SG11201810015YA - Particle for the encapsidation of a genome engineering system - Google Patents

Particle for the encapsidation of a genome engineering system

Info

Publication number
SG11201810015YA
SG11201810015YA SG11201810015YA SG11201810015YA SG11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA SG 11201810015Y A SG11201810015Y A SG 11201810015YA
Authority
SG
Singapore
Prior art keywords
encapsidation
particle
engineering system
genome engineering
viral rnas
Prior art date
Application number
SG11201810015YA
Other languages
English (en)
Inventor
Pascale Bouille
Régis Gayon
Lucille Lamouroux
Alexandra Iche
Original Assignee
Flash Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR1654332A external-priority patent/FR3051196B1/fr
Application filed by Flash Therapeutics filed Critical Flash Therapeutics
Publication of SG11201810015YA publication Critical patent/SG11201810015YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90Stable introduction of foreign DNA into chromosome
    • C12N15/902Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/70Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/85Fusion polypeptide containing an RNA binding domain
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/20Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16023Virus like particles [VLP]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16041Use of virus, viral particle or viral elements as a vector
    • C12N2740/16043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00Reverse transcribing RNA viruses
    • C12N2740/00011Details
    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
    • C12N2740/16051Methods of production or purification of viral material
    • C12N2740/16052Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2795/00Bacteriophages
    • C12N2795/00011Details
    • C12N2795/18011Details ssRNA Bacteriophages positive-sense
    • C12N2795/18111Leviviridae
    • C12N2795/18122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/24Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/30Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00Nucleic acids vectors
    • C12N2800/50Vectors for producing vectors

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SG11201810015YA 2016-05-13 2017-05-12 Particle for the encapsidation of a genome engineering system SG11201810015YA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR1654332A FR3051196B1 (fr) 2016-05-13 2016-05-13 Particule pour l'encapsidation d'un systeme d'ingenierie du genome
FR1660309 2016-10-24
FR1752818 2017-03-31
PCT/FR2017/051164 WO2017194902A2 (fr) 2016-05-13 2017-05-12 Particule pour l'encapsidation d'un système d'ingénierie du génome

Publications (1)

Publication Number Publication Date
SG11201810015YA true SG11201810015YA (en) 2018-12-28

Family

ID=59070995

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201810015YA SG11201810015YA (en) 2016-05-13 2017-05-12 Particle for the encapsidation of a genome engineering system

Country Status (12)

Country Link
US (1) US10870865B2 (ja)
EP (1) EP3455239B1 (ja)
JP (1) JP6982001B2 (ja)
CN (1) CN109415415A (ja)
AU (1) AU2017263137B2 (ja)
CA (1) CA3024376A1 (ja)
DK (1) DK3455239T3 (ja)
ES (1) ES2886919T3 (ja)
IL (1) IL262941B (ja)
PT (1) PT3455239T (ja)
SG (1) SG11201810015YA (ja)
WO (1) WO2017194902A2 (ja)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3294756B1 (fr) * 2015-05-15 2020-12-02 Flash Therapeutics Particule rétrovirale comportant au moins deux arn non viraux encapsidés différents
AU2019262029A1 (en) * 2018-05-01 2020-11-19 Wake Forest University Health Sciences Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
CN108504689B (zh) * 2018-05-29 2021-01-29 上海本导基因技术有限公司 慢病毒载体及其递送外源rna的方法
EP4247951A2 (en) * 2020-11-19 2023-09-27 Wake Forest University Health Sciences Vectors, systems and methods for eukaryotic gene editing

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1041152A1 (en) * 1996-10-17 2000-10-04 Oxford Biomedica (UK) Limited Retroviral vectors
GB0526210D0 (en) 2005-12-22 2006-02-01 Oxford Biomedica Ltd Vectors
CN108114276A (zh) * 2007-08-03 2018-06-05 巴斯德研究院 慢病毒基因转移载体及其医学应用
WO2013014537A1 (en) 2011-07-27 2013-01-31 Vectalys Virus-based vector compositions useful for transducing eukaryotic cells
WO2016049258A2 (en) * 2014-09-25 2016-03-31 The Broad Institute Inc. Functional screening with optimized functional crispr-cas systems

Also Published As

Publication number Publication date
JP2019514414A (ja) 2019-06-06
DK3455239T3 (da) 2021-07-05
WO2017194902A2 (fr) 2017-11-16
PT3455239T (pt) 2021-07-13
IL262941B (en) 2022-05-01
IL262941A (en) 2018-12-31
AU2017263137A1 (en) 2019-01-03
US10870865B2 (en) 2020-12-22
WO2017194902A3 (fr) 2018-01-18
EP3455239B1 (fr) 2021-04-07
CN109415415A (zh) 2019-03-01
CA3024376A1 (fr) 2017-11-16
JP6982001B2 (ja) 2021-12-17
US20200071720A1 (en) 2020-03-05
EP3455239A2 (fr) 2019-03-20
AU2017263137B2 (en) 2021-05-27
ES2886919T3 (es) 2021-12-21

Similar Documents

Publication Publication Date Title
MX2022006652A (es) Proteinas de capside modificadas para un suministro mejorado de vectores de parvovirus.
WO2018136396A3 (en) Crisprs
SG11201810015YA (en) Particle for the encapsidation of a genome engineering system
MX2019006467A (es) Composiciones y métodos para mejorar la expresión génica.
MA52645B1 (fr) Vaccins contre le virus respiratoire
CY1124453T1 (el) Πολυπεπτιδια που περιεχουν επικρατειες προσδεσης de novo και χρησεις αυτων
PH12019501130A1 (en) Viral delivery of neoantigens
MX2020011939A (es) Nuevas enzimas y sistemas crispr.
MX2019002946A (es) Anticuerpos anti-pd-1 y sus usos.
MX2017010857A (es) Metodos para la cobertura de secuencia de acidos nucleicos seleccionados como diana.
MX2018005392A (es) Acidos nucleicos modificados dirigidos a acidos nucleicos.
MX2019004499A (es) Sistemas de replicón de virus recombinante y usos de estos.
WO2015191693A3 (en) Method for gene editing
AU2016262093A8 (en) Enhancing endonuclease based gene editing in primary cells
NZ729012A (en) Recombinant modified vaccinia virus ankara (mva) filovirus vaccine
WO2017066764A3 (en) Modification of n-terminal region of capsid proteins for enhanced properties of adeno-associated viruses
AU2015286820A8 (en) Stabilization of poly(A) sequence encoding DNA sequences
WO2018191502A3 (en) Anti-cd137 antibodies and methods of use thereof
EA201201025A1 (ru) Молекулы нуклеиновых кислот гриппа и вакцины, изготовленные из них
WO2009124312A3 (en) Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same
EA201992232A1 (ru) Композиции и способы для иммуноонкологии
MX2017008096A (es) Pestivirus.
WO2018017747A3 (en) Oncolytic viruses targeting stat3
MX2017005524A (es) Metodos y composiciones para el virus del dengue recombinante para el desarrollo de vacunas y de diagnostico.
EA201890351A1 (ru) Рекомбинантный orf-вирусный вектор