SG11202000968TA - Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data - Google Patents

Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data

Info

Publication number
SG11202000968TA
SG11202000968TA SG11202000968TA SG11202000968TA SG11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA
Authority
SG
Singapore
Prior art keywords
lipids
identification
data
mass spectrometry
liquid chromatography
Prior art date
Application number
SG11202000968TA
Other languages
English (en)
Inventor
Dong-Yup Lee
Hock Chuan Yeo
Ying Swan Ho
Shuwen Chen
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11202000968TA publication Critical patent/SG11202000968TA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
SG11202000968TA 2017-08-07 2018-08-07 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data SG11202000968TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201706416R 2017-08-07
PCT/SG2018/050402 WO2019032049A1 (fr) 2017-08-07 2018-08-07 Analyse et identification rapides de lipides à partir de données de chromatographie liquide-spectrométrie de masse (lc-ms)

Publications (1)

Publication Number Publication Date
SG11202000968TA true SG11202000968TA (en) 2020-02-27

Family

ID=65272363

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000968TA SG11202000968TA (en) 2017-08-07 2018-08-07 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data

Country Status (5)

Country Link
US (1) US11143637B2 (fr)
EP (1) EP3665476A4 (fr)
CN (1) CN111164422B (fr)
SG (1) SG11202000968TA (fr)
WO (1) WO2019032049A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113514531B (zh) * 2021-04-27 2022-10-25 清华大学 一种化合物的碎片离子预测方法及应用
CN113624896A (zh) * 2021-08-11 2021-11-09 江南大学 一种乳品防伪溯源的组学分析方法
CN114894949B (zh) * 2022-04-12 2024-08-30 北京清谱科技有限公司 一种脂质精细结构分析流程和控制处理系统

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ES2385335T3 (es) * 2000-10-19 2012-07-23 Target Discovery, Inc. Marcaje de defecto de masa para la determinación de secuencias de oligómeros
US20030068825A1 (en) * 2001-07-13 2003-04-10 Washburn Michael P. System and method of determining proteomic differences
US7510880B2 (en) 2002-06-26 2009-03-31 Gross Richard W Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts
AU2003262824B2 (en) * 2002-08-22 2007-08-23 Applied Biosystems Inc. Method for characterizing biomolecules utilizing a result driven strategy
US7041968B2 (en) * 2003-03-20 2006-05-09 Science & Technology Corporation @ Unm Distance of flight spectrometer for MS and simultaneous scanless MS/MS
US7851742B2 (en) * 2004-05-20 2010-12-14 Waters Technologies Corporation Method and apparatus for identifying proteins in mixtures
US20060226082A1 (en) * 2005-03-15 2006-10-12 Mcmaster University Methods for substrate and modulator screening using enzyme-reactor chromatography/tandem mass spectrometry
WO2006133568A1 (fr) * 2005-06-16 2006-12-21 Caprion Pharmaceuticals Inc. Spectrometrie de masse virtuelle
GB0524782D0 (en) * 2005-12-05 2006-01-11 Chiron Srl Analysis of samples
WO2007104160A1 (fr) * 2006-03-14 2007-09-20 Caprion Pharmaceuticals Inc. Identification de biomolécules au moyen de profils d'expression en spectrométrie de masse
GB2463633B (en) * 2008-05-15 2013-02-27 Thermo Fisher Scient Bremen MS/MS data processing
CN106055895B (zh) * 2010-09-15 2021-02-19 Dh科技发展私人贸易有限公司 产物离子谱的数据独立获取及参考谱库匹配
MX340401B (es) * 2010-10-01 2016-07-07 Dow Agrosciences Llc * Cuantificacion y caracterizacion de alergenos.
SG193361A1 (en) * 2011-03-11 2013-10-30 Agency Science Tech & Res A method, an apparatus, and a computer program product for identifying metabolites from liquid chromatography-mass spectrometry measurements
EP2786130A4 (fr) * 2011-11-28 2015-08-12 Waters Technologies Corp Techniques pour quantification d'échantillons
US9074236B2 (en) * 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry
WO2013173642A1 (fr) 2012-05-18 2013-11-21 Sanford-Burnham Medical Research Institute Lipidomique à rendement élevé
CA2887908C (fr) * 2012-10-22 2022-06-21 President And Fellows Of Harvard College Proteomique quantitative multiplexe precise et sans interference faisant appel a la spectrometrie de masse
EP2835751A1 (fr) * 2013-08-06 2015-02-11 Commissariat A L'energie Atomique Et Aux Energies Alternatives Procédé de déconvolution d'informations moléculaires mixtes dans un échantillon complexe afin d'identifier des organismes
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US9847216B2 (en) * 2015-08-14 2017-12-19 Thermo Finnigan Llc Systems and methods for targeted top down discovery
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WO2018222345A1 (fr) * 2017-06-01 2018-12-06 Thermo Finnigan Llc Détermination automatisée de l'énergie de collision d'un spectromètre de masse
EP3958290B1 (fr) * 2017-06-02 2024-09-25 Thermo Fisher Scientific (Bremen) GmbH Spectromètre de masse hybride
US11211236B2 (en) * 2019-05-30 2021-12-28 Thermo Finnigan Llc Operating a mass spectrometer utilizing a promotion list

Also Published As

Publication number Publication date
EP3665476A1 (fr) 2020-06-17
US11143637B2 (en) 2021-10-12
CN111164422A (zh) 2020-05-15
WO2019032049A1 (fr) 2019-02-14
US20200240964A1 (en) 2020-07-30
CN111164422B (zh) 2023-05-02
EP3665476A4 (fr) 2021-05-05

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