SG11201900767VA - Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen - Google Patents
Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogenInfo
- Publication number
- SG11201900767VA SG11201900767VA SG11201900767VA SG11201900767VA SG11201900767VA SG 11201900767V A SG11201900767V A SG 11201900767VA SG 11201900767V A SG11201900767V A SG 11201900767VA SG 11201900767V A SG11201900767V A SG 11201900767VA SG 11201900767V A SG11201900767V A SG 11201900767VA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- coagulogen
- endotoxin
- substantially free
- rule
- Prior art date
Links
- 239000012480 LAL reagent Substances 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 6
- 108010045487 coagulogen Proteins 0.000 title abstract 4
- 239000002158 endotoxin Substances 0.000 title abstract 4
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 239000003593 chromogenic compound Substances 0.000 abstract 2
- 241000857902 Bursera graveolens Species 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 239000003643 water by type Substances 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- C12Q2337/12—Para-Nitroanilides p-NA
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/50—Lipopolysaccharides; LPS
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Water Supply & Treatment (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662370493P | 2016-08-03 | 2016-08-03 | |
| PCT/US2017/045137 WO2018026941A1 (fr) | 2016-08-03 | 2017-08-02 | Procédé de détection d'une endotoxine au moyen d'un lysat d'amébocyte de limule sensiblement exempt de coagulogène |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900767VA true SG11201900767VA (en) | 2019-02-27 |
Family
ID=61069187
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900767VA SG11201900767VA (en) | 2016-08-03 | 2017-08-02 | Method of detecting an endotoxin using limulus amebocyte lysate substantially free of coagulogen |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11156614B2 (fr) |
| EP (2) | EP3494226B1 (fr) |
| JP (1) | JP7044222B2 (fr) |
| KR (1) | KR102561368B1 (fr) |
| CN (1) | CN109790561B (fr) |
| IL (1) | IL264464B2 (fr) |
| SG (1) | SG11201900767VA (fr) |
| WO (1) | WO2018026941A1 (fr) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9950282B2 (en) | 2012-03-15 | 2018-04-24 | Flodesign Sonics, Inc. | Electronic configuration and control for acoustic standing wave generation |
| US9458450B2 (en) | 2012-03-15 | 2016-10-04 | Flodesign Sonics, Inc. | Acoustophoretic separation technology using multi-dimensional standing waves |
| US10704021B2 (en) | 2012-03-15 | 2020-07-07 | Flodesign Sonics, Inc. | Acoustic perfusion devices |
| US10967298B2 (en) | 2012-03-15 | 2021-04-06 | Flodesign Sonics, Inc. | Driver and control for variable impedence load |
| WO2015105955A1 (fr) | 2014-01-08 | 2015-07-16 | Flodesign Sonics, Inc. | Dispositif d'acoustophorèse avec double chambre acoustophorétique |
| US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
| US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
| US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
| US11459540B2 (en) | 2015-07-28 | 2022-10-04 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11474085B2 (en) | 2015-07-28 | 2022-10-18 | Flodesign Sonics, Inc. | Expanded bed affinity selection |
| US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
| US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
| KR102561368B1 (ko) | 2016-08-03 | 2023-08-01 | 론자 워커스빌 아이엔씨. | 실질적으로 코아굴로겐이 없는 리물루스 아메보사이트 라이세이트를 이용한 내독소 검출방법 |
| CA3041517A1 (fr) | 2016-10-19 | 2018-04-26 | Flodesign Sonics, Inc. | Extraction par affinite de cellules par un procede acoustique |
| WO2018132562A1 (fr) * | 2017-01-11 | 2018-07-19 | Lonza Walkersville, Inc. | Lysat d'amibocytes de limule clarifié sans coagulogène |
| EP3725092A4 (fr) | 2017-12-14 | 2021-09-22 | FloDesign Sonics, Inc. | Circuit d'excitation et circuit de commande de transducteur acoustique |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4322217A (en) | 1980-06-27 | 1982-03-30 | Mallinckrodt, Inc. | Process for preparing Limulus lysate |
| ES2098256T3 (es) * | 1989-10-30 | 1997-05-01 | Biowhittaker Inc | Ensayo cinetico para la endotoxina utilizando lisado amebocitico de limulus y sustrato cromogenico. |
| JP3122454B2 (ja) | 1990-09-27 | 2001-01-09 | 生化学工業株式会社 | カブトガニ・アメボサイト・ライセートの調製法 |
| US5208148A (en) | 1990-12-07 | 1993-05-04 | Molecular Probes, Inc. | Lipophilic fluorescent glycosidase substrates |
| US5576424A (en) | 1991-08-23 | 1996-11-19 | Molecular Probes, Inc. | Haloalkyl derivatives of reporter molecules used to analyze metabolic activity in cells |
| US5242805A (en) | 1991-08-23 | 1993-09-07 | Molecular Probes, Inc. | Long wavelength lipophilic fluorogenic glycosidase substrates |
| DE69229174T2 (de) | 1991-08-23 | 1999-09-16 | Molecular Probes Inc | Verwendung von haloalkylderivaten von reportermolekülen zur analyse der metabolischen aktivität in zellen |
| JP3242733B2 (ja) * | 1993-02-26 | 2001-12-25 | 生化学工業株式会社 | エンドトキシン特異的測定剤 |
| US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5773236A (en) | 1997-04-25 | 1998-06-30 | Molecule Probes, Inc. | Assay for glutathiane transferase using polyhaloaryl-substituted reporter molecules |
| JP2010522540A (ja) | 2007-03-21 | 2010-07-08 | アイディー バイオメディカル コーポレイション オブ ケベック | キメラ抗原 |
| US8394602B2 (en) | 2007-11-12 | 2013-03-12 | Hiroshima University | Luminescent method for measuring endotoxin |
| US7846678B2 (en) | 2008-08-18 | 2010-12-07 | BioDtech, Inc. | Enhancing endotoxin detection |
| MY155541A (en) | 2010-10-29 | 2015-10-30 | Universiti Malaysia Terengganu | Process for the preparation of amoebocyte lysate from the haemolymph of the horseshoe crab |
| CN102305788A (zh) | 2010-11-22 | 2012-01-04 | 天津市一瑞生物工程有限公司 | 革兰阴性菌脂多糖(内毒素)比色检测试剂盒的制备及其使用方法 |
| KR102561368B1 (ko) | 2016-08-03 | 2023-08-01 | 론자 워커스빌 아이엔씨. | 실질적으로 코아굴로겐이 없는 리물루스 아메보사이트 라이세이트를 이용한 내독소 검출방법 |
| WO2018132562A1 (fr) | 2017-01-11 | 2018-07-19 | Lonza Walkersville, Inc. | Lysat d'amibocytes de limule clarifié sans coagulogène |
| KR20200019739A (ko) * | 2017-06-28 | 2020-02-24 | 론자 워커스빌 아이엔씨. | 내독소 검출용 카트리지 |
-
2017
- 2017-08-02 KR KR1020197005917A patent/KR102561368B1/ko active IP Right Grant
- 2017-08-02 JP JP2019504062A patent/JP7044222B2/ja active Active
- 2017-08-02 WO PCT/US2017/045137 patent/WO2018026941A1/fr active Search and Examination
- 2017-08-02 EP EP17837616.6A patent/EP3494226B1/fr active Active
- 2017-08-02 EP EP21183657.2A patent/EP3943608B1/fr active Active
- 2017-08-02 IL IL264464A patent/IL264464B2/en unknown
- 2017-08-02 CN CN201780048853.4A patent/CN109790561B/zh active Active
- 2017-08-02 SG SG11201900767VA patent/SG11201900767VA/en unknown
- 2017-08-03 US US15/668,101 patent/US11156614B2/en active Active
-
2021
- 2021-09-23 US US17/482,918 patent/US11906521B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL264464B1 (en) | 2023-10-01 |
| EP3943608C0 (fr) | 2023-07-12 |
| EP3943608B1 (fr) | 2023-07-12 |
| EP3494226A4 (fr) | 2020-03-18 |
| IL264464B2 (en) | 2024-02-01 |
| EP3494226B1 (fr) | 2021-09-22 |
| KR102561368B1 (ko) | 2023-08-01 |
| CN109790561B (zh) | 2024-02-06 |
| WO2018026941A1 (fr) | 2018-02-08 |
| US11906521B2 (en) | 2024-02-20 |
| EP3943608A1 (fr) | 2022-01-26 |
| KR20190037284A (ko) | 2019-04-05 |
| JP2019526052A (ja) | 2019-09-12 |
| US20220074940A1 (en) | 2022-03-10 |
| JP7044222B2 (ja) | 2022-03-30 |
| US11156614B2 (en) | 2021-10-26 |
| CN109790561A (zh) | 2019-05-21 |
| EP3494226A1 (fr) | 2019-06-12 |
| US20180038864A1 (en) | 2018-02-08 |
| IL264464A (en) | 2019-02-28 |
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