SG11201706501VA - AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS - Google Patents

AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS

Info

Publication number
SG11201706501VA
SG11201706501VA SG11201706501VA SG11201706501VA SG11201706501VA SG 11201706501V A SG11201706501V A SG 11201706501VA SG 11201706501V A SG11201706501V A SG 11201706501VA SG 11201706501V A SG11201706501V A SG 11201706501VA SG 11201706501V A SG11201706501V A SG 11201706501VA
Authority
SG
Singapore
Prior art keywords
receptor agonists
amide compounds
amide
compounds
agonists
Prior art date
Application number
SG11201706501VA
Other languages
English (en)
Inventor
Ramakrishna Nirogi
Anil Karbhari Shinde
Abdul Rasheed Mohammed
Sangram Keshari Saraf
Narsimha Bogaraju
Ramkumar Subramanian
Pradeep Jayarajan
Gopinadh Bhyrapuneni
Venkateswarlu Jasti
Original Assignee
Suven Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Suven Life Sciences Ltd filed Critical Suven Life Sciences Ltd
Publication of SG11201706501VA publication Critical patent/SG11201706501VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/453Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
SG11201706501VA 2015-02-13 2016-01-07 AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS SG11201706501VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN709CH2015 2015-02-13
PCT/IN2016/000008 WO2016128990A1 (en) 2015-02-13 2016-01-07 Amide compounds as 5-ht4 receptor agonists

Publications (1)

Publication Number Publication Date
SG11201706501VA true SG11201706501VA (en) 2017-09-28

Family

ID=55588327

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201706501VA SG11201706501VA (en) 2015-02-13 2016-01-07 AMIDE COMPOUNDS AS 5-HT<sb>4</sb> RECEPTOR AGONISTS

Country Status (29)

Country Link
US (1) US9957257B2 (ru)
EP (1) EP3265459B1 (ru)
JP (1) JP6487564B2 (ru)
KR (1) KR101966576B1 (ru)
CN (1) CN107406434B (ru)
AU (1) AU2016217461B2 (ru)
BR (1) BR112017017275A2 (ru)
CA (1) CA2975973C (ru)
CY (1) CY1121898T1 (ru)
DK (1) DK3265459T3 (ru)
EA (1) EA034618B1 (ru)
ES (1) ES2734734T3 (ru)
HR (1) HRP20191179T1 (ru)
HU (1) HUE045667T2 (ru)
IL (1) IL253848B (ru)
LT (1) LT3265459T (ru)
MA (1) MA41633B1 (ru)
MD (1) MD3265459T2 (ru)
ME (1) ME03430B (ru)
MX (1) MX368214B (ru)
NZ (1) NZ734400A (ru)
PL (1) PL3265459T3 (ru)
PT (1) PT3265459T (ru)
RS (1) RS59066B1 (ru)
SG (1) SG11201706501VA (ru)
SI (1) SI3265459T1 (ru)
TR (1) TR201909997T4 (ru)
WO (1) WO2016128990A1 (ru)
ZA (1) ZA201705292B (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6083818B2 (ja) 2011-11-18 2017-02-22 ヘプタレス セラピューティクス リミテッドHeptares Therapeutics Limited ムスカリンm1受容体アゴニスト
GB201513743D0 (en) 2015-08-03 2015-09-16 Heptares Therapeutics Ltd Muscarinic agonists
GB201617454D0 (en) 2016-10-14 2016-11-30 Heptares Therapeutics Limited Pharmaceutical compounds
GB201709652D0 (en) * 2017-06-16 2017-08-02 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201810239D0 (en) 2018-06-22 2018-08-08 Heptares Therapeutics Ltd Pharmaceutical compounds
GB201819960D0 (en) 2018-12-07 2019-01-23 Heptares Therapeutics Ltd Pharmaceutical compounds
GB202020191D0 (en) 2020-12-18 2021-02-03 Heptares Therapeutics Ltd Pharmaceutical compounds
CN110818661B (zh) * 2019-12-02 2021-08-06 上海再启生物技术有限公司 5-ht4受体激动剂的关键中间体4-氨基-5-卤苯并呋喃-7-羧酸的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7964727B2 (en) 2003-11-24 2011-06-21 Pfizer Inc. Quinolonecarboxylic acid compounds having 5-HT4 receptor agonistic activity
WO2005092882A1 (en) * 2004-03-01 2005-10-06 Pfizer Japan, Inc. 4-amino-5-halogeno-benzamide derivatives as 5-ht4 receptor agonists for the treatment of gastrointestinal, cns, neurological and cardiovascular disorders
DK1856114T3 (en) 2005-02-25 2014-11-17 Raqualia Pharma Inc Benzisoxazol-DERIVATIVES
ES2333545T3 (es) 2005-07-22 2010-02-23 Pfizer, Inc. Derivados de indazolcarboxamida como agonistas de receptores 5ht4.
TW200732327A (en) * 2005-10-28 2007-09-01 Glaxo Group Ltd Novel compound
GB0525661D0 (en) * 2005-12-16 2006-01-25 Glaxo Group Ltd Novel compounds
GB0603550D0 (en) * 2006-02-22 2006-04-05 Glaxo Group Ltd Novel compounds
US8980922B2 (en) * 2010-02-12 2015-03-17 Raqualia Pharma Inc. 5-HT4 receptor agonists for the treatment of dementia
MX2012008721A (es) 2010-02-16 2012-08-17 Pfizer (r)-4-((4-((4-(tetrahidrofuran-3-iloxi)benzo[d]isoxazol-3-iloxi)m etil) tetrahidro-2h-piran-4-ol, un agonista pacial de receptores 5-ht4.
MX337721B (es) * 2011-09-19 2016-03-16 Suven Life Sciences Ltd Compuestos de heteroarilo como ligandos del receptor 5-ht4.
AP2015008742A0 (en) * 2013-03-20 2015-09-30 Suven Life Sciences Ltd 5-amino quinoline-8-carboxamide derivatives as 5-ht4 receptor agonists
EA029951B1 (ru) * 2013-12-16 2018-06-29 Сувен Лайф Сайенсиз Лимитед Соединения индазола в качестве агонистов 5-ht-рецептора

Also Published As

Publication number Publication date
AU2016217461A1 (en) 2017-09-14
IL253848B (en) 2018-01-31
SI3265459T1 (sl) 2019-09-30
LT3265459T (lt) 2019-08-26
DK3265459T3 (da) 2019-07-15
IL253848A0 (en) 2017-09-28
BR112017017275A2 (pt) 2018-04-17
EA034618B1 (ru) 2020-02-27
MX2017010348A (es) 2018-06-07
CN107406434B (zh) 2020-09-11
MA41633A (fr) 2019-05-15
EP3265459A1 (en) 2018-01-10
RS59066B1 (sr) 2019-09-30
NZ734400A (en) 2018-03-23
ME03430B (me) 2020-01-20
ZA201705292B (en) 2019-06-26
AU2016217461B2 (en) 2018-07-05
PT3265459T (pt) 2019-07-17
CN107406434A (zh) 2017-11-28
US9957257B2 (en) 2018-05-01
CA2975973C (en) 2019-07-16
TR201909997T4 (tr) 2019-07-22
EA201791829A1 (ru) 2018-05-31
HUE045667T2 (hu) 2020-01-28
KR101966576B1 (ko) 2019-04-05
ES2734734T3 (es) 2019-12-11
MA41633B1 (fr) 2019-07-31
WO2016128990A1 (en) 2016-08-18
CY1121898T1 (el) 2020-10-14
PL3265459T3 (pl) 2019-09-30
JP6487564B2 (ja) 2019-03-20
HRP20191179T1 (hr) 2019-10-04
CA2975973A1 (en) 2016-08-18
US20180051011A1 (en) 2018-02-22
EP3265459B1 (en) 2019-05-15
MX368214B (es) 2019-09-24
JP2018509396A (ja) 2018-04-05
KR20170117167A (ko) 2017-10-20
MD3265459T2 (ro) 2019-09-30

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