SG11202107439XA - Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same - Google Patents

Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

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Publication number
SG11202107439XA
SG11202107439XA SG11202107439XA SG11202107439XA SG11202107439XA SG 11202107439X A SG11202107439X A SG 11202107439XA SG 11202107439X A SG11202107439X A SG 11202107439XA SG 11202107439X A SG11202107439X A SG 11202107439XA SG 11202107439X A SG11202107439X A SG 11202107439XA
Authority
SG
Singapore
Prior art keywords
dioxopiperidin
oxoisoindolin
fluorobenzonitrile
piperazin
oxy
Prior art date
Application number
SG11202107439XA
Other languages
English (en)
Inventor
Artman, III
Antonio Ferretti
Lianfeng Huang
Udaykumar Jain
Hon-Wah Man
Paula Tavares-Greco
Wenju Wu
Nancy Tsou
Zhiwei Yin
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of SG11202107439XA publication Critical patent/SG11202107439XA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG11202107439XA 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same SG11202107439XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962790342P 2019-01-09 2019-01-09
PCT/US2020/012687 WO2020146463A1 (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Publications (1)

Publication Number Publication Date
SG11202107439XA true SG11202107439XA (en) 2021-08-30

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ID=69467745

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107439XA SG11202107439XA (en) 2019-01-09 2020-01-08 Solid forms comprising (s)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl) benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

Country Status (13)

Country Link
US (2) US11370777B2 (zh)
EP (1) EP3908582A1 (zh)
JP (1) JP7483722B2 (zh)
KR (1) KR20210125491A (zh)
CN (3) CN118324742A (zh)
AU (1) AU2020206694A1 (zh)
BR (1) BR112021013435A2 (zh)
CA (1) CA3125756A1 (zh)
EA (1) EA202191620A1 (zh)
IL (1) IL284680A (zh)
MX (1) MX2021008295A (zh)
SG (1) SG11202107439XA (zh)
WO (1) WO2020146463A1 (zh)

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CN113597301A (zh) * 2019-01-09 2021-11-02 细胞基因公司 包含(s)-4-(4-(4-(((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-4-基)氧基)甲基)苄基)哌嗪-1-基)-3-氟苄腈的药物组合物以及使用它的方法
US20230114674A1 (en) * 2020-01-20 2023-04-13 Kangpu Biopharmaceuticals, Ltd. Isoindoline derivative, and pharmaceutical composition and use thereof
MX2023012911A (es) 2021-05-27 2023-11-08 Celgene Corp Metodos de tratamiento del mieloma multiple usando terapia combinada.

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BR112021013435A2 (pt) 2021-10-19
CN118324742A (zh) 2024-07-12
JP7483722B2 (ja) 2024-05-15
JP2022518175A (ja) 2022-03-14
AU2020206694A1 (en) 2021-07-29
CA3125756A1 (en) 2020-07-16
US11370777B2 (en) 2022-06-28
CN114394954A (zh) 2022-04-26
US20220289713A1 (en) 2022-09-15
IL284680A (en) 2021-08-31
US20200216418A1 (en) 2020-07-09
EA202191620A1 (ru) 2021-11-01
KR20210125491A (ko) 2021-10-18
CN113597425A (zh) 2021-11-02
MX2021008295A (es) 2021-10-13
WO2020146463A1 (en) 2020-07-16
EP3908582A1 (en) 2021-11-17
CN114394954B (zh) 2024-04-02

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