SG11202009264WA - Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor - Google Patents

Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor

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Publication number
SG11202009264WA
SG11202009264WA SG11202009264WA SG11202009264WA SG11202009264WA SG 11202009264W A SG11202009264W A SG 11202009264WA SG 11202009264W A SG11202009264W A SG 11202009264WA SG 11202009264W A SG11202009264W A SG 11202009264WA SG 11202009264W A SG11202009264W A SG 11202009264WA
Authority
SG
Singapore
Prior art keywords
solid tumor
drug conjugates
antibody drug
disrupting agents
treat solid
Prior art date
Application number
SG11202009264WA
Other languages
English (en)
Inventor
Anthony Cao
Shyra Gardai
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of SG11202009264WA publication Critical patent/SG11202009264WA/en

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    • AHUMAN NECESSITIES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6805Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a vinca alkaloid
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    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6835Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
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    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/6889Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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SG11202009264WA 2018-03-23 2019-03-22 Use of antibody drug conjugates comprising tubulin disrupting agents to treat solid tumor SG11202009264WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862647346P 2018-03-23 2018-03-23
US201862658276P 2018-04-16 2018-04-16
PCT/US2019/023516 WO2019183438A1 (fr) 2018-03-23 2019-03-22 Utilisation de conjugués anticorps-médicament comprenant des agents de rupture de tubuline pour traiter une tumeur solide

Publications (1)

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SG11202009264WA true SG11202009264WA (en) 2020-10-29

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IL277338A (en) 2020-10-29
EP3768714A1 (fr) 2021-01-27
US20230110128A1 (en) 2023-04-13
TW202003047A (zh) 2020-01-16
CA3093731A1 (fr) 2019-09-26
WO2019183438A1 (fr) 2019-09-26
BR112020018948A2 (pt) 2021-01-05
MA52135A (fr) 2021-01-27
CN112189020A (zh) 2021-01-05
MX2020009842A (es) 2020-10-15
KR20200135841A (ko) 2020-12-03
AU2019240403A1 (en) 2020-10-08
US20190290775A1 (en) 2019-09-26

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