SG11201908360QA - In-situ fluidic inspection - Google Patents

In-situ fluidic inspection

Info

Publication number
SG11201908360QA
SG11201908360QA SG11201908360QA SG11201908360QA SG 11201908360Q A SG11201908360Q A SG 11201908360QA SG 11201908360Q A SG11201908360Q A SG 11201908360QA SG 11201908360Q A SG11201908360Q A SG 11201908360QA
Authority
SG
Singapore
Prior art keywords
international
california
san diego
illumina
air
Prior art date
Application number
Inventor
Sz-Chin Steven Lin
Richard Lemoine
Rajagopal Panchapakesan
Wesley A Cox-Muranami
Darren Segale
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of SG11201908360QA publication Critical patent/SG11201908360QA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0028—Valves having multiple inlets or outlets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K37/00—Special means in or on valves or other cut-off apparatus for indicating or recording operation thereof, or for enabling an alarm to be given
    • F16K37/0075—For recording or indicating the functioning of a valve in combination with test equipment
    • F16K37/0083—For recording or indicating the functioning of a valve in combination with test equipment by measuring valve parameters
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0013—Rotary valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01M—TESTING STATIC OR DYNAMIC BALANCE OF MACHINES OR STRUCTURES; TESTING OF STRUCTURES OR APPARATUS, NOT OTHERWISE PROVIDED FOR
    • G01M3/00—Investigating fluid-tightness of structures
    • G01M3/02—Investigating fluid-tightness of structures by using fluid or vacuum
    • G01M3/26—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors
    • G01M3/28—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds
    • G01M3/2876—Investigating fluid-tightness of structures by using fluid or vacuum by measuring rate of loss or gain of fluid, e.g. by pressure-responsive devices, by flow detectors for pipes, cables or tubes; for pipe joints or seals; for valves ; for welds for valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00801—Means to assemble
    • B01J2219/0081—Plurality of modules
    • B01J2219/00813—Fluidic connections
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0633—Valves, specific forms thereof with moving parts
    • B01L2400/0644—Valves, specific forms thereof with moving parts rotary valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K2099/0082—Microvalves adapted for a particular use
    • F16K2099/0084—Chemistry or biology, e.g. "lab-on-a-chip" technology

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 11 October 2018 (11.10.2018) WIPO I PCT ill~~~~~~~~ 011101010VIIIOH oI0 OH1110IIIIIDIDIIIIImmoiliollIE (10) International Publication Number WO 2018/187207 A3 (51) International Patent Classification: BOIL 3/00 (2006.01) B81C 99/00 (2010.01) (21) International Application Number: PCT/US2018/025686 (22) International Filing Date: 02 April 2018 (02.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,414 06 April 2017 (06.04.2017) US (71) Applicant: ILLUMINA, INC. [US/US]; 5200 Illumina Way, San Diego, California 92122 (US). (72) Inventors: LIN, Sz-Chin Steven; 5200 Illumina Way, San Diego, California 92122 (US). LEMOINE, Richard; 5200 Illumina Way, San Diego, California 92122 (US). PAN- CHAPAKESAN, Rajagopal; 5200 Illumina Way, San Diego, California 92122 (US). COX-MURANAMI, Wes- ley A.; 5200 Illumina Way, San Diego, California 92122 (US). SEGALE, Darren; 5200 Illumina Way, San Diego, California 92122 (US). (74) Agent: SCUDERI, Stephen P.; Heslin Rothenberg Farley & Mesiti P.C., 5 Columbia Circle, Albany, New York 12203 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: IN-SITU FLUIDIC INSPECTION FIG. 1B y100 (57) : A method includes engaging a well of a cartridge with a flow sensor of an instrument. The cartridge includes: a rotary valve including a rotatable port and a center port; the well in fluid communication with a channel, the channel including a channel port that the rotatable port is to align to in order to receive fluid from the well; and a flowcell including an inlet gasket in fluid communication with the center port. A source of pressurized air is connected to the flow sensor in order to establish a mass flow of air through a flow path. The flow path extends through one of the flow sensor, the channel, the rotary valve, and the flowcell. The mass flow of air through the flow path is measured with the flow sensor. It is determined if there is one of an air leak and an air blockage within the flow path. 10 I 56 [Continued on next page] W O 20 18/187 207 A3 WO 2018/187207 A3 MIDEDIMO 11111 OE IIMOIIMIEDMOHEIHMIHMOMECIE Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 03 January 2019 (03.01.2019)
SG11201908360Q 2017-04-06 2018-04-02 In-situ fluidic inspection SG11201908360QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762482414P 2017-04-06 2017-04-06
PCT/US2018/025686 WO2018187207A2 (en) 2017-04-06 2018-04-02 In-situ fluidic inspection

Publications (1)

Publication Number Publication Date
SG11201908360QA true SG11201908360QA (en) 2019-10-30

Family

ID=63712617

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202111048VA SG10202111048VA (en) 2017-04-06 2018-04-02 In-situ fluidic inspection
SG11201908360Q SG11201908360QA (en) 2017-04-06 2018-04-02 In-situ fluidic inspection

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202111048VA SG10202111048VA (en) 2017-04-06 2018-04-02 In-situ fluidic inspection

Country Status (5)

Country Link
US (3) US11351541B2 (en)
EP (2) EP4219011A3 (en)
CN (1) CN110494222B (en)
SG (2) SG10202111048VA (en)
WO (1) WO2018187207A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10202111048VA (en) * 2017-04-06 2021-11-29 Illumina Inc In-situ fluidic inspection
WO2018187201A1 (en) * 2017-04-06 2018-10-11 Illumina, Inc. Method and apparatus to identify fluidic path positions
AU2020399285A1 (en) * 2019-12-10 2021-09-30 Illumina Singapore Pte. Ltd. Actuation systems and methods for use with flow cells

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030012712A1 (en) * 2001-07-16 2003-01-16 Perlegen Sciences Apparatus for whole wafer processing
US20030077495A1 (en) * 2001-10-19 2003-04-24 Scartozzi John P. Fuel cell system, and method of testing a fuel cell for a gas leak
US20040179972A1 (en) 2003-03-14 2004-09-16 Nanostream, Inc. Systems and methods for detecting manufacturing defects in microfluidic devices
US8101431B2 (en) 2004-02-27 2012-01-24 Board Of Regents, The University Of Texas System Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
EP4105644A3 (en) * 2006-03-31 2022-12-28 Illumina, Inc. Systems and devices for sequence by synthesis analysis
KR101435942B1 (en) 2007-10-10 2014-09-02 삼성전자 주식회사 Automatic checking method and apparatus for microfluidic system
US7919062B2 (en) 2008-03-20 2011-04-05 Corning Incorporated Modular microfluidic system and method for building a modular microfludic system
WO2009134786A2 (en) 2008-04-30 2009-11-05 The Board Of Regents Of The University Of Texas System Quality control method and micro/nano-channeled devices
US8008080B2 (en) 2009-09-23 2011-08-30 Ecolab Usa Inc. Valve analytical system
JP5754190B2 (en) 2011-03-18 2015-07-29 ソニー株式会社 Microchip, sample liquid supply apparatus, sample liquid supply method, and analysis apparatus
JP5749534B2 (en) 2011-03-25 2015-07-15 浜松ホトニクス株式会社 Infrared image sensor and signal readout method
EP2707631B1 (en) 2011-05-12 2017-02-15 Fraunhofer Gesellschaft zur Förderung der angewandten Forschung E.V. Test station and method for testing fluidic components
ITTO20110565A1 (en) * 2011-06-28 2012-12-29 St Microelectronics Srl MULTILAYER STRUCTURE HAVING A MICROFLUID CHANNEL AND A SYSTEM FOR DETECTING LEAKS FROM THE MICROFLUID CHANNEL AND METHOD TO DETECT LOSSES IN A MICROFLUIDIC DEVICE
CN103105273A (en) 2013-01-24 2013-05-15 创斯达（南通）机电有限公司 Leak detector of sealed space leakage
US9561323B2 (en) 2013-03-14 2017-02-07 Fresenius Medical Care Holdings, Inc. Medical fluid cassette leak detection methods and devices
US9440233B2 (en) 2013-08-09 2016-09-13 Shark Kabushiki Kaisha Microfluidic device for serial fluidic operations
US10352746B2 (en) * 2013-09-18 2019-07-16 Hitachi Metals, Ltd. Mass flow meter including organic-material covering layers
KR102231650B1 (en) 2014-05-27 2021-03-23 일루미나, 인코포레이티드 Systems and methods for biochemical analysis including a base instrument and a removable cartridge
DK3151964T3 (en) * 2014-06-05 2020-04-14 Illumina Inc Systems and methods including a rotary valve for at least one sample preparation or sample analysis
CN106574729B (en) * 2014-06-17 2019-02-15 生命技术公司 Clamp flow regulator
WO2016004171A1 (en) 2014-07-03 2016-01-07 Centrillion Technology Holdings Corporation Device for storage and dispensing of reagents
US9851019B2 (en) 2014-08-29 2017-12-26 Fluke Corporation Device and method for valve signature testing
DE102014221499A1 (en) 2014-10-23 2016-04-28 Robert Bosch Gmbh Method and device for testing a microfluidic system
CN104696706B (en) * 2015-01-20 2017-08-04 哈尔滨工业大学 The microfluid stream quantity regulating device driven based on air pressure
EP3344903B1 (en) 2015-08-31 2019-09-25 bNovate Technologies SA Rotary valve and pump system with rotary valve
CN205333264U (en) 2015-12-18 2016-06-22 上海东富龙爱瑞思科技有限公司 Inflatable seal encloses online leak detection system
CN205826252U (en) 2016-07-11 2016-12-21 苏州怡丰工业设备有限公司 Disinfection cabinet sealing propertytest system
SG10202111048VA (en) * 2017-04-06 2021-11-29 Illumina Inc In-situ fluidic inspection

Also Published As

Publication number Publication date
EP4219011A3 (en) 2023-08-23
US11351541B2 (en) 2022-06-07
EP3606671B1 (en) 2023-02-08
WO2018187207A2 (en) 2018-10-11
WO2018187207A3 (en) 2019-01-03
US11724258B2 (en) 2023-08-15
EP3606671A2 (en) 2020-02-12
EP3606671A4 (en) 2021-01-27
US20220280940A1 (en) 2022-09-08
EP4219011A2 (en) 2023-08-02
CN110494222B (en) 2021-12-21
US20210299661A1 (en) 2021-09-30
SG10202111048VA (en) 2021-11-29
CN110494222A (en) 2019-11-22
US20230330671A1 (en) 2023-10-19

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