MX2021003187A - Inhibición de la peptidasa específica de ubiquitina 9x. - Google Patents
Inhibición de la peptidasa específica de ubiquitina 9x.Info
- Publication number
- MX2021003187A MX2021003187A MX2021003187A MX2021003187A MX2021003187A MX 2021003187 A MX2021003187 A MX 2021003187A MX 2021003187 A MX2021003187 A MX 2021003187A MX 2021003187 A MX2021003187 A MX 2021003187A MX 2021003187 A MX2021003187 A MX 2021003187A
- Authority
- MX
- Mexico
- Prior art keywords
- ubiquitin specific
- specific peptidase
- usp9x
- inhibiting ubiquitin
- inhibiting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/056—Ortho-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La descripción proporciona compuestos químicos nuevos que son útiles como inhibidores de la peptidasa específica de ubiquitina 9X (USP9X). Los compuestos que inhiben la USP9X son útiles en el tratamiento de enfermedades y trastornos relacionados con la modulación de USP9X, tales como el cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862733595P | 2018-09-19 | 2018-09-19 | |
PCT/US2019/051841 WO2020061261A1 (en) | 2018-09-19 | 2019-09-19 | Inhibiting ubiquitin specific peptidase 9x |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021003187A true MX2021003187A (es) | 2021-06-23 |
Family
ID=69887830
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2021003187A MX2021003187A (es) | 2018-09-19 | 2019-09-19 | Inhibición de la peptidasa específica de ubiquitina 9x. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230065368A1 (es) |
EP (1) | EP3852790A4 (es) |
JP (1) | JP2022501362A (es) |
KR (1) | KR20210061400A (es) |
CN (1) | CN113164571A (es) |
AU (1) | AU2019345053A1 (es) |
BR (1) | BR112021004599A2 (es) |
CA (1) | CA3113423A1 (es) |
IL (1) | IL281483A (es) |
MX (1) | MX2021003187A (es) |
SG (1) | SG11202102526QA (es) |
WO (1) | WO2020061261A1 (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3448859T (pt) | 2017-03-20 | 2019-10-25 | Forma Therapeutics Inc | Composições de pirrolopirrole como ativadores de piruvato quinase (pkr). |
EP3853206B1 (en) | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
CN113226356A (zh) | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
EP4126876A1 (en) | 2020-04-01 | 2023-02-08 | Global Blood Therapeutics, Inc. | Pyrrolidine-pyrazoles as pyruvate kinase activators |
TW202245758A (zh) | 2021-02-08 | 2022-12-01 | 美商全球血液治療公司 | 作為丙酮酸激酶活化劑之吡咯啶-吡唑 |
CN113416188B (zh) * | 2021-05-31 | 2022-12-13 | 河南偶联生物科技有限公司 | 一种[1,2,4]三唑并[1,5-a]吡啶化合物的合成方法 |
WO2023060134A1 (en) | 2021-10-06 | 2023-04-13 | Global Blood Therapeutics, Inc. | Lactam pyrrolidine-pyrazoles as pyruvate kinase activators |
WO2023116774A1 (zh) * | 2021-12-21 | 2023-06-29 | 赛诺哈勃药业(成都)有限公司 | 含二氮杂亚基磺酰结构的化合物及其在医药上的用途 |
WO2024112764A1 (en) * | 2022-11-21 | 2024-05-30 | Novo Nordisk Health Care Ag | Synthesis of pyrrolo[3,4-c]pyrroles |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
JP5852658B2 (ja) * | 2010-09-24 | 2016-02-03 | ザ リージェンツ オブ ザ ユニバーシティー オブ ミシガン | デユビキチナーゼ阻害剤およびその使用方法 |
WO2015054555A1 (en) * | 2013-10-10 | 2015-04-16 | The Regents Of The University Of Michigan | Deubiquitinase inhibitors and methods for use of the same |
WO2016181408A2 (en) * | 2015-05-11 | 2016-11-17 | Cadila Healthcare Limited | NOVEL SHORT-CHAIN PEPTIDES AS KAPPA (κ) OPIOID RECEPTORS (KOR) AGONIST |
CN107922415B (zh) * | 2015-09-24 | 2022-04-15 | 豪夫迈·罗氏有限公司 | 新的作为双重atx/ca抑制剂的二环化合物 |
PT3448859T (pt) * | 2017-03-20 | 2019-10-25 | Forma Therapeutics Inc | Composições de pirrolopirrole como ativadores de piruvato quinase (pkr). |
EP3852792A4 (en) * | 2018-09-19 | 2022-07-06 | Forma Therapeutics, Inc. | INHIBITION OF UBIQUITIN-SPECIFIC PEPTIDASE 9X |
EP3853206B1 (en) * | 2018-09-19 | 2024-04-10 | Novo Nordisk Health Care AG | Treating sickle cell disease with a pyruvate kinase r activating compound |
CN113226356A (zh) * | 2018-09-19 | 2021-08-06 | 福马治疗股份有限公司 | 活化丙酮酸激酶r |
WO2020191022A1 (en) * | 2019-03-18 | 2020-09-24 | Forma Therapeutics, Inc. | Inhibiting ubiquitin specific peptidase 9x |
-
2019
- 2019-09-19 EP EP19861899.3A patent/EP3852790A4/en not_active Withdrawn
- 2019-09-19 AU AU2019345053A patent/AU2019345053A1/en not_active Abandoned
- 2019-09-19 JP JP2021515194A patent/JP2022501362A/ja active Pending
- 2019-09-19 BR BR112021004599-6A patent/BR112021004599A2/pt not_active Application Discontinuation
- 2019-09-19 CN CN201980068936.9A patent/CN113164571A/zh active Pending
- 2019-09-19 MX MX2021003187A patent/MX2021003187A/es unknown
- 2019-09-19 SG SG11202102526QA patent/SG11202102526QA/en unknown
- 2019-09-19 US US17/277,500 patent/US20230065368A1/en active Pending
- 2019-09-19 WO PCT/US2019/051841 patent/WO2020061261A1/en active Search and Examination
- 2019-09-19 CA CA3113423A patent/CA3113423A1/en not_active Abandoned
- 2019-09-19 KR KR1020217011475A patent/KR20210061400A/ko unknown
-
2021
- 2021-03-14 IL IL281483A patent/IL281483A/en unknown
Also Published As
Publication number | Publication date |
---|---|
KR20210061400A (ko) | 2021-05-27 |
CA3113423A1 (en) | 2020-03-26 |
WO2020061261A1 (en) | 2020-03-26 |
SG11202102526QA (en) | 2021-04-29 |
JP2022501362A (ja) | 2022-01-06 |
EP3852790A4 (en) | 2022-08-10 |
IL281483A (en) | 2021-04-29 |
CN113164571A (zh) | 2021-07-23 |
US20230065368A1 (en) | 2023-03-02 |
AU2019345053A1 (en) | 2021-05-06 |
EP3852790A1 (en) | 2021-07-28 |
BR112021004599A2 (pt) | 2021-05-25 |
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