SG11201605858WA - Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity - Google Patents

Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity

Info

Publication number
SG11201605858WA
SG11201605858WA SG11201605858WA SG11201605858WA SG11201605858WA SG 11201605858W A SG11201605858W A SG 11201605858WA SG 11201605858W A SG11201605858W A SG 11201605858WA SG 11201605858W A SG11201605858W A SG 11201605858WA SG 11201605858W A SG11201605858W A SG 11201605858WA
Authority
SG
Singapore
Prior art keywords
metastatic
invasive
isolating
prediction
capacity
Prior art date
Application number
SG11201605858WA
Other languages
English (en)
Inventor
Julia Kirshner
Mukti Rajen Parikh
Original Assignee
Zpredicta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zpredicta Inc filed Critical Zpredicta Inc
Publication of SG11201605858WA publication Critical patent/SG11201605858WA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C12M25/04—Membranes; Filters in combination with well or multiwell plates, i.e. culture inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/42—Integrated assemblies, e.g. cassettes or cartridges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M35/00—Means for application of stress for stimulating the growth of microorganisms or the generation of fermentation or metabolic products; Means for electroporation or cell fusion
    • C12M35/08—Chemical, biochemical or biological means, e.g. plasma jet, co-culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/70—Undefined extracts
    • C12N2500/80—Undefined extracts from animals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2523/00—Culture process characterised by temperature

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
SG11201605858WA 2014-01-22 2015-01-21 Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity SG11201605858WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461930390P 2014-01-22 2014-01-22
US201562100375P 2015-01-06 2015-01-06
PCT/US2015/012282 WO2015112624A1 (fr) 2014-01-22 2015-01-21 Procédé et appareil permettant d'isoler des cellules envahissantes et métastatiques pour évaluer des agents thérapeutiques et prédire une capacité métastatique

Publications (1)

Publication Number Publication Date
SG11201605858WA true SG11201605858WA (en) 2016-08-30

Family

ID=53681904

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201605858WA SG11201605858WA (en) 2014-01-22 2015-01-21 Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity
SG10201805928WA SG10201805928WA (en) 2014-01-22 2015-01-21 Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201805928WA SG10201805928WA (en) 2014-01-22 2015-01-21 Method and apparatus for isolating invasive and metastatic cells for evaluating therapeutics and prediction of metastatic capacity

Country Status (11)

Country Link
US (2) US10501717B2 (fr)
EP (1) EP3097178A4 (fr)
JP (1) JP2017506066A (fr)
KR (1) KR20160106108A (fr)
CN (1) CN105980541A (fr)
AU (1) AU2015209434A1 (fr)
BR (1) BR112016016635A2 (fr)
CA (1) CA2937245A1 (fr)
IL (1) IL246804A0 (fr)
SG (2) SG11201605858WA (fr)
WO (1) WO2015112624A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014123947A1 (fr) * 2013-02-05 2014-08-14 Ohio State Innovation Foundation Test de galvanotaxie pour l'évaluation quantitative du potentiel métastatique de cellules cancéreuses
US9885031B2 (en) 2013-02-05 2018-02-06 Ohio State Innovation Foundation Galvanotaxis assay for quantitative assessment of the metastatic potential of cancer cells
KR20160106108A (ko) 2014-01-22 2016-09-09 제트프리딕타, 인코포레이티드 치료제를 평가하고 전이 능력을 예측하기 위해 침습성 및 전이성 세포를 분리하기 위한 방법 및 장치
CA3000718A1 (fr) * 2015-10-02 2017-04-06 Wake Forest University Health Sciences Procedes et appareil de modelisation in vitro des metastases cancereuses
US20190169562A1 (en) * 2016-07-29 2019-06-06 Zpredicta, Inc. Screening of immuno-modulatory therapies
JP2019524128A (ja) * 2016-08-03 2019-09-05 ウェイク・フォレスト・ユニヴァーシティ・ヘルス・サイエンシズ がんモデル化プラットフォームおよびその使用方法
CN107361024A (zh) * 2017-07-18 2017-11-21 郑州大学 一种食管鳞癌早期转移模型的建立方法
US20210171893A1 (en) * 2017-11-09 2021-06-10 Duke University Lymphovascular invasion bioreactor and methods of making and using same
KR20200116944A (ko) 2018-02-02 2020-10-13 웨이크 포리스트 유니버시티 헬스 사이언시즈 면역요법 관련 오가노이드 및 그의 제조 및 사용 방법
CN112986546B (zh) * 2021-03-02 2022-10-18 北京大学 一种用于监测三维基质中群体细胞侵袭的阻抗传感方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4829000A (en) 1985-08-30 1989-05-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Reconstituted basement membrane complex with biological activity
WO2003027256A2 (fr) 2001-09-27 2003-04-03 The Wistar Institute Procedes et compositions pour surveiller la migration cellulaire et identifier l'activite cytotoxique des lymphocytes t a prendre en compte sur le plan clinique
SG150387A1 (en) 2003-05-02 2009-03-30 Insception Bioscience Inc Apparatus and methods for amplification of blood stem cell numbers
EP2146728A4 (fr) * 2007-05-21 2010-12-29 Univ Wake Forest Health Sciences Cellules progénitrices provenant de l'urine et procédés pour leur utilisation
WO2010124207A1 (fr) * 2009-04-24 2010-10-28 The Ohio State University Système de micro-environnement interactif
PL2611472T3 (pl) * 2010-09-01 2017-02-28 Regents Of The University Of Minnesota Metody recelularyzacji tkanki lub narządu w celu poprawy wszczepialności
US9267101B2 (en) * 2010-10-08 2016-02-23 Naturin Viscofan Gmbh Cell culture insert
WO2013040445A1 (fr) 2011-09-15 2013-03-21 Whitehead Institute For Biomedical Research Réseaux pour le criblage à base de cellules et utilisations de ceux-ci
WO2013116729A1 (fr) 2012-02-02 2013-08-08 The Trustees Of The University Of Pennsylvania Système de culture cellulaire 3d microfabriqué
KR20160106108A (ko) 2014-01-22 2016-09-09 제트프리딕타, 인코포레이티드 치료제를 평가하고 전이 능력을 예측하기 위해 침습성 및 전이성 세포를 분리하기 위한 방법 및 장치
US20160178611A1 (en) 2014-04-07 2016-06-23 Bo Han Three-dimensional transglutaminase-crosslinked hydrogel for tumor engineering
US20190169562A1 (en) 2016-07-29 2019-06-06 Zpredicta, Inc. Screening of immuno-modulatory therapies

Also Published As

Publication number Publication date
CN105980541A (zh) 2016-09-28
KR20160106108A (ko) 2016-09-09
CA2937245A1 (fr) 2015-07-30
BR112016016635A2 (pt) 2017-08-08
US20160340635A1 (en) 2016-11-24
IL246804A0 (en) 2016-08-31
US11124756B2 (en) 2021-09-21
WO2015112624A1 (fr) 2015-07-30
AU2015209434A1 (en) 2016-08-04
JP2017506066A (ja) 2017-03-02
EP3097178A4 (fr) 2017-09-06
US20190284520A1 (en) 2019-09-19
EP3097178A1 (fr) 2016-11-30
SG10201805928WA (en) 2018-08-30
US10501717B2 (en) 2019-12-10

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