SG11201805687UA - Tangential flow filtration process for concentrating biomolecule solutions - Google Patents
Tangential flow filtration process for concentrating biomolecule solutionsInfo
- Publication number
- SG11201805687UA SG11201805687UA SG11201805687UA SG11201805687UA SG11201805687UA SG 11201805687U A SG11201805687U A SG 11201805687UA SG 11201805687U A SG11201805687U A SG 11201805687UA SG 11201805687U A SG11201805687U A SG 11201805687UA SG 11201805687U A SG11201805687U A SG 11201805687UA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- belasis
- avenue
- pct
- flow filtration
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 238000009295 crossflow filtration Methods 0.000 title abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 208000036366 Sensation of pressure Diseases 0.000 abstract 1
- 239000003086 colorant Substances 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/20—Accessories; Auxiliary operations
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Water Supply & Treatment (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Prostheses (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 13 July 2017 (13.07.2017) WIPO I PCT (10) International Publication Number WO 2017/118835 Al 11111111111111011101111111111101011111011101110111H1111101111111111111111110111111 W O 20 17 / 118835 Al (51) International Patent Classification: CO7K 1/34 (2006.01) (21) International Application Number: PCT/GB2016/053980 (22) International Filing Date: 19 December 2016 (19.12.2016) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1600287.5 7 January 2016 (07.01.2016) GB (71) Applicant: FUJIFILM DIOSYNTH BIOTECHNOLO- GIES UK LIMITED [GB/GB]; Belasis Avenue, Billing- ham TS23 1LH (GB). (72) Inventors: HEISE, Charles; Belasis Avenue, Billingham TS23 1LH (GB). NAGY, Tibor; Belasis Avenue, Billing- ham TS23 1LH (GB). (74) Agent: REVELL, Christopher; Fujifilm Imaging Color- ants Limited, 6th Floor, Acresfield, 8-10 Exchange Street, Manchester M2 7HA (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: TANGENTIAL FLOW FILTRATION PROCESS FOR CONCENTRATING BIOMOLECULE SOLUTIONS Figure 1 403 (57) : A method of concentration of a liquid comprising a biomolecule is provided. The method comprises passing the li- quid through a tangential flow filtration device under pressure, wherein the pressure applied is varied between at least a higher pres - sure and a lower pressure. Preferably, the variation in pressure is delivered by the use of a variable flow- controller, such as a valve.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1600287.5A GB201600287D0 (en) | 2016-01-07 | 2016-01-07 | Process |
| PCT/GB2016/053980 WO2017118835A1 (en) | 2016-01-07 | 2016-12-19 | Tangential flow filtration process for concentrating biomolecule solutions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805687UA true SG11201805687UA (en) | 2018-07-30 |
Family
ID=55445681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201805687UA SG11201805687UA (en) | 2016-01-07 | 2016-12-19 | Tangential flow filtration process for concentrating biomolecule solutions |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10934325B2 (en) |
| EP (1) | EP3400234A1 (en) |
| JP (1) | JP6951341B2 (en) |
| KR (1) | KR20180100206A (en) |
| CN (2) | CN116874554A (en) |
| AU (1) | AU2016384285B2 (en) |
| BR (1) | BR112018013645A2 (en) |
| CA (1) | CA3010431A1 (en) |
| GB (1) | GB201600287D0 (en) |
| RU (1) | RU2754855C2 (en) |
| SG (1) | SG11201805687UA (en) |
| WO (1) | WO2017118835A1 (en) |
| ZA (1) | ZA201804527B (en) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201600287D0 (en) * | 2016-01-07 | 2016-02-24 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process |
| GB201802593D0 (en) | 2018-02-16 | 2018-04-04 | Fujifilm Diosynth Biotechnologies Uk Ltd | Rig |
| US20210253633A1 (en) * | 2018-06-08 | 2021-08-19 | Bristol-Myers Squibb Company | Single pass tangential flow filtration hybrid configurations for enhancing concentration of macromolecule solutions |
| GB201818709D0 (en) | 2018-11-16 | 2019-01-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Mixer |
| GB201911687D0 (en) | 2019-08-15 | 2019-10-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Apparatus for purifying a liquid comprising a target substance |
| GB201911686D0 (en) | 2019-08-15 | 2019-10-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process for purifying target substances |
| GB201911685D0 (en) | 2019-08-15 | 2019-10-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process for purifying monoclonal antibodies |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3726613A (en) * | 1970-10-12 | 1973-04-10 | Casimir W Von | Pulsefree peristaltic pump |
| DE2223354A1 (en) * | 1972-05-12 | 1973-11-29 | Wolf Von Dipl Phys Casimir | METHOD AND DEVICE FOR SMOOTHING THE PUMPING PERFORMANCE OF PERISTAL PUMPS |
| US3951377A (en) * | 1974-11-07 | 1976-04-20 | The United States Of America As Represented By The Secretary Of The Navy | Rolling-gate, quiet-throttling, flow-control valve |
| US4037818A (en) * | 1975-08-26 | 1977-07-26 | International Telephone And Telegraph Corporation | Control valve |
| EP0079040A3 (en) * | 1981-11-06 | 1984-12-27 | Hydronautics, Incorporated | Method and apparatus for increasing the cross-flow filtration fluxes of liquids containing suspended solids |
| JPS58190447A (en) * | 1982-04-30 | 1983-11-07 | 株式会社クラレ | Pulse generating apparatus |
| JPS6443305A (en) * | 1987-08-10 | 1989-02-15 | Fuji Photo Film Co Ltd | Cross flow type filtration process |
| FR2737261B1 (en) * | 1995-07-27 | 1997-10-10 | Jean Francois Ognier | PERISTALTIC PUMP |
| US6011148A (en) * | 1996-08-01 | 2000-01-04 | Megabios Corporation | Methods for purifying nucleic acids |
| US6607669B2 (en) * | 2000-06-23 | 2003-08-19 | Scilog, Inc. | Method and apparatus for enhancing filtration yields in tangential flow filtration |
| US6910673B2 (en) * | 2002-01-28 | 2005-06-28 | Valve Teck, Inc. | Valve with calibrated flow orifice insert |
| US20040256329A1 (en) | 2003-06-13 | 2004-12-23 | Peter Meserol | Photodynamic biological fluid pathogen inactivation/filtering apparatus and method |
| US7510654B2 (en) * | 2005-12-29 | 2009-03-31 | Spf Innovations, Llc | Method and apparatus for the filtration of biological samples |
| AU2008277886B8 (en) | 2007-07-17 | 2013-08-01 | F. Hoffmann-La Roche Ag | Variable tangential flow filtration |
| US8795530B2 (en) | 2009-01-21 | 2014-08-05 | Smartflow Technologies, Inc. | Optimization of separation for viscous suspensions |
| CA2847302C (en) * | 2011-09-01 | 2021-02-16 | Chugai Seiyaku Kabushiki Kaisha | Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration |
| CN102423635A (en) * | 2011-10-17 | 2012-04-25 | 武汉普赛特膜技术循环利用有限公司 | Continuous cross flow membrane filtration equipment |
| AU2013222414B2 (en) * | 2012-02-21 | 2018-02-15 | Cytonics Corporation | Systems, compositions, and methods for transplantation |
| EP2698162A1 (en) * | 2012-08-15 | 2014-02-19 | Credentis AG | Method for producing a composition for treating a tooth lesion |
| US9533899B2 (en) | 2013-03-12 | 2017-01-03 | General Electric Company | Gasification waste water treatment using air separation unit oxygen |
| JP2017510452A (en) | 2014-03-07 | 2017-04-13 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | Apparatus and method for fractionation of biological products |
| US10324070B2 (en) | 2014-04-23 | 2019-06-18 | Chromatan Inc. | High efficiency continuous countercurrent tangential chromatography |
| WO2016033546A1 (en) * | 2014-08-29 | 2016-03-03 | Emd Millipore Corporation | Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate |
| EP3733209A1 (en) * | 2014-10-03 | 2020-11-04 | Synaffix B.V. | Sulfamide linker, conjugates thereof, and methods of preparation |
| US11191841B2 (en) * | 2015-10-06 | 2021-12-07 | Massachusetts Institute Of Technology | Supramolecular modification of proteins |
| GB201600287D0 (en) * | 2016-01-07 | 2016-02-24 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process |
-
2016
- 2016-01-07 GB GBGB1600287.5A patent/GB201600287D0/en not_active Ceased
- 2016-12-19 US US16/068,387 patent/US10934325B2/en active Active
- 2016-12-19 CA CA3010431A patent/CA3010431A1/en active Pending
- 2016-12-19 CN CN202310638983.0A patent/CN116874554A/en active Pending
- 2016-12-19 BR BR112018013645A patent/BR112018013645A2/en active Search and Examination
- 2016-12-19 WO PCT/GB2016/053980 patent/WO2017118835A1/en active Application Filing
- 2016-12-19 EP EP16816369.9A patent/EP3400234A1/en active Pending
- 2016-12-19 RU RU2018128566A patent/RU2754855C2/en active
- 2016-12-19 AU AU2016384285A patent/AU2016384285B2/en active Active
- 2016-12-19 JP JP2018535300A patent/JP6951341B2/en active Active
- 2016-12-19 KR KR1020187022660A patent/KR20180100206A/en not_active Application Discontinuation
- 2016-12-19 CN CN201680078270.1A patent/CN108779145B/en active Active
- 2016-12-19 SG SG11201805687UA patent/SG11201805687UA/en unknown
-
2018
- 2018-07-06 ZA ZA2018/04527A patent/ZA201804527B/en unknown
-
2021
- 2021-01-20 US US17/152,874 patent/US11685765B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| BR112018013645A2 (en) | 2019-01-22 |
| US10934325B2 (en) | 2021-03-02 |
| AU2016384285B2 (en) | 2023-11-02 |
| CN108779145B (en) | 2023-06-13 |
| JP2019505514A (en) | 2019-02-28 |
| GB201600287D0 (en) | 2016-02-24 |
| EP3400234A1 (en) | 2018-11-14 |
| AU2016384285A1 (en) | 2018-07-19 |
| KR20180100206A (en) | 2018-09-07 |
| ZA201804527B (en) | 2023-12-20 |
| RU2018128566A (en) | 2020-02-07 |
| CA3010431A1 (en) | 2017-07-13 |
| JP6951341B2 (en) | 2021-10-20 |
| CN116874554A (en) | 2023-10-13 |
| CN108779145A (en) | 2018-11-09 |
| US20190010189A1 (en) | 2019-01-10 |
| US11685765B2 (en) | 2023-06-27 |
| RU2754855C2 (en) | 2021-09-08 |
| WO2017118835A1 (en) | 2017-07-13 |
| US20210163530A1 (en) | 2021-06-03 |
| RU2018128566A3 (en) | 2020-03-27 |
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