SG11202003320SA - Dihydropyrimidine compounds and uses thereof in medicine - Google Patents
Dihydropyrimidine compounds and uses thereof in medicineInfo
- Publication number
- SG11202003320SA SG11202003320SA SG11202003320SA SG11202003320SA SG11202003320SA SG 11202003320S A SG11202003320S A SG 11202003320SA SG 11202003320S A SG11202003320S A SG 11202003320SA SG 11202003320S A SG11202003320S A SG 11202003320SA SG 11202003320S A SG11202003320S A SG 11202003320SA
- Authority
- SG
- Singapore
- Prior art keywords
- medicine
- dihydropyrimidine compounds
- dihydropyrimidine
- compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710978074 | 2017-10-18 | ||
| CN201810088129 | 2018-01-30 | ||
| CN201811049241 | 2018-09-10 | ||
| PCT/CN2018/110592 WO2019076310A1 (en) | 2017-10-18 | 2018-10-17 | DIHYDROPYRIMIDINE COMPOUNDS AND USES THEREOF IN MEDICINE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003320SA true SG11202003320SA (en) | 2020-05-28 |
Family
ID=66174293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003320SA SG11202003320SA (en) | 2017-10-18 | 2018-10-17 | Dihydropyrimidine compounds and uses thereof in medicine |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11261190B2 (ja) |
| EP (1) | EP3697792A4 (ja) |
| JP (1) | JP7202373B2 (ja) |
| KR (1) | KR102667040B1 (ja) |
| CN (1) | CN109678859B (ja) |
| AU (1) | AU2018351400B2 (ja) |
| CA (1) | CA3079557A1 (ja) |
| MY (1) | MY194405A (ja) |
| SG (1) | SG11202003320SA (ja) |
| WO (1) | WO2019076310A1 (ja) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109111451B (zh) | 2017-06-26 | 2020-08-11 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| WO2020125729A1 (en) | 2018-12-20 | 2020-06-25 | Janssen Pharmaceutica Nv | Heteroaryldihydropyrimidine derivatives and methods of treating hepatitis b infections |
| WO2020135439A1 (zh) * | 2018-12-25 | 2020-07-02 | 广东东阳光药业有限公司 | 氘代二氢嘧啶类化合物及其在药物中的应用 |
| CN111825676B (zh) * | 2019-04-15 | 2023-10-17 | 广东东阳光药业股份有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| CN111848627B (zh) * | 2019-04-30 | 2021-10-01 | 东莞市东阳光新药研发有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| SG11202111538PA (en) * | 2019-06-06 | 2021-11-29 | Hoffmann La Roche | Alternative process for the preparation of 4-phenyl-5-alkoxycarbonyl-2-thiazol-2-yl-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1h-imidazo[1,5-a]pyrazin-2-yl]-carboxylic acid |
| AU2020289537A1 (en) * | 2019-06-06 | 2021-11-25 | Aligos Therapeutics, Inc. | Heterocyclic compounds |
| CN112079837B (zh) * | 2019-06-14 | 2023-08-04 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的盐及其在药物中的应用 |
| WO2020255017A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| WO2020255016A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Combination of hepatitis b virus (hbv) vaccines and dihydropyrimidine derivatives as capsid assembly modulators |
| CN112707910A (zh) * | 2019-10-24 | 2021-04-27 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
| EP4229062A1 (en) * | 2020-10-15 | 2023-08-23 | Aligos Therapeutics, Inc. | Bicyclic compounds |
| JP2023551048A (ja) * | 2020-11-30 | 2023-12-06 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | ジヒドロピリミジン誘導体の塩、錯体、及び薬におけるその使用 |
| CN114621219A (zh) * | 2020-12-09 | 2022-06-14 | 上海维申医药有限公司 | 一种二氢嘧啶类化合物、其制备方法及应用 |
| WO2022166923A1 (zh) | 2021-02-05 | 2022-08-11 | 和博医药有限公司 | 苯基二氢嘧啶类化合物及其应用 |
| WO2022171072A1 (zh) * | 2021-02-09 | 2022-08-18 | 上海维申医药有限公司 | 一种二氢嘧啶类化合物、其制备方法及其应用 |
| CN114702498B (zh) * | 2021-12-23 | 2022-12-16 | 华南理工大学 | 二氢嘧啶衍生物的酸加成盐及其在药物中的应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19817262A1 (de) * | 1998-04-18 | 1999-10-21 | Bayer Ag | Neue 2-heterocyclisch substituierte Dihydropyrimidine |
| DE10013126A1 (de) | 2000-03-17 | 2001-09-20 | Bayer Ag | Arzneimittel gegen virale Erkrankungen |
| US9487534B2 (en) | 2011-08-02 | 2016-11-08 | Scripps Research Institute, A Not-For-Profit Public Benefit Corporation Of California | Modulators of virus assembly as antiviral agents |
| RU2014142598A (ru) | 2012-03-31 | 2016-05-27 | Ф. Хоффманн-Ля Рош Аг | Новые 4-метилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в |
| JP6533217B2 (ja) | 2013-05-17 | 2019-06-19 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｂ型肝炎ウイルス感染症の治療および予防のための６−架橋ヘテロアリールジヒドロピリミジン類 |
| CA2920415A1 (en) * | 2013-11-19 | 2015-05-28 | Sunshine Lake Pharma Co., Ltd. | Dihydropyrimidine compounds and their application in pharmaceuticals |
| CN104672225B (zh) | 2013-11-27 | 2019-02-12 | 广东东阳光药业有限公司 | 二氢嘧啶衍生物的制备方法及其中间体 |
| HUE041734T2 (hu) * | 2014-03-07 | 2019-05-28 | Hoffmann La Roche | Új, 6-tagú gyûrûvel kondenzált heteroarildihidropirimidinek hepatitisz B vírusfertõzés kezelésére és megelõzésére |
| KR102139708B1 (ko) | 2015-03-16 | 2020-07-31 | 에프. 호프만-라 로슈 아게 | Tlr7 작용제 및 hbv 캡시드 조립 억제제를 사용하는 병용 치료 |
| WO2017011552A1 (en) | 2015-07-13 | 2017-01-19 | Enanta Pharmaceuticals, Inc. | Hepatitis b antiviral agents |
| WO2017064156A1 (en) * | 2015-10-16 | 2017-04-20 | F. Hoffmann-La Roche Ag | Novel 6-fused and 2-heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection |
| MX2018005230A (es) * | 2015-11-03 | 2018-08-15 | Hoffmann La Roche | Terapia de combinacion de un inhibidor del ensamble de la capside del hbv y un interferon. |
| WO2017108630A1 (en) | 2015-12-21 | 2017-06-29 | F. Hoffmann-La Roche Ag | Combination therapy of an hbsag inhibitor and an hbv capsid assembly inhibitor |
| AR107633A1 (es) | 2016-02-19 | 2018-05-16 | Hoffmann La Roche | Procedimiento para la preparación del ácido 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidin-6-il-[metil]-3-oxo-5,6,8,8a-tetrahidro-1h-imidazo[1,5a]pirazin-2-il-carboxílico |
| WO2018045911A1 (zh) | 2016-09-09 | 2018-03-15 | 浙江海正药业股份有限公司 | 二氢嘧啶类化合物及其制备方法和用途 |
| CN108567783A (zh) | 2017-03-10 | 2018-09-25 | 彭晓梅 | 一种治疗冠心病的药物组合物 |
| CN109111451B (zh) | 2017-06-26 | 2020-08-11 | 广东东阳光药业有限公司 | 二氢嘧啶类化合物及其在药物中的应用 |
-
2018
- 2018-10-17 MY MYPI2020001830A patent/MY194405A/en unknown
- 2018-10-17 US US16/754,220 patent/US11261190B2/en active Active
- 2018-10-17 CN CN201811210586.9A patent/CN109678859B/zh active Active
- 2018-10-17 KR KR1020207013922A patent/KR102667040B1/ko active IP Right Grant
- 2018-10-17 WO PCT/CN2018/110592 patent/WO2019076310A1/en unknown
- 2018-10-17 SG SG11202003320SA patent/SG11202003320SA/en unknown
- 2018-10-17 JP JP2020522057A patent/JP7202373B2/ja active Active
- 2018-10-17 AU AU2018351400A patent/AU2018351400B2/en active Active
- 2018-10-17 EP EP18868606.7A patent/EP3697792A4/en active Pending
- 2018-10-17 CA CA3079557A patent/CA3079557A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR102667040B1 (ko) | 2024-05-20 |
| JP2020537677A (ja) | 2020-12-24 |
| AU2018351400A1 (en) | 2020-04-23 |
| AU2018351400B2 (en) | 2022-12-15 |
| US11261190B2 (en) | 2022-03-01 |
| WO2019076310A1 (en) | 2019-04-25 |
| CN109678859B (zh) | 2020-12-29 |
| KR20200072512A (ko) | 2020-06-22 |
| MY194405A (en) | 2022-11-30 |
| US20200283445A1 (en) | 2020-09-10 |
| EP3697792A1 (en) | 2020-08-26 |
| JP7202373B2 (ja) | 2023-01-11 |
| CA3079557A1 (en) | 2019-04-25 |
| CN109678859A (zh) | 2019-04-26 |
| EP3697792A4 (en) | 2021-10-13 |
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