SG11202003225YA - Amine-substituted heterocyclic compounds as ehmt2 inhibitors, salts thereof, and methods of synthesis thereof - Google Patents
Amine-substituted heterocyclic compounds as ehmt2 inhibitors, salts thereof, and methods of synthesis thereofInfo
- Publication number
- SG11202003225YA SG11202003225YA SG11202003225YA SG11202003225YA SG11202003225YA SG 11202003225Y A SG11202003225Y A SG 11202003225YA SG 11202003225Y A SG11202003225Y A SG 11202003225YA SG 11202003225Y A SG11202003225Y A SG 11202003225YA SG 11202003225Y A SG11202003225Y A SG 11202003225YA
- Authority
- SG
- Singapore
- Prior art keywords
- amine
- synthesis
- salts
- methods
- substituted heterocyclic
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762573917P | 2017-10-18 | 2017-10-18 | |
| PCT/US2018/056428 WO2019079540A1 (fr) | 2017-10-18 | 2018-10-18 | Composés hétérocycliques substitués par une amine, utilisés comme inhibiteurs de l'ehmt2, sels de ceux-ci, et leurs méthodes de synthèse |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202003225YA true SG11202003225YA (en) | 2020-05-28 |
Family
ID=66173899
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202003225YA SG11202003225YA (en) | 2017-10-18 | 2018-10-18 | Amine-substituted heterocyclic compounds as ehmt2 inhibitors, salts thereof, and methods of synthesis thereof |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20200247790A1 (fr) |
| EP (1) | EP3697762A4 (fr) |
| JP (2) | JP2021500334A (fr) |
| KR (1) | KR20200101330A (fr) |
| CN (1) | CN111417628A (fr) |
| AU (2) | AU2018353122B2 (fr) |
| BR (1) | BR112020007632A2 (fr) |
| CA (1) | CA3079273A1 (fr) |
| CL (1) | CL2020001009A1 (fr) |
| CO (1) | CO2020005944A2 (fr) |
| EA (1) | EA202090959A1 (fr) |
| IL (2) | IL301746B1 (fr) |
| MA (1) | MA50418A (fr) |
| MX (1) | MX2020007152A (fr) |
| SG (1) | SG11202003225YA (fr) |
| WO (1) | WO2019079540A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7185633B2 (ja) | 2017-02-17 | 2022-12-07 | トレベナ・インコーポレイテッド | ７員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法 |
| CN118021814A (zh) | 2017-04-21 | 2024-05-14 | Epizyme股份有限公司 | 用ehmt2抑制剂进行的组合疗法 |
| JP7244504B2 (ja) | 2017-10-18 | 2023-03-22 | インサイト・コーポレイション | ＰＩ３Ｋ－γ阻害剤としての三級ヒドロキシ基で置換された縮合イミダゾール誘導体 |
| CN114249785B (zh) * | 2020-09-23 | 2024-04-05 | 常州方圆制药有限公司 | 一种2-腺苷n-吡唑的衍生物瑞加德松的制备方法 |
| CN116406268A (zh) * | 2020-10-27 | 2023-07-07 | 特维娜有限公司 | δ-阿片样物质调节剂的结晶和无定形形式 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2004272288B2 (en) * | 2003-09-18 | 2008-11-13 | Novartis Ag | 2,4-di (phenylamino) pyrimidines useful in the treatment of proliferative disorders |
| BR122021011788B1 (pt) * | 2005-11-01 | 2022-01-25 | Impact Biomedicines, Inc | Inibidores de biaril meta pirimidina de cinases, composição farmacêutica e processo para preparar uma composição farmacêutica |
| US8604042B2 (en) * | 2005-11-01 | 2013-12-10 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| US9284272B2 (en) * | 2014-03-28 | 2016-03-15 | Abbvie Inc. | Inhibitors of histone methyltransferase G9a |
| US9840500B2 (en) * | 2014-06-16 | 2017-12-12 | Fundación Para La Investigación Médica Aplicada | Compounds as dual inhibitors of histone methyltransferases and DNA methyltransferases |
| CA2952474A1 (fr) * | 2014-06-23 | 2015-12-30 | Genentech, Inc. | Methodes de traitement du cancer et de prevention de la resistance aux medicaments anticancereux |
| LT3442947T (lt) * | 2016-04-15 | 2023-09-11 | Epizyme, Inc. | Aminu pakeisti arilo arba heteroarilo junginiai, kaip ehmt1 ir ehmt2 inhibitoriai |
| LT3555070T (lt) * | 2016-12-19 | 2023-09-11 | Epizyme, Inc. | Aminu pakeisti heterocikliniai junginiai, kaip ehmt2 inhibitoriai, ir jų panaudojimo būdai |
| AU2018243749A1 (en) * | 2017-03-31 | 2019-11-21 | Epizyme, Inc. | Methods of using EHMT2 inhibitors |
| CA3079412A1 (fr) * | 2017-10-18 | 2019-04-25 | Epizyme, Inc. | Procedes d'utilisation d'inhibiteurs d'ehmt2 dans des immunotherapies |
-
2018
- 2018-10-18 MA MA050418A patent/MA50418A/fr unknown
- 2018-10-18 SG SG11202003225YA patent/SG11202003225YA/en unknown
- 2018-10-18 CN CN201880077022.4A patent/CN111417628A/zh active Pending
- 2018-10-18 WO PCT/US2018/056428 patent/WO2019079540A1/fr unknown
- 2018-10-18 US US16/756,565 patent/US20200247790A1/en not_active Abandoned
- 2018-10-18 EP EP18869308.9A patent/EP3697762A4/fr active Pending
- 2018-10-18 EA EA202090959A patent/EA202090959A1/ru unknown
- 2018-10-18 JP JP2020521599A patent/JP2021500334A/ja not_active Withdrawn
- 2018-10-18 IL IL301746A patent/IL301746B1/en unknown
- 2018-10-18 AU AU2018353122A patent/AU2018353122B2/en active Active
- 2018-10-18 MX MX2020007152A patent/MX2020007152A/es unknown
- 2018-10-18 KR KR1020207013781A patent/KR20200101330A/ko not_active Application Discontinuation
- 2018-10-18 CA CA3079273A patent/CA3079273A1/fr active Pending
- 2018-10-18 BR BR112020007632-5A patent/BR112020007632A2/pt unknown
-
2020
- 2020-04-15 CL CL2020001009A patent/CL2020001009A1/es unknown
- 2020-04-16 IL IL273974A patent/IL273974B2/en unknown
- 2020-05-15 CO CONC2020/0005944A patent/CO2020005944A2/es unknown
-
2022
- 2022-03-24 US US17/703,155 patent/US20220324851A1/en active Pending
-
2023
- 2023-01-11 JP JP2023002371A patent/JP2023036991A/ja active Pending
-
2024
- 2024-02-22 AU AU2024201165A patent/AU2024201165A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL273974A (en) | 2020-05-31 |
| IL301746A (en) | 2023-05-01 |
| US20220324851A1 (en) | 2022-10-13 |
| AU2024201165A1 (en) | 2024-03-14 |
| CA3079273A1 (fr) | 2019-04-25 |
| KR20200101330A (ko) | 2020-08-27 |
| US20200247790A1 (en) | 2020-08-06 |
| JP2023036991A (ja) | 2023-03-14 |
| CL2020001009A1 (es) | 2020-12-18 |
| BR112020007632A2 (pt) | 2020-09-29 |
| WO2019079540A1 (fr) | 2019-04-25 |
| IL301746B1 (en) | 2024-09-01 |
| MA50418A (fr) | 2021-04-07 |
| IL273974B2 (en) | 2023-08-01 |
| MX2020007152A (es) | 2020-12-10 |
| EP3697762A1 (fr) | 2020-08-26 |
| JP2021500334A (ja) | 2021-01-07 |
| IL273974B1 (en) | 2023-04-01 |
| EA202090959A1 (ru) | 2020-07-13 |
| EP3697762A4 (fr) | 2021-04-07 |
| CN111417628A (zh) | 2020-07-14 |
| AU2018353122B2 (en) | 2023-11-23 |
| CO2020005944A2 (es) | 2020-07-31 |
| AU2018353122A1 (en) | 2020-06-04 |
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