SG11202000968TA - Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data - Google Patents

Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data

Info

Publication number
SG11202000968TA
SG11202000968TA SG11202000968TA SG11202000968TA SG11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA SG 11202000968T A SG11202000968T A SG 11202000968TA
Authority
SG
Singapore
Prior art keywords
lipids
identification
data
mass spectrometry
liquid chromatography
Prior art date
Application number
SG11202000968TA
Inventor
Dong-Yup Lee
Hock Chuan Yeo
Ying Swan Ho
Shuwen Chen
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11202000968TA publication Critical patent/SG11202000968TA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
    • G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/86—Signal analysis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0431—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components for liquid samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/027—Liquid chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2570/00—Omics, e.g. proteomics, glycomics or lipidomics; Methods of analysis focusing on the entire complement of classes of biological molecules or subsets thereof, i.e. focusing on proteomes, glycomes or lipidomes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/72—Mass spectrometers
SG11202000968TA 2017-08-07 2018-08-07 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data SG11202000968TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201706416R 2017-08-07
PCT/SG2018/050402 WO2019032049A1 (en) 2017-08-07 2018-08-07 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data

Publications (1)

Publication Number Publication Date
SG11202000968TA true SG11202000968TA (en) 2020-02-27

Family

ID=65272363

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202000968TA SG11202000968TA (en) 2017-08-07 2018-08-07 Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data

Country Status (5)

Country Link
US (1) US11143637B2 (en)
EP (1) EP3665476A4 (en)
CN (1) CN111164422B (en)
SG (1) SG11202000968TA (en)
WO (1) WO2019032049A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113514531B (en) * 2021-04-27 2022-10-25 清华大学 Fragment ion prediction method and application of compound
CN113624896A (en) * 2021-08-11 2021-11-09 江南大学 Dairy product anti-counterfeiting traceability omics analysis method

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1358458T3 (en) * 2000-10-19 2012-06-18 Target Discovery Inc Mass defect labeling to determine oligomer sequences
WO2003006951A2 (en) * 2001-07-13 2003-01-23 Syngenta Participations Ag System and method of determining proteomic differences
US7510880B2 (en) * 2002-06-26 2009-03-31 Gross Richard W Multidimensional mass spectrometry of serum and cellular lipids directly from biologic extracts
AU2003262824B2 (en) * 2002-08-22 2007-08-23 Applied Biosystems Inc. Method for characterizing biomolecules utilizing a result driven strategy
US7041968B2 (en) * 2003-03-20 2006-05-09 Science & Technology Corporation @ Unm Distance of flight spectrometer for MS and simultaneous scanless MS/MS
JP5008564B2 (en) * 2004-05-20 2012-08-22 ウオーターズ・テクノロジーズ・コーポレイシヨン Method and apparatus for identifying proteins in a mixture
US20060226082A1 (en) * 2005-03-15 2006-10-12 Mcmaster University Methods for substrate and modulator screening using enzyme-reactor chromatography/tandem mass spectrometry
US20060287834A1 (en) * 2005-06-16 2006-12-21 Kearney Paul E Virtual mass spectrometry
GB0524782D0 (en) * 2005-12-05 2006-01-11 Chiron Srl Analysis of samples
WO2007104160A1 (en) * 2006-03-14 2007-09-20 Caprion Pharmaceuticals Inc. Identification of biomolecules through expression patterns in mass spectrometry
GB2463633B (en) * 2008-05-15 2013-02-27 Thermo Fisher Scient Bremen MS/MS data processing
CN103109345B (en) * 2010-09-15 2016-06-22 Dh科技发展私人贸易有限公司 The Dynamic data exchange of product ion spectrum obtains and reference spectra storehouse coupling
EP2622341A4 (en) * 2010-10-01 2014-08-06 Dow Agrosciences Llc Quantification and characterization of allergens
US20140088885A1 (en) * 2011-03-11 2014-03-27 Dong-Yup LEE Method, an apparatus, and a computer program product for identifying metabolites from liquid chromatography-mass spectrometry measurements
US9810669B2 (en) * 2011-11-28 2017-11-07 Waters Technologies Corporation Techniques for quantification of samples
US9074236B2 (en) * 2012-05-01 2015-07-07 Oxoid Limited Apparatus and methods for microbial identification by mass spectrometry
WO2013173642A1 (en) 2012-05-18 2013-11-21 Sanford-Burnham Medical Research Institute High-throughput lipidomics
EP2909618B1 (en) * 2012-10-22 2021-02-17 President and Fellows of Harvard College Accurate and interference-free multiplexed quantitative proteomics using mass spectrometry
EP2835751A1 (en) * 2013-08-06 2015-02-11 Commissariat A L'energie Atomique Et Aux Energies Alternatives Method of deconvolution of mixed molecular information in a complex sample to identify organism(s)
US10115576B2 (en) * 2013-12-12 2018-10-30 Waters Technologies Corporation Method and an apparatus for analyzing a complex sample
US20180340174A1 (en) * 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
GB2533156B (en) * 2014-12-12 2018-06-27 Thermo Fisher Scient Bremen Gmbh Method of determining the structure of a macromolecular assembly
US10591448B2 (en) * 2015-04-14 2020-03-17 Waters Technologies Corporation Structural elucidation of isotopically labeled analytes
US9847216B2 (en) * 2015-08-14 2017-12-19 Thermo Finnigan Llc Systems and methods for targeted top down discovery
US10770276B2 (en) * 2015-08-31 2020-09-08 Yale University Techniques of mass spectrometry for isotopomer analysis and related systems and methods
WO2018009834A1 (en) * 2016-07-07 2018-01-11 Berg Llc Lipid, protein, and metabolite markers for the diagnosis and treatment of prostate cancer
GB2559395B (en) * 2017-02-03 2020-07-01 Thermo Fisher Scient Bremen Gmbh High resolution MS1 based quantification
EP3631838B1 (en) * 2017-06-01 2021-09-15 Thermo Finnigan LLC Automated determination of mass spectrometer collision energy
EP3410463B1 (en) * 2017-06-02 2021-07-28 Thermo Fisher Scientific (Bremen) GmbH Hybrid mass spectrometer
US11211236B2 (en) * 2019-05-30 2021-12-28 Thermo Finnigan Llc Operating a mass spectrometer utilizing a promotion list

Also Published As

Publication number Publication date
WO2019032049A1 (en) 2019-02-14
CN111164422A (en) 2020-05-15
US20200240964A1 (en) 2020-07-30
US11143637B2 (en) 2021-10-12
EP3665476A4 (en) 2021-05-05
CN111164422B (en) 2023-05-02
EP3665476A1 (en) 2020-06-17

Similar Documents

Publication Publication Date Title
ZA201901986B (en) Devices and methods for sample analysis
ZA201901985B (en) Devices and methods for sample analysis
EP3304064A4 (en) Methods for mass spectrometric quantitation of analytes extracted from a microsampling device
GB201811292D0 (en) Instrument for analytical sample preparation
IL253666A0 (en) Hyperspectral analysis device for analyzing different types of samples
EP3508842A4 (en) Mass spectrometric data analysis apparatus and analysis method
EP3540425A4 (en) Data analysis apparatus for chromatography mass spectrometry
GB2566586B (en) Rapid energized dispersive solid phase extraction (SPE) for analytical analysis
EP3512862A4 (en) Devices and methods for sample analysis
SG11201710470TA (en) Mass spectrometric detection and analysis method
EP3570980A4 (en) Methods and devices for sample analysis
IL273981A (en) Methods and devices for performing an analytical measurement
GB201802581D0 (en) Analysis of food samples
EP3572805A4 (en) Analysis data analytics method and analysis data analytics device
EP3574392A4 (en) Selection of an extended display identification data standard
ZA201908559B (en) Target-enriched multiplexed parallel analysis for assessment of tumor biomarkers
IL282878A (en) Methods and devices for performing an analytical measurement
EP3724352A4 (en) Portable devices and methods for analyzing samples
SG10201700573SA (en) Network analysis of transaction data for target identification
SG11202000968TA (en) Rapid analysis and identification of lipids from liquid chromatography-mass spectrometry (lc-ms) data
EP3483600A4 (en) Data processing device for chromatograph mass analysis
GB201721430D0 (en) Method and device for microscopy-based imaging of samples
EP3454058A4 (en) Mass spectrometry data analysis device and program for mass spectrometry data analysis
EP3630358A4 (en) Devices and methods for rapid sample processing and analysis
GB201621927D0 (en) Mass spectrometric analysis of lipids