SG11202006169PA - Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto - Google Patents

Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto

Info

Publication number
SG11202006169PA
SG11202006169PA SG11202006169PA SG11202006169PA SG11202006169PA SG 11202006169P A SG11202006169P A SG 11202006169PA SG 11202006169P A SG11202006169P A SG 11202006169PA SG 11202006169P A SG11202006169P A SG 11202006169PA SG 11202006169P A SG11202006169P A SG 11202006169PA
Authority
SG
Singapore
Prior art keywords
aav
adeno
vector
associated virus
gene introduced
Prior art date
Application number
SG11202006169PA
Other languages
English (en)
Inventor
Seung Shin Yu
Jae Gyun Jeong
Jung Hun Lee
Su Bin Kim
Original Assignee
Helixmith Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Helixmith Co Ltd filed Critical Helixmith Co Ltd
Publication of SG11202006169PA publication Critical patent/SG11202006169PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
SG11202006169PA 2017-12-29 2018-12-28 Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto SG11202006169PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20170184738 2017-12-29
PCT/KR2018/016937 WO2019132624A1 (ko) 2017-12-29 2018-12-28 하이브리드 hgf 유전자가 도입된 aav(아데노-연관 바이러스) 벡터

Publications (1)

Publication Number Publication Date
SG11202006169PA true SG11202006169PA (en) 2020-07-29

Family

ID=67067977

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202006169PA SG11202006169PA (en) 2017-12-29 2018-12-28 Adeno-associated virus (aav) vector having hybrid hgf gene introduced thereto

Country Status (10)

Country Link
US (1) US11634728B2 (ko)
EP (1) EP3733855A4 (ko)
JP (1) JP7140353B2 (ko)
KR (1) KR102112476B1 (ko)
CN (1) CN111542613B (ko)
AU (1) AU2018395121B2 (ko)
CA (1) CA3086046C (ko)
RU (1) RU2762367C1 (ko)
SG (1) SG11202006169PA (ko)
WO (1) WO2019132624A1 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022211454A1 (ko) * 2021-03-29 2022-10-06 주식회사 헬릭스미스 샤르코-마리-투스병 예방 또는 치료용 약제학적 조성물
KR20230152503A (ko) 2022-04-27 2023-11-03 주식회사 헬릭스미스 척수강 내 투여에 최적화 된 간세포 성장인자 유전자가 도입된 aav 벡터

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
KR100562824B1 (ko) 2002-03-20 2006-03-23 주식회사 바이로메드 유전자 발현효율이 높으며 간세포 성장인자의 두 가지이형체를 동시에 발현하는 하이브리드 간세포 성장인자유전자
CN1536085A (zh) 2003-04-09 2004-10-13 中国人民解放军军事医学科学院野战输 人肝细胞生长因子基因重组逆转录病毒载体的构建
CN1876818A (zh) 2005-06-07 2006-12-13 北京诺思兰德生物技术有限责任公司 一类能在真核细胞中高效表达人肝细胞生长因子的重组质粒
MX2008000058A (es) 2005-07-07 2008-03-19 Genzyme Corp Vectores aav que codifican superoxido dismutasa.
JP2009515520A (ja) * 2005-11-10 2009-04-16 レセプター バイオロジックス， インコーポレイテッド 肝細胞成長因子イントロン融合蛋白
RU2470995C2 (ru) 2008-04-09 2012-12-27 Вайромед Ко., Лтд. Лиофилизированные днк-составы для увеличенной экспрессии плазмидной днк
MX356669B (es) * 2009-05-02 2018-06-08 Genzyme Corp Terapia genica para trastornos neurodegenerativos.
WO2013034157A1 (en) 2011-09-05 2013-03-14 Nsgene A/S Treatment of allodynia, hyperalgsia, spontaneous pain, and phantom pain
AU2012333408B2 (en) * 2011-11-03 2016-05-26 Viromed Co., Ltd. Gene therapy for diabetic neuropathy using an HGF isoform
EA033803B1 (ru) 2012-02-07 2019-11-27 Global Bio Therapeutics Inc Способ доставки нуклеиновых кислот с разделением, их композиции и использование
BR112014020325A2 (pt) 2012-02-17 2017-08-08 Childrens Hospital Philadelphia composições de vetor do aav e métodos para a transferência de gene para as células, órgãos e tecidos
JP2016523835A (ja) * 2013-05-15 2016-08-12 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 中枢神経系へのアデノ随伴ウイルスを介した遺伝子導入
KR102445330B1 (ko) * 2013-07-12 2022-09-19 더 칠드런스 호스피탈 오브 필라델피아 Ａａｖ 벡터 및 항―ａａｖ （아데노-관련 바이러스） 중화 항체에 대한 검정
BR112016008267A2 (pt) * 2013-10-22 2017-10-03 Viromed Co Ltd Composição para prevenir ou tratar esclerose lateral amiotrófica usando duas ou mais isoformas de fator de crescimento de hepatócito
CN107073078B (zh) * 2014-09-26 2021-07-06 赫利世弥斯株式会社 利用肝细胞生长因子和基质细胞衍生因子1α的用于预防或治疗外周动脉疾病的组合物
CN107109407A (zh) 2014-11-14 2017-08-29 沃雅戈治疗公司 治疗肌萎缩性侧索硬化(als)的组合物和方法

Also Published As

Publication number Publication date
KR102112476B1 (ko) 2020-05-19
AU2018395121A1 (en) 2020-07-30
EP3733855A4 (en) 2021-03-03
AU2018395121B2 (en) 2022-10-06
WO2019132624A1 (ko) 2019-07-04
CA3086046C (en) 2023-02-21
US20210071199A1 (en) 2021-03-11
CN111542613B (zh) 2023-11-21
CA3086046A1 (en) 2019-07-04
RU2762367C1 (ru) 2021-12-20
JP2021506283A (ja) 2021-02-22
KR20190082139A (ko) 2019-07-09
CN111542613A (zh) 2020-08-14
US11634728B2 (en) 2023-04-25
EP3733855A1 (en) 2020-11-04
JP7140353B2 (ja) 2022-09-22

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