SG11202109279PA - Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells - Google Patents

Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

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Publication number
SG11202109279PA
SG11202109279PA SG11202109279PA SG11202109279PA SG11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA SG 11202109279P A SG11202109279P A SG 11202109279PA
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Singapore
Prior art keywords
cells
day
human
thymic epithelial
pharyngeal
Prior art date
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SG11202109279PA
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English (en)
Inventor
Pena Rafael Gras
Megan Sykes
Nichole Danzl
Mohsen Khosravi-Maharlooei
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Univ Columbia
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Publication of SG11202109279PA publication Critical patent/SG11202109279PA/en

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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/065—Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/26—Lymph; Lymph nodes; Thymus; Spleen; Splenocytes; Thymocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/55—Glands not provided for in groups A61K35/22 - A61K35/545, e.g. thyroids, parathyroids or pineal glands
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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SG11202109279PA 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells SG11202109279PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962827383P 2019-04-01 2019-04-01
PCT/US2020/025955 WO2020205859A1 (en) 2019-04-01 2020-03-31 Methods of promoting thymic epithelial cell and thymic epithelial cell progenitor differentiation of pluripotent stem cells

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SG11202109279PA true SG11202109279PA (en) 2021-09-29

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US (1) US20220127569A1 (cg-RX-API-DMAC7.html)
EP (1) EP3947639A4 (cg-RX-API-DMAC7.html)
JP (2) JP7740706B2 (cg-RX-API-DMAC7.html)
KR (1) KR20210146297A (cg-RX-API-DMAC7.html)
CN (2) CN113646423B (cg-RX-API-DMAC7.html)
AU (1) AU2020253429B2 (cg-RX-API-DMAC7.html)
CA (1) CA3135377A1 (cg-RX-API-DMAC7.html)
IL (1) IL286936A (cg-RX-API-DMAC7.html)
MX (1) MX2021012041A (cg-RX-API-DMAC7.html)
SG (1) SG11202109279PA (cg-RX-API-DMAC7.html)
WO (1) WO2020205859A1 (cg-RX-API-DMAC7.html)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4142754A4 (en) * 2020-04-28 2024-06-12 The Regents Of The University Of California METHODS FOR IN VITRO GENERATION OF THYMIC CELLS
US20240076618A1 (en) * 2021-01-15 2024-03-07 The Board Of Trustees Of The Leland Stanford Junior University Generation of induced human thymic epithelial cells and its application in cell-based immunotherapies
CN113215081B (zh) * 2021-06-01 2023-04-14 华中科技大学同济医学院附属同济医院 诱导干细胞分化为甲状旁腺细胞的方法及其组合物
KR20240075885A (ko) * 2021-10-15 2024-05-29 타이뮨 테라퓨틱스, 인코포레이티드 가슴샘 세포 및 제조 방법
EP4293110A1 (en) 2022-06-17 2023-12-20 Nantes Université Process for obtaining functional lymphocytes cells
WO2025136749A1 (en) * 2023-12-19 2025-06-26 The Board Of Trustees Of The Leland Stanford Junior University Thymic epithelial cells and methods of producing and using the same
CN119614476B (zh) * 2024-11-13 2026-05-15 广州市第一人民医院（广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院） 胸腺类器官的构建方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL156200A0 (en) 2000-12-22 2003-12-23 Univ Edinburgh Thymic epithelial progenitor cells and pharmaceutical compositions containing the same
WO2010143529A1 (ja) * 2009-06-09 2010-12-16 国立大学法人名古屋大学 多能性幹細胞を胸腺上皮へ分化誘導する方法
JP2013524836A (ja) * 2010-04-25 2013-06-20 マウント・シナイ・スクール・オブ・メディスン 多能性細胞からの前部前腸内胚葉の生成
CN102732479B (zh) * 2011-03-31 2014-08-27 北京大学 胸腺上皮前体细胞的制备方法及其专用培养基
US9657273B2 (en) * 2012-10-12 2017-05-23 Industry-University Cooperation Foundation Sogang University Method for suppressing teratoma formation via selective cell death induction in undifferentiated human-induced pluripotent stem cells
WO2014134213A1 (en) 2013-02-27 2014-09-04 The Regents Of The University Of California Generation of thymic epithelial progenitor cells in vitro
WO2019060336A1 (en) 2017-09-20 2019-03-28 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services IN VITRO GENERATION OF THYMIC ORGANOID FROM HUMAN PLURIPOTENT STEM CELLS
EP3959304A4 (en) * 2019-04-26 2023-01-25 The Regents Of The University Of Colorado, A Body Corporate GENERATION OF FUNCTIONAL AND PATIENT-SPECIFIC THYMUS TISSUE IN VIVO FROM INDUCED PLURIPOTENTS STEM CELLS
CA3159010A1 (en) * 2019-11-25 2021-06-03 Yong Fan Thymus organoids bioengineered form human pluripotent stem cells

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AU2020253429A1 (en) 2021-09-09
EP3947639A1 (en) 2022-02-09
EP3947639A4 (en) 2023-01-25
AU2020253429B2 (en) 2026-05-28
IL286936A (en) 2021-10-31
CN113646423A (zh) 2021-11-12
KR20210146297A (ko) 2021-12-03
JP2024153768A (ja) 2024-10-29
WO2020205859A1 (en) 2020-10-08
CN119351306A (zh) 2025-01-24
CN113646423B (zh) 2024-10-01
JP2022527338A (ja) 2022-06-01
JP7740706B2 (ja) 2025-09-17
CA3135377A1 (en) 2020-10-08
MX2021012041A (es) 2021-11-03
US20220127569A1 (en) 2022-04-28

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