da) * 1991-12-23 1991-12-23 Lundbeck & Co As H Behandling af psykoser
US5599774A (en) * 1992-01-22 1997-02-04 Imperial Chemical Industries Plc N-arylindoles and their use as herbicides
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater
US5240927A (en) * 1992-05-19 1993-08-31 Hoechst-Roussel Pharmaceuticals Incorporated Benzo[β]thiophen-3-yl piperazines as antipsychotic agents
EP0664801A1 (en) * 1992-08-05 1995-08-02 JOHN WYETH & BROTHER LIMITED Amide derivatives
TW251284B (no) * 1992-11-02 1995-07-11 Pfizer
EP0716649B1 (en) * 1993-08-31 1998-09-09 Pfizer Inc. 5-arylindole derivatives
DK139593D0 (da) * 1993-12-16 1993-12-16 Lundbeck & Co As H Compounds
US5468768A (en) * 1994-01-06 1995-11-21 Bristol-Myers Squibb Company Antimigraine derivatives of indolylcycloalkanylamines
GB9417310D0 (en) 1994-08-27 1994-10-19 Pfizer Ltd Therapeutic agents
US5521196A (en) * 1994-10-05 1996-05-28 Eli Lilly And Company 5-HT1F agonists for the treatment of migraine
US5521197A (en) * 1994-12-01 1996-05-28 Eli Lilly And Company 3-<1-alkylenearyl>-4-<1,2,3,6-tetrahydropyridinyl>-and 3-<1-alkylenearyl>-4-piperidinyl-1h-indoles: new 5-HT1F agonists
AU702322B2 (en) * 1995-03-20 1999-02-18 Eli Lilly And Company 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles: new 5-ht1f agonists
KR100466955B1 (ko) * 1996-02-26 2005-06-10 에자이 가부시키가이샤 항종양제함유조성물
GB9700895D0 (en) * 1997-01-17 1997-03-05 Lilly Co Eli Pharmaceutical compounds
DE19707628A1 (de) * 1997-02-26 1998-08-27 Merck Patent Gmbh Oxazolidinone
AR013669A1 (es) * 1997-10-07 2001-01-10 Smithkline Beecham Corp Compuestos y metodos
GB9805716D0 (en) * 1998-03-17 1998-05-13 Merck Sharp & Dohme Therapeutic agents
GB9815317D0 (en) * 1998-07-15 1998-09-16 Merck Sharp & Dohme Therapeutic agents
GB9816263D0 (en) 1998-07-24 1998-09-23 Merck Sharp & Dohme Therapeutic agents
US5994352A (en) * 1998-11-13 1999-11-30 Pfizer Inc. 5-arylindole derivatives
DE60000405T2 (de) * 1999-01-07 2003-08-07 Wyeth, Madison 1,4-disubstitutierte cyclohexanderivate zur behandlung von depression
US6200994B1 (en) 1999-01-07 2001-03-13 American Home Products Corp 1,4-Disubstituted cyclohexane derivatives for the treatment of depression
EP1173432B9 (en) * 1999-04-21 2008-10-15 NPS Allelix Corp. Piperidine-indole compounds having 5-ht6 affinity
US6281207B1 (en) * 1999-09-15 2001-08-28 Reed Richter Treatment of movement disorders by administration of mirtazapine
MXPA04009365A (es) * 2002-03-27 2005-01-25 Lundbeck & Co As H Metodo para la manufactura de sertindol.
JP2022512588A (ja) 2018-10-05 2022-02-07 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１アンチトリプシンのモジュレーター
UY38696A (es) * 2019-05-14 2020-11-30 Vertex Pharma Moduladores de alfa-1 antitripsina
CA3229361A1 (en) * 2021-08-20 2023-02-23 Abdelmalik Slassi 3-cycloamino-indole compounds as serotonergic agents useful for the treatment of disorders related thereto

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB944443A (no) * 1959-09-25 1900-01-01
DE2322470A1 (de) * 1973-05-04 1974-11-21 Boehringer Sohn Ingelheim Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
FR2533924A1 (fr) * 1982-10-05 1984-04-06 Roussel Uclaf Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant
IE55972B1 (en) * 1982-10-07 1991-03-13 Kefalas As Phenylindene derivatives,acid addition salts thereof,and methods of preparation
GB8427125D0 (en) * 1984-10-26 1984-12-05 Lundbeck & Co As H Organic compounds
IE58370B1 (en) * 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives

Also Published As

Publication number Publication date
ES2064973T3 (es) 1995-02-01
AU644186B2 (en) 1993-12-02
EP0465398B1 (en) 1994-12-14
FI101223B (fi) 1998-05-15
GR3015286T3 (en) 1995-06-30
NO178191B (no) 1995-10-30
EP0465398A3 (en) 1992-03-04
NO912301L (no) 1992-01-03
IL98495A0 (en) 1992-07-15
NO912301D0 (no) 1991-06-14
PT98168B (pt) 1998-12-31
KR950010163B1 (ko) 1995-09-11
DE69105839T2 (de) 1995-04-27
AU8014491A (en) 1992-01-02
NZ238757A (en) 1993-08-26
FI913194A0 (fi) 1991-07-01
CA2045955A1 (en) 1992-01-03
DE69105839D1 (de) 1995-01-26
DK158590D0 (da) 1990-07-02
FI913194A (fi) 1992-01-03
IL98495A (en) 1995-06-29
ZA915110B (en) 1992-05-27
JP3057109B2 (ja) 2000-06-26
JPH04253976A (ja) 1992-09-09
HK52195A (en) 1995-04-13
PT98168A (pt) 1992-05-29
EP0465398A2 (en) 1992-01-08
ATE115576T1 (de) 1994-12-15
CA2045955C (en) 2002-08-27
IE912000A1 (en) 1992-01-15
US5216001A (en) 1993-06-01
DK0465398T3 (da) 1995-05-22
FI101223B1 (fi) 1998-05-15
IE65339B1 (en) 1995-10-18
KR920002586A (ko) 1992-02-28
NO178191C (no) 1996-02-07

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