SG11202104413TA - Filterable duocarmycin-containing antibody-drug conjugate compositions and related methods - Google Patents
Filterable duocarmycin-containing antibody-drug conjugate compositions and related methodsInfo
- Publication number
- SG11202104413TA SG11202104413TA SG11202104413TA SG11202104413TA SG11202104413TA SG 11202104413T A SG11202104413T A SG 11202104413TA SG 11202104413T A SG11202104413T A SG 11202104413TA SG 11202104413T A SG11202104413T A SG 11202104413TA SG 11202104413T A SG11202104413T A SG 11202104413TA
- Authority
- SG
- Singapore
- Prior art keywords
- duocarmycin
- filterable
- drug conjugate
- related methods
- containing antibody
- Prior art date
Links
- 239000000611 antibody drug conjugate Substances 0.000 title 1
- 229940049595 antibody-drug conjugate Drugs 0.000 title 1
- VQNATVDKACXKTF-XELLLNAOSA-N duocarmycin Chemical compound COC1=C(OC)C(OC)=C2NC(C(=O)N3C4=CC(=O)C5=C([C@@]64C[C@@H]6C3)C=C(N5)C(=O)OC)=CC2=C1 VQNATVDKACXKTF-XELLLNAOSA-N 0.000 title 1
- 229960005501 duocarmycin Drugs 0.000 title 1
- 229930184221 duocarmycin Natural products 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18205459 | 2018-11-09 | ||
| PCT/EP2019/080084 WO2020094561A1 (en) | 2018-11-09 | 2019-11-04 | Filterable duocarmycin-containing antibody-drug conjugate compositions and related methods |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202104413TA true SG11202104413TA (en) | 2021-05-28 |
Family
ID=64270729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202104413TA SG11202104413TA (en) | 2018-11-09 | 2019-11-04 | Filterable duocarmycin-containing antibody-drug conjugate compositions and related methods |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20210386867A1 (es) |
| EP (1) | EP3876997B1 (es) |
| JP (1) | JP2022506860A (es) |
| KR (1) | KR20210091752A (es) |
| CN (1) | CN112969478B (es) |
| AU (1) | AU2019376457A1 (es) |
| BR (1) | BR112021008293A2 (es) |
| CA (1) | CA3118788A1 (es) |
| CL (1) | CL2021001199A1 (es) |
| DK (1) | DK3876997T3 (es) |
| ES (1) | ES2926980T3 (es) |
| HR (1) | HRP20221197T1 (es) |
| HU (1) | HUE059919T2 (es) |
| IL (1) | IL282913B2 (es) |
| LT (1) | LT3876997T (es) |
| MX (1) | MX2021005484A (es) |
| PL (1) | PL3876997T3 (es) |
| PT (1) | PT3876997T (es) |
| SG (1) | SG11202104413TA (es) |
| WO (1) | WO2020094561A1 (es) |
| ZA (1) | ZA202102798B (es) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI412367B (zh) | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| RU2562232C2 (ru) | 2008-11-03 | 2015-09-10 | Синтарга Б.В. | Новые аналоги сс-1065 и их конъюгаты |
| CA2796712C (en) | 2010-04-21 | 2017-02-28 | Syntarga B.V. | Novel conjugates of cc-1065 analogs and bifunctional linkers |
| HUE046816T2 (hu) * | 2013-10-11 | 2020-03-30 | Asana Biosciences Llc | Fehérje-polimer-gyógyszer konjugátumok |
| JP6560681B2 (ja) | 2013-12-27 | 2019-08-14 | ザイムワークス インコーポレイティド | 薬物結合体のためのスルホンアミド含有連結系 |
| RU2689779C2 (ru) * | 2014-01-10 | 2019-05-29 | Синтон Байофармасьютикалс Б. В. | Дуокармициновые adc, демонстрирующие улучшенную противоопухолевую активность in vivo |
| JP6517240B2 (ja) | 2014-05-22 | 2019-05-22 | シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． | 抗体へのリンカー薬物の部位特異的コンジュゲーションおよび得られるａｄｃ |
| LT3152191T (lt) * | 2014-06-05 | 2019-08-26 | Synthon Biopharmaceuticals B.V. | Pagerintas duokarmicino provaistų gavimo būdas |
| JP6522806B2 (ja) * | 2015-07-10 | 2019-05-29 | シントン・バイオファーマシューティカルズ・ビー．ブイ．Ｓｙｎｔｈｏｎ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｂ．Ｖ． | 抗体デュオカルマイシン薬物複合体を含む組成物 |
| RU2728101C2 (ru) * | 2015-09-22 | 2020-07-28 | Байондис Б.В. | Лечение syd985 пациентов с t-dm1 рефрактерным раком |
| TWI660741B (zh) * | 2015-11-03 | 2019-06-01 | 財團法人工業技術研究院 | 抗體藥物複合物及其製造方法 |
-
2019
- 2019-11-04 IL IL282913A patent/IL282913B2/en unknown
- 2019-11-04 HU HUE19795572A patent/HUE059919T2/hu unknown
- 2019-11-04 DK DK19795572.7T patent/DK3876997T3/da active
- 2019-11-04 US US17/291,141 patent/US20210386867A1/en active Pending
- 2019-11-04 LT LTEPPCT/EP2019/080084T patent/LT3876997T/lt unknown
- 2019-11-04 BR BR112021008293-0A patent/BR112021008293A2/pt unknown
- 2019-11-04 SG SG11202104413TA patent/SG11202104413TA/en unknown
- 2019-11-04 WO PCT/EP2019/080084 patent/WO2020094561A1/en unknown
- 2019-11-04 AU AU2019376457A patent/AU2019376457A1/en active Pending
- 2019-11-04 CA CA3118788A patent/CA3118788A1/en active Pending
- 2019-11-04 HR HRP20221197TT patent/HRP20221197T1/hr unknown
- 2019-11-04 ES ES19795572T patent/ES2926980T3/es active Active
- 2019-11-04 EP EP19795572.7A patent/EP3876997B1/en active Active
- 2019-11-04 PL PL19795572.7T patent/PL3876997T3/pl unknown
- 2019-11-04 PT PT197955727T patent/PT3876997T/pt unknown
- 2019-11-04 KR KR1020217017573A patent/KR20210091752A/ko active Search and Examination
- 2019-11-04 MX MX2021005484A patent/MX2021005484A/es unknown
- 2019-11-04 JP JP2021524477A patent/JP2022506860A/ja active Pending
- 2019-11-04 CN CN201980073803.0A patent/CN112969478B/zh active Active
-
2021
- 2021-04-26 ZA ZA2021/02798A patent/ZA202102798B/en unknown
- 2021-05-06 CL CL2021001199A patent/CL2021001199A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3876997T3 (pl) | 2022-12-19 |
| KR20210091752A (ko) | 2021-07-22 |
| MX2021005484A (es) | 2021-06-18 |
| CN112969478B (zh) | 2023-10-27 |
| ZA202102798B (en) | 2022-08-31 |
| CL2021001199A1 (es) | 2021-12-17 |
| US20210386867A1 (en) | 2021-12-16 |
| HRP20221197T1 (hr) | 2022-12-09 |
| BR112021008293A2 (pt) | 2021-08-03 |
| CA3118788A1 (en) | 2020-05-14 |
| DK3876997T3 (da) | 2022-09-26 |
| IL282913B2 (en) | 2024-07-01 |
| EP3876997B1 (en) | 2022-08-03 |
| CN112969478A (zh) | 2021-06-15 |
| EP3876997A1 (en) | 2021-09-15 |
| IL282913B1 (en) | 2024-03-01 |
| HUE059919T2 (hu) | 2023-01-28 |
| AU2019376457A1 (en) | 2021-05-27 |
| PT3876997T (pt) | 2022-11-11 |
| WO2020094561A1 (en) | 2020-05-14 |
| ES2926980T3 (es) | 2022-10-31 |
| JP2022506860A (ja) | 2022-01-17 |
| IL282913A (en) | 2021-06-30 |
| LT3876997T (lt) | 2022-11-10 |
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