SG11202006712XA - Treatment of ophthalmologic diseases - Google Patents

Treatment of ophthalmologic diseases

Info

Publication number
SG11202006712XA
SG11202006712XA SG11202006712XA SG11202006712XA SG11202006712XA SG 11202006712X A SG11202006712X A SG 11202006712XA SG 11202006712X A SG11202006712X A SG 11202006712XA SG 11202006712X A SG11202006712X A SG 11202006712XA SG 11202006712X A SG11202006712X A SG 11202006712XA
Authority
SG
Singapore
Prior art keywords
treatment
ophthalmologic diseases
ophthalmologic
diseases
Prior art date
Application number
SG11202006712XA
Other languages
English (en)
Inventor
Aaron Osborne
Jayashree Sahni
Robert James Weikert
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Publication of SG11202006712XA publication Critical patent/SG11202006712XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Endocrinology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11202006712XA 2018-02-06 2019-02-05 Treatment of ophthalmologic diseases SG11202006712XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862627103P 2018-02-06 2018-02-06
US201862729333P 2018-09-10 2018-09-10
PCT/EP2019/052704 WO2019154776A1 (fr) 2018-02-06 2019-02-05 Traitement de maladies ophthalmologiques

Publications (1)

Publication Number Publication Date
SG11202006712XA true SG11202006712XA (en) 2020-08-28

Family

ID=65352014

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006712XA SG11202006712XA (en) 2018-02-06 2019-02-05 Treatment of ophthalmologic diseases

Country Status (12)

Country Link
US (2) US20210139576A1 (fr)
EP (1) EP3749359A1 (fr)
JP (3) JP7005772B2 (fr)
KR (1) KR20200119274A (fr)
CN (1) CN111699004A (fr)
AU (1) AU2019219004A1 (fr)
CA (1) CA3088355A1 (fr)
IL (1) IL276383B2 (fr)
MX (1) MX2020007527A (fr)
SG (1) SG11202006712XA (fr)
TW (1) TWI831764B (fr)
WO (1) WO2019154776A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9840553B2 (en) 2014-06-28 2017-12-12 Kodiak Sciences Inc. Dual PDGF/VEGF antagonists
AU2016381964B2 (en) 2015-12-30 2024-02-15 Kodiak Sciences Inc. Antibodies and conjugates thereof
CA3089481A1 (fr) 2018-01-26 2019-08-01 The Regents Of The University Of California Methodes et compositions pour le traitement de troubles angiogeniques a l'aide d'agents anti-vegf
TWI785360B (zh) * 2019-08-06 2022-12-01 美商建南德克公司 眼科疾病之個人化治療
WO2021072265A1 (fr) 2019-10-10 2021-04-15 Kodiak Sciences Inc. Procédés de traitement d'un trouble oculaire
AU2020393842A1 (en) 2019-11-25 2022-06-16 The Regents Of The University Of California Long-acting VEGF inhibitors for intraocular neovascularization
AU2021335509A1 (en) * 2020-09-04 2023-03-09 F. Hoffmann-La Roche Ag Antibody that binds to VEGF-A and ANG2 and methods of use
TW202221027A (zh) * 2020-09-17 2022-06-01 大陸商江蘇恆瑞醫藥股份有限公司 特異性結合vegf和ang-2的雙特異性抗原結合分子
KR20230162791A (ko) * 2021-03-30 2023-11-28 에이비프로 코퍼레이션 항-ANG2 x VEGF 다중특이적 항체를 사용하여 맥락막 혈관신생을 치료하는 방법
CN117100845A (zh) * 2022-10-24 2023-11-24 景泽生物医药(合肥)股份有限公司 重组人奥克纤溶酶在制备治疗脉络膜血管疾病药物中的用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
AU743758B2 (en) 1997-04-07 2002-02-07 Genentech Inc. Anti-VEGF antibodies
ES2246069T3 (es) 1997-05-02 2006-02-01 Genentech, Inc. Procedimiento de preparacion de anticuerpos multiespecificos que tienen componentes comunes y multimericos.
JP5620626B2 (ja) 2005-03-31 2014-11-05 中外製薬株式会社 会合制御によるポリペプチド製造方法
AR060070A1 (es) 2006-03-24 2008-05-21 Merck Patent Gmbh Dominios proteicos heterodimericos obtenidos por ingenieria
WO2007147901A1 (fr) 2006-06-22 2007-12-27 Novo Nordisk A/S Production d'anticorps bispécifiques
US8242247B2 (en) 2007-12-21 2012-08-14 Hoffmann-La Roche Inc. Bivalent, bispecific antibodies
PL2235064T3 (pl) 2008-01-07 2016-06-30 Amgen Inc Sposób otrzymywania cząsteczek przeciwciał z heterodimerycznymi fc z zastosowaniem kierujących efektów elektrostatycznych
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
ES2708124T3 (es) 2009-04-27 2019-04-08 Oncomed Pharm Inc Procedimiento para preparar moléculas heteromultiméricas
DK2519543T3 (en) 2009-12-29 2016-09-26 Emergent Product Dev Seattle HETERODIMER BINDING PROTEINS AND USE THEREOF
AR080794A1 (es) 2010-03-26 2012-05-09 Hoffmann La Roche Anticuerpos bivalentes biespecificos anti- vegf/ anti-ang-2
US9527926B2 (en) 2010-05-14 2016-12-27 Rinat Neuroscience Corp. Heterodimeric proteins and methods for producing and purifying them
EP2635607B1 (fr) 2010-11-05 2019-09-04 Zymeworks Inc. Conception d'anticorps hétérodimérique stable ayant des mutations dans le domaine fc
SG10201802789VA (en) * 2011-01-13 2018-05-30 Regeneron Pharma Use of a vegf antagonist to treat angiogenic eye disorders
US9527925B2 (en) 2011-04-01 2016-12-27 Boehringer Ingelheim International Gmbh Bispecific binding molecules binding to VEGF and ANG2
CA2859667C (fr) 2011-12-20 2022-05-24 Medimmune, Llc Polypeptides modifies pour des echafaudages d'anticorps bispecifiques
CN114163530A (zh) 2012-04-20 2022-03-11 美勒斯公司 用于产生免疫球蛋白样分子的方法和手段
EP3495387B1 (fr) * 2012-07-13 2021-09-01 Roche Glycart AG Anticorps bispécifiques anti-vegf/anti-ang-2 et leur utilisation dans le traitement des maladies vasculaires oculaires
CA2879597C (fr) * 2012-08-21 2021-01-12 Opko Pharmaceuticals, Llc Formulation ophtalmique de liposomes pour traitement des maladies du segment posterieur
EP3878866A1 (fr) * 2013-04-29 2021-09-15 F. Hoffmann-La Roche AG Anticorps asymétrique modifié de liaison fc-récepteur et procédés d'utilisation
KR20150063728A (ko) 2013-12-02 2015-06-10 삼성전자주식회사 항 VEGF-C/항 Ang2 이중 특이 항체
TWI806150B (zh) * 2014-11-07 2023-06-21 瑞士商諾華公司 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物
US20160144025A1 (en) * 2014-11-25 2016-05-26 Regeneron Pharmaceuticals, Inc. Methods and formulations for treating vascular eye diseases
CN112826934A (zh) * 2014-12-11 2021-05-25 拜耳医药保健有限责任公司 具有小的活动性脉络膜新生血管病变的年龄相关性黄斑变性的治疗
AR103477A1 (es) * 2015-01-28 2017-05-10 Lilly Co Eli Compuestos de vegfa / ang2
US10654922B2 (en) 2016-05-13 2020-05-19 Askgene Pharma Inc. Angiopoietin 2, VEGF dual antagonists

Also Published As

Publication number Publication date
US20210139576A1 (en) 2021-05-13
MX2020007527A (es) 2020-09-09
KR20200119274A (ko) 2020-10-19
AU2019219004A1 (en) 2020-07-16
IL276383A (en) 2020-09-30
CN111699004A (zh) 2020-09-22
CA3088355A1 (fr) 2019-08-15
IL276383B1 (en) 2023-09-01
JP2021506947A (ja) 2021-02-22
JP7005772B2 (ja) 2022-02-10
JP2022046738A (ja) 2022-03-23
JP7273204B2 (ja) 2023-05-12
WO2019154776A1 (fr) 2019-08-15
EP3749359A1 (fr) 2020-12-16
US20230416353A1 (en) 2023-12-28
JP2023099094A (ja) 2023-07-11
TWI831764B (zh) 2024-02-11
TW202000700A (zh) 2020-01-01
IL276383B2 (en) 2024-01-01

Similar Documents

Publication Publication Date Title
IL276383A (en) Treatment of ophthalmological diseases
SG11202006374VA (en) Treatment of demyelinating diseases
IL268357A (en) Photoreceptor cells for the treatment of retinal diseases
IL289405A (en) Personalized treatment of eye diseases
IL282643A (en) Soft combinations for the treatment of hematological diseases
ZA201903003B (en) Treatment of neurological diseases
SG11202010585WA (en) New treatment of interstitial lung diseases
ZA202002075B (en) Compounds, compositions and methods for treatment of eye disorders and skin diseases
IL269698B (en) Methods for preventing or treating eye diseases
GB202015959D0 (en) Treatment of diseases involving NAD
SG11202001595SA (en) Angio-3 for treatment of retinal angiogenic diseases
GB201805100D0 (en) Treatment of sarcopenic diseases
SG11202007082PA (en) Composition used for therapeutic treatment of skin disease
IL282361A (en) Treatment for neurological diseases
IL282898A (en) Ophthalmic compounds and methods for treating skin and eye diseases
GB201914516D0 (en) Treatment of eye disease
SG11202010034WA (en) TREATMENT OF SKIN DISEASES OR DISORDERS BY DELIVERY OF ANTI-OSMRß ANTIBODY
IL259381B (en) Miravegron for the treatment of retinal diseases
GB201909438D0 (en) Treatment of diseases
GB201604359D0 (en) Treatment of tissue disorders
GB201805556D0 (en) Treatment of ophthalmological conditions
GB201904764D0 (en) Treatment of ophthalmological conditions
GB201811911D0 (en) Treatment of disease
GB201811912D0 (en) Treatment of disease
GB201810974D0 (en) Treatment of disease