SG11201808538QA - Trans-splicing rna (tsrna) - Google Patents

Trans-splicing rna (tsrna)

Info

Publication number
SG11201808538QA
SG11201808538QA SG11201808538QA SG11201808538QA SG11201808538QA SG 11201808538Q A SG11201808538Q A SG 11201808538QA SG 11201808538Q A SG11201808538Q A SG 11201808538QA SG 11201808538Q A SG11201808538Q A SG 11201808538QA SG 11201808538Q A SG11201808538Q A SG 11201808538QA
Authority
SG
Singapore
Prior art keywords
tsrna
trans
splicing rna
splicing
rna
Prior art date
Application number
SG11201808538QA
Other languages
English (en)
Inventor
Volker Patzel
Sushmita Poddar
Original Assignee
Nat Univ Singapore
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nat Univ Singapore filed Critical Nat Univ Singapore
Publication of SG11201808538QA publication Critical patent/SG11201808538QA/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
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    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67General methods for enhancing the expression
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Biotechnology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
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  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Cell Biology (AREA)
SG11201808538QA 2016-04-01 2017-03-31 Trans-splicing rna (tsrna) SG11201808538QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201605586 2016-04-01
PCT/SG2017/050183 WO2017171654A1 (fr) 2016-04-01 2017-03-31 Arn de transépissage (tsrna)

Publications (1)

Publication Number Publication Date
SG11201808538QA true SG11201808538QA (en) 2018-10-30

Family

ID=59966148

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808538QA SG11201808538QA (en) 2016-04-01 2017-03-31 Trans-splicing rna (tsrna)

Country Status (7)

Country Link
US (2) US11517583B2 (fr)
EP (1) EP3436590A4 (fr)
JP (2) JP7229467B2 (fr)
CN (1) CN109642241B (fr)
AU (1) AU2017240703B2 (fr)
SG (1) SG11201808538QA (fr)
WO (1) WO2017171654A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021076656A1 (fr) * 2019-10-15 2021-04-22 University Of Massachusetts Trans-épissage d'arn amélioré par éditeur d'arn
CA3168903A1 (fr) * 2020-02-07 2021-08-12 University Of Rochester Assemblage et expression d'arn a mediation par ribozyme
GB202102118D0 (en) 2021-02-15 2021-03-31 Cambridge Entpr Ltd RNA Trans-Splicing molecule
GB202108855D0 (en) 2021-06-21 2021-08-04 Cambridge Entpr Ltd Methods of eukaryotic gene expression
CN113584169A (zh) * 2021-07-28 2021-11-02 南京大学 一种与肝癌相关的血清tsRNA标志物、探针及其应用
KR20240052034A (ko) * 2021-09-03 2024-04-22 태시트 테라퓨틱스, 인코포레이티드 스플라이세오솜 구성요소의 동원을 통한 rna 편집
WO2023140792A2 (fr) * 2022-01-18 2023-07-27 National University Of Singapore Arn de transépissage (arnts)

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU730305B2 (en) * 1995-12-15 2001-03-01 Intronn Llc Therapeutic molecules generated by trans-splicing
US6280978B1 (en) * 1995-12-15 2001-08-28 Intronn Holdings, Llc Methods and compositions for use in spliceosome mediated RNA trans-splicing
DE10139492B4 (de) * 2001-08-13 2004-06-09 Eul, Joachim, Dr. Verfahren zur Reparatur einer mutierten RNA aus einer gendefekten DNA und zum gezielten Abtöten von Tumorzellen durch RNA-Transspleißen sowie Verfahren zum Nachweis von natürlich-transgespleißter zellulärer RNA
JP4475944B2 (ja) * 2002-04-30 2010-06-09 アイコン・ジェネティクス・ゲーエムベーハー トランススプライシングに基づく増幅ベクター
AU2003237449A1 (en) * 2002-06-05 2003-12-22 Virxsys Corporation Spliceosome mediated RNA trans-splicing and correction of factor VIII genetic defects
EP1579004B1 (fr) * 2002-10-23 2010-06-16 VIRxSYS Corporation Procedes de criblage destines a identifier des molecules de pre-trans-epissage efficaces
US7192709B2 (en) 2004-03-15 2007-03-20 Digigenomics Co., Ltd. Methods for identification, assessment, prevention, and therapy of cancer
KR100958293B1 (ko) * 2008-03-27 2010-05-19 단국대학교 산학협력단 테오필린에 의해 표적 특이적 rna 치환 활성이 조절되는알로스테릭 트랜스―스플라이싱 그룹 i 리보자임
KR20110036996A (ko) * 2009-10-05 2011-04-13 전남대학교산학협력단 편평세포암 진단 마커인 ho-1 및 이의 용도
WO2012056441A1 (fr) * 2010-10-28 2012-05-03 Nanodoc Ltd. Compositions et procédés pour le clivage spécifique d'arn exogène dans une cellule
EP2742128A4 (fr) * 2011-08-12 2015-03-18 Virxsys Corp Compositions et procédés pour l'induction de l'apoptose
KR101293620B1 (ko) 2011-08-19 2013-08-13 국립암센터 트랜스-스플라이싱 라이보자임 및 암치료 유전자를 포함하는 재조합 아데노바이러스 및 이의 용도
GB201219762D0 (en) * 2012-11-02 2012-12-19 Bauer Johann A RNA trans-splicing molecule (RTM) for use in the treatment of cancer
KR101429696B1 (ko) * 2012-11-21 2014-08-13 국립암센터 안전성 및 항암활성이 증가된 재조합 아데노바이러스 및 이의 용도
US20140283156A1 (en) * 2013-03-14 2014-09-18 Cold Spring Harbor Laboratory Trans-splicing ribozymes and silent recombinases

Also Published As

Publication number Publication date
JP2019509756A (ja) 2019-04-11
AU2017240703A1 (en) 2018-10-18
EP3436590A1 (fr) 2019-02-06
EP3436590A4 (fr) 2019-12-04
CN109642241A (zh) 2019-04-16
WO2017171654A1 (fr) 2017-10-05
US20190111072A1 (en) 2019-04-18
US11517583B2 (en) 2022-12-06
US20240075051A1 (en) 2024-03-07
AU2017240703B2 (en) 2020-05-21
CN109642241B (zh) 2023-06-27
JP2023055809A (ja) 2023-04-18
JP7229467B2 (ja) 2023-02-28

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