SG10202010606YA - Method for reducing the trisulfide level in proteins - Google Patents

Method for reducing the trisulfide level in proteins

Info

Publication number
SG10202010606YA
SG10202010606YA SG10202010606YA SG10202010606YA SG10202010606YA SG 10202010606Y A SG10202010606Y A SG 10202010606YA SG 10202010606Y A SG10202010606Y A SG 10202010606YA SG 10202010606Y A SG10202010606Y A SG 10202010606YA SG 10202010606Y A SG10202010606Y A SG 10202010606YA
Authority
SG
Singapore
Prior art keywords
proteins
reducing
trisulfide
trisulfide level
level
Prior art date
Application number
SG10202010606YA
Inventor
Aline Zimmer
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG10202010606YA publication Critical patent/SG10202010606YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018Culture media for cell or tissue culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00Specific components of cell culture medium
    • C12N2500/30Organic components
    • C12N2500/32Amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
SG10202010606YA 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins SG10202010606YA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP16167461 2016-04-28

Publications (1)

Publication Number Publication Date
SG10202010606YA true SG10202010606YA (en) 2020-11-27

Family

ID=56008475

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201809408SA SG11201809408SA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins
SG10202010606YA SG10202010606YA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201809408SA SG11201809408SA (en) 2016-04-28 2017-04-25 Method for reducing the trisulfide level in proteins

Country Status (8)

Country Link
US (1) US11220668B2 (en)
EP (1) EP3448871B1 (en)
JP (1) JP7253381B2 (en)
KR (1) KR102425040B1 (en)
CN (1) CN109071595A (en)
ES (1) ES2967868T3 (en)
SG (2) SG11201809408SA (en)
WO (1) WO2017186654A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201708655D0 (en) * 2017-05-31 2017-07-12 Ucb Biopharma Sprl Cell culture methods
EP3492582A1 (en) * 2017-12-01 2019-06-05 UCB Biopharma SPRL Cell culture methods
CN117534728A (en) * 2024-01-10 2024-02-09 哈尔滨吉象隆生物技术有限公司 Preparation method of octreotide trisulfide bond impurity E

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011041721A1 (en) 2009-10-02 2011-04-07 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
KR20120107793A (en) 2011-03-22 2012-10-04 엘지이노텍 주식회사 Display device and light conversion member
WO2012158551A1 (en) * 2011-05-13 2012-11-22 Biogen Idec Ma Inc. Methods of preventing and removing trisulfide bonds
AR093460A1 (en) * 2012-11-14 2015-06-10 Merck Patent Ges Mit Beschränkter Haftung CELL CULTURE MEDIA
JP6845218B2 (en) * 2015-07-30 2021-03-17 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung How to increase glutathione levels in cells

Also Published As

Publication number Publication date
JP7253381B2 (en) 2023-04-06
EP3448871B1 (en) 2023-10-11
WO2017186654A1 (en) 2017-11-02
JP2019514918A (en) 2019-06-06
CN109071595A (en) 2018-12-21
KR20190003603A (en) 2019-01-09
US11220668B2 (en) 2022-01-11
US20200255796A1 (en) 2020-08-13
ES2967868T3 (en) 2024-05-06
KR102425040B1 (en) 2022-07-25
EP3448871A1 (en) 2019-03-06
SG11201809408SA (en) 2018-11-29

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