SG11201606275WA - Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders - Google Patents
Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disordersInfo
- Publication number
- SG11201606275WA SG11201606275WA SG11201606275WA SG11201606275WA SG11201606275WA SG 11201606275W A SG11201606275W A SG 11201606275WA SG 11201606275W A SG11201606275W A SG 11201606275WA SG 11201606275W A SG11201606275W A SG 11201606275WA SG 11201606275W A SG11201606275W A SG 11201606275WA
- Authority
- SG
- Singapore
- Prior art keywords
- acamprosate
- baclofen
- treatment
- combination
- medium chain
- Prior art date
Links
- KPYSYYIEGFHWSV-UHFFFAOYSA-N Baclofen Chemical compound OC(=O)CC(CN)C1=CC=C(Cl)C=C1 KPYSYYIEGFHWSV-UHFFFAOYSA-N 0.000 title 1
- 208000012902 Nervous system disease Diseases 0.000 title 1
- 208000025966 Neurological disease Diseases 0.000 title 1
- AFCGFAGUEYAMAO-UHFFFAOYSA-N acamprosate Chemical compound CC(=O)NCCCS(O)(=O)=O AFCGFAGUEYAMAO-UHFFFAOYSA-N 0.000 title 1
- 229960004047 acamprosate Drugs 0.000 title 1
- 229960000794 baclofen Drugs 0.000 title 1
- 229940057917 medium chain triglycerides Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Emergency Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461938340P | 2014-02-11 | 2014-02-11 | |
| PCT/EP2015/052694 WO2015121218A1 (en) | 2014-02-11 | 2015-02-10 | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201606275WA true SG11201606275WA (en) | 2016-08-30 |
Family
ID=52544464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201606275WA SG11201606275WA (en) | 2014-02-11 | 2015-02-10 | Combination of baclofen, acamprosate and medium chain triglycerides for the treatment of neurological disorders |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10905672B2 (ja) |
| EP (1) | EP3104850A1 (ja) |
| JP (1) | JP6619744B2 (ja) |
| KR (1) | KR20160111013A (ja) |
| CN (1) | CN106456583B (ja) |
| AU (1) | AU2015217796B2 (ja) |
| CA (1) | CA2938361A1 (ja) |
| EA (1) | EA201691602A1 (ja) |
| IL (1) | IL246856A0 (ja) |
| MX (1) | MX2016010409A (ja) |
| SG (1) | SG11201606275WA (ja) |
| WO (1) | WO2015121218A1 (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160111013A (ko) | 2014-02-11 | 2016-09-23 | 파넥스트 | 신경질환의 치료를 위한 바클로펜, 아캄프로세이트 및 중쇄 트리-글리세리드의 조합 |
| AU2016258624B2 (en) | 2015-05-04 | 2021-07-29 | Confluence Pharmaceuticals, Llc | Sprinkle formulations of acamprosate |
| US20180008612A1 (en) * | 2016-07-11 | 2018-01-11 | Taho Pharmaceuticals Ltd. | Transdermal delivery system containing galantamine or salts thereof |
| BR112019019098A2 (pt) | 2017-03-15 | 2020-04-22 | Cerecin Inc | composições farmacêuticas tendo altos carregamentos de fármaco de triglicerídeos de cadeia média, seu método de produção e seu uso |
| KR20200005576A (ko) | 2017-05-17 | 2020-01-15 | 컨플루언스 파마슈티컬스, 엘엘씨 | 호모타우린 및 이의 염의 제형 |
| CN111902138A (zh) * | 2018-01-29 | 2020-11-06 | 法奈克斯公司 | 在乙酰胆碱酯酶抑制剂治疗失去反应的患者中对阿兹海默氏病的基于巴氯芬和阿坎酸的治疗 |
| CN112566629B (zh) * | 2018-03-15 | 2023-11-17 | 睿升公司 | 具有高药物装载的中链甘油三酯的药物组合物及其相关方法 |
| CN111166868A (zh) * | 2019-07-17 | 2020-05-19 | 江苏西宏生物医药有限公司 | 一种用于治疗神经疾病和障碍的组合物 |
| KR20210072569A (ko) * | 2019-12-09 | 2021-06-17 | 주식회사 종근당 | 도네페질 및 메만틴을 포함하는 복합 제제 |
| JP2023525712A (ja) * | 2020-05-19 | 2023-06-19 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 認知機能を改善するためのｍｃｔ製剤 |
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| ES2323940T3 (es) * | 2000-05-01 | 2009-07-28 | Accera, Inc. | Uso de trigliceridos de cadena media para el tratamiento y prevencion de la enfermedad de alzheimer. |
| AU2002316231A1 (en) | 2002-02-19 | 2003-09-29 | Xenoport, Inc. | Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof |
| US7109239B2 (en) | 2003-08-20 | 2006-09-19 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs, methods of synthesis and use |
| US7227028B2 (en) | 2003-12-30 | 2007-06-05 | Xenoport, Inc. | Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof |
| US20080206332A1 (en) | 2007-01-11 | 2008-08-28 | Kidney David J | Sustained release oral dosage forms of a prodrug of r-baclofen and methods of treatment |
| WO2009005519A1 (en) * | 2007-06-29 | 2009-01-08 | Accera, Inc. | Combinations of medium chain triglycerides and therapeutic agents for the treatment and prevention of alzheimer's disease and other diseases resulting from reduced neuronal metabolism |
| WO2009033079A1 (en) | 2007-09-07 | 2009-03-12 | Xenoport, Inc. | Externally masked neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| US20090069419A1 (en) | 2007-09-07 | 2009-03-12 | Bernd Jandeleit | Masked carboxylate neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use |
| CL2008002960A1 (es) * | 2007-10-04 | 2009-05-08 | Bio Arch Lab Inc | Método para producir 2-ceto-3-desoxi d-gluconato (kdg), basado en proporciopnar acido-desoxi l-eritro hexocelulosa uronico (dehu), y contactar dicha molecula con un microorganismo recombinante que codofica una dehu-hidrogenasa. |
| US20090099253A1 (en) | 2007-10-15 | 2009-04-16 | Xenoport, Inc. | Internally Masked Neopentyl Sulfonyl Ester Cyclization Release Prodrugs of Acamprosate, Compositions Thereof, and Methods of Use |
| TW200936123A (en) | 2007-11-06 | 2009-09-01 | Xenoport Inc | Use of prodrugs of GABAb agonists for treating neuropathic and musculoskeletal pain |
| EP2065038A1 (en) | 2007-11-30 | 2009-06-03 | Pharnext | New therapeutic approaches for treating Charcot-Marie-Tooth disease |
| WO2009096985A1 (en) | 2008-02-01 | 2009-08-06 | Xenoport, Inc. | Sustained release particulate oral dosage forms of (r)-baclofen prodrugs and methods of treatment |
| US20100137442A2 (en) | 2008-02-01 | 2010-06-03 | Xenoport, Inc. | Sustained Release Particulate Oral Dosage Forms of (R)-Baclofen and Methods of Treatment |
| JP5721230B2 (ja) | 2008-04-29 | 2015-05-20 | ファーネクストＰｈａｒｎｅｘｔ | 血管新生の調節を通したアルツハイマー病および関連障害の処置のための新たな治療アプローチ |
| EP3560496A1 (en) | 2008-04-29 | 2019-10-30 | Pharnext | Combination compositions for treating alzheimer disease and related disorders with zonisamide and acamprosate |
| MX2010011880A (es) | 2008-04-29 | 2011-05-25 | Pharnext | Nuevos enfoques terapeuticos para tratar la enfermedad del alzheimer y trastornos relacionados mediante una modulacion de la respuesta de estres celular. |
| EP2135607A1 (en) | 2008-06-18 | 2009-12-23 | Pharnext | Combination of pilocarpin and methimazol for treating Charcot-MarieTooth disease and related disorders |
| NZ594648A (en) | 2009-03-03 | 2013-12-20 | Xenoport Inc | Sustained release oral dosage forms of an r-baclofen prodrug |
| US8344028B2 (en) | 2009-04-17 | 2013-01-01 | Xenoport, Inc. | Gamma-amino-butyric acid derivatives as GABAB receptor ligands |
| US9393241B2 (en) | 2009-06-02 | 2016-07-19 | Pharnext | Compositions for treating CMT and related disorders |
| EP2263665A1 (en) | 2009-06-02 | 2010-12-22 | Pharnext | New compositions for treating CMT and related disorders |
| US9387206B2 (en) | 2009-11-03 | 2016-07-12 | Pharnext | Therapeutic approaches for treating Alzheimer's disease |
| EP2322163A1 (en) | 2009-11-03 | 2011-05-18 | Pharnext | New therapeutics approaches for treating alzheimer disease |
| US9494605B2 (en) | 2009-11-20 | 2016-11-15 | Pharnext | Diagnostic tools for charcot-marie-tooth disease |
| AU2010336921A1 (en) | 2009-12-30 | 2012-07-26 | Baylor Research Institute | Anaplerotic therapy for Alzheimer's disease and the aging brain |
| US9867837B2 (en) | 2011-03-01 | 2018-01-16 | Pharnext | Compositions for treating neurological disorders |
| US9241933B2 (en) | 2011-03-01 | 2016-01-26 | Pharnext | Compositions for treating amyotrophic lateral sclerosis |
| UA115968C2 (uk) | 2011-03-01 | 2018-01-25 | Фарнекст | Нові композиції для лікування неврологічних захворювань |
| WO2012117075A2 (en) | 2011-03-01 | 2012-09-07 | Pharnext | Treatment of cerebral ischemia |
| EP2705842A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US10010515B2 (en) | 2011-03-01 | 2018-07-03 | Pharnext | Therapeutic approaches for treating Parkinson's disease |
| US9248111B2 (en) | 2011-03-01 | 2016-02-02 | Pharnext | Therapeutic approaches for treating parkinson's disease |
| US9931326B2 (en) | 2011-03-29 | 2018-04-03 | Pharnext | Composition comprising torasemide and baclofen for treating neurological disorders |
| AU2013291970B2 (en) | 2012-07-18 | 2017-09-28 | Pharnext | Baclofen and acamprosate based therapy of Macular Degeneration disorders |
| EP2705841A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Combinations of nootropic agents for treating cognitive dysfunctions |
| EP2705843A1 (en) | 2012-09-05 | 2014-03-12 | Pharnext | Therapeutic approaches for treating epilepsy and related disorders through reduction of epileptogenesis |
| EP2727587A1 (en) | 2012-10-30 | 2014-05-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
| EA029478B1 (ru) | 2013-06-05 | 2018-03-30 | Фарнекст | Стабильные растворы объединенных активных фармацевтических ингредиентов для перорального применения |
| EP3062782A1 (en) | 2013-10-30 | 2016-09-07 | Pharnext | Compositions, methods and uses for the treatment of diabetes and related conditions by controlling blood glucose level |
| KR20160111013A (ko) | 2014-02-11 | 2016-09-23 | 파넥스트 | 신경질환의 치료를 위한 바클로펜, 아캄프로세이트 및 중쇄 트리-글리세리드의 조합 |
| US9700036B1 (en) | 2015-04-08 | 2017-07-11 | Justin P. Chatelain | Duck decoy device |
| US9700037B1 (en) | 2014-09-08 | 2017-07-11 | Justin P. Chatelain | Duck decoy device |
-
2015
- 2015-02-10 KR KR1020167025118A patent/KR20160111013A/ko not_active Application Discontinuation
- 2015-02-10 CA CA2938361A patent/CA2938361A1/en not_active Abandoned
- 2015-02-10 CN CN201580008144.4A patent/CN106456583B/zh not_active Expired - Fee Related
- 2015-02-10 AU AU2015217796A patent/AU2015217796B2/en not_active Ceased
- 2015-02-10 SG SG11201606275WA patent/SG11201606275WA/en unknown
- 2015-02-10 EA EA201691602A patent/EA201691602A1/ru unknown
- 2015-02-10 EP EP15705551.8A patent/EP3104850A1/en not_active Withdrawn
- 2015-02-10 WO PCT/EP2015/052694 patent/WO2015121218A1/en active Application Filing
- 2015-02-10 JP JP2016551144A patent/JP6619744B2/ja not_active Expired - Fee Related
- 2015-02-10 MX MX2016010409A patent/MX2016010409A/es unknown
- 2015-02-10 US US15/117,774 patent/US10905672B2/en active Active
-
2016
- 2016-07-20 IL IL246856A patent/IL246856A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2017505786A (ja) | 2017-02-23 |
| US10905672B2 (en) | 2021-02-02 |
| WO2015121218A1 (en) | 2015-08-20 |
| EA201691602A1 (ru) | 2017-03-31 |
| EP3104850A1 (en) | 2016-12-21 |
| IL246856A0 (en) | 2016-08-31 |
| MX2016010409A (es) | 2016-11-30 |
| AU2015217796B2 (en) | 2020-04-30 |
| KR20160111013A (ko) | 2016-09-23 |
| US20160354335A1 (en) | 2016-12-08 |
| CA2938361A1 (en) | 2015-08-20 |
| JP6619744B2 (ja) | 2019-12-11 |
| AU2015217796A1 (en) | 2016-08-18 |
| CN106456583B (zh) | 2020-04-07 |
| CN106456583A (zh) | 2017-02-22 |
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