SG11201811307SA - Arrangement for in-line holography microscopy - Google Patents

Arrangement for in-line holography microscopy

Info

Publication number
SG11201811307SA
SG11201811307SA SG11201811307SA SG11201811307SA SG11201811307SA SG 11201811307S A SG11201811307S A SG 11201811307SA SG 11201811307S A SG11201811307S A SG 11201811307SA SG 11201811307S A SG11201811307S A SG 11201811307SA SG 11201811307S A SG11201811307S A SG 11201811307SA
Authority
SG
Singapore
Prior art keywords
international
cuvette
arrangement
exit
pct
Prior art date
Application number
SG11201811307SA
Inventor
Esa Hämäläinen
Tero Kesti
Original Assignee
Uwater Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uwater Oy filed Critical Uwater Oy
Publication of SG11201811307SA publication Critical patent/SG11201811307SA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging
    • G01N15/0227—Investigating particle size or size distribution by optical means, e.g. by light scattering, diffraction, holography or imaging using imaging, e.g. a projected image of suspension; using holography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N15/1436—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement the optical arrangement forming an integrated apparatus with the sample container, e.g. a flow cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/41—Refractivity; Phase-affecting properties, e.g. optical path length
    • G01N21/45—Refractivity; Phase-affecting properties, e.g. optical path length using interferometric methods; using Schlieren methods
    • G01N21/453—Holographic interferometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/18—Water
    • G01N33/1826—Water organic contamination in water
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G01N15/01—
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N15/1434—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement
    • G01N2015/1454—Electro-optical investigation, e.g. flow cytometers using an analyser being characterised by its optical arrangement using phase shift or interference, e.g. for improving contrast
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Electro-optical investigation, e.g. flow cytometers
    • G01N2015/1493—Particle size
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0378—Shapes
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H1/00—Holographic processes or apparatus using light, infrared or ultraviolet waves for obtaining holograms or for obtaining an image from them; Details peculiar thereto
    • G03H1/04—Processes or apparatus for producing holograms
    • G03H1/0443—Digital holography, i.e. recording holograms with digital recording means
    • G03H2001/0447—In-line recording arrangement
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2210/00—Object characteristics
    • G03H2210/50—Nature of the object
    • G03H2210/55—Having particular size, e.g. irresolvable by the eye
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2210/00—Object characteristics
    • G03H2210/62—Moving object
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03H—HOLOGRAPHIC PROCESSES OR APPARATUS
    • G03H2222/00—Light sources or light beam properties
    • G03H2222/50—Geometrical property of the irradiating beam
    • G03H2222/52—Divergent beam

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111111111111111111111111111111111111111111111111111111011111111111110111111 International Bureau (10) International Publication Number 0 (43) International Publication Date ......0\"\" WO 2017/220861 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: (72) Inventors: HAMALAINEN, Esa; Ketunkuja 5, 37100 GO1N 15/02 (2006.01) G01N 21/85 (2006.01) Nokia (FI). KESTI, Tero; Kotkansiivenkatu 2 A 6, 33720 G01N 15/10 (2006.01) G03H 1/00 (2006.01) Tampere (FI). GO1N 21/05 (2006.01) (74) Agent: PAPULA OY; P.O. Box 981, 00101 Helsinki (FI). (21) International Application Number: PCT/FI2017/050464 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 21 June 2017 (21.06.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, (26) Publication Language: English KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, (30) Priority Data: MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, 16175692.9 22 June 2016 (22.06.2016) EP OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, (71) Applicant: UWATER OY [FIIFI]; Korkeakoulunkatu 10, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. 33720 Tampere (FI). (54) Title: ARRANGEMENT FOR IN-LINE HOLOGRAPHY MICROSCOPY 101 10 0 21 120 170 162 160 ® . 15 . 171 r 161 163 152 , - 110 150 153 Fig. ,-, (57) : A measuring arrangement (101) comprises an illuminating arrangement Il (120) defining an inner volume (121)for receiving a fluid (130) possibly comprising V; ot cuvette being arranged to receive the coherent light and let it exit therefrom through C::::) the entrance opening (150) being closed by an entrance window (151), whereby the e• 1 scatter part of the light, the scattered and non-scattered light interfering to form interference ei ---- sensor being configured to capture a hologram digital image frame (170) by receiving IN exit window (152) arranged to close the exit opening (153) of the cuvette. The image 1-1 © the cuvette(120). ei '140 (110) to emit coherent light (111);a cuvette microscopic objects (140) of foreign origin, the opposite entrance and exit openings(150, 153), possible microscopic objects present in the fluid fringes; an image sensor (160), the image the light propagated across the cuvette; and an sensor (160) is mounted in direct contact with C [Continued on next page] WO 2017/220861 Al IMEDIM0110101011M110EM001011010IIM1111110111111111111111111111111 (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3))
SG11201811307SA 2016-06-22 2017-06-21 Arrangement for in-line holography microscopy SG11201811307SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16175692.9A EP3260840B1 (en) 2016-06-22 2016-06-22 Arrangement for in-line holography microscopy
PCT/FI2017/050464 WO2017220861A1 (en) 2016-06-22 2017-06-21 Arrangement for in-line holography microscopy

Publications (1)

Publication Number Publication Date
SG11201811307SA true SG11201811307SA (en) 2019-01-30

Family

ID=56203202

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201811307SA SG11201811307SA (en) 2016-06-22 2017-06-21 Arrangement for in-line holography microscopy

Country Status (10)

Country Link
US (1) US10830687B2 (en)
EP (1) EP3260840B1 (en)
KR (1) KR20190022690A (en)
CN (1) CN109416309B (en)
AU (1) AU2017281681B2 (en)
CA (1) CA3028095A1 (en)
EA (1) EA039437B1 (en)
SG (1) SG11201811307SA (en)
WO (1) WO2017220861A1 (en)
ZA (1) ZA201900410B (en)

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Publication number Priority date Publication date Assignee Title
EP3839636B1 (en) * 2019-12-20 2024-03-13 Imec VZW A device for detecting particles in air
EP3839478B1 (en) * 2019-12-20 2024-03-20 Imec Vzw A device for detecting particles in air
EP3839479B1 (en) * 2019-12-20 2024-04-03 IMEC vzw A device for detecting particles in air
CN113820843B (en) * 2021-07-22 2022-08-26 西安电子科技大学 High-resolution quantitative phase microscope system based on annular LED illumination
CA3231986A1 (en) * 2021-09-17 2023-03-23 Accelerate Diagnostics, Inc. Lens-free holographic optical system for high sensitivity label-free cell and microbial growth detection and quantification
CN116026729B (en) * 2023-03-03 2024-03-15 浙江大学 Portable microplastic detection device based on digital coaxial holographic microscopy

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US4243883A (en) * 1979-01-19 1981-01-06 Midwest Cardiovascular Institute Foundation Blood hematocrit monitoring system
US5048524A (en) * 1989-03-03 1991-09-17 Camino Laboratories, Inc. Blood parameter measurement
US5331958A (en) * 1992-03-31 1994-07-26 University Of Manitoba Spectrophotometric blood analysis
US5385539A (en) * 1992-06-30 1995-01-31 Advanced Haemotechnologies Apparatus for monitoring hematocrit levels of blood
US5619043A (en) * 1994-09-21 1997-04-08 Laser Sensor Technology, Inc. System for acquiring an image of a multi-phase fluid by measuring backscattered light
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US9007433B2 (en) * 2009-10-20 2015-04-14 The Regents Of The University Of California Incoherent lensfree cell holography and microscopy on a chip
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WO2012082776A2 (en) * 2010-12-14 2012-06-21 The Regents Of The University Of California Method and device for holographic opto-fluidic microscopy
WO2014012031A1 (en) * 2012-07-13 2014-01-16 The Regents Of The University Of California High throughput lens-free three-dimensional tracking of sperm
CN106132299B (en) * 2014-03-31 2020-04-14 索尼公司 Measuring device, measuring method, program, and recording medium
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CN105651656B (en) * 2016-04-01 2018-09-11 黄恺 The device and its working method of grain shape are analyzed based on laser hologram imaging method
WO2017196995A1 (en) * 2016-05-11 2017-11-16 The Regents Of The University Of California Method and system for pixel super-resolution of multiplexed holographic color images

Also Published As

Publication number Publication date
KR20190022690A (en) 2019-03-06
US10830687B2 (en) 2020-11-10
CN109416309B (en) 2021-12-21
EA039437B1 (en) 2022-01-27
EP3260840A1 (en) 2017-12-27
AU2017281681A1 (en) 2019-02-07
EA201892750A1 (en) 2019-06-28
ZA201900410B (en) 2022-08-31
WO2017220861A1 (en) 2017-12-28
CN109416309A (en) 2019-03-01
AU2017281681B2 (en) 2022-02-24
EP3260840B1 (en) 2023-06-07
EP3260840C0 (en) 2023-06-07
US20190250559A1 (en) 2019-08-15
CA3028095A1 (en) 2017-12-28

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