SG11202110986YA - Method for purifying fc region-modified antibody - Google Patents

Method for purifying fc region-modified antibody

Info

Publication number
SG11202110986YA
SG11202110986YA SG11202110986YA SG11202110986YA SG11202110986YA SG 11202110986Y A SG11202110986Y A SG 11202110986YA SG 11202110986Y A SG11202110986Y A SG 11202110986YA SG 11202110986Y A SG11202110986Y A SG 11202110986YA SG 11202110986Y A SG11202110986Y A SG 11202110986YA
Authority
SG
Singapore
Prior art keywords
purifying
region
modified antibody
antibody
modified
Prior art date
Application number
SG11202110986YA
Other languages
English (en)
Inventor
Tetsuya Wakabayashi
Yuichiro Shimizu
Masahiro Fukunaga
Eiji Majima
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of SG11202110986YA publication Critical patent/SG11202110986YA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
SG11202110986YA 2019-04-10 2020-04-09 Method for purifying fc region-modified antibody SG11202110986YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2019074738 2019-04-10
PCT/JP2020/015904 WO2020209318A1 (fr) 2019-04-10 2020-04-09 Procédé de purification d'anticorps modifié en région fc

Publications (1)

Publication Number Publication Date
SG11202110986YA true SG11202110986YA (en) 2021-11-29

Family

ID=72752051

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202110986YA SG11202110986YA (en) 2019-04-10 2020-04-09 Method for purifying fc region-modified antibody

Country Status (13)

Country Link
US (1) US20220213140A1 (fr)
EP (1) EP3954696A4 (fr)
JP (1) JPWO2020209318A1 (fr)
KR (1) KR20210149779A (fr)
CN (1) CN113906042A (fr)
AU (1) AU2020273072A1 (fr)
BR (1) BR112021020204A2 (fr)
CA (1) CA3136398A1 (fr)
IL (1) IL286982A (fr)
MX (1) MX2021012251A (fr)
SG (1) SG11202110986YA (fr)
TW (1) TW202104244A (fr)
WO (1) WO2020209318A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI564021B (zh) 2008-04-11 2017-01-01 Chugai Pharmaceutical Co Ltd Repeated binding of antigen to antigen binding molecules
MX365235B (es) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno.
CA2963760A1 (fr) 2014-12-19 2016-06-23 Yoshinao Ruike Anticorps anti-myostatine, polypeptides contenant des variants de regions fc, et procedes d'utilisation
CA3026050A1 (fr) 2016-08-05 2018-02-08 Chugai Seiyaku Kabushiki Kaisha Composition pour la prophylaxie ou le traitement de maladies liees a il-8

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
DK0585287T3 (da) 1990-07-10 2000-04-17 Cambridge Antibody Tech Fremgangsmåde til fremstilling af specifikke bindingsparelementer
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
KR100272077B1 (ko) 1990-08-29 2000-11-15 젠팜인터내셔날,인코포레이티드 이종 항체를 생산할 수 있는 전이유전자를 가진 인간이외의 동물
GB9022547D0 (en) 1990-10-17 1990-11-28 Wellcome Found Purified immunoglobulin
AU668349B2 (en) 1991-04-25 1996-05-02 Chugai Seiyaku Kabushiki Kaisha Reconstituted human antibody against human interleukin 6 receptor
WO1993006213A1 (fr) 1991-09-23 1993-04-01 Medical Research Council Production d'anticorps chimeriques - une approche combinatoire
ES2341666T3 (es) 1991-12-02 2010-06-24 Medimmune Limited Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
CA2124967C (fr) 1991-12-17 2008-04-08 Nils Lonberg Animaux transgeniques non humains capables de produire des anticorps heterologues
CA2131151A1 (fr) 1992-03-24 1994-09-30 Kevin S. Johnson Methodes de production d'elements formant des paires specifiques de liaison
JPH07509137A (ja) 1992-07-24 1995-10-12 セル　ジェネシス，インク． 異種抗体の生産
EP0754225A4 (fr) 1993-04-26 2001-01-31 Genpharm Int Animaux transgeniques capables de produire des anticorps heterologues
GB9313509D0 (en) 1993-06-30 1993-08-11 Medical Res Council Chemisynthetic libraries
JPH09506508A (ja) 1993-12-03 1997-06-30 メディカル リサーチ カウンシル 組換え結合タンパク質およびペプチド
WO1996002576A1 (fr) 1994-07-13 1996-02-01 Chugai Seiyaku Kabushiki Kaisha Anticorps humain reconstitue contre l'interleukine-8 humaine
KR20050085971A (ko) 1995-04-27 2005-08-29 아브게닉스, 인크. 면역화된 제노마우스 유래의 인간 항체
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
CN101987870B (zh) 2004-07-15 2013-07-03 赞科股份有限公司 优化的Fc变体
EP2845865A1 (fr) 2004-11-12 2015-03-11 Xencor Inc. Variantes Fc avec liaison altérée en FcRn
DE602006003695D1 (de) 2005-01-05 2009-01-02 F Star Biotech Forsch & Entw Synthetische Immunoglobulindomänen mit in Regionen des Moleküls, die sich von den die Komplementarität bestimmenden Bereichen unterscheiden, modifizierten Bindeeigenschaften
JP4179517B2 (ja) 2006-02-21 2008-11-12 プロテノバ株式会社 イムノグロブリン親和性リガンド
WO2007097361A1 (fr) * 2006-02-21 2007-08-30 Protenova Co., Ltd. Ligand presentant une affinite pour les immunoglobulines
JP5624276B2 (ja) 2006-03-31 2014-11-12 中外製薬株式会社 抗体の血中動態を制御する方法
ES2566957T3 (es) 2007-09-26 2016-04-18 Chugai Seiyaku Kabushiki Kaisha Región constante de anticuerpo modificado
EP3575317A1 (fr) 2007-12-26 2019-12-04 Xencor, Inc. Variants fc avec liaison altérée à fcrn
TWI564021B (zh) 2008-04-11 2017-01-01 Chugai Pharmaceutical Co Ltd Repeated binding of antigen to antigen binding molecules
JP5229888B2 (ja) * 2008-09-30 2013-07-03 独立行政法人産業技術総合研究所 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤
TWI667257B (zh) 2010-03-30 2019-08-01 中外製藥股份有限公司 促進抗原消失之具有經修飾的ＦｃＲｎ親和力之抗體
CN103052649B (zh) 2010-07-29 2015-12-16 Xencor公司 具有修改的等电点的抗体
MX365235B (es) 2010-11-30 2019-05-28 Chugai Pharmaceutical Co Ltd Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno.
WO2012132067A1 (fr) 2011-03-30 2012-10-04 中外製薬株式会社 Rétention de molécules de liaison d'antigène dans le plasma sanguin et procédé pour modifier l'immunogénicité
US10065995B2 (en) * 2011-03-25 2018-09-04 Kaneka Corporation Protein for affinity-separation matrix
TW201817745A (zh) 2011-09-30 2018-05-16 日商中外製藥股份有限公司 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子
SG11201401101XA (en) 2011-09-30 2014-08-28 Chugai Pharmaceutical Co Ltd Antigen-binding molecule for promoting loss of antigens
DK2857419T3 (da) 2012-05-30 2021-03-29 Chugai Pharmaceutical Co Ltd Antigen-bindende molekyle til eliminering af aggregerede antigener
CA2874721A1 (fr) 2012-05-30 2013-12-05 Tomoyuki Igawa Molecule de liaison d'antigene specifique a un tissu cible
WO2014145159A2 (fr) 2013-03-15 2014-09-18 Permeon Biologics, Inc. Anticorps à charge génétiquement modifiée ou compositions de protéines de ciblage à pénétration améliorée et méthodes d'utilisation
JP6153801B2 (ja) 2013-07-23 2017-06-28 旭化成ホームズ株式会社 ノズル
WO2015034000A1 (fr) * 2013-09-04 2015-03-12 プロテノバ株式会社 Multimère du domaine de liaison de l'immunoglobuline
JP2015185254A (ja) 2014-03-20 2015-10-22 日立マクセル株式会社 非水電解質二次電池
CA2963760A1 (fr) * 2014-12-19 2016-06-23 Yoshinao Ruike Anticorps anti-myostatine, polypeptides contenant des variants de regions fc, et procedes d'utilisation
KR20240058997A (ko) 2015-12-18 2024-05-03 추가이 세이야쿠 가부시키가이샤 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법

Also Published As

Publication number Publication date
MX2021012251A (es) 2021-11-12
CN113906042A (zh) 2022-01-07
US20220213140A1 (en) 2022-07-07
CA3136398A1 (fr) 2020-10-15
WO2020209318A1 (fr) 2020-10-15
EP3954696A4 (fr) 2023-07-26
TW202104244A (zh) 2021-02-01
AU2020273072A1 (en) 2021-12-09
BR112021020204A2 (pt) 2021-12-07
KR20210149779A (ko) 2021-12-09
IL286982A (en) 2021-12-01
EP3954696A1 (fr) 2022-02-16
JPWO2020209318A1 (fr) 2020-10-15

Similar Documents

Publication Publication Date Title
IL286982A (en) A method for purifying an fc region-modified antibody
EP3306310A4 (fr) Procédé de quantification d'anticorps monoclonal
EP3294766C0 (fr) Anticorps humanisé ou fragment de celui-ci spécifique pour cd3
IL281570A (en) Methods for the purification of multispecific heterodimeric antibodies
IL265016B (en) A method for purifying antibodies
EP3845548A4 (fr) Procédé de purification d'un anticorps ou d'une molécule de type anticorps
EP3805246A4 (fr) Procédé de purification de polypeptide à chaîne longue
IL280140A (en) Antigen purification method
EP3521299A4 (fr) Procédé de purification de protéine recombinée
IL282035A (en) Method for purifying cannabinoids
IL272807B2 (en) A method for cleaning proteins
EP3904320A4 (fr) Procédé de purification d'hexafluorobutadiène
EP3291837A4 (fr) Cocktails d'anticorps monoclonaux pour le traitement d'infections à ebola
EP3092002A4 (fr) Procédé de purification d'anticorps monoclonaux
IL277056A (en) Methods for purifying antibodies
EP3375875A4 (fr) AGENT DE SÉPARATION POUR DES ANTICORPS POLYCLONAUX HUMAINS DE TYPE IgG DÉRIVÉS DE SÉRUM ET PROCÉDÉ POUR LA SÉPARATION D'ANTICORPS POLYCLONAUX HUMAINS DE TYPE IgG DÉRIVÉS DE SÉRUM L'UTILISANT
GB201806736D0 (en) Method for virus purification
IL289959A (en) Antibody purification methods
EP3336172A4 (fr) Procédé de production d'un anticorps monoclonal spécifique d'un antigène
EP3738681A4 (fr) Procédé de fabrication d'un dispositif de purification de gaz d'échappement
EP3560571C0 (fr) Procede de purification de fructose
IL258189A (en) Antibodies from humans against prostate-specific antigen (5I.10)
GB201911685D0 (en) Process for purifying monoclonal antibodies
EP4019930A4 (fr) Procédé de purification d'huiles
IL279684A (en) A method for purifying cysteamine