SG11202008162WA - Heteroaryl compounds as type ii irak inhibitors and uses hereof - Google Patents
Heteroaryl compounds as type ii irak inhibitors and uses hereofInfo
- Publication number
- SG11202008162WA SG11202008162WA SG11202008162WA SG11202008162WA SG11202008162WA SG 11202008162W A SG11202008162W A SG 11202008162WA SG 11202008162W A SG11202008162W A SG 11202008162WA SG 11202008162W A SG11202008162W A SG 11202008162WA SG 11202008162W A SG11202008162W A SG 11202008162WA
- Authority
- SG
- Singapore
- Prior art keywords
- type
- heteroaryl compounds
- irak inhibitors
- uses hereof
- hereof
- Prior art date
Links
- 125000001072 heteroaryl group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862652981P | 2018-04-05 | 2018-04-05 | |
PCT/EP2019/058186 WO2019192962A1 (en) | 2018-04-05 | 2019-04-01 | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202008162WA true SG11202008162WA (en) | 2020-09-29 |
Family
ID=66165920
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202008162WA SG11202008162WA (en) | 2018-04-05 | 2019-04-01 | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US11873303B2 (ko) |
EP (1) | EP3774797A1 (ko) |
JP (1) | JP7328987B6 (ko) |
KR (1) | KR20200140302A (ko) |
CN (1) | CN112236429A (ko) |
AU (1) | AU2019249721A1 (ko) |
BR (1) | BR112020018383A2 (ko) |
CA (1) | CA3092625A1 (ko) |
IL (1) | IL277408B1 (ko) |
MX (1) | MX2020009234A (ko) |
SG (1) | SG11202008162WA (ko) |
TW (1) | TW202005968A (ko) |
WO (1) | WO2019192962A1 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019192962A1 (en) * | 2018-04-05 | 2019-10-10 | Merck Patent Gmbh | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
WO2020142559A1 (en) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibitors of menin-mll interaction |
SG11202106304RA (en) | 2018-12-31 | 2021-07-29 | Biomea Fusion Llc | Irreversible inhibitors of menin-mll interaction |
AU2020355359B2 (en) * | 2019-09-26 | 2023-08-24 | Shenzhen Targetrx, Inc. | Substituted aromatic fused ring derivative and composition comprising same, and use thereof |
WO2021226547A2 (en) * | 2020-05-08 | 2021-11-11 | Halia Therapeutics, Inc. | Targeted nek7 inhibition for modulation of the nlrp3 inflammasome |
MX2022013984A (es) * | 2020-05-08 | 2023-01-30 | Halia Therapeutics Inc | Inhibidores de cinasa 7 relacionada con el gen nunca en mitosis a (nek7). |
CA3186041A1 (en) * | 2020-06-08 | 2021-12-16 | Halia Therapeutics, Inc. | Inhibitors of nek7 kinase |
WO2022212326A1 (en) * | 2021-03-29 | 2022-10-06 | Halia Therapeutics, Inc. | Nek7 inhibitors |
WO2022216680A1 (en) * | 2021-04-05 | 2022-10-13 | Halia Therapeutics, Inc. | Nek7 inhibitors |
US20230405151A1 (en) | 2022-04-12 | 2023-12-21 | Genzyme Corporation | Use of irak4 modulators for gene therapy |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20061119A1 (es) | 2005-01-19 | 2006-11-27 | Aventis Pharma Sa | PIRAZOLO PIRIDINAS SUSTITUIDAS COMO INHIBIDORES DE CINASAS FAK, KDR Y Tie |
GB0507575D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
DE102005037499A1 (de) | 2005-08-09 | 2007-02-15 | Merck Patent Gmbh | Pyrazolderivate |
RU2604062C2 (ru) | 2010-07-13 | 2016-12-10 | Ф.Хоффманн-Ля Рош Аг | ПРОИЗВОДНЫЕ ПИРАЗОЛО[1,5-a]ПИРИМИДИНА И ТИЕНО[3,2-b]ПИРИМИДИНА В КАЧЕСТВЕ МОДУЛЯТОРОВ IRAK-4 |
EP3049086A4 (en) * | 2013-09-27 | 2017-02-22 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
EA201690952A1 (ru) | 2013-11-08 | 2016-08-31 | Такеда Фармасьютикал Компани Лимитед | Пиразол для лечения аутоиммунных расстройств |
CA2945819A1 (en) * | 2014-04-22 | 2015-10-29 | Nimbus Iris, Inc. | Irak inhibitors and uses thereof |
BR112016029853A2 (pt) * | 2014-06-20 | 2017-08-22 | Aurigene Discovery Tech Ltd | compostos de indazol substituído como inibidores de irak4 |
MX2017009624A (es) * | 2015-02-06 | 2017-11-20 | Merck Patent Gmbh | Macrociclos de piridazinona como inhibidores de cinasas asociadas al receptor de interleucina 1(irak) y sus usos. |
MA41559A (fr) | 2015-09-08 | 2017-12-26 | Taiho Pharmaceutical Co Ltd | Composé de pyrimidine condensé ou un sel de celui-ci |
SG10201911665UA (en) * | 2016-04-15 | 2020-01-30 | Cancer Research Tech Ltd | Heterocyclic compounds as ret kinase inhibitors |
WO2017205762A1 (en) * | 2016-05-27 | 2017-11-30 | Pharmacyclics Llc | Inhibitors of interleukin-1 receptor-associated kinase |
US20190203253A1 (en) | 2016-07-05 | 2019-07-04 | University Of Saskatchewan | Methods of identifying and treating cancer patients with an ephb6 deficiency |
WO2019192962A1 (en) * | 2018-04-05 | 2019-10-10 | Merck Patent Gmbh | Heteroaryl compounds as type ii irak inhibitors and uses hereof |
-
2019
- 2019-04-01 WO PCT/EP2019/058186 patent/WO2019192962A1/en active Application Filing
- 2019-04-01 MX MX2020009234A patent/MX2020009234A/es unknown
- 2019-04-01 CN CN201980024556.5A patent/CN112236429A/zh active Pending
- 2019-04-01 IL IL277408A patent/IL277408B1/en unknown
- 2019-04-01 EP EP19717239.8A patent/EP3774797A1/en active Pending
- 2019-04-01 KR KR1020207031143A patent/KR20200140302A/ko not_active Application Discontinuation
- 2019-04-01 CA CA3092625A patent/CA3092625A1/en active Pending
- 2019-04-01 AU AU2019249721A patent/AU2019249721A1/en active Pending
- 2019-04-01 SG SG11202008162WA patent/SG11202008162WA/en unknown
- 2019-04-01 US US17/046,751 patent/US11873303B2/en active Active
- 2019-04-01 BR BR112020018383-0A patent/BR112020018383A2/pt unknown
- 2019-04-01 JP JP2020554096A patent/JP7328987B6/ja active Active
- 2019-04-03 TW TW108111900A patent/TW202005968A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
EP3774797A1 (en) | 2021-02-17 |
CA3092625A1 (en) | 2019-10-10 |
JP2021520356A (ja) | 2021-08-19 |
IL277408B1 (en) | 2024-04-01 |
BR112020018383A2 (pt) | 2020-12-29 |
CN112236429A (zh) | 2021-01-15 |
US20210163487A1 (en) | 2021-06-03 |
AU2019249721A1 (en) | 2020-09-17 |
WO2019192962A1 (en) | 2019-10-10 |
RU2020135904A (ru) | 2022-05-05 |
JP7328987B2 (ja) | 2023-08-17 |
JP7328987B6 (ja) | 2023-10-25 |
MX2020009234A (es) | 2020-10-12 |
IL277408A (en) | 2020-11-30 |
TW202005968A (zh) | 2020-02-01 |
US11873303B2 (en) | 2024-01-16 |
KR20200140302A (ko) | 2020-12-15 |
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