SG11202112064XA - Synthesis of labeled imidazo[1,2-a]pyrimidines - Google Patents

Synthesis of labeled imidazo[1,2-a]pyrimidines

Info

Publication number
SG11202112064XA
SG11202112064XA SG11202112064XA SG11202112064XA SG11202112064XA SG 11202112064X A SG11202112064X A SG 11202112064XA SG 11202112064X A SG11202112064X A SG 11202112064XA SG 11202112064X A SG11202112064X A SG 11202112064XA SG 11202112064X A SG11202112064X A SG 11202112064XA
Authority
SG
Singapore
Prior art keywords
pyrimidines
imidazo
labeled
synthesis
labeled imidazo
Prior art date
Application number
SG11202112064XA
Other languages
English (en)
Inventor
Kyle Bradley Pascual Clagg
Nicholas Andrew White
Haiming Zhang
Francis Gosselin
William Nack
Paul O'shea
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG11202112064XA publication Critical patent/SG11202112064XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C07F9/24—Esteramides
    • C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11202112064XA 2019-05-09 2020-05-07 Synthesis of labeled imidazo[1,2-a]pyrimidines SG11202112064XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962845840P 2019-05-09 2019-05-09
US201962937069P 2019-11-18 2019-11-18
PCT/US2020/031952 WO2020227575A1 (en) 2019-05-09 2020-05-07 Synthesis of labeled imidazo[1,2-a]pyrimidines

Publications (1)

Publication Number Publication Date
SG11202112064XA true SG11202112064XA (en) 2021-11-29

Family

ID=70775603

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202112064XA SG11202112064XA (en) 2019-05-09 2020-05-07 Synthesis of labeled imidazo[1,2-a]pyrimidines

Country Status (13)

Country Link
US (2) US11325912B2 (ko)
EP (2) EP3966216A1 (ko)
JP (2) JP7369208B2 (ko)
KR (1) KR20220005065A (ko)
CN (2) CN114026092A (ko)
AU (1) AU2020267664B2 (ko)
BR (1) BR112021022395A2 (ko)
CA (1) CA3138873C (ko)
IL (1) IL287887A (ko)
MX (1) MX2021013574A (ko)
SG (1) SG11202112064XA (ko)
TW (2) TWI751548B (ko)
WO (2) WO2020227575A1 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7369208B2 (ja) * 2019-05-09 2023-10-25 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 標識されたイミダゾ［１，２－ａ］ピリミジンの合成
CN114621191B (zh) * 2022-04-18 2023-08-15 东南大学 Ezh2抑制剂及其制备和应用
CN115015443B (zh) * 2022-07-22 2023-11-10 浙江省疾病预防控制中心 一种茶叶和/或咖啡中丙烯酰胺和甲基咪唑类化合物的同时检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE588247A (ko) * 1959-03-03 1900-01-01
WO2009000412A1 (en) * 2007-06-26 2008-12-31 Sanofi Aventis A regioselective metal catalyzed synthesis of annelated benzimidazoles and azabenzimidazoles
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
JP2012521988A (ja) * 2009-03-23 2012-09-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 神経学的障害を検知するためのイメージング剤
MX2016014615A (es) * 2014-05-13 2017-03-06 Hoffmann La Roche Compuestos heterociclicos deuterados y su uso como agentes formadores de imagenes.
BR112017004140B1 (pt) 2014-08-29 2023-01-10 Chdi Foundation, Inc. Agente de imagemamento, seu uso e compostos
CN107108604B (zh) 2014-10-27 2020-07-24 豪夫迈·罗氏有限公司 制备三环内酰胺化合物的方法
GB2548839B (en) 2016-03-29 2021-02-24 Great Matter Pharma Ab New uses and methods
IL290809B2 (en) 2016-11-01 2024-01-01 Arvinas Operations Inc PROTACS Targeted Tau-Protein and Related Methods of Use
JP7369208B2 (ja) * 2019-05-09 2023-10-25 エフ・ホフマン－ラ・ロシュ・アクチェンゲゼルシャフト 標識されたイミダゾ［１，２－ａ］ピリミジンの合成

Also Published As

Publication number Publication date
AU2020267664A1 (en) 2021-12-02
WO2020227575A1 (en) 2020-11-12
US20200354369A1 (en) 2020-11-12
JP7369208B2 (ja) 2023-10-25
JP2022531936A (ja) 2022-07-12
WO2020227576A1 (en) 2020-11-12
TWI751548B (zh) 2022-01-01
EP3966215A1 (en) 2022-03-16
BR112021022395A2 (pt) 2021-12-28
TW202235420A (zh) 2022-09-16
CN114026092A (zh) 2022-02-08
CA3138873A1 (en) 2020-11-12
CN114423763A (zh) 2022-04-29
US11325912B2 (en) 2022-05-10
EP3966216A1 (en) 2022-03-16
US20200369670A1 (en) 2020-11-26
IL287887A (en) 2022-01-01
TW202108586A (zh) 2021-03-01
TWI804079B (zh) 2023-06-01
MX2021013574A (es) 2021-12-10
AU2020267664B2 (en) 2023-04-27
US11136330B2 (en) 2021-10-05
CA3138873C (en) 2024-01-09
KR20220005065A (ko) 2022-01-12
JP7384926B2 (ja) 2023-11-21
JP2022531011A (ja) 2022-07-05

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