SG11201811183WA - Anti-infective heterocyclic compounds and uses thereof - Google Patents
Anti-infective heterocyclic compounds and uses thereofInfo
- Publication number
- SG11201811183WA SG11201811183WA SG11201811183WA SG11201811183WA SG11201811183WA SG 11201811183W A SG11201811183W A SG 11201811183WA SG 11201811183W A SG11201811183W A SG 11201811183WA SG 11201811183W A SG11201811183W A SG 11201811183WA SG 11201811183W A SG11201811183W A SG 11201811183WA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- uppsala
- co7d
- pct
- heterocyclic compounds
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/46—Phenazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/38—[b, e]-condensed with two six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/20—[b, e]-condensed with two six-membered rings with hydrogen atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
- C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
- C07D279/18—[b, e]-condensed with two six-membered rings
- C07D279/22—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom
- C07D279/24—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom
- C07D279/28—[b, e]-condensed with two six-membered rings with carbon atoms directly attached to the ring nitrogen atom with hydrocarbon radicals, substituted by amino radicals, attached to the ring nitrogen atom with other substituents attached to the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/06—Peri-condensed systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111 0 11111111111111111111111111111011011110 111111111011111111111 011111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/222466 Al 28 December 2017 (28.12.2017) WIP0 I PCT (51) International Patent Classification: EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, C07D 417/12 (2006.01) C07D 513/06 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, C07D 417/14 (2006.01) A61K 31/5415 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 279/20 (2006.01) A61K 31/538 (2006.01) KM, CO7D 279/28 (2006.01) A61P 31/00 (2006.01) ML, MR, NE, SN, TD, TG). CO7D 513/04 (2006.01) Published: (21) International Application Number: — with international search report (Art. 21(3)) PCT/SE2017/050697 — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of (22) International Filing Date: amendments (Rule 48.2(h)) 22 June 2017 (22.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1650906-9 23 June 2016 (23.06.2016) SE (71) Applicant: BIOIMICS AB [SE/SE]; Sandstensvagen 7, 752 67 Uppsala (SE). (72) Inventors: KIRSEBOM, Leif; Vreta Strandvag 20, 755 _ 91 Uppsala (SE). UPADHAYAYA, Ram Shankar; Her- = ragsvagen 197, lgh 1203, 752 69 Uppsala (SE). KETHIRI, Raghava Reddy; H No. 227, Shri Nilaya, Karishma Hills, Subramanya Pura Post, Bangalore 560 061 (IN). VIRTA- =_ NEN, Anders; Sandstensvagen 7, 752 67 Uppsala (SE). (74) Agent: ZACCO SWEDEN AB; P.O. Box 5581, Val- hallavagen 117N, 114 85 Stockholm (SE). = (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, = = = HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = = KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, = MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. = = = (84) Designated States (unless otherwise indicated, for every = kind of regional protection available): ARIPO (BW, GH, — GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, 1-1 (54) Title: ANTI-INFECTIVE HETEROCYCLIC COMPOUNDS AND USES THEREOF V::+ (57) : The present invention relates to heterocyclic compounds of Formula I useful as R 1 R 2 71' anti-infective agents. The present invention further relates to a method of treating an infection I el N e•1 4 --..... R x 1 „_ , N X 2 ' ',, -\"--- ' '''''' '-' .* * 1 X5 by administering such compounds, and to pharmaceutical compositions comprising such com- pounds. I I X 4*I''' R3 IN -- --- '\"- --'' '' , A , '\" ---- `• X 3 ';. l'* R 8 N (I) C
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1650906 | 2016-06-23 | ||
PCT/SE2017/050697 WO2017222466A1 (en) | 2016-06-23 | 2017-06-22 | Anti-infective heterocyclic compounds and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201811183WA true SG11201811183WA (en) | 2019-01-30 |
Family
ID=59285299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201811183WA SG11201811183WA (en) | 2016-06-23 | 2017-06-22 | Anti-infective heterocyclic compounds and uses thereof |
Country Status (13)
Country | Link |
---|---|
US (1) | US11130741B2 (en) |
EP (1) | EP3475277B1 (en) |
JP (1) | JP2019518771A (en) |
KR (1) | KR20190025920A (en) |
CN (1) | CN109641889A (en) |
AU (1) | AU2017279905B2 (en) |
BR (1) | BR112018076734A2 (en) |
CA (1) | CA3028347A1 (en) |
IL (1) | IL263651A (en) |
MX (1) | MX2018016339A (en) |
RU (1) | RU2019101646A (en) |
SG (1) | SG11201811183WA (en) |
WO (1) | WO2017222466A1 (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020169682A1 (en) * | 2019-02-19 | 2020-08-27 | Yncrea Hauts De France | Hydrazide derivatives and their specific use as antibacterial agents by controlling acinetobacter baumannii bacterium |
WO2024062043A1 (en) * | 2022-09-21 | 2024-03-28 | Universiteit Antwerpen | Substituted phenothiazines as ferroptosis inhibitors |
CN115947671B (en) * | 2022-11-21 | 2023-09-26 | 荣灿生物医药技术(上海)有限公司 | Lipid compound containing urethane bond and application thereof |
CN115806503A (en) * | 2022-12-02 | 2023-03-17 | 中国海洋大学 | Selective histone deacetylase inhibitor as well as preparation method and application thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL106170C (en) * | 1955-12-23 | |||
GB812109A (en) * | 1956-08-23 | 1959-04-15 | Basf Ag | Improvements in the dyeing of structures of linear aromatic polyesters |
DE1160442B (en) | 1959-03-18 | 1964-01-02 | Degussa | Process for the preparation of 3-trifluoromethylphenthiazines |
US3082210A (en) | 1959-10-29 | 1963-03-19 | Rhone Poulenc Sa | New 10-(azetidinyl-alkyl)phenthiazines |
DE2214699A1 (en) * | 1972-03-25 | 1973-09-27 | Hoechst Ag | Yellow-orange-red-red/violet water-insol phenoxazine or - phenthiazine dyes - for dyeing printing synthetic and semi-synthetic |
FR2810318B1 (en) * | 2000-06-15 | 2005-09-23 | Laurent Galey | DIAMANO-PHENOTHIAZINE DERIVATIVES |
AU2003222197A1 (en) | 2002-01-16 | 2003-09-02 | The Regents Of The University Of California | Inhibition of rna function |
MXPA06012566A (en) | 2004-04-30 | 2007-05-09 | Bkg Pharma Aps | Treatment of infectious diseases. |
MX2009007235A (en) * | 2007-01-05 | 2009-10-16 | Bkg Pharma Aps | Low-carbohydrate milk with original calcium. |
EP2246349A1 (en) * | 2009-04-20 | 2010-11-03 | BKG Pharma ApS | Treatment of infectious diseases |
US8809317B2 (en) * | 2011-03-29 | 2014-08-19 | Prosetta Antiviral Inc. | Antiviral compounds |
JP5868955B2 (en) * | 2010-04-30 | 2016-02-24 | プロセッタ アンチバイラル インコーポレイテッド | Antiviral compounds |
WO2012122716A1 (en) * | 2011-03-17 | 2012-09-20 | Merck Sharp & Dohme Corp. | Tetracyclic xanthene derivatives and methods of use thereof for treatment of viral diseases |
CN103781481B (en) | 2011-08-02 | 2018-12-14 | 亥姆霍兹慕尼黑中心-德国环境健康研究中心 (Gmbh) | Selective depression of the phenothiazine derivative to MALT1 protease |
CN104812394B (en) * | 2012-11-26 | 2018-10-19 | 开普敦大学 | Phenothiazine derivative and its phthisical purposes for the treatment of |
CN103709122B (en) * | 2013-11-29 | 2016-05-25 | 四川大学 | Antitumor and the antifungal compound being used for the treatment of |
-
2017
- 2017-06-22 AU AU2017279905A patent/AU2017279905B2/en not_active Expired - Fee Related
- 2017-06-22 MX MX2018016339A patent/MX2018016339A/en unknown
- 2017-06-22 JP JP2018567199A patent/JP2019518771A/en not_active Ceased
- 2017-06-22 RU RU2019101646A patent/RU2019101646A/en not_active Application Discontinuation
- 2017-06-22 WO PCT/SE2017/050697 patent/WO2017222466A1/en unknown
- 2017-06-22 CA CA3028347A patent/CA3028347A1/en not_active Abandoned
- 2017-06-22 BR BR112018076734-4A patent/BR112018076734A2/en not_active IP Right Cessation
- 2017-06-22 KR KR1020197001706A patent/KR20190025920A/en not_active Application Discontinuation
- 2017-06-22 EP EP17735653.2A patent/EP3475277B1/en active Active
- 2017-06-22 CN CN201780051840.2A patent/CN109641889A/en active Pending
- 2017-06-22 US US16/312,627 patent/US11130741B2/en active Active
- 2017-06-22 SG SG11201811183WA patent/SG11201811183WA/en unknown
-
2018
- 2018-12-11 IL IL263651A patent/IL263651A/en unknown
Also Published As
Publication number | Publication date |
---|---|
RU2019101646A (en) | 2020-07-23 |
JP2019518771A (en) | 2019-07-04 |
MX2018016339A (en) | 2019-09-04 |
US20190233384A1 (en) | 2019-08-01 |
EP3475277B1 (en) | 2021-10-20 |
CA3028347A1 (en) | 2017-12-28 |
EP3475277A1 (en) | 2019-05-01 |
CN109641889A (en) | 2019-04-16 |
KR20190025920A (en) | 2019-03-12 |
US11130741B2 (en) | 2021-09-28 |
IL263651A (en) | 2019-01-31 |
AU2017279905A1 (en) | 2019-01-31 |
RU2019101646A3 (en) | 2020-07-23 |
AU2017279905B2 (en) | 2021-10-14 |
BR112018076734A2 (en) | 2019-03-26 |
WO2017222466A1 (en) | 2017-12-28 |
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