SG11201708472WA - Crystalline fgfr4 inhibitor compound and uses thereof - Google Patents

Crystalline fgfr4 inhibitor compound and uses thereof

Info

Publication number
SG11201708472WA
SG11201708472WA SG11201708472WA SG11201708472WA SG11201708472WA SG 11201708472W A SG11201708472W A SG 11201708472WA SG 11201708472W A SG11201708472W A SG 11201708472WA SG 11201708472W A SG11201708472W A SG 11201708472WA SG 11201708472W A SG11201708472W A SG 11201708472WA
Authority
SG
Singapore
Prior art keywords
crystalline
inhibitor compound
fgfr4 inhibitor
fgfr4
compound
Prior art date
Application number
SG11201708472WA
Other languages
English (en)
Inventor
George Moniz
Kristen Sanders
Arani Chanda
Kenshi Yoshida
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11201708472WA publication Critical patent/SG11201708472WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48Two nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201708472WA 2015-04-14 2016-04-13 Crystalline fgfr4 inhibitor compound and uses thereof SG11201708472WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562147313P 2015-04-14 2015-04-14
PCT/US2016/027334 WO2016168331A1 (en) 2015-04-14 2016-04-13 Crystalline fgfr4 inhibitor compound and uses thereof

Publications (1)

Publication Number Publication Date
SG11201708472WA true SG11201708472WA (en) 2017-11-29

Family

ID=55806857

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201810057UA SG10201810057UA (en) 2015-04-14 2016-04-13 Crystalline fgfr4 inhibitor compound and uses thereof
SG11201708472WA SG11201708472WA (en) 2015-04-14 2016-04-13 Crystalline fgfr4 inhibitor compound and uses thereof

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10201810057UA SG10201810057UA (en) 2015-04-14 2016-04-13 Crystalline fgfr4 inhibitor compound and uses thereof

Country Status (13)

Country Link
US (2) US10562888B2 (ko)
EP (1) EP3283465B1 (ko)
JP (3) JP6431622B2 (ko)
KR (1) KR102548229B1 (ko)
CN (1) CN107660200B (ko)
AU (2) AU2016248056B2 (ko)
CA (1) CA2982562C (ko)
ES (1) ES2864712T3 (ko)
IL (1) IL254974B (ko)
MX (1) MX2017013248A (ko)
RU (1) RU2763328C2 (ko)
SG (2) SG10201810057UA (ko)
WO (1) WO2016168331A1 (ko)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3283465B1 (en) * 2015-04-14 2021-01-06 Eisai R&D Management Co., Ltd. Crystalline fgfr4 inhibitor compound and uses thereof
US11357769B2 (en) 2016-05-10 2022-06-14 Eisai R&D Management Co., Ltd. Drug combinations for reducing cell viability and/or cell proliferation
CN109803684B (zh) * 2016-08-23 2022-08-23 卫材 R&D 管理有限公司 用于治疗肝细胞癌的组合疗法
CN109952290B (zh) * 2016-11-17 2022-05-03 广东众生药业股份有限公司 Fgfr4抑制剂及其制备方法和应用
CN109422760B (zh) * 2017-09-01 2022-05-27 南京圣和药物研发有限公司 Fgfr4抑制剂及其应用
BR112020014112A2 (pt) 2018-01-10 2020-12-01 Eisai R&D Management Co., Ltd. terapias de combinação para o tratamento de carcinoma hepatocelular
JP2023533903A (ja) 2020-05-15 2023-08-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 Fgfr4阻害剤の経口製剤によるがんの治療方法
US20230172867A1 (en) 2020-05-15 2023-06-08 Eisai R&D Management Co., Ltd. A method for treating cancer with an oral dosage form of an fgfr4 inhibitor

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DE69939168D1 (de) 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
MXPA06001098A (es) 2003-07-29 2006-04-24 Irm Llc Compuestos y composiciones utiles como inhibidores de proteina cinasa.
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CA2634047C (en) 2005-12-21 2016-04-12 Novartis Ag Pyrimidinyl aryl urea derivatives being fgf inhibitors
EP1918376A1 (en) 2006-11-03 2008-05-07 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. FGFR4 promotes cancer cell resistance in response to chemotherapeutic drugs
US20090062320A1 (en) 2007-08-28 2009-03-05 Vito Guagnano Method of Treating Disorders Mediated by the Fibroblast Growth Factor Receptor
ES2711249T3 (es) 2008-06-27 2019-04-30 Celgene Car Llc Compuestos de heteroarilo y usos de los mismos
AR079257A1 (es) 2009-12-07 2012-01-04 Novartis Ag Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas
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SG181850A1 (en) 2010-01-14 2012-08-30 Univ Yale Inhibitors of receptor tyrosine kinases (rtk) and methods of use thereof
WO2011153553A2 (en) 2010-06-04 2011-12-08 The Regents Of The University Of California Methods and compositions for kinase inhibition
AR085934A1 (es) 2011-04-08 2013-11-06 Ab Science Tratamiento de mieloma multiple con masitinib
CN102816162B (zh) 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
EP2804630B1 (en) 2012-01-18 2017-10-18 F. Hoffmann-La Roche AG Methods of using fgf19 modulators
JP5343177B1 (ja) 2012-02-28 2013-11-13 アステラス製薬株式会社 含窒素芳香族へテロ環化合物
SG11201500125QA (en) 2012-07-11 2015-02-27 Blueprint Medicines Corp Inhibitors of the fibroblast growth factor receptor
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EA201591137A1 (ru) 2013-03-15 2016-02-29 Селджен Авиломикс Рисерч, Инк. Ингибиторы mk2 и их применения
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MY184733A (en) * 2013-10-18 2021-04-20 Eisai R&D Man Co Ltd Pyrimidine fgfr4 inhibitors
WO2015061572A1 (en) 2013-10-25 2015-04-30 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
US9695165B2 (en) 2014-01-15 2017-07-04 Blueprint Medicines Corporation Inhibitors of the fibroblast growth factor receptor
EP3283465B1 (en) * 2015-04-14 2021-01-06 Eisai R&D Management Co., Ltd. Crystalline fgfr4 inhibitor compound and uses thereof
CN108884097B (zh) 2016-05-20 2021-05-28 浙江海正药业股份有限公司 嘧啶类衍生物、其制备方法和其在医药上的用途
JP7103952B2 (ja) 2016-05-20 2022-07-20 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 Fgfr4阻害剤、その製造方法及び応用

Also Published As

Publication number Publication date
ES2864712T3 (es) 2021-10-14
JP2018511635A (ja) 2018-04-26
EP3283465B1 (en) 2021-01-06
AU2016248056A1 (en) 2017-11-02
JP2018188465A (ja) 2018-11-29
KR20180003559A (ko) 2018-01-09
CA2982562C (en) 2023-06-13
US20200317645A1 (en) 2020-10-08
KR102548229B1 (ko) 2023-06-27
CN107660200A (zh) 2018-02-02
RU2017139246A (ru) 2019-05-14
AU2016248056B2 (en) 2020-07-23
RU2017139246A3 (ko) 2019-10-22
CA2982562A1 (en) 2016-10-20
IL254974B (en) 2021-06-30
WO2016168331A1 (en) 2016-10-20
JP6431622B2 (ja) 2018-11-28
US10562888B2 (en) 2020-02-18
CN107660200B (zh) 2022-01-11
EP3283465A1 (en) 2018-02-21
SG10201810057UA (en) 2018-12-28
US11498916B2 (en) 2022-11-15
BR112017022243A2 (pt) 2018-07-10
JP2021050231A (ja) 2021-04-01
IL254974A0 (en) 2017-12-31
AU2020257131A1 (en) 2020-11-19
US20180093972A1 (en) 2018-04-05
MX2017013248A (es) 2018-07-06
RU2763328C2 (ru) 2021-12-28

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