SG11201903882VA - Il-2 variants for the treatment of autoimmune diseases - Google Patents
Il-2 variants for the treatment of autoimmune diseasesInfo
- Publication number
- SG11201903882VA SG11201903882VA SG11201903882VA SG11201903882VA SG11201903882VA SG 11201903882V A SG11201903882V A SG 11201903882VA SG 11201903882V A SG11201903882V A SG 11201903882VA SG 11201903882V A SG11201903882V A SG 11201903882VA SG 11201903882V A SG11201903882V A SG 11201903882VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- english
- pct
- november
- administering
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6813—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin the drug being a peptidic cytokine, e.g. an interleukin or interferon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Dermatology (AREA)
- Neurology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Transplantation (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662419118P | 2016-11-08 | 2016-11-08 | |
PCT/US2017/060534 WO2018089420A1 (en) | 2016-11-08 | 2017-11-08 | Il-2 variants for the treatment of autoimmune diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201903882VA true SG11201903882VA (en) | 2019-05-30 |
Family
ID=62065637
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201903882VA SG11201903882VA (en) | 2016-11-08 | 2017-11-08 | Il-2 variants for the treatment of autoimmune diseases |
Country Status (15)
Country | Link |
---|---|
US (2) | US11077172B2 (ja) |
EP (1) | EP3538548A4 (ja) |
JP (2) | JP2019532996A (ja) |
KR (1) | KR20190083656A (ja) |
CN (1) | CN110167957A (ja) |
AU (1) | AU2017359172A1 (ja) |
CA (1) | CA3041334A1 (ja) |
CL (1) | CL2019001265A1 (ja) |
CO (1) | CO2019005922A2 (ja) |
EA (1) | EA201991142A1 (ja) |
EC (1) | ECSP19041447A (ja) |
IL (1) | IL266178A (ja) |
MX (1) | MX2019005400A (ja) |
SG (1) | SG11201903882VA (ja) |
WO (1) | WO2018089420A1 (ja) |
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US9959384B2 (en) | 2013-12-10 | 2018-05-01 | Bioniz, Llc | Methods of developing selective peptide antagonists |
KR102654684B1 (ko) | 2015-10-09 | 2024-04-04 | 바이오니즈 테라퓨틱스, 아이엔씨. | 감마-c-사이토카인 활성의 조정 |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
CA3056630A1 (en) | 2017-03-15 | 2018-09-20 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
WO2018217989A1 (en) | 2017-05-24 | 2018-11-29 | Pandion Therapeutics, Inc. | Targeted immunotolerance |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
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AU2019233576A1 (en) | 2018-03-13 | 2020-09-17 | Cancer Research Technology Limited | Anti-CD25 for tumour specific cell depletion |
KR20200136453A (ko) | 2018-03-28 | 2020-12-07 | 브리스톨-마이어스 스큅 컴퍼니 | 인터루킨-2/인터루킨-2 수용체 알파 융합 단백질 및 사용 방법 |
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WO2020007937A1 (en) * | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Use of interleukin-2 for treating systemic sclerosis |
US10703776B2 (en) | 2018-08-06 | 2020-07-07 | Medikine, Inc. | IL-2RBeta binding compounds |
WO2020130300A1 (ko) * | 2018-12-21 | 2020-06-25 | 한미약품 주식회사 | 신규 면역 억제 인터루킨 2 |
BR112021021878A2 (pt) * | 2019-05-03 | 2022-01-18 | Bioniz Llc | Modulação dos efeitos de sinalização da gama-c-citocina para tratamento da alopecia e distúrbios associados |
AU2020279240A1 (en) | 2019-05-20 | 2021-12-23 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
CN110642934B (zh) * | 2019-09-10 | 2022-08-23 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
JP7427286B2 (ja) | 2019-11-05 | 2024-02-05 | メディカイン、インコーポレイテッド | IL-2RβγC結合化合物 |
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KR20220116513A (ko) | 2019-12-20 | 2022-08-23 | 리제너론 파아마슈티컬스, 인크. | 신규 il2 작용제 및 이의 사용 방법 |
AU2021206449A1 (en) | 2020-01-10 | 2022-07-21 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
CN115362168A (zh) | 2020-01-14 | 2022-11-18 | 辛德凯因股份有限公司 | 偏向化il2突变蛋白方法和组合物 |
AU2021207661A1 (en) * | 2020-01-14 | 2022-07-21 | Synthekine, Inc. | IL2 muteins |
MX2022009390A (es) | 2020-02-03 | 2022-11-16 | Medikine Inc | Compuestos de unión a il-7r¿¿c. |
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CN106659757B (zh) | 2014-04-24 | 2022-01-28 | 利兰斯坦福初级大学董事会 | 白介素2的超级激动剂、部分激动剂和拮抗剂 |
AU2015292889C1 (en) | 2014-07-21 | 2023-01-19 | Delinia, Inc. | Molecules that selectively activate regulatory T cells for the treatment of autoimmune diseases |
PL3180020T3 (pl) * | 2014-08-11 | 2019-06-28 | Delinia, Inc. | Modyfikowane warianty il-2, które selektywnie aktywują limfocyty t regulatorowe do leczenia chorób autoimmunologicznych |
US20170216403A1 (en) | 2014-08-12 | 2017-08-03 | Massachusetts Institute Of Technology | Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker |
WO2016057651A1 (en) | 2014-10-09 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Multiple-variable il-2 dose regimen for treating immune disorders |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
JP7422480B2 (ja) * | 2016-05-04 | 2024-01-26 | アムジエン・インコーポレーテツド | 制御性t細胞の増殖のためのインターロイキン-2変異タンパク質 |
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2017
- 2017-11-08 EA EA201991142A patent/EA201991142A1/ru unknown
- 2017-11-08 WO PCT/US2017/060534 patent/WO2018089420A1/en unknown
- 2017-11-08 CN CN201780068887.XA patent/CN110167957A/zh active Pending
- 2017-11-08 MX MX2019005400A patent/MX2019005400A/es unknown
- 2017-11-08 AU AU2017359172A patent/AU2017359172A1/en not_active Abandoned
- 2017-11-08 JP JP2019523626A patent/JP2019532996A/ja active Pending
- 2017-11-08 KR KR1020197016263A patent/KR20190083656A/ko not_active IP Right Cessation
- 2017-11-08 US US15/806,787 patent/US11077172B2/en active Active
- 2017-11-08 EP EP17869254.7A patent/EP3538548A4/en active Pending
- 2017-11-08 CA CA3041334A patent/CA3041334A1/en active Pending
- 2017-11-08 SG SG11201903882VA patent/SG11201903882VA/en unknown
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2019
- 2019-04-22 IL IL266178A patent/IL266178A/en unknown
- 2019-05-08 CL CL2019001265A patent/CL2019001265A1/es unknown
- 2019-06-06 CO CONC2019/0005922A patent/CO2019005922A2/es unknown
- 2019-06-10 EC ECSENADI201941447A patent/ECSP19041447A/es unknown
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2021
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2022
- 2022-05-17 JP JP2022080574A patent/JP2022119829A/ja active Pending
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MX2019005400A (es) | 2019-08-05 |
US20180125941A1 (en) | 2018-05-10 |
KR20190083656A (ko) | 2019-07-12 |
JP2022119829A (ja) | 2022-08-17 |
EA201991142A1 (ru) | 2019-10-31 |
US11077172B2 (en) | 2021-08-03 |
JP2019532996A (ja) | 2019-11-14 |
AU2017359172A1 (en) | 2019-05-16 |
CN110167957A (zh) | 2019-08-23 |
EP3538548A4 (en) | 2020-08-19 |
CL2019001265A1 (es) | 2019-10-04 |
US20210308222A1 (en) | 2021-10-07 |
CO2019005922A2 (es) | 2019-08-30 |
ECSP19041447A (es) | 2019-07-31 |
WO2018089420A1 (en) | 2018-05-17 |
IL266178A (en) | 2019-06-30 |
EP3538548A1 (en) | 2019-09-18 |
CA3041334A1 (en) | 2018-05-17 |
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