SG11202102526QA - Inhibiting ubiquitin specific peptidase 9x - Google Patents
Inhibiting ubiquitin specific peptidase 9xInfo
- Publication number
- SG11202102526QA SG11202102526QA SG11202102526QA SG11202102526QA SG11202102526QA SG 11202102526Q A SG11202102526Q A SG 11202102526QA SG 11202102526Q A SG11202102526Q A SG 11202102526QA SG 11202102526Q A SG11202102526Q A SG 11202102526QA SG 11202102526Q A SG11202102526Q A SG 11202102526QA
- Authority
- SG
- Singapore
- Prior art keywords
- ubiquitin specific
- specific peptidase
- inhibiting ubiquitin
- inhibiting
- peptidase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862733595P | 2018-09-19 | 2018-09-19 | |
| PCT/US2019/051841 WO2020061261A1 (en) | 2018-09-19 | 2019-09-19 | Inhibiting ubiquitin specific peptidase 9x |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202102526QA true SG11202102526QA (en) | 2021-04-29 |
Family
ID=69887830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202102526QA SG11202102526QA (en) | 2018-09-19 | 2019-09-19 | Inhibiting ubiquitin specific peptidase 9x |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230065368A1 (ja) |
| EP (1) | EP3852790A4 (ja) |
| JP (1) | JP2022501362A (ja) |
| KR (1) | KR20210061400A (ja) |
| CN (1) | CN113164571A (ja) |
| AU (1) | AU2019345053A1 (ja) |
| BR (1) | BR112021004599A2 (ja) |
| CA (1) | CA3113423A1 (ja) |
| IL (1) | IL281483A (ja) |
| MX (1) | MX2021003187A (ja) |
| SG (1) | SG11202102526QA (ja) |
| WO (1) | WO2020061261A1 (ja) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MD3483164T2 (ro) | 2017-03-20 | 2020-07-31 | Forma Therapeutics Inc | Compoziții pirolopirolice ca activatori ai piruvat kinazei (PKR) |
| WO2020061255A1 (en) | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| US20230159538A1 (en) | 2020-04-01 | 2023-05-25 | Global Blood Therapeutics, Inc. | Pyrrolidine-pyrazoles as pyruvate kinase activators |
| WO2022170200A1 (en) | 2021-02-08 | 2022-08-11 | Global Blood Therapeutics, Inc. | 1-(2-sulfonyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4h)-yl]-ethanone derivatives as pyruvate kinase (pkr) and pkm2 activators for the treatment of sickle cell disease |
| CN113416188B (zh) * | 2021-05-31 | 2022-12-13 | 河南偶联生物科技有限公司 | 一种[1,2,4]三唑并[1,5-a]吡啶化合物的合成方法 |
| WO2023060134A1 (en) | 2021-10-06 | 2023-04-13 | Global Blood Therapeutics, Inc. | Lactam pyrrolidine-pyrazoles as pyruvate kinase activators |
| TWI841134B (zh) * | 2021-12-21 | 2024-05-01 | 大陸商賽諾哈勃藥業（成都）有限公司 | 含二氮雜亞基磺醯結構的化合物及其在醫藥上的用途 |
| WO2024112764A1 (en) * | 2022-11-21 | 2024-05-30 | Novo Nordisk Health Care Ag | Synthesis of pyrrolo[3,4-c]pyrroles |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| AU2011305315A1 (en) * | 2010-09-24 | 2013-03-28 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| AU2014331777A1 (en) * | 2013-10-10 | 2016-05-05 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
| WO2016181408A2 (en) * | 2015-05-11 | 2016-11-17 | Cadila Healthcare Limited | NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST |
| PE20180552A1 (es) * | 2015-09-24 | 2018-04-02 | Hoffmann La Roche | Nuevos compuestos biciclicos como inhibidores duales de atx/ca |
| MD3483164T2 (ro) * | 2017-03-20 | 2020-07-31 | Forma Therapeutics Inc | Compoziții pirolopirolice ca activatori ai piruvat kinazei (PKR) |
| WO2020061255A1 (en) * | 2018-09-19 | 2020-03-26 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US20200129485A1 (en) * | 2018-09-19 | 2020-04-30 | Forma Therapeutics, Inc. | Treating sickle cell disease with a pyruvate kinase r activating compound |
| EP3852792A4 (en) * | 2018-09-19 | 2022-07-06 | Forma Therapeutics, Inc. | INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X |
| WO2020191022A1 (en) * | 2019-03-18 | 2020-09-24 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 9x |
-
2019
- 2019-09-19 US US17/277,500 patent/US20230065368A1/en not_active Abandoned
- 2019-09-19 KR KR1020217011475A patent/KR20210061400A/ko unknown
- 2019-09-19 WO PCT/US2019/051841 patent/WO2020061261A1/en active Search and Examination
- 2019-09-19 MX MX2021003187A patent/MX2021003187A/es unknown
- 2019-09-19 SG SG11202102526QA patent/SG11202102526QA/en unknown
- 2019-09-19 JP JP2021515194A patent/JP2022501362A/ja active Pending
- 2019-09-19 CA CA3113423A patent/CA3113423A1/en not_active Abandoned
- 2019-09-19 EP EP19861899.3A patent/EP3852790A4/en not_active Withdrawn
- 2019-09-19 BR BR112021004599-6A patent/BR112021004599A2/pt not_active Application Discontinuation
- 2019-09-19 AU AU2019345053A patent/AU2019345053A1/en not_active Abandoned
- 2019-09-19 CN CN201980068936.9A patent/CN113164571A/zh active Pending
-
2021
- 2021-03-14 IL IL281483A patent/IL281483A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP3852790A1 (en) | 2021-07-28 |
| AU2019345053A1 (en) | 2021-05-06 |
| KR20210061400A (ko) | 2021-05-27 |
| MX2021003187A (es) | 2021-06-23 |
| CA3113423A1 (en) | 2020-03-26 |
| EP3852790A4 (en) | 2022-08-10 |
| US20230065368A1 (en) | 2023-03-02 |
| BR112021004599A2 (pt) | 2021-05-25 |
| WO2020061261A1 (en) | 2020-03-26 |
| JP2022501362A (ja) | 2022-01-06 |
| IL281483A (en) | 2021-04-29 |
| CN113164571A (zh) | 2021-07-23 |
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