SG152923A1 - Biochemical methods for measuring metabolic fitness of tissues or whole organisms - Google Patents

Biochemical methods for measuring metabolic fitness of tissues or whole organisms

Info

Publication number
SG152923A1
SG152923A1 SG200706374-6A SG2007063746A SG152923A1 SG 152923 A1 SG152923 A1 SG 152923A1 SG 2007063746 A SG2007063746 A SG 2007063746A SG 152923 A1 SG152923 A1 SG 152923A1
Authority
SG
Singapore
Prior art keywords
aerobic
metabolic fitness
tissues
biochemical methods
fitness
Prior art date
Application number
SG200706374-6A
Other languages
English (en)
Inventor
Marc K Hellerstein
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of SG152923A1 publication Critical patent/SG152923A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0491—Sugars, nucleosides, nucleotides, oligonucleotides, nucleic acids, e.g. DNA, RNA, nucleic acid aptamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0402—Organic compounds carboxylic acid carriers, fatty acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5076—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving cell organelles, e.g. Golgi complex, endoplasmic reticulum
    • G01N33/5079—Mitochondria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG200706374-6A 2002-09-16 2003-09-16 Biochemical methods for measuring metabolic fitness of tissues or whole organisms SG152923A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41102902P 2002-09-16 2002-09-16

Publications (1)

Publication Number Publication Date
SG152923A1 true SG152923A1 (en) 2009-06-29

Family

ID=31994237

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200706374-6A SG152923A1 (en) 2002-09-16 2003-09-16 Biochemical methods for measuring metabolic fitness of tissues or whole organisms

Country Status (9)

Country Link
US (1) US20040081994A1 (fr)
EP (1) EP1545628A4 (fr)
JP (1) JP2005539069A (fr)
AU (1) AU2003275037A1 (fr)
CA (1) CA2498583A1 (fr)
HK (1) HK1079707A1 (fr)
SG (1) SG152923A1 (fr)
TW (1) TW200502394A (fr)
WO (1) WO2004024941A2 (fr)

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WO2003068919A2 (fr) * 2002-02-12 2003-08-21 The Regents Of The University Of California Mesure de vitesses de biosynthese et de degradation de molecules biologiques inaccessibles ou peu accessibles a un echantillonnage direct, de maniere non invasive, par incorporation d'etiquettes dans des derives metaboliques et des produits cataboliques
WO2003087314A2 (fr) * 2002-04-05 2003-10-23 The Regents Of The University Of California Procede permettant d'isoler et de mesurer la proliferation de cellules retenant des marqueurs a long terme et de cellules souches
CA2494715C (fr) 2002-07-30 2014-07-08 The Regents Of The University Of California Procede de mesure automatique a grande echelle des taux de flux moleculaire par spectrometrie de masse
US20060105339A1 (en) * 2002-09-04 2006-05-18 Marc Hellerstein Methods for measuring the rates of replication and death of microbial infectious agents in an infected
SG149699A1 (en) * 2002-09-13 2009-02-27 Univ California Methods for measuring rates of reverse cholesterol transport in vivo, as an index of anti-atherogenesis
US20070248540A1 (en) * 2002-09-16 2007-10-25 The Regents Of The University Of California Biochemical methods for measuring metabolic fitness of tissues or whole organisms
JP4611025B2 (ja) * 2002-11-04 2011-01-12 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 体内のブドウ糖または脂肪酸の代謝に関する高処理量測定のための重水素化ブドウ糖または脂肪の耐性試験
US7262020B2 (en) * 2003-07-03 2007-08-28 The Regents Of The University Of California Methods for comparing relative flux rates of two or more biological molecules in vivo through a single protocol
US20050202406A1 (en) * 2003-11-25 2005-09-15 The Regents Of The University Of California Method for high-throughput screening of compounds and combinations of compounds for discovery and quantification of actions, particularly unanticipated therapeutic or toxic actions, in biological systems
ATE554391T1 (de) * 2003-12-19 2012-05-15 Max Planck Gesellschaft Verfahren zur analyse von metaboliten
TW200538738A (en) 2004-02-20 2005-12-01 Univ California Molecular flux rates through critical pathways measured by stable isotope labeling in vivo, as biomarkers of drug action and disease activity
WO2005094327A2 (fr) * 2004-03-29 2005-10-13 The Regents Of The University Of California Isolation de cellules epitheliales ou de leurs contenus biochimiques a partir de feces apres marquage isotopique in vivo
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JP4488852B2 (ja) * 2004-09-17 2010-06-23 味の素ゼネラルフーヅ株式会社 体内脂肪低減作用を有する組成物
US20060251576A1 (en) * 2005-05-03 2006-11-09 The Regents Of The University Of California Methods for measuring cholesterol metabolism and transport
TW200711660A (en) * 2005-06-10 2007-04-01 Univ California Monitoring two dimensions of diabetes pathogenesis separately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development
KR101300336B1 (ko) * 2006-01-24 2013-08-28 아지노모또 제네럴 푸즈, 인크. 혈압의 강하 작용 및/또는 상승 억제 작용을 갖는 조성물 및 이를 함유하는 음식물
JP4771882B2 (ja) * 2006-07-21 2011-09-14 味の素ゼネラルフーヅ株式会社 糖尿病または糖尿病性合併症の治療、予防、または改善作用を有する組成物およびこれを含有する飲料
KR100940511B1 (ko) 2007-08-20 2010-03-08 미토테크 주식회사 미토콘드리아 기반 대사진단 시스템 및 대사진단 방법
JP5526379B2 (ja) * 2009-06-25 2014-06-18 独立行政法人製品評価技術基盤機構 新規化合物の同定法
US9110008B2 (en) 2010-07-26 2015-08-18 Los Gatos Research Method for isotopic analysis of water in bodily fluids
JP2014526685A (ja) * 2011-09-08 2014-10-06 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 代謝流量測定、画像化、および顕微鏡法
JP5821447B2 (ja) * 2011-09-13 2015-11-24 大正製薬株式会社 カルジオリピンを用いた疲労の判定方法
JP6024939B2 (ja) * 2011-10-12 2016-11-16 国立大学法人金沢大学 薬物代謝機能測定方法
CA2858368A1 (fr) 2011-12-07 2013-06-13 Glaxosmithkline Llc Procedes de determination de la masse musculaire squelettique totale du corps
US9134319B2 (en) 2013-03-15 2015-09-15 The Regents Of The University Of California Method for replacing biomarkers of protein kinetics from tissue samples by biomarkers of protein kinetics from body fluids after isotopic labeling in vivo
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Also Published As

Publication number Publication date
WO2004024941A2 (fr) 2004-03-25
EP1545628A2 (fr) 2005-06-29
CA2498583A1 (fr) 2004-03-25
HK1079707A1 (zh) 2006-04-13
AU2003275037A1 (en) 2004-04-30
JP2005539069A (ja) 2005-12-22
TW200502394A (en) 2005-01-16
EP1545628A4 (fr) 2010-07-28
WO2004024941A3 (fr) 2004-11-11
US20040081994A1 (en) 2004-04-29

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