SG11201609478PA - Exendin-4 derivatives as selective glucagon receptor agonists - Google Patents

Exendin-4 derivatives as selective glucagon receptor agonists

Info

Publication number
SG11201609478PA
SG11201609478PA SG11201609478PA SG11201609478PA SG11201609478PA SG 11201609478P A SG11201609478P A SG 11201609478PA SG 11201609478P A SG11201609478P A SG 11201609478PA SG 11201609478P A SG11201609478P A SG 11201609478PA SG 11201609478P A SG11201609478P A SG 11201609478PA
Authority
SG
Singapore
Prior art keywords
exendin
derivatives
receptor agonists
glucagon receptor
selective glucagon
Prior art date
Application number
SG11201609478PA
Inventor
Torsten Haack
Siegfried Stengelin
Andreas Evers
Michael Wagner
Bernd Henkel
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201609478PA publication Critical patent/SG11201609478PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
SG11201609478PA 2014-06-18 2015-06-17 Exendin-4 derivatives as selective glucagon receptor agonists SG11201609478PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14305935 2014-06-18
PCT/EP2015/063607 WO2015193381A1 (en) 2014-06-18 2015-06-17 Exendin-4 derivatives as selective glucagon receptor agonists

Publications (1)

Publication Number Publication Date
SG11201609478PA true SG11201609478PA (en) 2016-12-29

Family

ID=50981447

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201609478PA SG11201609478PA (en) 2014-06-18 2015-06-17 Exendin-4 derivatives as selective glucagon receptor agonists

Country Status (26)

Country Link
US (1) US9932381B2 (en)
EP (1) EP3157949B1 (en)
JP (1) JP6581606B2 (en)
KR (1) KR20170018433A (en)
CN (1) CN106715466B (en)
AR (1) AR100888A1 (en)
AU (1) AU2015276203B2 (en)
BR (1) BR112016029582A2 (en)
CA (1) CA2951077A1 (en)
CY (1) CY1121032T1 (en)
DK (1) DK3157949T3 (en)
ES (1) ES2691534T3 (en)
HR (1) HRP20181708T1 (en)
HU (1) HUE039702T2 (en)
IL (1) IL249583A0 (en)
LT (1) LT3157949T (en)
MX (1) MX367348B (en)
PL (1) PL3157949T3 (en)
PT (1) PT3157949T (en)
RU (1) RU2017101377A (en)
SG (1) SG11201609478PA (en)
SI (1) SI3157949T1 (en)
TR (1) TR201815158T4 (en)
TW (1) TW201613633A (en)
UY (1) UY36179A (en)
WO (1) WO2015193381A1 (en)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3456340T (en) 2007-01-08 2022-05-25 Univ Pennsylvania Glp-1 receptor antagonist for use in the treatment of congenital hyperinsulinism
UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
PL2934567T3 (en) 2012-12-21 2018-10-31 Sanofi Exendin-4 derivatives as dual glp1/gip- or trigonal glp1/gip/glucagon agonists
TW201609799A (en) 2013-12-13 2016-03-16 賽諾菲公司 Dual GLP-1/GIP receptor agonists
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
TW201625669A (en) 2014-04-07 2016-07-16 賽諾菲公司 Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
TW201625668A (en) 2014-04-07 2016-07-16 賽諾菲公司 Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
TW201625670A (en) 2014-04-07 2016-07-16 賽諾菲公司 Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
US10772556B2 (en) * 2014-11-05 2020-09-15 Cláudio Afonso Ambrósio Method and system for monitoring and treating hypoglycemia
WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications
HUE055728T2 (en) 2015-05-22 2021-12-28 Univ Leland Stanford Junior Treatment of post-bariatric hypoglycemia with exendin(9-39)
AR105319A1 (en) 2015-06-05 2017-09-27 Sanofi Sa PROPHARMS THAT INCLUDE A DUAL AGONIST GLU-1 / GLUCAGON CONJUGATE HIALURONIC ACID CONNECTOR
AR105284A1 (en) 2015-07-10 2017-09-20 Sanofi Sa DERIVATIVES OF EXENDINA-4 AS SPECIFIC DUAL PEPTIDE AGONISTS OF GLP-1 / GLUCAGÓN RECEPTORS
TWI622596B (en) 2015-10-26 2018-05-01 美國禮來大藥廠 Glucagon receptor agonists
LT3389697T (en) * 2015-12-14 2021-02-10 Antaros Medical Ab Selective glucagon receptor agonists comprising a chelating moiety for imaging purposes
CN113456802A (en) * 2015-12-29 2021-10-01 派格生物医药(苏州)股份有限公司 Compositions comprising a GLP-1 receptor agonist and a glucagon receptor agonist and uses thereof
US10653753B2 (en) 2016-03-04 2020-05-19 Eiger Biopharmaceuticals, Inc. Treatment of hyperinsulinemic hypoglycemia with exendin-4 derivatives
JP2019535734A (en) 2016-11-21 2019-12-12 アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Buffered formulation of exendin (9-39)
CN112236826A (en) * 2018-05-04 2021-01-15 英赛罗公司 Safety constraints for drug delivery systems based on control algorithms
FR3118872B1 (en) 2021-01-15 2024-02-02 Oreal MULTIPHASIC COMPOSITION COMPRISING AN ALPHA-HYDROXYACID
WO2022131141A1 (en) 2020-12-14 2022-06-23 L'oreal Multi-phase composition comprising alpha hydroxy acid

Family Cites Families (419)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU225496B1 (en) 1993-04-07 2007-01-29 Scios Inc Pharmaceutical compositions of prolonged delivery, containing peptides
US6284727B1 (en) 1993-04-07 2001-09-04 Scios, Inc. Prolonged delivery of peptides
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
US5641757A (en) 1994-12-21 1997-06-24 Ortho Pharmaceutical Corporation Stable 2-chloro-2'-deoxyadenosine formulations
EP0966297B2 (en) 1996-08-08 2013-02-27 Amylin Pharmaceuticals, Inc. Regulation of gastrointestinal motility
CA2264243C (en) 1996-08-30 2004-10-05 Novo Nordisk A/S Glp-1 derivatives
US6458924B2 (en) 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
DE122007000044I2 (en) 1997-01-07 2011-05-05 Amylin Pharmaceuticals Inc USE OF EXEDINES AND THEIR ANTAGONISTS TO REDUCE FOOD CONSUMPTION
US6410511B2 (en) 1997-01-08 2002-06-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US7312196B2 (en) 1997-01-08 2007-12-25 Amylin Pharmaceuticals, Inc. Formulations for amylin agonist peptides
US6723530B1 (en) 1997-02-05 2004-04-20 Amylin Pharmaceuticals, Inc. Polynucleotides encoding proexendin, and methods and uses thereof
US7157555B1 (en) 1997-08-08 2007-01-02 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
DK1019077T4 (en) 1997-08-08 2011-03-07 Amylin Pharmaceuticals Inc New exendin agonist compounds
US7220721B1 (en) 1997-11-14 2007-05-22 Amylin Pharmaceuticals, Inc. Exendin agonist peptides
US7223725B1 (en) 1997-11-14 2007-05-29 Amylin Pharmaceuticals, Inc. Exendin agonist compounds
DK1032587T4 (en) 1997-11-14 2013-04-08 Amylin Pharmaceuticals Llc New exendin agonist compounds
NZ504258A (en) 1997-11-14 2002-12-20 Amylin Pharmaceuticals Inc Exendin 3 and 4 agonist compounds for the treatment of diabetes
ES2316161T3 (en) 1998-01-09 2009-04-01 Amylin Pharmaceuticals, Inc. FORMULATIONS FOR PEPTIDES AGONIST AMILINA WITH INSULIN.
US6703359B1 (en) 1998-02-13 2004-03-09 Amylin Pharmaceuticals, Inc. Inotropic and diuretic effects of exendin and GLP-1
AU3247799A (en) 1998-02-27 1999-09-15 Novo Nordisk A/S Glp-1 derivatives of glp-1 and exendin with protracted profile of action
JP4394279B2 (en) 1998-03-09 2010-01-06 ジーランド ファーマ アクティーゼルスカブ Pharmacologically active peptide conjugates with reduced propensity to enzymatic hydrolysis
AU2612599A (en) 1998-03-13 1999-10-11 Novo Nordisk A/S Stabilized aqueous peptide solutions
US6998387B1 (en) 1998-03-19 2006-02-14 Amylin Pharmaceuticals, Inc. Human appetite control by glucagon-like peptide receptor binding compounds
MXPA00012286A (en) 1998-06-12 2002-10-17 Bionebraska Inc GLUCAGON-LIKE PEPTIDE-1 IMPROVES beta-CELL RESPONSE TO GLUCOSE IN SUBJECTS WITH IMPAIRED GLUCOSE TOLERANCE.
EP2028269B1 (en) 1998-08-10 2015-10-21 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Differentiation of non-insulin producing cells into insulin producing cells by GLP-1 or Exendin-4 and uses thereof
EP1113799A4 (en) 1998-09-17 2004-06-09 Lilly Co Eli Protein formulations
US7259136B2 (en) 1999-04-30 2007-08-21 Amylin Pharmaceuticals, Inc. Compositions and methods for treating peripheral vascular disease
US6284725B1 (en) 1998-10-08 2001-09-04 Bionebraska, Inc. Metabolic intervention with GLP-1 to improve the function of ischemic and reperfused tissue
US6429197B1 (en) 1998-10-08 2002-08-06 Bionebraska, Inc. Metabolic intervention with GLP-1 or its biologically active analogues to improve the function of the ischemic and reperfused brain
ATE307603T1 (en) 1998-12-22 2005-11-15 Lilly Co Eli STORAGE STABLE LIQUID COMPOSITIONS OF GLUCAGON-LIKE PEPTIDE-1
CA2356706C (en) 1999-01-14 2014-09-30 Amylin Pharmaceuticals, Inc. Novel exendin agonist formulations and methods of administration thereof
US20030087820A1 (en) 1999-01-14 2003-05-08 Young Andrew A. Novel exendin agonist formulations and methods of administration thereof
US7399489B2 (en) 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
CN100425284C (en) 1999-01-14 2008-10-15 安米林药品公司 Methods for glucagon suppression
CN1344248A (en) 1999-03-17 2002-04-10 诺沃挪第克公司 Method for acylating peptides and novel acylating agents
US6451974B1 (en) 1999-03-17 2002-09-17 Novo Nordisk A/S Method of acylating peptides and novel acylating agents
JP2002544127A (en) 1999-04-30 2002-12-24 アミリン・ファーマシューティカルズ，インコーポレイテッド Modified exendins and exendin agonists
US6924264B1 (en) 1999-04-30 2005-08-02 Amylin Pharmaceuticals, Inc. Modified exendins and exendin agonists
US6514500B1 (en) 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
WO2000069911A1 (en) 1999-05-17 2000-11-23 Conjuchem, Inc. Long lasting insulinotropic peptides
US6849714B1 (en) 1999-05-17 2005-02-01 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US6482799B1 (en) 1999-05-25 2002-11-19 The Regents Of The University Of California Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial
US6506724B1 (en) 1999-06-01 2003-01-14 Amylin Pharmaceuticals, Inc. Use of exendins and agonists thereof for the treatment of gestational diabetes mellitus
US6344180B1 (en) 1999-06-15 2002-02-05 Bionebraska, Inc. GLP-1 as a diagnostic test to determine β-cell function and the presence of the condition of IGT and type II diabetes
US6528486B1 (en) 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US6972319B1 (en) 1999-09-28 2005-12-06 Bayer Pharmaceuticals Corporation Pituitary adenylate cyclase activating peptide (PACAP)receptor 3 (R3) agonists and their pharmacological methods of use
GB9930882D0 (en) 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
ES2227115T5 (en) 2000-01-10 2014-10-30 Amylin Pharmaceuticals, Inc. Use of exendins and their agonists for the treatment of hypertriglyceridemia
MXPA02009031A (en) 2000-03-14 2004-08-19 Amylin Pharmaceuticals Inc Effects of glucagon like peptide 1 (7 36) on antro pyloro duodenal motility.
WO2001087322A2 (en) 2000-05-17 2001-11-22 Bionebraska, Inc. Peptide pharmaceutical formulations
AU6323001A (en) 2000-05-19 2001-12-03 Bionebraska Inc Treatment of acute coronary syndrome with glp-1
AU2001284985A1 (en) 2000-08-18 2002-03-04 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
US7507714B2 (en) 2000-09-27 2009-03-24 Bayer Corporation Pituitary adenylate cyclase activating peptide (PACAP) receptor 3 (R3) agonists and their pharmacological methods of use
AU775663B2 (en) 2000-10-20 2004-08-12 Amylin Pharmaceuticals, Inc. Treatment of hibernating myocardium and diabetic cardiomyopathy with a GLP-1 peptide
PT1355942E (en) 2000-12-07 2008-11-21 Lilly Co Eli Glp-1 fusion proteins
CA2431173A1 (en) 2000-12-13 2002-06-20 Eli Lilly And Company Chronic treatment regimen using glucagon-like insulinotropic peptides
GB2371227A (en) 2001-01-10 2002-07-24 Grandis Biotech Gmbh Crystallisation - resistant aqueous growth hormone formulations
US6573237B2 (en) 2001-03-16 2003-06-03 Eli Lilly And Company Protein formulations
CN1162446C (en) 2001-05-10 2004-08-18 上海华谊生物技术有限公司 Insulinotropic hormone secretion peptide derivative
US7144863B2 (en) 2001-06-01 2006-12-05 Eli Lilly And Company GLP-1 formulations with protracted time action
ES2298378T3 (en) 2001-06-28 2008-05-16 Novo Nordisk A/S STABLE FORMULATION OF MODIFIED GLP-1.
WO2003092581A2 (en) 2001-07-16 2003-11-13 Hk Pharmaceuticals, Inc. Capture compounds, collections thereof and methods for analyzing the proteome and complex compositions
EP2275117B1 (en) 2001-07-31 2016-10-26 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services GLP-1, exendin-4, peptide analogs and uses thereof
JP2005508895A (en) 2001-08-28 2005-04-07 イーライ・リリー・アンド・カンパニー Premix of GLP-1 and basal insulin
JP2005508360A (en) 2001-10-19 2005-03-31 イーライ・リリー・アンド・カンパニー GLP-1 and insulin biphasic mixture
EP2277888A3 (en) 2001-12-21 2011-04-27 Human Genome Sciences, Inc. Fusion proteins of albumin and erythropoietin
EP1463752A4 (en) 2001-12-21 2005-07-13 Human Genome Sciences Inc Albumin fusion proteins
US7105489B2 (en) 2002-01-22 2006-09-12 Amylin Pharmaceuticals, Inc. Methods and compositions for treating polycystic ovary syndrome
EP2409569B1 (en) 2002-02-20 2017-08-16 Emisphere Technologies, Inc. Method for administering GLP-1 molecules
AU2003219958B2 (en) 2002-02-27 2006-01-05 Immunex Corporation Polypeptide formulation
DK1502102T3 (en) 2002-03-11 2009-05-04 Caprotec Bioanalytics Gmbh Compounds and Methods for Analyzing the Proteome
US7141240B2 (en) 2002-03-12 2006-11-28 Cedars-Sinai Medical Center Glucose-dependent insulin-secreting cells transfected with a nucleotide sequence encoding GLP-1
AU2003226913A1 (en) 2002-04-04 2003-10-20 Novo Nordisk A/S Glp-1 agonist and cardiovascular complications
US6861236B2 (en) 2002-05-24 2005-03-01 Applied Nanosystems B.V. Export and modification of (poly)peptides in the lantibiotic way
EP1515749B1 (en) 2002-06-14 2012-08-15 Novo Nordisk A/S Combined use of a modulator of cd3 and a glp-1 compound
US20040037826A1 (en) 2002-06-14 2004-02-26 Michelsen Birgitte Koch Combined use of a modulator of CD3 and a GLP-1 compound
DE10227232A1 (en) 2002-06-18 2004-01-15 Aventis Pharma Deutschland Gmbh Sour insulin preparations with improved stability
EP2028192A1 (en) 2002-07-04 2009-02-25 Zealand Pharma A/S GLP-1 and methods for treating diabetes
US20070065469A1 (en) 2002-07-09 2007-03-22 Michael Betz Liquid formulations with high concentration of human growth hormone (high) comprising glycine
JP2005535652A (en) 2002-07-09 2005-11-24 サンド・アクチエンゲゼルシヤフト High concentration liquid preparation of human growth hormone (hGH) containing 1,2-propylene glycol
US20080260838A1 (en) 2003-08-01 2008-10-23 Mannkind Corporation Glucagon-like peptide 1 (glp-1) pharmaceutical formulations
US20040038865A1 (en) 2002-08-01 2004-02-26 Mannkind Corporation Cell transport compositions and uses thereof
WO2004012672A2 (en) 2002-08-01 2004-02-12 Mannkind Corporation Cell transport compositions and uses thereof
ME00396B (en) 2002-08-21 2011-05-10 Boehringer Ingelheim Pharma 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
EP1546200A2 (en) 2002-10-02 2005-06-29 Zealand Pharma A/S Stabilized exendin-4 compounds
US6969702B2 (en) 2002-11-20 2005-11-29 Neuronova Ab Compounds and methods for increasing neurogenesis
WO2004045592A2 (en) 2002-11-20 2004-06-03 Neuronova Ab Compounds and methods for increasing neurogenesis
US20050209142A1 (en) 2002-11-20 2005-09-22 Goran Bertilsson Compounds and methods for increasing neurogenesis
EP1610811A4 (en) 2002-12-17 2008-03-26 Amylin Pharmaceuticals Inc Prevention and treatment of cardiac arrhythmias
US20040209803A1 (en) 2002-12-19 2004-10-21 Alain Baron Compositions for the treatment and prevention of nephropathy
US7790681B2 (en) 2002-12-17 2010-09-07 Amylin Pharmaceuticals, Inc. Treatment of cardiac arrhythmias with GLP-1 receptor ligands
ES2512499T3 (en) 2003-04-08 2014-10-24 Yeda Research And Development Co., Ltd. Pegylated Reversible Drugs
WO2004089985A1 (en) 2003-04-11 2004-10-21 Novo Nordisk A/S Stable pharmaceutical compositions
ES2383752T3 (en) 2003-05-15 2012-06-26 Trustees Of Tufts College GLP-1 stable analogs
US7947261B2 (en) 2003-05-23 2011-05-24 Nektar Therapeutics Conjugates formed from polymer derivatives having particular atom arrangements
ES2725808T3 (en) 2003-05-23 2019-09-27 Nektar Therapeutics PEG derivatives containing two PEG chains
EP1631308B1 (en) 2003-05-30 2013-07-31 Amylin Pharmaceuticals, LLC Novel methods and compositions for enhanced transmucosal delivery of peptides and proteins
CN1812808B (en) 2003-06-03 2012-07-04 诺沃挪第克公司 Stabilized pharmaceutical peptide compositions
PL1633391T3 (en) 2003-06-03 2012-03-30 Novo Nordisk As Stabilized pharmaceutical peptide compositions
WO2004105781A2 (en) 2003-06-03 2004-12-09 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
JP4936884B2 (en) 2003-06-03 2012-05-23 ノボ・ノルデイスク・エー／エス Stabilized pharmaceutical peptide composition
US8921311B2 (en) 2003-08-01 2014-12-30 Mannkind Corporation Method for treating hyperglycemia
EP2107069B1 (en) 2003-08-05 2013-01-16 Novo Nordisk A/S Novel insulin derivatives
EP1664108B1 (en) 2003-08-21 2009-10-14 Novo Nordisk A/S Separation of polypeptides comprising a racemized amino acid
US20060247167A1 (en) 2003-09-01 2006-11-02 Novo Nordisk A/S Stable formulations of peptides
JP5518282B2 (en) 2003-09-01 2014-06-11 ノヴォ ノルディスク アー／エス Stable peptide formulation
TW200522976A (en) 2003-09-19 2005-07-16 Novo Nordisk As Novel plasma protein affinity tags
US20060287221A1 (en) 2003-11-13 2006-12-21 Novo Nordisk A/S Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
ATE525083T1 (en) 2003-11-13 2011-10-15 Novo Nordisk As PHARMACEUTICAL COMPOSITION COMPRISING AN INSULINOTROPIC GLP-1(7-37) ANALOG, ASP(B28) INSULIN, AND A SURFACE-ACTIVE COMPOUND
US20050106214A1 (en) 2003-11-14 2005-05-19 Guohua Chen Excipients in drug delivery vehicles
US20050281879A1 (en) 2003-11-14 2005-12-22 Guohua Chen Excipients in drug delivery vehicles
PL3300721T3 (en) 2003-11-20 2019-08-30 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
CA2546843C (en) 2003-11-20 2015-01-06 Neuronova Ab Compounds and methods for increasing neurogenesis
CN102816228A (en) 2003-12-03 2012-12-12 诺和诺德公司 Single-chain insulin
AU2004298996A1 (en) 2003-12-10 2005-06-30 Nektar Therapeutics Al, Corporation Compositions comprising two different populations of polymer-active agent conjugates
US20050143303A1 (en) 2003-12-26 2005-06-30 Nastech Pharmaceutical Company Inc. Intranasal administration of glucose-regulating peptides
WO2007065156A2 (en) 2005-12-02 2007-06-07 Nastech Pharmaceutical Company Inc. Pharmaceutical formulation for increased epithelial permeability of glucose-regulating peptide
US20060210614A1 (en) 2003-12-26 2006-09-21 Nastech Pharmaceutical Company Inc. Method of treatment of a metabolic disease using intranasal administration of exendin peptide
JP5638177B2 (en) 2004-02-11 2014-12-10 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc Pancreatic polypeptide family motif and polypeptide containing the motif
WO2006083254A1 (en) 2004-02-11 2006-08-10 Amylin Pharmaceuticals, Inc. Amylin family peptides and methods for making and using them
US8076288B2 (en) 2004-02-11 2011-12-13 Amylin Pharmaceuticals, Inc. Hybrid polypeptides having glucose lowering activity
CA2555877C (en) 2004-02-11 2015-11-24 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
US7399744B2 (en) 2004-03-04 2008-07-15 Amylin Pharmaceuticals, Inc. Methods for affecting body composition
US20060110423A1 (en) 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
US7456254B2 (en) 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
MXPA06011924A (en) 2004-04-15 2007-06-11 Alkermes Inc Polymer-based sustained release device.
WO2005117584A2 (en) 2004-05-28 2005-12-15 Amylin Pharmaceuticals, Inc Improved transmucosal delivery of peptides and proteins
US20090069226A1 (en) 2004-05-28 2009-03-12 Amylin Pharmaceuticals, Inc. Transmucosal delivery of peptides and proteins
CN1950078A (en) 2004-06-11 2007-04-18 诺和诺德公司 Counteracting drug-induced obesity using glp-1 agonists
US7534763B2 (en) * 2004-07-02 2009-05-19 Bristol-Myers Squibb Company Sustained release GLP-1 receptor modulators
ES2618028T3 (en) 2004-07-19 2017-06-20 Biocon Limited Insulin-oligomer conjugates, formulations and uses thereof.
EP1771573A4 (en) 2004-07-21 2009-02-18 Ambrx Inc Biosynthetic polypeptides utilizing non-naturally encoded amino acids
RU2007107808A (en) 2004-08-03 2008-09-10 Байорексис Фармасьютикал Корпорейшн (Us) COMBINED TREATMENT WITH THE USE OF TRANSFERRIN FILLED PROTEINS CONTAINING GLP-1
US8710181B2 (en) 2004-08-31 2014-04-29 Novo Nordisk A/S Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
DE102004043153B4 (en) 2004-09-03 2013-11-21 Philipps-Universität Marburg Invention relating to GLP-1 and exendin
JP2008513384A (en) 2004-09-17 2008-05-01 ノボ ノルディスク アクティーゼルスカブ Pharmaceutical composition containing insulin and insulinotropic peptide
EP3173072A1 (en) 2004-10-01 2017-05-31 Ramscor, Inc. Conveniently implantable sustained release drug compositions
WO2006037811A2 (en) 2004-10-07 2006-04-13 Novo Nordisk A/S Protracted exendin-4 compounds
US7595294B2 (en) 2004-10-08 2009-09-29 Transition Therapeutics, Inc. Vasoactive intestinal polypeptide pharmaceuticals
AU2005295756B2 (en) 2004-10-13 2012-02-02 Isis Parmaceuticals, Inc. Antisense modulation of PTP1B expression
US7442682B2 (en) 2004-10-19 2008-10-28 Nitto Denko Corporation Transepithelial delivery of peptides with incretin hormone activities
CN101056650A (en) 2004-11-12 2007-10-17 诺和诺德公司 Stable formulations of insulinoptropic peptides
US20090011976A1 (en) 2004-11-12 2009-01-08 Novo Nordisk A/S Stable Formulations Of Peptides
EP2494983B1 (en) 2004-11-12 2019-04-24 Novo Nordisk A/S Stable formulations of glp-1
CA2589800A1 (en) 2004-12-02 2006-06-08 Domantis Limited Bispecific domain antibodies targeting serum albumin and glp-1 or pyy
EP3000826A1 (en) 2004-12-13 2016-03-30 Amylin Pharmaceuticals, LLC Pancreatic polypeptide family motifs, polypeptides and methods comprising the same
CN101111267B (en) 2004-12-21 2012-12-05 尼克塔治疗公司 Stabilized polymeric thiol reagents
EA011166B1 (en) 2004-12-22 2009-02-27 Эли Лилли Энд Компани Glp-1 analog fusion protein formulations
US20070021336A1 (en) 2004-12-24 2007-01-25 Christen Anderson Use of GLP-1 and agonists thereof to prevent cardiac myocyte apoptosis
US8097586B2 (en) 2005-01-14 2012-01-17 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exedins and uses thereof
US8716221B2 (en) 2005-01-14 2014-05-06 Wuxi Grandchamp Pharmaceutical Technology Co., Ltd. Modified exendins and uses thereof
EP1848541A4 (en) 2005-02-07 2013-01-16 Pharmalight Inc Method and device for ophthalmic administration of active pharmaceutical ingredients
EP1853627A2 (en) 2005-02-11 2007-11-14 Amylin Pharmaceuticals, Inc. Gip analog and hybrid polypeptides with selectable properties
US8263545B2 (en) 2005-02-11 2012-09-11 Amylin Pharmaceuticals, Inc. GIP analog and hybrid polypeptides with selectable properties
WO2007022123A2 (en) 2005-08-11 2007-02-22 Amylin Pharmaceuticals, Inc. Hybrid polypeptides with selectable properties
WO2006097535A2 (en) 2005-03-18 2006-09-21 Novo Nordisk A/S Peptide agonists of the glucagon family with secretin like activity
DK1888103T3 (en) 2005-04-11 2012-04-23 Amylin Pharmaceuticals Inc USE OF GLP-1, EXENDIN AND AGONISTS THEREOF TO DELAY OR PREVENT CARDIAL REMODELING
WO2006114396A1 (en) 2005-04-24 2006-11-02 Novo Nordisk A/S Injection device
US8097584B2 (en) 2005-05-25 2012-01-17 Novo Nordisk A/S Stabilized formulations of insulin that comprise ethylenediamine
PL1888031T3 (en) 2005-06-06 2013-04-30 Camurus Ab Glp-1 analogue formulations
GB0511986D0 (en) 2005-06-13 2005-07-20 Imp College Innovations Ltd Novel compounds and their effects on feeding behaviour
PL1891105T3 (en) 2005-06-13 2012-09-28 Imperial Innovations Ltd Oxyntomodulin analogues and their effects on feeding behaviour
WO2006138572A2 (en) 2005-06-16 2006-12-28 Nektar Therapeutics Al, Corporation Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates
WO2007019331A2 (en) 2005-08-04 2007-02-15 Nektar Therapeutics Al, Corporation Conjugates of a g-csf moiety and a polymer
CN101277722A (en) 2005-08-06 2008-10-01 王庆华 Composition and method for prevention and treatment of type I diabetes
JP5693817B2 (en) 2005-08-19 2015-04-01 アミリン・ファーマシューティカルズ, リミテッド・ライアビリティ・カンパニーAmylin Pharmaceuticals, Llc Diabetes treatment and weight loss
EP1928423B1 (en) 2005-09-14 2015-12-09 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
RU2440143C2 (en) 2005-09-20 2012-01-20 Новартис Аг Application of dpp-iv inhibitor for reduction of glycemia acute exacerbation
WO2007047834A2 (en) 2005-10-18 2007-04-26 Biocon Limited Oral peptide conjugates for metabolic diseases
US7687608B2 (en) 2005-10-19 2010-03-30 Smartcells, Inc. Methods for reducing the mitogenicity of lectin compositions
US8338368B2 (en) 2005-11-07 2012-12-25 Indiana University Research And Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
US8039432B2 (en) 2005-11-09 2011-10-18 Conjuchem, Llc Method of treatment of diabetes and/or obesity with reduced nausea side effect
US8293726B2 (en) 2005-12-02 2012-10-23 Vianova Labs, Inc. Treatment of cancer and other diseases
WO2007067964A2 (en) 2005-12-08 2007-06-14 Nastech Pharmaceutical Company Inc. Mucosal delivery of stabilized formulations of exendin
US8293869B2 (en) 2005-12-16 2012-10-23 Nektar Therapeutics Polymer conjugates of GLP-1
US8841255B2 (en) 2005-12-20 2014-09-23 Duke University Therapeutic agents comprising fusions of vasoactive intestinal peptide and elastic peptides
US20130172274A1 (en) 2005-12-20 2013-07-04 Duke University Methods and compositions for delivering active agents with enhanced pharmacological properties
ES2779992T3 (en) 2005-12-20 2020-08-21 Univ Duke Methods and compositions for delivering active agents with enhanced pharmacological properties
CN101400363B (en) 2006-01-18 2012-08-29 昌达生物科技公司 Pharmaceutical compositions with enhanced stability
WO2007092772A2 (en) 2006-02-03 2007-08-16 Medimmune, Inc. Protein formulations
US7704953B2 (en) 2006-02-17 2010-04-27 Mdrna, Inc. Phage displayed cell binding peptides
AU2007227202B2 (en) 2006-03-21 2013-08-22 Amylin Pharmaceuticals, Llc Peptide-peptidase inhibitor conjugates and methods of using same
US20100087365A1 (en) 2006-04-13 2010-04-08 Roland Cherif-Cheikh Pharmaceutical Compositions of Hglp-1, Exendin-4 and Analogs Thereof
CA2646400A1 (en) 2006-04-14 2007-10-25 Mannkind Corporation Glucagon-like peptide 1(glp-1) pharmaceutical formulations
DE202006006388U1 (en) 2006-04-20 2007-08-30 Tegometall (International) Ag Shelf shelf
PE20080251A1 (en) 2006-05-04 2008-04-25 Boehringer Ingelheim Int USES OF DPP IV INHIBITORS
US8299024B2 (en) 2006-05-12 2012-10-30 Amylin Pharmaceuticals, Llc Methods to restore glycemic control
EA200870575A1 (en) 2006-05-26 2009-08-28 Амилин Фармасьютикалз, Инк. COMPOSITIONS AND METHODS OF TREATMENT OF CONSTITUAL HEART FAILURE
EP2021014A1 (en) * 2006-05-26 2009-02-11 Brystol-Myers Squibb Company Sustained release glp-1 receptor modulators
PT2038423E (en) 2006-06-21 2013-03-27 Biocon Ltd A method of producing biologically active polypeptide having insulinotropic activity
ES2530390T3 (en) 2006-07-05 2015-03-02 Foamix Pharmaceuticals Ltd Foaming vehicle of carboxylic acid and pharmaceutical compositions thereof
KR101193722B1 (en) 2006-07-24 2013-01-11 바이오렉시스 파마슈티칼 코포레이션 Exendin fusion proteins
US7928186B2 (en) 2006-08-02 2011-04-19 Phoenix Pharmaceuticals, Inc. Cell permeable bioactive peptide conjugates
WO2008016729A1 (en) 2006-08-04 2008-02-07 Nastech Pharmaceutical Company Inc. Compositions for intranasal delivery of human insulin and uses thereof
ES2422864T3 (en) 2006-08-09 2013-09-16 Intarcia Therapeutics, Inc Osmotic release systems and piston units
US8497240B2 (en) 2006-08-17 2013-07-30 Amylin Pharmaceuticals, Llc DPP-IV resistant GIP hybrid polypeptides with selectable properties
CA2660835A1 (en) 2006-08-17 2008-02-21 Amylin Pharmaceuticals, Inc. Dpp-iv resistant gip hybrid polypeptides with selectable propperties
US20090318353A1 (en) 2006-08-25 2009-12-24 Novo Nordisk A/S Acylated Exendin-4 Compounds
CN101125207B (en) 2006-11-14 2012-09-05 上海华谊生物技术有限公司 Exendin or its analogs with polyethylene group and its preparation and application
US20100168011A1 (en) 2006-12-12 2010-07-01 Amylin Pharmaceuticals, Inc. Pharmaceutical Formulations and Methods for Making the Same
TWI428346B (en) 2006-12-13 2014-03-01 Imp Innovations Ltd Novel compounds and their effects on feeding behaviour
CN101663317A (en) 2007-01-05 2010-03-03 CovX科技爱尔兰有限公司 glucagon-like protein-1 receptor (glp-1r) agonist compounds
RU2432361C2 (en) 2007-01-05 2011-10-27 КовЭкс Текнолоджиз Айэлэнд Лимитед Glucagon-like protein-1 receptor (glp-1r) agonist compounds
ES2628063T3 (en) 2007-01-05 2017-08-01 Indiana University Research And Technology Corporation Glucagon analogs showing greater solubility in physiological pH buffers
US20090098130A1 (en) 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
WO2008098212A2 (en) 2007-02-08 2008-08-14 Diobex, Inc. Extended release formulations of glucagon and other peptides and proteins
JP6017754B2 (en) 2007-02-15 2016-11-02 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ Glucagon / GLP-1 receptor co-agonist
US8420598B2 (en) 2007-04-20 2013-04-16 B & L Delipharm Corp. Mono modified exendin with polyethylene glycol or its derivatives and uses thereof
RU2440097C2 (en) 2007-04-23 2012-01-20 Интарсия Терапьютикс, Инк. Method of treating insulin-independent diabetes and obesity, osmotic delivery system and method for making it
US8236760B2 (en) 2007-04-27 2012-08-07 Cedars-Sinsai Medical Center Use of GLP-1 receptor agonists for the treatment of short bowel syndrome
US7829664B2 (en) 2007-06-01 2010-11-09 Boehringer Ingelheim International Gmbh Modified nucleotide sequence encoding glucagon-like peptide-1 (GLP-1), nucleic acid construct comprising same for production of glucagon-like peptide-1 (GLP-1), human cells comprising said construct and insulin-producing constructs, and methods of use thereof
CA2689909C (en) 2007-06-08 2016-04-05 Ascendis Pharma As Long-acting polymeric prodrugs of exendin
WO2008152403A1 (en) 2007-06-15 2008-12-18 Zealand Pharma A/S Glucagon analogues
CA2691695C (en) 2007-07-10 2014-03-18 Eli Lilly And Company Glp-1-fc fusion protein formulation
US20110034373A1 (en) 2007-08-03 2011-02-10 Eli Lilly And Company Use of an fgf-21 compound and a glp-1 compound for the treatment of obesity
CN101366692A (en) 2007-08-15 2009-02-18 江苏豪森药业股份有限公司 Stable Exenatide formulation
PT2193142E (en) 2007-08-30 2015-04-22 Curedm Group Holdings Llc Compositions and methods of using proislet peptides and analogs thereof
CN101842109B (en) 2007-09-05 2014-01-29 诺沃-诺迪斯克有限公司 Peptides derivatized with A-B-C-D- and their therapeutical use
WO2009035540A2 (en) 2007-09-07 2009-03-19 Ipsen Pharma S.A.S. Analogues of exendin-4 and exendin-3
WO2009055742A2 (en) 2007-10-24 2009-04-30 Mannkind Corporation Delivery of active agents
WO2009055740A2 (en) 2007-10-24 2009-04-30 Mannkind Corporation Method of preventing adverse effects by glp-1
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
US8980830B2 (en) 2007-10-30 2015-03-17 Indiana University Research And Technology Corporation Peptide compounds exhibiting glucagon antagonist and GLP-1 agonist activity
CA2707861A1 (en) 2007-10-30 2009-05-07 Indiana University Research And Technology Corporation Glucagon antagonists
PT2597103T (en) 2007-11-16 2017-02-08 Novo Nordisk As Stable pharmaceutical compositions comprising liraglutide and degludec
WO2009067268A1 (en) 2007-11-23 2009-05-28 Michael Rothkopf Methods of enhancing diabetes resolution
CN101444618B (en) 2007-11-26 2012-06-13 杭州九源基因工程有限公司 Pharmaceutical preparation containing exenatide
CN102026666B (en) 2007-12-11 2013-10-16 常山凯捷健生物药物研发（河北）有限公司 Formulation of insulinotropic peptide conjugates
WO2009099763A1 (en) 2008-01-30 2009-08-13 Indiana University Research And Technology Corporation Ester-based peptide prodrugs
DK2596805T3 (en) 2008-02-01 2021-12-13 Ascendis Pharma As Prodrug comprising a drug-linker conjugate
KR101283734B1 (en) 2008-02-06 2013-07-08 바이오콘 리미티드 Fermentation medias and processes thereof
WO2009114959A1 (en) 2008-03-20 2009-09-24 中国人民解放军军事医学科学院毒物药物研究所 Injectalble sustained-release pharmaceutical formulation and method for preparing it
US20110034385A1 (en) 2008-04-07 2011-02-10 National Institute Of Immunology Compositions Useful for the Treatment of Diabetes and Other Chronic Disorder
BRPI0912384A2 (en) 2008-05-07 2015-10-13 Merrion Res Iii Ltd composition and method for preparing a composition
US20110263496A1 (en) 2008-05-21 2011-10-27 Amylin Pharmaceuticals, Inc. Exendins to lower cholesterol and triglycerides
EP2288918A1 (en) 2008-05-23 2011-03-02 Amylin Pharmaceuticals, Inc. Glp-1 receptor agonist bioassays
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
CA2982550C (en) 2008-06-13 2020-08-25 Mannkind Corporation A dry powder inhaler and system for drug delivery
CN102105159B (en) 2008-06-17 2015-07-08 印第安纳大学研究及科技有限公司 GIP-based mixed agonists for treatment of metabolic disorders and obesity
WO2009155257A1 (en) 2008-06-17 2009-12-23 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility and stability physiological ph buffers
US8765669B2 (en) 2008-06-17 2014-07-01 Glytech, Inc. Glycosylated GLP-1 peptide
ES2579502T3 (en) 2008-06-17 2016-08-11 Indiana University Research And Technology Corporation Glucagon / GLP-1 receptor coagonists
EP2926825A1 (en) 2008-06-27 2015-10-07 Duke University Therapeutic agents comprising elastin-like peptides
EP2303247A4 (en) 2008-07-21 2012-08-01 Syneron Medical Ltd Transdermal system for extended delivery of incretins and incretin mimetic peptides
WO2010013012A2 (en) 2008-08-01 2010-02-04 Lund University Bioscience Ab Novel polypeptides and uses thereof
CN101670096B (en) 2008-09-11 2013-01-16 杭州九源基因工程有限公司 Medicinal preparation containing exenatide
NZ592283A (en) 2008-10-17 2012-09-28 Sanofi Aventis Deutschland Combination of an insulin and the GLP-1 agonist AVE0010
EP2373681B1 (en) 2008-12-10 2017-01-18 Glaxosmithkline LLC Pharmaceutical compositions of albiglutide
AU2008365559B2 (en) 2008-12-15 2016-02-25 Zealand Pharma A/S Glucagon analogues
JP5635529B2 (en) 2008-12-15 2014-12-03 ジーランド ファーマ アクティーゼルスカブ Glucagon analog
BRPI0823379A2 (en) 2008-12-15 2015-07-14 Zealand Pharma As Glucagon analogs
KR20110126592A (en) 2008-12-15 2011-11-23 질랜드 파마 에이/에스 Glucagon analogues
KR20110110174A (en) 2008-12-19 2011-10-06 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Amide based glucagon superfamily peptide prodrugs
CN101538323B (en) 2009-01-13 2012-05-09 深圳翰宇药业股份有限公司 Method for purifying Exenatide
WO2010096052A1 (en) 2009-02-19 2010-08-26 Merck Sharp & Dohme Corp. Oxyntomodulin analogs
WO2010102148A2 (en) 2009-03-04 2010-09-10 Mannkind Corporation An improved dry powder drug delivery system
JP5608686B2 (en) 2009-03-05 2014-10-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング Drug delivery device with retractable needle
EP2413955A4 (en) 2009-04-01 2012-12-26 Amylin Pharmaceuticals Inc N-terminus conformationally constrained glp-1 receptor agonist compounds
WO2010118034A2 (en) 2009-04-06 2010-10-14 Board Of Regents, The University Of Texas System Cyclic peptide analogues for non-invasive imaging of pancreatic beta-cells
RU2503688C2 (en) 2009-04-22 2014-01-10 Алтеоген, Инк Fused protein or peptide with increased half lifetime in vivo, which is maintained due to slow release in vivo, and method for increasing half lifetime in vivo using it
CN101870728A (en) 2009-04-23 2010-10-27 派格生物医药(苏州)有限公司 Novel Exendin variant and conjugate thereof
CN101559041B (en) 2009-05-19 2014-01-15 中国科学院过程工程研究所 Polypeptide medicament sustained release microsphere or microcapsule preparation with uniform grain size and preparation method thereof
WO2010133676A1 (en) 2009-05-20 2010-11-25 Sanofi-Aventis Deutschland Gmbh A system comprising a drug delivery device and a cartridge provided with a bung and a method of identifying the cartridge
DK2432526T3 (en) 2009-05-20 2021-09-13 Sanofi Aventis Deutschland PROPOSERS FOR CYLINDERS CONTAINING A MEDICINAL PRODUCT IN MEDICINAL DELIVERY DEVICES
EP2435061A4 (en) 2009-05-28 2013-03-27 Amylin Pharmaceuticals Inc Glp-1 receptor agonist compounds for sleep enhancement
CN102802657A (en) 2009-06-11 2012-11-28 诺沃-诺迪斯克有限公司 GLP-1 and FGF21 combinations for treatment of diabetes type 2
WO2010148089A1 (en) 2009-06-16 2010-12-23 Indiana University Research And Technology Corporation Gip receptor-active glucagon compounds
RU2012103240A (en) 2009-07-02 2013-08-10 Ангиокем Инк. MULTI-DIMENSIONAL PEPTIDE CONJUGATES AND THEIR APPLICATION
PT2454282E (en) 2009-07-13 2015-06-23 Zealand Pharma As Acylated glucagon analogues
CN101601646B (en) 2009-07-22 2011-03-23 南京凯瑞尔纳米生物技术有限公司 Nasal cavity drop for treating diabetes and preparation method thereof
WO2011011675A1 (en) 2009-07-23 2011-01-27 Zelos Therapeutics, Inc. Pharmaceutically acceptable formulations/compositions for peptidyl drugs
WO2011012718A1 (en) 2009-07-31 2011-02-03 Ascendis Pharma As Prodrugs comprising an insulin linker conjugate
WO2011017835A1 (en) 2009-08-11 2011-02-17 Nanjing University Preparation method of protein or peptide nanoparticles for in vivo drug delivery by unfolding and refolding
CN101993485B (en) 2009-08-20 2013-04-17 重庆富进生物医药有限公司 Peptide analog homologous dimer capable of accelerating insulin secretion and application thereof
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
US20120276098A1 (en) 2009-09-30 2012-11-01 Bruce Hamilton Drug fusions and conjugates with extended half life
WO2011049713A2 (en) 2009-10-22 2011-04-28 Biodel Inc. Stabilized glucagon solutions
US20110097386A1 (en) 2009-10-22 2011-04-28 Biodel, Inc. Stabilized glucagon solutions
US9610329B2 (en) 2009-10-22 2017-04-04 Albireo Pharma, Inc. Stabilized glucagon solutions
CA2778890A1 (en) 2009-10-30 2011-05-05 Otsuka Chemical Co., Ltd. Glycosylated form of antigenic glp-1 analogue
US20120294855A1 (en) 2009-11-03 2012-11-22 Eli Lilly & Company Glp-1 receptor agonist compounds for obstructive sleep apnea
MX2012005186A (en) 2009-11-13 2012-06-08 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist, an insulin, and methionine.
MX2012005184A (en) 2009-11-13 2012-06-08 Sanofi Aventis Deutschland Pharmaceutical composition comprising a glp-1 agonist and methionine.
ES2658168T3 (en) 2009-12-15 2018-03-08 Cirius Therapeutics, Inc. PPAR-sparing thiazolidinedione salts for the treatment of metabolic diseases
WO2011084459A1 (en) 2009-12-15 2011-07-14 Metabolic Solutions Development Company Ppar-sparing thiazolidinediones and combinations for the treatment of obesity and other metabolic diseases
RU2012130011A (en) 2009-12-15 2014-01-27 МЕТАБОЛИК СОЛЮШНЗ ДЕВЕЛОПМЕНТ КОМПАНИ, ЭлЭлСи PPAR-REDUCING THIAZOLIDINDIONS AND COMBINATIONS FOR TREATMENT OF DIABETES AND OTHER METABOLISM DISORDERS
KR20120103711A (en) 2009-12-15 2012-09-19 메타볼릭 솔루션스 디벨롭먼트 컴퍼니, 엘엘씨 Ppar-sparing thiazolidinediones and combinations for the treatment of neurodegenerative diseases
EP3000482B1 (en) 2009-12-16 2021-04-21 Novo Nordisk A/S Double-acylated glp-1 derivatives
US8703701B2 (en) 2009-12-18 2014-04-22 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
WO2011075623A1 (en) 2009-12-18 2011-06-23 Latitude Pharmaceuticals, Inc. One - phase gel compos ition compri s ing phos pholi pids
CN101798588B (en) 2009-12-21 2015-09-09 上海仁会生物制药股份有限公司 GLP-1 receptor stimulant Determination of biological activity method
JO2976B1 (en) 2009-12-22 2016-03-15 ايلي ليلي اند كومباني Oxyntomodulin peptide analogue ‎
AR079344A1 (en) 2009-12-22 2012-01-18 Lilly Co Eli PEPTIDAL ANALOG OF OXINTOMODULIN, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS AND USES TO PREPARE A USEFUL MEDICINAL PRODUCT TO TREAT NON-INSULINED INDEPENDENT DIABETES AND / OR OBESITY
KR20120128129A (en) 2010-01-20 2012-11-26 질랜드 파마 에이/에스 Treatment of cardiac conditions
RU2012136450A (en) 2010-01-27 2014-03-10 Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн CONJUGATES GLUCAGON ANTAGONIST - GIP AGONIST AND COMPOSITIONS FOR TREATMENT OF METABOLIC DISORDERS AND OBESITY
TR201902092T4 (en) 2010-02-01 2019-03-21 Sanofi Aventis Deutschland A method of fixing a cartridge in a cartridge holder, a drug delivery device, and a cartridge holder.
WO2011109784A1 (en) 2010-03-05 2011-09-09 Conjuchem, Llc Formulation of insulinotropic peptide conjugates
EP2552950A1 (en) 2010-03-26 2013-02-06 Novo Nordisk A/S Novel glucagon analogues
AR080592A1 (en) 2010-03-26 2012-04-18 Lilly Co Eli PEPTIDE WITH ACTIVITY FOR GIP-R AND GLP-1-R, FAMILY FORMULATION THAT UNDERSTANDS IT, ITS USE TO PREPARE A USEFUL MEDICINAL PRODUCT FOR THE TREATMENT OF MELLITUS DIABETES AND TO INDICATE WEIGHT LOSS
CN103179976A (en) 2010-05-13 2013-06-26 印第安纳大学研究及科技有限公司 Glucagon superfamily peptides exhibiting g protein-coupled receptor activity
WO2011143209A1 (en) 2010-05-13 2011-11-17 Indiana University Research And Technology Corporation Glucagon superfamily peptides exhibiting nuclear hormone receptor activity
AU2011202239C1 (en) 2010-05-19 2017-03-16 Sanofi Long-acting formulations of insulins
EA201291009A1 (en) 2010-05-20 2013-05-30 Глаксо Груп Лимитед IMPROVED CONNECTING OPTIONS AGAINST SERUM ALBUMIN
US8263554B2 (en) 2010-06-09 2012-09-11 Amylin Pharmaceuticals, Inc. Methods of using GLP-1 receptor agonists to treat pancreatitis
CN101891823B (en) 2010-06-11 2012-10-03 北京东方百泰生物科技有限公司 Exendin-4 and analog fusion protein thereof
US8636711B2 (en) 2010-06-14 2014-01-28 Legacy Emanuel Hospital & Health Center Stabilized glucagon solutions and uses therefor
AU2011271097B2 (en) 2010-06-21 2014-11-27 Mannkind Corporation Dry powder drug delivery system and methods
AR081975A1 (en) 2010-06-23 2012-10-31 Zealand Pharma As GLUCAGON ANALOGS
CN103179979A (en) 2010-06-24 2013-06-26 印第安纳大学研究及科技有限公司 Amide based glucagon superfamily peptide prodrugs
US9234023B2 (en) 2010-06-24 2016-01-12 Biousian Biosystems, Inc. Glucagon-like peptide-1 glycopeptides
WO2012012352A2 (en) 2010-07-19 2012-01-26 Amidebio, Llc Modified peptides and proteins
WO2012012460A1 (en) 2010-07-19 2012-01-26 Xeris Pharmaceuticals, Inc. Stable glucagon formulations for the treatment of hypoglycemia
BR112013002096A2 (en) 2010-07-28 2019-09-24 Amylin Pharmaceuticals Inc glp-1 receptor agonist compounds having stabilized regions
CN102397558B (en) 2010-09-09 2013-08-14 中国人民解放军军事医学科学院毒物药物研究所 Positioning pegylation modified compound of Exendin-4 analog and application thereof
EP2438930A1 (en) 2010-09-17 2012-04-11 Sanofi-Aventis Deutschland GmbH Prodrugs comprising an exendin linker conjugate
WO2012050923A2 (en) 2010-09-28 2012-04-19 Amylin Pharmaceuticals, Inc. Engineered polypeptides having enhanced duration of action
CA2816114C (en) 2010-11-03 2019-02-12 Jan Jezek Novel composition comprising glucagon
KR101931392B1 (en) 2010-11-09 2018-12-20 맨카인드 코포레이션 Composition comprising a serotonin receptor agonist and a diketopiperazine for treating migraines
EP2460552A1 (en) 2010-12-06 2012-06-06 Sanofi-Aventis Deutschland GmbH Drug delivery device with locking arrangement for dose button
RS60321B1 (en) 2010-12-16 2020-07-31 Novo Nordisk As Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2- hydroxybenzoyl)amino)caprylic acid
KR20130132931A (en) 2010-12-22 2013-12-05 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon analogs exhibiting gip receptor activity
WO2012088157A2 (en) 2010-12-22 2012-06-28 Amylin Pharmaceuticals, Inc. Glp-1 receptor agonists for islet cell transplantation
CN102532301B (en) 2010-12-31 2014-09-03 上海医药工业研究院 Novel Exendin-4 analogues and preparation method thereof
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
CN102100906A (en) 2011-02-18 2011-06-22 深圳翰宇药业股份有限公司 Medicinal preparation of exenatide and preparation method thereof
CN105853348B (en) 2011-03-10 2019-08-30 Xeris药物公司 Parenteral injection stablizing solution
CN102718858B (en) 2011-03-29 2014-07-02 天津药物研究院 Glucagon-like peptide-1 (GLP-1) analogue monomer and dimer, preparation method therefor and application thereof
CN102718868A (en) 2011-03-30 2012-10-10 上海华谊生物技术有限公司 Fixed point mono-substituted pegylation of Exendin analogue and preparation method thereof
US9790262B2 (en) 2011-04-05 2017-10-17 Longevity Biotech, Inc. Compositions comprising glucagon analogs and methods of making and using the same
EP2696897A2 (en) 2011-04-11 2014-02-19 Yeda Research and Development Co. Ltd. Albumin binding probes and drug conjugates thereof
WO2012150503A2 (en) 2011-05-03 2012-11-08 Zealand Pharma A/S Glu-glp-1 dual agonist signaling-selective compounds
CN102766204B (en) 2011-05-05 2014-10-15 天津药物研究院 Glucagon-like peptide-1 mutant polypeptide, its preparation method and application thereof
CN111701028A (en) 2011-05-18 2020-09-25 梅德瑞斯糖尿病有限责任公司 Improved peptide medicine for insulin resistance
US20140221282A1 (en) 2011-05-25 2014-08-07 Astrazeneca Pharmaceuticals Lp Long duration dual hormone conjugates
DE102011102879B4 (en) 2011-05-31 2014-03-27 Pewag Schneeketten Gmbh & Co Kg Chain link for anti-skid chains for vehicle tires, as well as anti-skid chain comprising such chain links
UA113626C2 (en) * 2011-06-02 2017-02-27 A COMPOSITION FOR THE TREATMENT OF DIABETES CONTAINING THE DURABLE INSULIN CON conjugate AND THE DUAL ACTION INSULINOTROPIC PIPIDE
CN103764673A (en) 2011-06-10 2014-04-30 北京韩美药品有限公司 Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof
EP2718318B1 (en) 2011-06-10 2018-07-25 Hanmi Science Co., Ltd. Novel oxyntomodulin derivatives and pharmaceutical composition for treating obesity comprising the same
UA114709C2 (en) 2011-06-17 2017-07-25 Ханмі Сайенс Ко., Лтд. CONJUGATE CONTAINING OXYNTOMODULIN DERIVATIVES, THE FACILITY OF THE IMMUNOGLOBULIN AND THE NON-REPTIDYL POLYMER, AND ITS APPLICATION
US9156902B2 (en) 2011-06-22 2015-10-13 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
US9309301B2 (en) 2011-06-22 2016-04-12 Indiana University Research And Technology Corporation Glucagon/GLP-1 receptor co-agonists
CN103906528A (en) 2011-06-24 2014-07-02 安米林药品有限责任公司 Methods of treating diabetes with sustained release formulations of GLP-1 receptor agonists
KR101357117B1 (en) 2011-06-28 2014-02-06 비앤엘델리팜 주식회사 PEGylated Exendin-4 analogues or its derivatives, preparation method thereof and pharmaceutical composition containing the same for preventing and treating a diabetes
WO2013004983A1 (en) 2011-07-04 2013-01-10 Imperial Innovations Limited Novel compounds and their effects on feeding behaviour
US9382304B2 (en) 2011-07-08 2016-07-05 Amylin Pharmaceuticals, Llc Engineered polypeptides having enhanced duration of action with reduced immunogenicity
AU2012293463B2 (en) 2011-08-10 2016-08-04 Adocia Injectable solution of at least one type of basal insulin
EP2747832A4 (en) 2011-08-24 2015-01-07 Phasebio Pharmaceuticals Inc Formulations of active agents for sustained release
WO2013029279A1 (en) 2011-09-03 2013-03-07 深圳市健元医药科技有限公司 Novel glp-i analogue, preparation method and use thereof
IN2014CN02448A (en) 2011-09-23 2015-06-19 Novo Nordisk As
SG11201401175SA (en) 2011-10-28 2014-09-26 Sanofi Aventis Deutschland Treatment protocol of diabetes type 2
CN102363633B (en) 2011-11-16 2013-11-20 天津拓飞生物科技有限公司 Glucagon like peptide-1 mutant polypeptide and preparation method, medicinal composition and use thereof
KR20140097151A (en) 2011-11-17 2014-08-06 인디애나 유니버시티 리서치 앤드 테크놀로지 코퍼레이션 Glucagon superfamily peptides exhibiting glucocorticoid receptor activity
JP5819005B2 (en) 2011-11-29 2015-11-18 ジュロックス プロプライエタリー リミテッド Pharmaceutical composition
CA2859387A1 (en) 2011-12-16 2013-06-20 Moderna Therapeutics, Inc. Modified nucleoside, nucleotide, and nucleic acid compositions
WO2013093720A2 (en) 2011-12-22 2013-06-27 Pfizer Inc. Anti-diabetic compounds
BR112014015681A2 (en) 2011-12-23 2019-09-24 Boehringer Ingelheim Int glucagon analogs
JP2015503565A (en) 2011-12-29 2015-02-02 ラティチュード ファーマシューティカルズ インコーポレイテッドＬａｔｉｔｕｄｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Stabilized glucagon nanoemulsion
EP2814461B1 (en) 2012-01-09 2019-07-24 Adocia Injectable solution having a ph of 7 and including at least basal insulin, the pi of which is between 5.8 and 8.5, and a substituted co-poly(amino acid)
EP2844269A4 (en) 2012-03-28 2016-01-06 Amylin Pharmaceuticals Llc Transmucosal delivery of engineered polypeptides
WO2013148871A1 (en) 2012-03-28 2013-10-03 Amylin Pharmaceuticals, Llc Engineered polypeptides
AU2013243951A1 (en) 2012-04-02 2014-10-30 Moderna Therapeutics, Inc. Modified polynucleotides for the production of secreted proteins
CN104411338A (en) 2012-04-02 2015-03-11 现代治疗公司 Modified polynucleotides for the production of biologics and proteins associated with human disease
WO2013163162A1 (en) 2012-04-24 2013-10-31 Amylin Pharmaceuticals, Llc Site-specific enzymatic modification of exendins and analogs thereof
US20130289241A1 (en) 2012-04-26 2013-10-31 Shanghai Ambiopharm, Inc. Method for preparing exenatide
US8901484B2 (en) 2012-04-27 2014-12-02 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
WO2013182217A1 (en) 2012-04-27 2013-12-12 Sanofi-Aventis Deutschland Gmbh Quantification of impurities for release testing of peptide products
MX356958B (en) 2012-05-03 2018-06-20 Zealand Pharma As Glucagon-like-peptide-2 (glp-2) analogues.
EP2664374A1 (en) 2012-05-15 2013-11-20 F. Hoffmann-La Roche AG Lysin-glutamic acid dipeptide derivatives
CN103421094A (en) 2012-05-24 2013-12-04 上海医药工业研究院 Polypeptide compound with EPO-like activity
US20150174209A1 (en) 2012-05-25 2015-06-25 Amylin Pharmaceuticals. Llc Insulin-pramlintide compositions and methods for making and using them
KR20150013898A (en) 2012-05-25 2015-02-05 메르크 파텐트 게엠베하 Bimesogenic compounds and mesogenic media
CA2875743A1 (en) 2012-06-14 2013-12-19 Sanofi Exendin-4 peptide analogues
MY185217A (en) 2012-06-21 2021-04-30 Hoffmann La Roche Analogs of glucagon exhibiting gip receptor activity
US9802012B2 (en) 2012-07-12 2017-10-31 Mannkind Corporation Dry powder drug delivery system and methods
ES2620111T3 (en) 2012-07-23 2017-06-27 Zealand Pharma A/S Glucagon analogues
AR092862A1 (en) 2012-07-25 2015-05-06 Hanmi Pharm Ind Co Ltd LIQUID FORMULATION OF PROLONGED ACTION INSULIN AND AN INSULINOTROPIC PEPTIDE AND PREPARATION METHOD
AR094821A1 (en) 2012-07-25 2015-09-02 Hanmi Pharm Ind Co Ltd LIQUID FORMULATION OF AN INSULINOTROPIC PEPTIDE CONJUGATE OF PROLONGED ACTION
KR101968344B1 (en) 2012-07-25 2019-04-12 한미약품 주식회사 A composition for treating hyperlipidemia comprising oxyntomodulin analog
EP2931300A1 (en) 2012-08-14 2015-10-21 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
WO2014027253A1 (en) 2012-08-14 2014-02-20 Wockhardt Limited Pharmaceutical microparticulate compositions of polypeptides
CN102816244A (en) 2012-08-23 2012-12-12 无锡和邦生物科技有限公司 Fusion protein of exendin-4 peptide and human serum albumin (HSA) and preparation method thereof
CN102827270A (en) 2012-09-13 2012-12-19 无锡和邦生物科技有限公司 Pegylated exenatide ramification and use thereof
US9546205B2 (en) 2012-09-17 2017-01-17 Imperial Innovations Limited Peptide analogues of glucagon and GLP1
TWI608013B (en) 2012-09-17 2017-12-11 西蘭製藥公司 Glucagon analogues
UA116217C2 (en) 2012-10-09 2018-02-26 Санофі Exendin-4 derivatives as dual glp1/glucagon agonists
KR101993393B1 (en) 2012-11-06 2019-10-01 한미약품 주식회사 A composition for treating diabetes or diabesity comprising oxyntomodulin analog
MY197849A (en) 2012-11-06 2023-07-20 Hanmi Pharm Ind Co Ltd Liquid formulation of protein conjugate comprising the oxyntomodulin and an immunoglobulin fragment
EP3434696A1 (en) 2012-11-20 2019-01-30 Mederis Diabetes, LLC Improved peptide pharmaceuticals for insulin resistance
TWI617574B (en) 2012-12-11 2018-03-11 梅迪繆思有限公司 Glucagon and glp-1 co-agonists for the treatment of obesity
PL2934567T3 (en) 2012-12-21 2018-10-31 Sanofi Exendin-4 derivatives as dual glp1/gip- or trigonal glp1/gip/glucagon agonists
CN103908657A (en) 2012-12-31 2014-07-09 复旦大学附属华山医院 Use of glucagons-like peptide-1 analogue in preparation of ophthalmic disease drug
CN105324397B (en) 2013-03-14 2020-01-14 印第安纳大学研究及科技有限公司 Insulin-incretin conjugates
JP2016512213A (en) 2013-03-14 2016-04-25 メディミューン リミテッド Pegylated glucagon and GLP-1 co-agonist for the treatment of obesity
EP2986314A4 (en) 2013-03-15 2016-04-13 Univ Indiana Res & Tech Corp Prodrugs with prolonged action
RS59124B1 (en) 2013-04-18 2019-09-30 Novo Nordisk As Stable, protracted glp-1/glucagon receptor co-agonists for medical use
JP2014227368A (en) 2013-05-21 2014-12-08 国立大学法人帯広畜産大学 Glucagon analog for treating diabetes mellitus and hyperglycemia condition
CN103304660B (en) 2013-07-12 2016-08-10 上海昂博生物技术有限公司 A kind of synthetic method of Arg34Lys26-(N-EPSILON-(N-ALPHA-Palmitoyl-L-GAMMA-glutamyl))-GLP-1[7-37]
CN103405753B (en) 2013-08-13 2016-05-11 上海仁会生物制药股份有限公司 Stable insulin secretion accelerating peptide liquid drugs injection pharmaceutical composition
US9988429B2 (en) 2013-10-17 2018-06-05 Zealand Pharma A/S Glucagon analogues
DK3057984T3 (en) 2013-10-17 2018-10-08 Zealand Pharma As ACYLED GLUCAGON ANALOGS
EA035688B1 (en) 2013-11-06 2020-07-27 Зилэнд Фарма А/С Glucagon-glp-1-gip triple agonist compounds
WO2015086730A1 (en) 2013-12-13 2015-06-18 Sanofi Non-acylated exendin-4 peptide analogues
WO2015086728A1 (en) 2013-12-13 2015-06-18 Sanofi Exendin-4 peptide analogues as dual glp-1/gip receptor agonists
EP3080149A1 (en) 2013-12-13 2016-10-19 Sanofi Dual glp-1/glucagon receptor agonists
EP3080151A1 (en) 2013-12-13 2016-10-19 Sanofi Exendin-4 peptide analogues
TW201609800A (en) 2013-12-13 2016-03-16 賽諾菲公司 EXENDIN-4 peptide analogues as dual GLP-1/glucagon receptor agonists
TW201609799A (en) 2013-12-13 2016-03-16 賽諾菲公司 Dual GLP-1/GIP receptor agonists
CN103665148B (en) 2013-12-17 2016-05-11 中国药科大学 A kind of Polypeptide-k of Orally-administrable and method for making thereof and purposes
CN103980358B (en) 2014-01-03 2016-08-31 杭州阿诺生物医药科技股份有限公司 A kind of method preparing Arg34Lys26-(N-EPSILON-(N-ALPHA-Palmitoyl-L-GAMMA-glutamyl))-GLP-1[7-37]
US9895424B2 (en) 2014-01-09 2018-02-20 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
EP3091995B1 (en) 2014-01-09 2024-03-20 Sanofi Stabilized pharmaceutical formulations of insulin aspart
TW201625668A (en) 2014-04-07 2016-07-16 賽諾菲公司 Exendin-4 derivatives as peptidic dual GLP-1/glucagon receptor agonists
TW201625670A (en) 2014-04-07 2016-07-16 賽諾菲公司 Dual GLP-1/glucagon receptor agonists derived from EXENDIN-4
TW201625669A (en) 2014-04-07 2016-07-16 賽諾菲公司 Peptidic dual GLP-1/glucagon receptor agonists derived from Exendin-4
US9932381B2 (en) 2014-06-18 2018-04-03 Sanofi Exendin-4 derivatives as selective glucagon receptor agonists
CN104926934B (en) 2014-09-23 2016-11-09 蒋先兴 Oxyntomodulin analogs
AR105284A1 (en) 2015-07-10 2017-09-20 Sanofi Sa DERIVATIVES OF EXENDINA-4 AS SPECIFIC DUAL PEPTIDE AGONISTS OF GLP-1 / GLUCAGÓN RECEPTORS

Also Published As

Publication number Publication date
CN106715466A (en) 2017-05-24
LT3157949T (en) 2018-11-12
IL249583A0 (en) 2017-02-28
CY1121032T1 (en) 2019-12-11
HRP20181708T1 (en) 2018-12-28
AU2015276203A1 (en) 2016-12-15
RU2017101377A3 (en) 2019-02-06
AR100888A1 (en) 2016-11-09
AU2015276203B2 (en) 2019-01-31
RU2017101377A (en) 2018-07-19
TR201815158T4 (en) 2018-11-21
WO2015193381A1 (en) 2015-12-23
EP3157949B1 (en) 2018-07-18
CN106715466B (en) 2020-09-15
MX367348B (en) 2019-08-15
BR112016029582A2 (en) 2017-10-31
TW201613633A (en) 2016-04-16
MX2016016868A (en) 2017-03-27
US9932381B2 (en) 2018-04-03
US20150368311A1 (en) 2015-12-24
JP2017523147A (en) 2017-08-17
JP6581606B2 (en) 2019-09-25
PL3157949T3 (en) 2018-12-31
SI3157949T1 (en) 2018-11-30
EP3157949A1 (en) 2017-04-26
HUE039702T2 (en) 2019-01-28
CA2951077A1 (en) 2015-12-23
UY36179A (en) 2016-01-29
PT3157949T (en) 2018-11-09
ES2691534T3 (en) 2018-11-27
DK3157949T3 (en) 2018-11-12
KR20170018433A (en) 2017-02-17

Similar Documents

Publication Publication Date Title
HRP20181708T1 (en) Exendin-4 derivatives as selective glucagon receptor agonists
HRP20190388T1 (en) Exendin-4 derivatives as peptidic dual glp-1 / glucagon receptor agonists
ZA201802371B (en) Glucagon receptor agonists
IL252257A0 (en) Insulin receptor partial agonists
IL248013A0 (en) Dual glp-1/glucagon receptor agonists derived from exendin-4
IL256748A (en) New exendin-4 derivatives as selective peptidic dual glp-1 / glucagon receptor agonists
IL281375B (en) Glucagon derivatives with improved stability
IL247769A0 (en) Peptidic dual glp-1 / glucagon receptor agonists derived from exendin-4
HK1231382A1 (en) Muscarinic receptor agonists
HK1246323A1 (en) Glucagon derivatives
HRP20182016T1 (en) Ethynyl derivatives
HK1251831A1 (en) Cyclopropylmethanamines as selective 5-ht(2c) receptor agonists