SG11201909644QA - Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same - Google Patents

Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same

Info

Publication number
SG11201909644QA
SG11201909644QA SG11201909644QA SG11201909644QA SG 11201909644Q A SG11201909644Q A SG 11201909644QA SG 11201909644Q A SG11201909644Q A SG 11201909644QA SG 11201909644Q A SG11201909644Q A SG 11201909644QA
Authority
SG
Singapore
Prior art keywords
singapore
international
pluripotent stem
cells
fluorescent compounds
Prior art date
Application number
Inventor
Sandhya Sriram
Shigeki Sugii
Young Tae Chang
Nam-Young Kang
Original Assignee
Agency Science Tech & Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agency Science Tech & Res filed Critical Agency Science Tech & Res
Publication of SG11201909644QA publication Critical patent/SG11201909644QA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/022—Boron compounds without C-boron linkages
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0606—Pluripotent embryonic cells, e.g. embryonic stem cells [ES]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Reproductive Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Transplantation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

R 0) q F (R7)p W O 20 19/0098 10 Al Rio (I) N R11 (R2)m N, B \" N F F (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 10 January 2019 (10.01.2019) WIPO I PCT omit VIII VIII 10 o III IIIII 11o1H H 010 11011111° oimIE (10) International Publication Number WO 2019/009810 Al (51) International Patent Classification: C07F 5/02 (2006.01) G01N 33/533 (2006.01) C09B 57/00 (2006.01) (21) International Application Number: PCT/SG2018/050329 (22) International Filing Date: 04 July 2018 (04.07.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 10201705493P 04 July 2017 (04.07.2017) SG (71) Applicant: AGENCY FOR SCIENCE, TECHNOLO- GY AND RESEARCH [SG/SG]; 1 Fusionopolis Way, #20-10, Connexis North Tower, Singapore 138632 (SG). (72) Inventors: SRIRAM, Sandhya; c/o Singapore Bioimaging Consortium, 11 Biopolis Way, #01-02, Helios, Singapore 138667 (SG). SUGII, Shigeki; c/o Singapore Bioimag- ing Consortium, 11 Biopolis Way, #01-02, Helios, Singa- pore 138667 (SG). CHANG, Young Tae; c/o Singapore Bioimaging Consortium, 11 Biopolis Way, #01-02, Helios, Singapore 138667 (SG). KANG, Nam-Young; c/o Singa- pore Bioimaging Consortium, 11 Biopolis Way, #01-02, Helios, Singapore 138667 (SG). (74) Agent: VIERING, JENTSCHURA & PARTNER LLP; P.O. Box 1088, Rochor Post Office, Rochor Road, Singa- pore 911833 (SG). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE (54) Title: FLUORESCENT COMPOUNDS SPECIFIC FOR PLURIPOTENT STEM CELLS AND REPROGRAMMING-READY CELLS AND METHODS OF USING THE SAME (57) : The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts there- of. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.
SG11201909644Q 2017-07-04 2018-07-04 Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same SG11201909644QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SG10201705493P 2017-07-04
PCT/SG2018/050329 WO2019009810A1 (en) 2017-07-04 2018-07-04 Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same

Publications (1)

Publication Number Publication Date
SG11201909644QA true SG11201909644QA (en) 2019-11-28

Family

ID=64950253

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909644Q SG11201909644QA (en) 2017-07-04 2018-07-04 Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same

Country Status (3)

Country Link
US (2) US11634437B2 (en)
SG (1) SG11201909644QA (en)
WO (1) WO2019009810A1 (en)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120263689A1 (en) 2009-09-10 2012-10-18 The Salk Institute For Biological Studies Adipose-derived induced pluripotent stem cells
WO2012027266A2 (en) 2010-08-24 2012-03-01 New York University Methods for dectecting embryonic stem cells, induced pluripotent stem cells, or cells undergoing reprogramming to produce induced pluripotent stem cells
SG190173A1 (en) 2010-11-24 2013-07-31 Univ Singapore Bodipy structure fluorescence dye for neural stem cell probe
US9267949B2 (en) 2011-06-15 2016-02-23 National University Of Singapore Alkylamino BODIPY dyes as selective fluorescent probes for proteins and mouse embryonic stem cells
WO2014109713A1 (en) 2013-01-14 2014-07-17 National Univeristy Of Singapore Fluorescent cell cycle probe having m-phase specificity
WO2016073385A1 (en) 2014-11-03 2016-05-12 Agency For Science, Technology And Research Compounds for the diagnosis or treatment of disorders associated with protein or peptide oligomers
WO2016171619A1 (en) * 2015-04-24 2016-10-27 Nanyang Technological University Chemical fluorescent probes for detecting biofilms

Also Published As

Publication number Publication date
WO2019009810A1 (en) 2019-01-10
US11634437B2 (en) 2023-04-25
US20200123179A1 (en) 2020-04-23
US20230339983A1 (en) 2023-10-26

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