SG11202103733SA - Compositions and methods for transgene expression from an albumin locus - Google Patents

Compositions and methods for transgene expression from an albumin locus

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Publication number
SG11202103733SA
SG11202103733SA SG11202103733SA SG11202103733SA SG11202103733SA SG 11202103733S A SG11202103733S A SG 11202103733SA SG 11202103733S A SG11202103733S A SG 11202103733SA SG 11202103733S A SG11202103733S A SG 11202103733SA SG 11202103733S A SG11202103733S A SG 11202103733SA
Authority
SG
Singapore
Prior art keywords
seq
sequence
nucleic acid
rna
construct
Prior art date
Application number
SG11202103733SA
Other languages
English (en)
Inventor
Jonathan Finn
Hon-Ren Huang
Moitri Roy
Kehdih Lai
Rachel Sattler
Christos Kyratsous
Cheng Wang
Original Assignee
Intellia Therapeutics Inc
Regeneron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc, Regeneron Pharma filed Critical Intellia Therapeutics Inc
Publication of SG11202103733SA publication Critical patent/SG11202103733SA/en

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    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A61K48/0041—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid the non-active part being polymeric
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
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    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/15—Humanized animals
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
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SG11202103733SA 2018-10-18 2019-10-18 Compositions and methods for transgene expression from an albumin locus SG11202103733SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862747402P 2018-10-18 2018-10-18
US201962840346P 2019-04-29 2019-04-29
PCT/US2019/057086 WO2020082042A2 (en) 2018-10-18 2019-10-18 Compositions and methods for transgene expression from an albumin locus

Publications (1)

Publication Number Publication Date
SG11202103733SA true SG11202103733SA (en) 2021-05-28

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SG11202103733SA SG11202103733SA (en) 2018-10-18 2019-10-18 Compositions and methods for transgene expression from an albumin locus

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US (3) US20200270617A1 (enExample)
EP (1) EP3867381A2 (enExample)
JP (2) JP7472121B2 (enExample)
KR (2) KR20260048369A (enExample)
CN (1) CN114207130A (enExample)
AU (2) AU2019361203B2 (enExample)
BR (1) BR112021007343A2 (enExample)
CA (1) CA3116918A1 (enExample)
CO (1) CO2021006363A2 (enExample)
IL (2) IL282236B1 (enExample)
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MY (1) MY208564A (enExample)
PH (1) PH12021550844A1 (enExample)
SA (1) SA521421766B1 (enExample)
SG (1) SG11202103733SA (enExample)
TW (2) TW202507011A (enExample)
WO (1) WO2020082042A2 (enExample)

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KR20250075694A (ko) 2022-09-28 2025-05-28 리제너론 파마슈티칼스 인코포레이티드 세포 기반 요법을 강화하기 위한 항체 저항성 변형 수용체
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