SG11201805154YA - Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof - Google Patents
Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereofInfo
- Publication number
- SG11201805154YA SG11201805154YA SG11201805154YA SG11201805154YA SG11201805154YA SG 11201805154Y A SG11201805154Y A SG 11201805154YA SG 11201805154Y A SG11201805154Y A SG 11201805154YA SG 11201805154Y A SG11201805154Y A SG 11201805154YA SG 11201805154Y A SG11201805154Y A SG 11201805154YA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- chuo
- tokyo
- limited
- honcho
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 1111111101111011101010111110101111101110111011101011111111011111111101111011111 International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... ..or::,,, WO 2017/111787 Al 29 June 2017(29.06.2017) WIPO I PCT (51) International Patent Classification: CHI SANKYO COMPANY, LIMITED, 3-5-1, Nihonbashi C07D 487/04 (2006.01) A61P 35/00 (2006.01) Honcho, Chuo-ku, Tokyo 103-8426 (JP). C07D 405/12 (2006.01) A61P 29/00 (2006.01) A61K 31/519 (2006.01) A61P 31/12 (2006.01) (74) Agents: ELRIFI, Ivor et al.; Cooley LLP, 1299 Pennsylvania Avenue, N.W., Washington, District of (21) International Application Number: Columbia 20004 (US). PCT/US2015/000285 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: 23 December 2015 (23.12.2015) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (71) Applicant: ARQULE, INC. [US/US]; One Wall Street, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, Burlington, Massachusetts 01803 (US). PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (72) Inventors: LAPIERRE, Jean-Marc; 1 Alexandra Drive, SD, SE, SG, SK, SL, 5M, ST, 5V, 5Y, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. Pelham, New Hampshire 03076 (US). EATHIRAJ, Sud- harshan; 24 Ptarmigan Drive, Shrewsbury, Massachusetts (84) Designated States (unless otherwise indicated, for every 01545 (US). NAMDEV, Nivedita; 18 Briarwood Drive, kind of regional protection available): ARIPO (BW, GH, Westford, Massachusetts 01545 (US). SCHWARTZ, Bri- an; 18 October Hill Rd., Woodbridge, Connecticut 06525 GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (US). OTA, Yusuke; c/o DAIICHI SANKYO COM- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, PANY, LIMITED, 3-5-1, Nihonbashi Honcho, Chuo-ku, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, Tokyo 103-8426 (JP). MOMOSE, Takayuki; c/o DAII- LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, CHI SANKYO COMPANY, LIMITED, 3-5-1, Nihonbashi SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = Honcho, Chuo-ku, Tokyo 103-8426 (JP). TSUNEMI, To- GW, KM, ML, MR, NE, SN, TD, TG). — moyuki; c/o DAIICHI SANKYO COMPANY, LIMITED, 3-5-1, Nihonbashi Honcho, Chuo-ku, Tokyo 103-8426 Published: (JP). INAGAKI, Hiroaki; c/o DAIICHI SANKYO COM- — with international search report (Art. 21(3)) PANY, LIMITED, 3-5-1, Nihonbashi Honcho, Chuo-ku, _ _ Tokyo 103-8426 (JP). NAKAYAMA, Kiyoshi; c/o DAII- = = = = = = Title: TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE AND METHODS OF USE THEREOF = (54) = C) HO CI — '`-''''NH 0 1-1 ® OPh (I) IN N GO LI ,, IN 1-1 N N H 1-1 1-1 IN 1-1 (57) : The application relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, tautomer, prod- = mg, solvate, metabolite, polymorph, analog or derivative thereof, which modulates the activity of BTK, a pharmaceutical composi - \" tion comprising the compound of Formula (I), and a method of treating or preventing a disease in which BTK plays a role.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2015/000285 WO2017111787A1 (en) | 2015-12-23 | 2015-12-23 | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201805154YA true SG11201805154YA (en) | 2018-07-30 |
Family
ID=59090991
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201805154YA SG11201805154YA (en) | 2015-12-23 | 2015-12-23 | Tetrahydropyranyl amino-pyrrolopyrimidinone and methods of use thereof |
Country Status (28)
| Country | Link |
|---|---|
| EP (2) | EP3882250B1 (en) |
| JP (1) | JP6634520B2 (en) |
| KR (2) | KR102547188B1 (en) |
| CN (2) | CN108699062B (en) |
| AU (3) | AU2015417922B2 (en) |
| CA (1) | CA3008446C (en) |
| CY (1) | CY1124210T1 (en) |
| DK (2) | DK3394065T3 (en) |
| ES (2) | ES2942743T3 (en) |
| FI (1) | FI3882250T3 (en) |
| HR (2) | HRP20230379T1 (en) |
| HU (2) | HUE055221T2 (en) |
| IL (2) | IL259938B (en) |
| LT (2) | LT3394065T (en) |
| MA (1) | MA56553B1 (en) |
| MD (1) | MD3882250T2 (en) |
| MX (1) | MX2018007815A (en) |
| MY (1) | MY193177A (en) |
| PH (1) | PH12018501390A1 (en) |
| PL (2) | PL3394065T3 (en) |
| PT (2) | PT3394065T (en) |
| RS (2) | RS64141B1 (en) |
| RU (1) | RU2715421C2 (en) |
| SA (1) | SA518391836B1 (en) |
| SG (1) | SG11201805154YA (en) |
| SI (2) | SI3882250T1 (en) |
| WO (1) | WO2017111787A1 (en) |
| ZA (1) | ZA201804091B (en) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201901197PA (en) * | 2016-08-24 | 2019-03-28 | Arqule Inc | Amino-pyrrolopyrimidinone compounds and methods of use thereof |
| CN109956870A (en) * | 2017-12-14 | 2019-07-02 | 南京卡文迪许生物工程技术有限公司 | A kind of Luo Shasi his synthetic method and its midbody compound |
| WO2021093839A1 (en) * | 2019-11-13 | 2021-05-20 | 南京明德新药研发有限公司 | Pyrrolopyrimidine compound as btk inhibitor and use thereof |
| CN112812100B (en) * | 2019-11-18 | 2022-04-05 | 四川海思科制药有限公司 | Compound capable of degrading BTK kinase, preparation method and pharmaceutical application thereof |
| CN112608318B (en) * | 2019-12-16 | 2023-09-08 | 成都海博为药业有限公司 | Compound as protein kinase inhibitor and application thereof |
| JP7011638B2 (en) * | 2019-12-16 | 2022-02-10 | アークル インコーポレイテッド | Tetrahydropyranylamino-pyrrolopyrimidinone and how to use it |
| CN112574200B (en) * | 2021-02-26 | 2021-06-11 | 安润医药科技（苏州）有限公司 | Small molecule inhibitors of BTK and/or mutant C481S of BTK |
| CN115028633B (en) * | 2021-03-08 | 2023-12-22 | 药雅科技(上海)有限公司 | Preparation and application of pyrrolopyrimidine compound |
| CN114761410B (en) * | 2021-04-06 | 2023-08-25 | 广州必贝特医药股份有限公司 | Pyrrolopyrimidinone compounds and application thereof |
| WO2022213932A1 (en) * | 2021-04-06 | 2022-10-13 | 广州必贝特医药股份有限公司 | Pyrrolopyrimidinone compound and application thereof |
| KR20240004588A (en) * | 2021-05-12 | 2024-01-11 | 제지앙 롱샴 바이오-테크 파르마. 씨오., 엘티디. | Crystalline form of pyrrolopyrimidine compounds and method for producing the same |
| WO2023110970A1 (en) | 2021-12-14 | 2023-06-22 | Netherlands Translational Research Center Holding B.V | Macrocyclic btk inhibitors |
| CN114409654A (en) * | 2021-12-30 | 2022-04-29 | 安徽普利药业有限公司 | Intermediate synthesis method of BTK inhibitor |
| CN115894500A (en) * | 2022-11-02 | 2023-04-04 | 中国药科大学 | Compound serving as BTK kinase inhibitor and preparation method and application thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| PE20121335A1 (en) * | 2009-11-18 | 2012-10-12 | Plexxikon Inc | AMIDA-DERIVED COMPOUNDS AS RAF KINASES INHIBITORS |
| US8377946B1 (en) * | 2011-12-30 | 2013-02-19 | Pharmacyclics, Inc. | Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors |
| WO2014164729A1 (en) * | 2013-03-12 | 2014-10-09 | Arqule, Inc. | Substituted tricyclic pyrazolo-pyrimidine compounds |
| EP2970300B1 (en) * | 2013-03-15 | 2018-05-16 | Boehringer Ingelheim International GmbH | Heteroaromatic compounds as btk inhibitors |
| GB201309085D0 (en) * | 2013-05-20 | 2013-07-03 | Redx Pharma Ltd | Compounds |
| GB201410430D0 (en) * | 2014-06-11 | 2014-07-23 | Redx Pharma Ltd | Compounds |
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2015
- 2015-12-23 CA CA3008446A patent/CA3008446C/en active Active
- 2015-12-23 SG SG11201805154YA patent/SG11201805154YA/en unknown
- 2015-12-23 EP EP21165852.1A patent/EP3882250B1/en active Active
- 2015-12-23 KR KR1020187020899A patent/KR102547188B1/en active IP Right Grant
- 2015-12-23 CN CN201580085832.0A patent/CN108699062B/en active Active
- 2015-12-23 KR KR1020237020794A patent/KR20230098690A/en not_active Application Discontinuation
- 2015-12-23 PL PL15911490T patent/PL3394065T3/en unknown
- 2015-12-23 LT LTEP15911490.9T patent/LT3394065T/en unknown
- 2015-12-23 PL PL21165852.1T patent/PL3882250T3/en unknown
- 2015-12-23 PT PT159114909T patent/PT3394065T/en unknown
- 2015-12-23 MY MYPI2018001066A patent/MY193177A/en unknown
- 2015-12-23 ES ES21165852T patent/ES2942743T3/en active Active
- 2015-12-23 FI FIEP21165852.1T patent/FI3882250T3/en active
- 2015-12-23 SI SI201531934T patent/SI3882250T1/en unknown
- 2015-12-23 WO PCT/US2015/000285 patent/WO2017111787A1/en active Application Filing
- 2015-12-23 AU AU2015417922A patent/AU2015417922B2/en active Active
- 2015-12-23 CN CN202110663289.5A patent/CN113307811B/en active Active
- 2015-12-23 HU HUE15911490A patent/HUE055221T2/en unknown
- 2015-12-23 HU HUE21165852A patent/HUE061761T2/en unknown
- 2015-12-23 MX MX2018007815A patent/MX2018007815A/en unknown
- 2015-12-23 RU RU2018126793A patent/RU2715421C2/en active
- 2015-12-23 PT PT211658521T patent/PT3882250T/en unknown
- 2015-12-23 RS RS20230294A patent/RS64141B1/en unknown
- 2015-12-23 ES ES15911490T patent/ES2868884T3/en active Active
- 2015-12-23 SI SI201531588T patent/SI3394065T1/en unknown
- 2015-12-23 MD MDE20220501T patent/MD3882250T2/en unknown
- 2015-12-23 DK DK15911490.9T patent/DK3394065T3/en active
- 2015-12-23 MA MA56553A patent/MA56553B1/en unknown
- 2015-12-23 DK DK21165852.1T patent/DK3882250T3/en active
- 2015-12-23 LT LTEP21165852.1T patent/LT3882250T/en unknown
- 2015-12-23 RS RS20210646A patent/RS61887B1/en unknown
- 2015-12-23 EP EP15911490.9A patent/EP3394065B1/en active Active
- 2015-12-23 JP JP2018533095A patent/JP6634520B2/en active Active
- 2015-12-23 HR HRP20230379TT patent/HRP20230379T1/en unknown
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2018
- 2018-06-11 IL IL259938A patent/IL259938B/en active IP Right Grant
- 2018-06-19 ZA ZA2018/04091A patent/ZA201804091B/en unknown
- 2018-06-20 SA SA518391836A patent/SA518391836B1/en unknown
- 2018-06-28 PH PH12018501390A patent/PH12018501390A1/en unknown
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2019
- 2019-03-13 AU AU2019201737A patent/AU2019201737B2/en active Active
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2020
- 2020-06-04 AU AU2020203690A patent/AU2020203690B2/en active Active
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2021
- 2021-04-22 IL IL282572A patent/IL282572B/en unknown
- 2021-05-26 HR HRP20210844TT patent/HRP20210844T1/en unknown
- 2021-05-31 CY CY20211100469T patent/CY1124210T1/en unknown
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