SG11201811160XA - Treatment for myopia - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 December 2017 (28.12.2017) WIP0 I PCT Iiiimmomiolollmolomm VIII iflo Hs (10) International Publication Number WO 2017/219080 Al 1-1 GC 1-1 N 1-1 O O (51) International Patent Classification: A61K 31/198 (2006.01) A61P 27/02 (2006.01) A61K 31/04 (2006.01) (21) International Application Number: PCT/AU2017/050627 (22) International Filing Date: 21 June 2017 (21.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 2016902429 21 June 2016 (21.06.2016) AU (71) Applicant: THE UNIVERSITY OF NEWCASTLE [AU/AU]; 130 University Drive, Callaghan, New South Wales 2308 (AU). (72) Inventor: MCFADDEN, Sally Anne; 56 Dawson Street, Cooks Hill, New South Wales 2300 (AU). (74) Agent: DAVIES COLLISON CAVE PTY LTD; 255 Elizabeth Street, Sydney, New South Wales 2000 (AU). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) = (54) Title: TREATMENT FOR MYOPIA FIGURE 1 A B Diffe re nce in Refrac t ive Erro r ( D) Diffe re nce in Ocu la Le r ng t h (p. m) 150 100 50 0 -50 - 100 - 150 -6D Plano Rec -6D Plano Rec (57) : Provided herein are methods for treating or preventing myopia, or for inhibiting the development of myopia, comprising administering to a subject in need thereof an effective amount of an agent capable of increasing nitric oxide levels in one or more ocular cells or an agent capable of promoting or increasing the expression and/or activity of nNOS in one or more ocular cells. Also provided are methods for inducing or promoting nNOS expression and/or activity in one or more ocular cells, comprising exposing said cells to an effective amount of L-arginine.