SG11202002479XA - Modifying the specificity of plant non-coding rna molecules for silencing gene expression - Google Patents
Modifying the specificity of plant non-coding rna molecules for silencing gene expressionInfo
- Publication number
- SG11202002479XA SG11202002479XA SG11202002479XA SG11202002479XA SG11202002479XA SG 11202002479X A SG11202002479X A SG 11202002479XA SG 11202002479X A SG11202002479X A SG 11202002479XA SG 11202002479X A SG11202002479X A SG 11202002479XA SG 11202002479X A SG11202002479X A SG 11202002479XA
- Authority
- SG
- Singapore
- Prior art keywords
- specificity
- modifying
- gene expression
- rna molecules
- coding rna
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title 1
- 230000030279 gene silencing Effects 0.000 title 1
- 108091027963 non-coding RNA Proteins 0.000 title 1
- 102000042567 non-coding RNA Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
- A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
- A01H5/00—Angiosperms, i.e. flowering plants, characterised by their plant parts; Angiosperms characterised otherwise than by their botanic taxonomy
- A01H5/10—Seeds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/111—General methods applicable to biologically active non-coding nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8201—Methods for introducing genetic material into plant cells, e.g. DNA, RNA, stable or transient incorporation, tissue culture methods adapted for transformation
- C12N15/8213—Targeted insertion of genes into the plant genome by homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8261—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield
- C12N15/8271—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance
- C12N15/8279—Phenotypically and genetically modified plants via recombinant DNA technology with agronomic (input) traits, e.g. crop yield for stress resistance, e.g. heavy metal resistance for biotic stress resistance, pathogen resistance, disease resistance
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8216—Methods for controlling, regulating or enhancing expression of transgenes in plant cells
- C12N15/8218—Antisense, co-suppression, viral induced gene silencing [VIGS], post-transcriptional induced gene silencing [PTGS]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/113—Antisense targeting other non-coding nucleic acids, e.g. antagomirs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
- Y02A40/10—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in agriculture
- Y02A40/146—Genetically Modified [GMO] plants, e.g. transgenic plants
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Botany (AREA)
- Developmental Biology & Embryology (AREA)
- Environmental Sciences (AREA)
- Mycology (AREA)
- Virology (AREA)
- Physiology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1715113.5A GB201715113D0 (en) | 2017-09-19 | 2017-09-19 | Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA |
GBGB1715116.8A GB201715116D0 (en) | 2017-09-19 | 2017-09-19 | Modifying the specificity of non-coding RNA molecules for silencing of target RNA in eukaryotic cells |
GBGB1719516.5A GB201719516D0 (en) | 2017-11-23 | 2017-11-23 | Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA |
PCT/IB2018/057160 WO2019058255A1 (en) | 2017-09-19 | 2018-09-18 | MODIFICATION OF THE SPECIFICITY OF VEGETABLE NON-CODANT RNA MOLECULES FOR THE SILENCING OF GENE EXPRESSION |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202002479XA true SG11202002479XA (en) | 2020-04-29 |
Family
ID=63840882
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002479XA SG11202002479XA (en) | 2017-09-19 | 2018-09-18 | Modifying the specificity of plant non-coding rna molecules for silencing gene expression |
SG11202002481RA SG11202002481RA (en) | 2017-09-19 | 2018-09-18 | Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202002481RA SG11202002481RA (en) | 2017-09-19 | 2018-09-18 | Modifying the specificity of non-coding rna molecules for silencing gene expression in eukaryotic cells |
Country Status (13)
Country | Link |
---|---|
US (4) | US11555199B2 (ja) |
EP (3) | EP4170029A3 (ja) |
JP (3) | JP7462553B2 (ja) |
KR (3) | KR20230050424A (ja) |
CN (2) | CN111448318A (ja) |
AU (3) | AU2018336126A1 (ja) |
BR (2) | BR112020005416A2 (ja) |
CA (2) | CA3074948A1 (ja) |
DK (1) | DK3684930T3 (ja) |
ES (1) | ES2915576T3 (ja) |
IL (2) | IL273460B1 (ja) |
SG (2) | SG11202002479XA (ja) |
WO (2) | WO2019058253A1 (ja) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020005416A2 (pt) | 2017-09-19 | 2020-09-29 | Tropic Biosciences UK Limited | modificação da especificidade de moléculas de rna não codificante para silenciar expressão gênica em células eucarióticas |
EP3794130A4 (en) | 2018-05-16 | 2022-07-27 | Synthego Corporation | METHODS AND SYSTEMS FOR DESIGN AND USE OF GUIDE RNA |
CN110857438B (zh) * | 2018-08-20 | 2022-05-17 | 中国烟草总公司黑龙江省公司牡丹江烟草科学研究所 | 一种高效产生siRNA的烟草花叶病毒基因片段、弱毒疫苗、制备方法及其应用 |
EP3931321A1 (en) | 2019-03-01 | 2022-01-05 | Syngenta Crop Protection AG | Suppression of target gene expression through genome editing of native mirnas |
GB201903520D0 (en) * | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells |
GB201903521D0 (en) | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | No title |
GB201903519D0 (en) * | 2019-03-14 | 2019-05-01 | Tropic Biosciences Uk Ltd | Introducing silencing activity to dysfunctional rna molecules and modifying their specificity against a gene of interest |
CN110551719B (zh) * | 2019-07-30 | 2023-06-02 | 中山大学 | 长链非编码rna基因alex1及其在提高水稻白叶枯病抗性中的应用 |
CN111508558B (zh) * | 2020-03-23 | 2021-12-14 | 广州赛业百沐生物科技有限公司 | 一种基于CRISPR-Cas9技术设计点突变模型的方法及系统 |
CN111676220B (zh) * | 2020-05-21 | 2022-03-29 | 扬州大学 | 杨树长链非编码RNA lnc11及其应用 |
WO2022006310A2 (en) * | 2020-06-30 | 2022-01-06 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions for genome editing and methods of use thereof |
CN114073760B (zh) * | 2020-08-21 | 2024-02-13 | 北京大学 | Rdr蛋白在肿瘤治疗中的应用 |
US20240000970A1 (en) * | 2020-12-01 | 2024-01-04 | Emendobio Inc. | Differential knockout of a heterozygous allele of lrrk2 |
CN112359049B (zh) * | 2020-12-10 | 2022-01-28 | 昆明理工大学 | 一种岷江百合几丁质酶基因LrCHI2及其应用 |
CN112795568B (zh) * | 2021-01-06 | 2023-07-18 | 河南农业大学 | 一种控制玉米雌穗穗粗杂种优势的非编码基因的应用及其前体序列 |
GB202103256D0 (en) | 2021-03-09 | 2021-04-21 | Tropic Biosciences Uk Ltd | Method for silencing genes |
CN114134155B (zh) * | 2021-06-29 | 2023-09-12 | 中国农业科学院油料作物研究所 | 一种mlo基因突变体及其制备方法与应用 |
CN113444727B (zh) * | 2021-06-30 | 2022-06-21 | 中国热带农业科学院热带生物技术研究所 | 一种LncRNA及其应用 |
WO2023275255A1 (en) | 2021-07-02 | 2023-01-05 | Tropic Biosciences UK Limited | Delay or prevention of browning in banana fruit |
KR102573952B1 (ko) * | 2021-08-09 | 2023-09-01 | 경상국립대학교산학협력단 | E2와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도 |
KR102584891B1 (ko) * | 2021-08-09 | 2023-10-04 | 경상국립대학교산학협력단 | GmIPK1 유전자교정 시스템 및 이의 용도 |
KR102574819B1 (ko) * | 2021-08-09 | 2023-09-04 | 경상국립대학교산학협력단 | P34와 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도 |
KR102573947B1 (ko) * | 2021-08-09 | 2023-09-01 | 경상국립대학교산학협력단 | 콩 유전자교정 효율 증대를 위한 유전자교정 시스템 및 이의 용도 |
KR102573948B1 (ko) * | 2021-08-09 | 2023-09-01 | 경상국립대학교산학협력단 | Mips1과 이의 상동체 동시 타겟 유전자교정 시스템 및 이의 용도 |
GB202112865D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to black sigatoka disease in banana |
GB202112866D0 (en) | 2021-09-09 | 2021-10-27 | Tropic Biosciences Uk Ltd | Resistance to fusarium wilt in a banana |
CN114807128B (zh) * | 2022-03-24 | 2023-09-01 | 四川农业大学 | 一种lncRNA-BTRL及其应用 |
CN114794029B (zh) * | 2022-06-09 | 2023-02-28 | 上海大学 | 一种计数秀丽隐杆线虫子宫内发育胚胎数目的方法 |
CN116064644B (zh) * | 2022-10-10 | 2023-10-10 | 中国农业科学院生物技术研究所 | SbAGO1b蛋白及其编码基因在调控植物抗虫性中的应用 |
CN116103334A (zh) * | 2022-11-16 | 2023-05-12 | 西北农林科技大学 | 一种猕猴桃抗溃疡病基因功能筛选专用瞬时转化体系 |
CN115976050B (zh) * | 2022-11-16 | 2024-06-18 | 西北农林科技大学 | 猕猴桃感病基因及其适用的vigs沉默体系构建 |
GB202305021D0 (en) | 2023-04-04 | 2023-05-17 | Tropic Biosciences Uk Ltd | Methods for generating breaks in a genome |
Family Cites Families (73)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
CA1192510A (en) | 1981-05-27 | 1985-08-27 | Lawrence E. Pelcher | Rna plant virus vector or portion thereof, a method of construction thereof, and a method of producing a gene derived product therefrom |
JPS6054684A (ja) | 1983-09-05 | 1985-03-29 | Teijin Ltd | 新規dνa及びハイブリツドdνa |
US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
CA1288073C (en) | 1985-03-07 | 1991-08-27 | Paul G. Ahlquist | Rna transformation vector |
US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
GB8608850D0 (en) | 1986-04-11 | 1986-05-14 | Diatech Ltd | Packaging system |
JPS6314693A (ja) | 1986-07-04 | 1988-01-21 | Sumitomo Chem Co Ltd | 植物ウイルスrnaベクタ− |
ES2039474T3 (es) | 1986-12-05 | 1993-10-01 | Ciba-Geigy Ag | Procedimineto mejorado para la transformacion de protoplastos vegetales. |
US5015580A (en) | 1987-07-29 | 1991-05-14 | Agracetus | Particle-mediated transformation of soybean plants and lines |
DE3850683T2 (de) | 1987-02-09 | 1994-10-27 | Lubrizol Genetics Inc | Hybrides RNS-Virus. |
US5316931A (en) | 1988-02-26 | 1994-05-31 | Biosource Genetics Corp. | Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes |
US5416011A (en) | 1988-07-22 | 1995-05-16 | Monsanto Company | Method for soybean transformation and regeneration |
US5693507A (en) | 1988-09-26 | 1997-12-02 | Auburn University | Genetic engineering of plant chloroplasts |
US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
JP3209744B2 (ja) | 1990-01-22 | 2001-09-17 | デカルブ・ジェネティクス・コーポレーション | 結実能力のある遺伝子変換コーン |
US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
US6403865B1 (en) | 1990-08-24 | 2002-06-11 | Syngenta Investment Corp. | Method of producing transgenic maize using direct transformation of commercially important genotypes |
US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
US5591616A (en) | 1992-07-07 | 1997-01-07 | Japan Tobacco, Inc. | Method for transforming monocotyledons |
US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
HUT70467A (en) | 1992-07-27 | 1995-10-30 | Pioneer Hi Bred Int | An improved method of agrobactenium-mediated transformation of cultvred soyhean cells |
US5998193A (en) * | 1994-06-24 | 1999-12-07 | Gene Shears Pty., Ltd. | Ribozymes with optimized hybridizing arms, stems, and loops, tRNA embedded ribozymes and compositions thereof |
US5693512A (en) | 1996-03-01 | 1997-12-02 | The Ohio State Research Foundation | Method for transforming plant tissue by sonication |
US5981840A (en) | 1997-01-24 | 1999-11-09 | Pioneer Hi-Bred International, Inc. | Methods for agrobacterium-mediated transformation |
JP2002534129A (ja) | 1999-01-14 | 2002-10-15 | モンサント テクノロジー エルエルシー | ダイズ形質転換方法 |
US9567591B2 (en) | 2003-05-15 | 2017-02-14 | Mello Biotechnology, Inc. | Generation of human embryonic stem-like cells using intronic RNA |
US20050203047A1 (en) | 2004-03-10 | 2005-09-15 | Ulrich Thomann | Delivery vectors for short interfering RNA, micro-RNA and antisense RNA |
IL179285A (en) | 2004-05-14 | 2011-04-28 | Rosetta Genomics Ltd | Micrornas and uses thereof |
EP2484758B1 (en) | 2005-10-18 | 2013-10-02 | Precision Biosciences | Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity |
US20080280848A1 (en) | 2005-10-28 | 2008-11-13 | Volker Patzel | Structures of Active Guide Rna Molecules and Method of Selection |
BRPI0814244B1 (pt) | 2007-06-07 | 2018-10-09 | Agriculture And Agri Food Canada | método para obtenção de uma planta geneticamente engenheirada |
BRPI0817911B8 (pt) | 2007-10-05 | 2022-06-28 | Dow Agrosciences Llc | Processos para transferência de substâncias moleculares para dentro de células vegetais e processo para expressão de um gene |
US8212019B2 (en) * | 2008-07-30 | 2012-07-03 | University Of Massachusetts | Nucleic acid silencing sequences |
EP2292176B1 (en) | 2009-09-07 | 2019-01-09 | Nobel Biocare Services AG | Implantation set |
US9150854B2 (en) * | 2010-12-02 | 2015-10-06 | Keygene N.V. | Targeted alteration of DNA |
EP2819703A4 (en) | 2012-02-29 | 2015-11-18 | Benitec Biopharma Ltd | TREATMENT OF PAIN |
US10000753B2 (en) | 2013-01-08 | 2018-06-19 | Benitec Biopharma Limited | Age-related macular degeneration treatment |
BR112016002385A2 (pt) | 2013-08-07 | 2017-09-12 | Harvard College | animal não humano, célula, tecido ou embrião, vetor de alvejamento, constructo de vetor de alvejamento, e, métodos para produzir um animal não humano e para modificar um lócus de incrna em uma célula pluripotente |
MX2016002118A (es) | 2013-08-22 | 2016-06-28 | Du Pont | Modificacion del genoma de plantas por medio del uso de sistemas de ácido ribonucléico (arn) guía/ endonucleasa cas y metodos de uso. |
KR20160089530A (ko) * | 2013-12-12 | 2016-07-27 | 더 브로드 인스티튜트, 인코퍼레이티드 | Hbv 및 바이러스 질병 및 질환을 위한 crisprcas 시스템 및 조성물의 전달,용도 및 치료적 적용 |
PL3105328T3 (pl) | 2014-02-11 | 2020-10-19 | The Regents Of The University Of Colorado, A Body Corporate | Umożliwiana przez CRISPR multipleksowa modyfikacja genomu |
US20160076093A1 (en) | 2014-08-04 | 2016-03-17 | University Of Washington | Multiplex homology-directed repair |
EP3227447B1 (en) | 2014-12-03 | 2024-04-24 | Agilent Technologies, Inc. | Guide rna with chemical modifications |
US20170327834A1 (en) | 2014-12-15 | 2017-11-16 | Syngenta Participations Ag | Pesticidal microrna carriers and use thereof |
CN108368502B (zh) | 2015-06-03 | 2022-03-18 | 内布拉斯加大学董事委员会 | 使用单链dna的dna编辑 |
CN106701752B (zh) | 2015-09-01 | 2019-07-12 | 清华大学 | 人工合成的microRNA簇及其构建方法与所用合成microRNA单元 |
CA3011458A1 (en) | 2016-01-14 | 2017-07-20 | The Brigham And Women's Hospital, Inc. | Genome editing for treating glioblastoma |
CN105647962A (zh) * | 2016-02-15 | 2016-06-08 | 浙江大学 | 运用CRISPR-Cas9系统敲除水稻MIRNA393b茎环序列的基因编辑方法 |
CN106367435B (zh) | 2016-09-07 | 2019-11-08 | 电子科技大学 | 一种水稻miRNA定向敲除的方法 |
EP3601579B1 (en) | 2017-03-31 | 2023-10-04 | Pioneer Hi-Bred International, Inc. | Expression modulating elements and use thereof |
BR112020005416A2 (pt) | 2017-09-19 | 2020-09-29 | Tropic Biosciences UK Limited | modificação da especificidade de moléculas de rna não codificante para silenciar expressão gênica em células eucarióticas |
EP3931321A1 (en) | 2019-03-01 | 2022-01-05 | Syngenta Crop Protection AG | Suppression of target gene expression through genome editing of native mirnas |
-
2018
- 2018-09-18 BR BR112020005416-0A patent/BR112020005416A2/pt unknown
- 2018-09-18 JP JP2020515770A patent/JP7462553B2/ja active Active
- 2018-09-18 ES ES18786034T patent/ES2915576T3/es active Active
- 2018-09-18 DK DK18786034.1T patent/DK3684930T3/da active
- 2018-09-18 BR BR112020005444-5A patent/BR112020005444A2/pt unknown
- 2018-09-18 KR KR1020237008634A patent/KR20230050424A/ko active Application Filing
- 2018-09-18 AU AU2018336126A patent/AU2018336126A1/en active Pending
- 2018-09-18 WO PCT/IB2018/057143 patent/WO2019058253A1/en unknown
- 2018-09-18 CN CN201880074921.9A patent/CN111448318A/zh active Pending
- 2018-09-18 EP EP22170070.1A patent/EP4170029A3/en active Pending
- 2018-09-18 CN CN201880073961.1A patent/CN111373044A/zh active Pending
- 2018-09-18 CA CA3074948A patent/CA3074948A1/en active Pending
- 2018-09-18 CA CA3074946A patent/CA3074946A1/en active Pending
- 2018-09-18 JP JP2020515764A patent/JP7422069B2/ja active Active
- 2018-09-18 WO PCT/IB2018/057160 patent/WO2019058255A1/en unknown
- 2018-09-18 US US16/648,748 patent/US11555199B2/en active Active
- 2018-09-18 SG SG11202002479XA patent/SG11202002479XA/en unknown
- 2018-09-18 US US16/648,779 patent/US20200270604A1/en active Pending
- 2018-09-18 AU AU2018336128A patent/AU2018336128B2/en active Active
- 2018-09-18 IL IL273460A patent/IL273460B1/en unknown
- 2018-09-18 EP EP18786033.3A patent/EP3684929A1/en active Pending
- 2018-09-18 KR KR1020207011255A patent/KR20200051808A/ko not_active Application Discontinuation
- 2018-09-18 EP EP18786034.1A patent/EP3684930B1/en active Active
- 2018-09-18 KR KR1020207011282A patent/KR102510576B1/ko active IP Right Grant
- 2018-09-18 SG SG11202002481RA patent/SG11202002481RA/en unknown
-
2020
- 2020-03-19 IL IL273461A patent/IL273461A/en unknown
-
2023
- 2023-01-10 US US18/152,722 patent/US20230340512A1/en active Pending
- 2023-01-10 US US18/152,718 patent/US20230279414A1/en active Pending
- 2023-04-04 AU AU2023202078A patent/AU2023202078A1/en active Pending
- 2023-08-25 JP JP2023137627A patent/JP2023179432A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL273460A (en) | Changing the specificity of plant non-coding RNA sequences to silence gene expression | |
IL287033A (en) | Regulation of nuclease-mediated gene expression | |
IL268856A (en) | Methods for the purification of messenger RNA | |
IL268857A (en) | Methods for the purification of messenger RNA | |
LT3636764T (lt) | 3`utr sekos, skirtos rnr stabilizavimui | |
EP3224353C0 (en) | TARGETED REMOVAL OF BACTERIAL GENES | |
EP3331355A4 (en) | PATHOGENRESISTENT ANIMALS WITH MODIFIED CD163 GENES | |
GB201903520D0 (en) | Modifying the specificity of non-coding rna molecules for silencing genes in eukaryotic cells | |
HK1244032A1 (zh) | 控制基因表達的天然型mirna及其用途 | |
EP3158067A4 (en) | Compositions and methods for regulating gene expression via rna interference | |
ZA202001649B (en) | Rna molecules | |
GB2551964B (en) | Method of treating biomass to remove RNA | |
ZA201900116B (en) | Methods to improve genetic transformation of sorghum | |
EP3099795A4 (en) | Oligonucleotides and methods for treatment of cardiomyopathy using rna interference | |
MX2016012206A (es) | Variantes de t7 rna polimerasa con rango de substrato expandido y rendimiento de transcripcion mejorado. | |
CL2016002961A1 (es) | Enzimas de citoquinina sintasa, constructos y métodos relacionados | |
EP3274466A4 (en) | Directional amplification of rna | |
IL256387A (en) | Transgenic algae and their use for the administration of inhibitory RNA molecules | |
GB201907380D0 (en) | Mediators of gene silencing | |
EP3631006A4 (en) | DNA STABILIZATION OF RNA | |
PL3313998T3 (pl) | Sposób enzymatycznego wytwarzania alkoholu izoamylowego | |
GB201719516D0 (en) | Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA | |
GB201715113D0 (en) | Modifying the specificity of plant non-coding RNA molecules for silencing of target RNA | |
GB201715116D0 (en) | Modifying the specificity of non-coding RNA molecules for silencing of target RNA in eukaryotic cells | |
GB201817990D0 (en) | Enzymatic nucleic acid molecules |