SG11201610600SA - Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy - Google Patents

Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy

Info

Publication number
SG11201610600SA
SG11201610600SA SG11201610600SA SG11201610600SA SG11201610600SA SG 11201610600S A SG11201610600S A SG 11201610600SA SG 11201610600S A SG11201610600S A SG 11201610600SA SG 11201610600S A SG11201610600S A SG 11201610600SA SG 11201610600S A SG11201610600S A SG 11201610600SA
Authority
SG
Singapore
Prior art keywords
methods
combination
radiation therapy
cancer treatment
antagonists against
Prior art date
Application number
SG11201610600SA
Other languages
English (en)
Inventor
Ross Stewart
Michelle Morrow
Robert Wilkinson
Edmund Poon
Simon Dovedi
Tim Illidge
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53498965&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201610600S(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of SG11201610600SA publication Critical patent/SG11201610600SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Radiation-Therapy Devices (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201610600SA 2014-06-17 2015-06-17 Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy SG11201610600SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462013157P 2014-06-17 2014-06-17
PCT/EP2015/063552 WO2015193352A1 (en) 2014-06-17 2015-06-17 Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy

Publications (1)

Publication Number Publication Date
SG11201610600SA true SG11201610600SA (en) 2017-01-27

Family

ID=53498965

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202108654PA SG10202108654PA (en) 2014-06-17 2015-06-17 Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy
SG11201610600SA SG11201610600SA (en) 2014-06-17 2015-06-17 Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG10202108654PA SG10202108654PA (en) 2014-06-17 2015-06-17 Methods of cancer treatment with antagonists against pd-1 and pd-l1 in combination with radiation therapy

Country Status (19)

Country Link
US (2) US10092645B2 (zh)
EP (2) EP3157629B1 (zh)
JP (4) JP6877147B2 (zh)
KR (3) KR102592781B1 (zh)
CN (1) CN107073107A (zh)
AU (3) AU2015276173B2 (zh)
BR (1) BR112016028964A2 (zh)
CA (1) CA2950046C (zh)
DK (1) DK3157629T3 (zh)
ES (1) ES2933603T3 (zh)
HU (1) HUE060689T2 (zh)
IL (1) IL249133B (zh)
MX (3) MX2016015346A (zh)
PL (1) PL3157629T3 (zh)
PT (1) PT3157629T (zh)
RU (1) RU2711408C2 (zh)
SG (2) SG10202108654PA (zh)
TW (2) TWI781021B (zh)
WO (1) WO2015193352A1 (zh)

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EA035037B1 (ru) 2013-12-12 2020-04-21 Шанхай Хэнжуй Фармасьютикал Ко., Лтд. Антитело к pd-1, его антигенсвязывающий фрагмент и их медицинское применение
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對ｐｄ-１的人類抗體
TWI680138B (zh) 2014-01-23 2019-12-21 美商再生元醫藥公司 抗ｐｄ-ｌ１之人類抗體
WO2015109391A1 (en) 2014-01-24 2015-07-30 Children's Hospital Of Eastern Ontario Research Institute Inc. Smc combination therapy for the treatment of cancer
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RS64588B1 (sr) 2015-12-22 2023-10-31 Regeneron Pharma Kombinacija anti-pd-1 antitela i bispecifičnih anti-cd20/anti-cd3 antitela za lečenje kancera
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AR108377A1 (es) * 2016-05-06 2018-08-15 Medimmune Llc Proteínas de unión biespecíficas y sus usos
TWI822521B (zh) * 2016-05-13 2023-11-11 美商再生元醫藥公司 藉由投予pd-1抑制劑治療皮膚癌之方法
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EP3491026A4 (en) 2016-07-29 2020-07-29 OBI Pharma, Inc. HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS
WO2018071307A1 (en) 2016-10-12 2018-04-19 Eli Lilly And Company Targeted treatment of mature t-cell lymphoma
EP3532494A4 (en) 2016-10-26 2020-06-03 The Children's Medical Center Corporation METHOD AND COMPOSITIONS FOR MODULATING TRANSFORMATION GROWTH FACTOR BETA-REGULATED FUNCTIONS
TWI767959B (zh) 2016-11-21 2022-06-21 台灣浩鼎生技股份有限公司 共軛生物分子、醫藥組成物及方法
BR112019011582A2 (pt) 2016-12-07 2019-10-22 Agenus Inc. anticorpos e métodos de utilização dos mesmos
WO2018151836A1 (en) 2017-02-17 2018-08-23 Fred Hutchinson Cancer Research Center Combination therapies for treatment of bcma-related cancers and autoimmune disorders
CA3054289A1 (en) 2017-02-21 2018-08-30 Regeneron Pharmaceuticals, Inc. Anti-pd-1 antibodies for treatment of lung cancer
US11603407B2 (en) 2017-04-06 2023-03-14 Regeneron Pharmaceuticals, Inc. Stable antibody formulation
WO2019094265A1 (en) * 2017-11-10 2019-05-16 Armo Biosciences, Inc. Pd1 polypeptide binding molecules
KR20200083574A (ko) * 2017-11-13 2020-07-08 크레센도 바이오로직스 리미티드 Cd137 및 psma에 결합하는 분자
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KR102167539B1 (ko) * 2018-12-28 2020-10-20 한국원자력의학원 방사선 치료 시 변화되는 암 세포의 면역관문인자 발현수준을 측정하는 단계를 포함하는 방사선 치료 예후 예측을 위한 정보제공방법 및 방사선 치료 병용 암 치료용 조성물
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Also Published As

Publication number Publication date
JP2017525661A (ja) 2017-09-07
JP7258981B2 (ja) 2023-04-17
CA2950046C (en) 2023-02-14
JP2020121978A (ja) 2020-08-13
HUE060689T2 (hu) 2023-04-28
AU2015276173A1 (en) 2016-12-22
WO2015193352A1 (en) 2015-12-23
CN107073107A (zh) 2017-08-18
KR20170015460A (ko) 2017-02-08
KR20230113847A (ko) 2023-08-01
AU2020210207A1 (en) 2020-08-20
KR20220082097A (ko) 2022-06-16
TWI781021B (zh) 2022-10-11
TW201617093A (zh) 2016-05-16
IL249133B (en) 2022-04-01
DK3157629T3 (da) 2022-12-19
AU2015276173B2 (en) 2020-08-20
TW202228777A (zh) 2022-08-01
KR102592781B1 (ko) 2023-10-20
EP3157629B1 (en) 2022-10-05
JP2022031638A (ja) 2022-02-22
BR112016028964A2 (pt) 2017-10-17
PL3157629T3 (pl) 2023-01-30
US10092645B2 (en) 2018-10-09
MX2021004828A (es) 2021-09-21
CA2950046A1 (en) 2015-12-23
EP3157629A1 (en) 2017-04-26
RU2711408C2 (ru) 2020-01-17
AU2023202654A1 (en) 2023-05-18
RU2017101312A (ru) 2018-07-20
US20160051672A1 (en) 2016-02-25
ES2933603T3 (es) 2023-02-10
SG10202108654PA (en) 2021-09-29
PT3157629T (pt) 2022-12-20
MX2021004821A (es) 2021-08-19
TWI751101B (zh) 2022-01-01
EP4144412A1 (en) 2023-03-08
RU2017101312A3 (zh) 2019-01-29
JP6877147B2 (ja) 2021-05-26
MX2016015346A (es) 2017-08-10
US20190192655A1 (en) 2019-06-27
JP2023093538A (ja) 2023-07-04
IL249133A0 (en) 2017-01-31
AU2020210207B2 (en) 2023-02-02

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