SG11201809408SA - Method for reducing the trisulfide level in proteins - Google Patents

Method for reducing the trisulfide level in proteins

Info

Publication number
SG11201809408SA
SG11201809408SA SG11201809408SA SG11201809408SA SG11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA SG 11201809408S A SG11201809408S A SG 11201809408SA
Authority
SG
Singapore
Prior art keywords
international
pct
proteins
trisulfide
english
Prior art date
Application number
SG11201809408SA
Other languages
English (en)
Inventor
Aline Zimmer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201809408SA publication Critical patent/SG11201809408SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
SG11201809408SA 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins SG11201809408SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16167461 2016-04-28
PCT/EP2017/059691 WO2017186654A1 (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins

Publications (1)

Publication Number Publication Date
SG11201809408SA true SG11201809408SA (en) 2018-11-29

Family

ID=56008475

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201809408SA SG11201809408SA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins
SG10202010606YA SG10202010606YA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10202010606YA SG10202010606YA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins

Country Status (8)

Country Link
US (1) US11220668B2 (zh)
EP (1) EP3448871B1 (zh)
JP (1) JP7253381B2 (zh)
KR (1) KR102425040B1 (zh)
CN (1) CN109071595A (zh)
ES (1) ES2967868T3 (zh)
SG (2) SG11201809408SA (zh)
WO (1) WO2017186654A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708655D0 (en) * 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
EP3492582A1 (en) * 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods
CN117534728A (zh) * 2024-01-10 2024-02-09 哈尔滨吉象隆生物技术有限公司 一种奥曲肽三硫键杂质e的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011041721A1 (en) 2009-10-02 2011-04-07 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
KR20120107793A (ko) 2011-03-22 2012-10-04 엘지이노텍 주식회사 표시장치 및 광 변환 부재
WO2012158551A1 (en) 2011-05-13 2012-11-22 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
AR093460A1 (es) * 2012-11-14 2015-06-10 Merck Patent Ges Mit Beschränkter Haftung Medios de cultivo celular
JP6845218B2 (ja) 2015-07-30 2021-03-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung 細胞におけるグルタチオンレベルを増加させる方法

Also Published As

Publication number Publication date
KR102425040B1 (ko) 2022-07-25
CN109071595A (zh) 2018-12-21
US20200255796A1 (en) 2020-08-13
EP3448871A1 (en) 2019-03-06
US11220668B2 (en) 2022-01-11
SG10202010606YA (en) 2020-11-27
ES2967868T3 (es) 2024-05-06
JP7253381B2 (ja) 2023-04-06
JP2019514918A (ja) 2019-06-06
WO2017186654A1 (en) 2017-11-02
EP3448871B1 (en) 2023-10-11
KR20190003603A (ko) 2019-01-09

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