SG11201900528PA - Customizable facility - Google Patents

Customizable facility

Info

Publication number
SG11201900528PA
SG11201900528PA SG11201900528PA SG11201900528PA SG11201900528PA SG 11201900528P A SG11201900528P A SG 11201900528PA SG 11201900528P A SG11201900528P A SG 11201900528PA SG 11201900528P A SG11201900528P A SG 11201900528PA SG 11201900528P A SG11201900528P A SG 11201900528PA
Authority
SG
Singapore
Prior art keywords
visp
lonzastrasse
international
applicant
customizable
Prior art date
Application number
SG11201900528PA
Inventor
Leander Biffiger
Sandra Carbonneau
Tristan Wilkins
Andre Collioud
Jonathan Fortin
Dominik Imbolden
Torsten Schmidt
Stefan Stoffel
Diego Studer
Christoph Vogel
Stefan Widmer
Lesley Wood
Alexander Zahiri
Original Assignee
Lonza Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza Ag filed Critical Lonza Ag
Publication of SG11201900528PA publication Critical patent/SG11201900528PA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/44Multiple separable units; Modules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M43/00Combinations of bioreactors or fermenters with other apparatus
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B67OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67DDISPENSING, DELIVERING OR TRANSFERRING LIQUIDS, NOT OTHERWISE PROVIDED FOR
    • B67D7/00Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes
    • B67D7/02Apparatus or devices for transferring liquids from bulk storage containers or reservoirs into vehicles or into portable containers, e.g. for retail sale purposes for transferring liquids other than fuel or lubricants
    • B67D7/0288Container connection means
    • B67D7/0294Combined with valves

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Mechanical Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • General Factory Administration (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Forklifts And Lifting Vehicles (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Eye Examination Apparatus (AREA)

Abstract

% V 1560 1510 1540 1550 FIG. 12 1510 1520 1530 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 February 2018 (08.02.2018) WIP0 I PCT onion °nolo oliolomu ioo Elmo ow (10) International Publication Number WO 2018/026577 Al (51) International Patent Classification: C12M 3/00 (2006.01) E04H 5/02 (2006.01) C12M 1/12 (2006.01) (21) International Application Number: PCT/US2017/043768 (22) International Filing Date: 25 July 2017 (25.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/370,041 02 August 2016 (02.08.2016) US (71) Applicant: LONZA LTD [CH/CH]; Lonzastrasse, 3930 Visp (CH). (72) Inventor; and (71) Applicant (for US only): WILKINS, Tristan [US/US]; 101 International Drive, Portsmouth, NH 03801 (US). (72) Inventors: BIFFIGER, Leander; Lonzastrasse, 3930 Visp (CH). CARBONNEAU, Sandra; 101 International Drive, Portsmouth, NH 03801 (CH). COLLIOUD, Andre; Lon- zastrasse, 3930 Visp (CH). FORTIN, Jonathan; 101 In- ternational Drive, Portsmouth, NH 03801 (CH). IMBOLD- EN, Dominik; Lonzastrasse, 3930 Visp (CH). SCHMIDT, Torsten; Lonzastrasse, 3930 Visp (CH). STOFFEL, Ste- fan; Lonzastrasse, 3930 Visp (CH). STUDER, Diego; Lon- zastrasse, 3930 Visp (CH). VOGEL, Christoph; Lonzas- trasse, 3930 Visp (CH). WIDMER, Stefan; Lonzastrasse, 3930 Visp (CH). WOOD, Lesley; Lonzastrasse, 3930 Visp (CH). ZAHIRI, Alexander; Lonzastrasse, 3930 Visp (CH). (74) Agent: COLLAZO, Diana, M. et al.; Lando & Anastasi, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: CUSTOMIZABLE FACILITY 1500 1510 1530 1510 1530 11 N kr) N N O GC 1-1 O N C (57) : A campus for fabricating at least one pharmaceutical product has one or more customizable facilities each configured to manufacture the at least one pharmaceutical product, a media/buffer plant, and a utility building connected by a utility line to the media/buffer plant and/or the one or more customizable facilities to provide at least one first utility to the media/buffer plant and/or the one or more customizable facilities via the utility line. [Continued on next page] WO 2018/026577 Al IMEDIM01101 DIDIRDERI00 1EE11H100111111111111110111111111111 OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))
SG11201900528PA 2016-08-02 2017-07-25 Customizable facility SG11201900528PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662370041P 2016-08-02 2016-08-02
PCT/US2017/043768 WO2018026577A1 (en) 2016-08-02 2017-07-25 Customizable facility

Publications (1)

Publication Number Publication Date
SG11201900528PA true SG11201900528PA (en) 2019-02-27

Family

ID=59593161

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201900528PA SG11201900528PA (en) 2016-08-02 2017-07-25 Customizable facility
SG11201900609PA SG11201900609PA (en) 2016-08-02 2017-08-02 Method and system for providing buffer solutions

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201900609PA SG11201900609PA (en) 2016-08-02 2017-08-02 Method and system for providing buffer solutions

Country Status (8)

Country Link
US (3) US10669518B2 (en)
EP (2) EP3478821A1 (en)
JP (5) JP2019525765A (en)
KR (4) KR102423233B1 (en)
CN (2) CN109715782A (en)
IL (4) IL264374B2 (en)
SG (2) SG11201900528PA (en)
WO (2) WO2018026577A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015148704A1 (en) 2014-03-25 2015-10-01 Terumo Bct, Inc. Passive replacement of media
WO2017004592A1 (en) 2015-07-02 2017-01-05 Terumo Bct, Inc. Cell growth with mechanical stimuli
US11965175B2 (en) 2016-05-25 2024-04-23 Terumo Bct, Inc. Cell expansion
US11104874B2 (en) 2016-06-07 2021-08-31 Terumo Bct, Inc. Coating a bioreactor
US11685883B2 (en) 2016-06-07 2023-06-27 Terumo Bct, Inc. Methods and systems for coating a cell growth surface
WO2018184028A2 (en) 2017-03-31 2018-10-04 Terumo Bct, Inc. Cell expansion
US12071607B2 (en) 2018-06-01 2024-08-27 Lonza Ltd. Midscale model for organic growth and phasing
KR20210126015A (en) 2019-02-11 2021-10-19 론자 리미티드 Buffer formulation methods and systems
KR102409145B1 (en) * 2020-03-23 2022-06-15 프레스티지바이오로직스 주식회사 Buffer Preparation and Transfer System for Production of Antibody Pharmaceuticals
GB2627011A (en) * 2023-02-13 2024-08-14 Lacey & Saltykov Arch Ltd A pair of vertically-adjacent storeys for a building configured for mixed laboratory use

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE9014558U1 (en) * 1989-11-24 1991-01-03 Bourdichon, Alain, Tacoronte, Teneriffa Prefabricated, transportable room element for the construction of pharmaceutical plants
US5272071A (en) 1989-12-22 1993-12-21 Applied Research Systems Ars Holding N.V. Method for the modification of the expression characteristics of an endogenous gene of a given cell line
GB9022545D0 (en) 1990-10-17 1990-11-28 Wellcome Found Culture medium
JPH0733717B2 (en) * 1991-06-17 1995-04-12 戸田建設株式会社 Multi-purpose production system construction method and building
DE4218615C1 (en) * 1992-06-05 1993-07-15 Nukem Gmbh, 8755 Alzenau, De
IT1258959B (en) 1992-06-09 1996-03-11 MOBILE MODULES PLANT FOR THE DEVELOPMENT AND PRODUCTION OF BIOTECHNOLOGICAL PRODUCTS ON A PILOT SCALE
CA2293632C (en) 1997-06-12 2011-11-29 Research Corporation Technologies, Inc. Artificial antibody polypeptides
US6393775B1 (en) 1998-04-24 2002-05-28 Udo Ingmar Staschik Utilities container
US6688048B2 (en) * 1998-04-24 2004-02-10 Udo I. Staschik Utilities container
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
US20010047628A1 (en) 1999-12-21 2001-12-06 Roy Mouton Relocatable fire, storm and contaminant resistant modular building structures
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
WO2003095765A1 (en) * 2002-05-08 2003-11-20 PETTUS, Candace, Gale Modular containment unit
GB0224760D0 (en) 2002-10-25 2002-12-04 Jowett E C Waste water treatment station in shipping container
US7515994B2 (en) * 2003-10-17 2009-04-07 Technikrom, Inc. Accurate blending module and method
US8298054B2 (en) 2004-02-03 2012-10-30 Xcellerex, Inc. System and method for manufacturing
CN1654282A (en) * 2004-02-11 2005-08-17 巴克斯特国际公司 Big capacity flexible container
AU2005223452B2 (en) * 2004-03-16 2008-05-15 Newage Industries, Inc. Process equipment tracking system
US20050235581A1 (en) 2004-04-26 2005-10-27 Intellectual Property, Llc System for production of standard size dwellings using a satellite manufacturing facility
MXPA06014099A (en) 2004-06-04 2007-05-09 Xcellerex Inc Disposable bioreactor systems and methods.
US7445927B2 (en) * 2004-09-03 2008-11-04 The United States Of America As Represented By The Secretary Of The Navy Bioreactor system for biological degradation of oily sludge
DE102005036763B4 (en) * 2005-08-04 2007-07-26 Inheco Industrial Heating And Cooling Gmbh System of several incubators
WO2007067656A2 (en) 2005-12-05 2007-06-14 Hope Ernest G Prevalidated, modular good manufacturing practice-compliant facility
US8405508B2 (en) * 2006-08-09 2013-03-26 Emd Millipore Corporation Use of gamma hardened RFID tags in pharmaceutical devices
JP2010524467A (en) 2007-04-16 2010-07-22 モメンタ ファーマシューティカルズ インコーポレイテッド Defined glycoprotein products and related methods
EP2254983A1 (en) 2008-01-25 2010-12-01 Xcellerex, Inc. Information acquisition and management systems and methods in bioreactor systems and manufacturing facilities
EP2103548B1 (en) * 2008-03-22 2014-10-01 Pall Corporation System comprising a tote and a flexible container
CN101981600B (en) * 2008-03-27 2013-03-27 通用电气医疗集团生物科学生物方法公司 A method for preventing an unauthorized use of disposable bioprocess components
US20090256679A1 (en) * 2008-04-11 2009-10-15 General Electric Company Rfid based methods and systems for use in manufacturing and monitoring applications
CA2668253C (en) * 2008-06-03 2016-07-26 Richard F. Ablett Plant waste bio-product pomace extract concentrates and processes of producing same
AU2009330055B2 (en) * 2008-12-23 2015-11-05 Xoma (Us) Llc Flexible manufacturing system
EP2216395A1 (en) 2009-02-09 2010-08-11 Lonza Biologics plc. Bioreactor for the cultivation of mammalian cells
US9192069B2 (en) 2013-08-05 2015-11-17 Rosendin Electric, Inc. Modular power skid assembled with different electrical cabinets and components mounted on the skid
US9398717B2 (en) 2009-05-29 2016-07-19 Rosendin Electric, Inc. Modular power skid assembled with different electrical cabinets and components mounted on the skid
US9795957B2 (en) 2009-08-16 2017-10-24 G-Con Manufacturing, Inc. Modular, self-contained, mobile clean room
US9670689B2 (en) 2010-04-06 2017-06-06 Schneider Electric It Corporation Container based data center solutions
US10371394B2 (en) 2010-09-20 2019-08-06 Biologics Modular Llc Mobile, modular cleanroom facility
WO2012122413A1 (en) 2011-03-08 2012-09-13 University Of Maryland Baltimore County Microscale bioprocessing system and method for protein manufacturing
JP6133883B2 (en) * 2011-11-04 2017-05-24 日東電工株式会社 Method for producing lipid nanoparticles for drug delivery
RU2014134205A (en) * 2012-03-07 2016-04-27 ДжиИ Хелткер Байо-Сайсенсиз Корп. Replaceable valve and flexible containers for pressure-resistant bioreactors
WO2013134023A1 (en) 2012-03-08 2013-09-12 Google Inc. Controlling data center cooling
EP2900362A1 (en) * 2012-09-28 2015-08-05 Promethera Biosciences S.A. Mobile facility for preparing and distributing cell-based medicinal products
US9158345B1 (en) 2012-10-15 2015-10-13 Google Inc. Managing computer performance
US20140335566A1 (en) * 2013-05-10 2014-11-13 BioCapacity On Demand, LLC Mobile vessel or carrier for the manufacturing production and purification of biologics
US20150159127A1 (en) * 2013-05-10 2015-06-11 BioCapacity On Demand, LLC Mobile vessel or carrier for the manufacturing production, purification and sterile fill and finish of biologics
CN105723036B (en) 2013-10-14 2019-12-27 吉康制造有限公司 Unit for connecting modular moving spaces
WO2015117883A1 (en) * 2014-02-07 2015-08-13 Cmc Biologics A/S A bioreactor arrangement and continuous process for producing and capturing a biopolymer
US20160376784A1 (en) 2015-06-25 2016-12-29 Erden Timur Method and system for urban room structures
US9617748B2 (en) 2015-04-21 2017-04-11 Kasita, LLC Modular housing units, reusable support structure, and utility connector
CN205176586U (en) * 2015-11-01 2016-04-20 郭敏强 Environmental monitoring system of pharmacy enterprise

Also Published As

Publication number Publication date
JP7075927B2 (en) 2022-05-26
WO2018026956A1 (en) 2018-02-08
IL307217A (en) 2023-11-01
JP2019525765A (en) 2019-09-12
IL307847A (en) 2023-12-01
JP7526756B2 (en) 2024-08-01
JP3239085U (en) 2022-09-13
IL264374B2 (en) 2024-03-01
EP3478821A1 (en) 2019-05-08
KR20220104297A (en) 2022-07-26
KR102480770B1 (en) 2022-12-22
KR102423233B1 (en) 2022-07-19
IL264374B1 (en) 2023-11-01
KR20190037288A (en) 2019-04-05
IL264373B2 (en) 2024-03-01
IL264373A (en) 2019-02-28
EP3478817A1 (en) 2019-05-08
US20180037861A1 (en) 2018-02-08
WO2018026577A1 (en) 2018-02-08
KR20220114091A (en) 2022-08-17
JP2024144457A (en) 2024-10-11
IL264374A (en) 2019-02-28
US20200283718A1 (en) 2020-09-10
US10669518B2 (en) 2020-06-02
IL264373B1 (en) 2023-11-01
CN109715778A (en) 2019-05-03
CN109715782A (en) 2019-05-03
US20240132830A1 (en) 2024-04-25
JP2019524125A (en) 2019-09-05
KR102423233B9 (en) 2024-08-22
KR20190037289A (en) 2019-04-05
US11898137B2 (en) 2024-02-13
SG11201900609PA (en) 2019-02-27
JP2022097744A (en) 2022-06-30

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