SG11201507244TA - Antibiotic conjugates directly linked with steroid drugs - Google Patents
Antibiotic conjugates directly linked with steroid drugsInfo
- Publication number
- SG11201507244TA SG11201507244TA SG11201507244TA SG11201507244TA SG11201507244TA SG 11201507244T A SG11201507244T A SG 11201507244TA SG 11201507244T A SG11201507244T A SG 11201507244TA SG 11201507244T A SG11201507244T A SG 11201507244TA SG 11201507244T A SG11201507244T A SG 11201507244TA
- Authority
- SG
- Singapore
- Prior art keywords
- directly linked
- steroid drugs
- antibiotic conjugates
- conjugates directly
- antibiotic
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
- A61K47/552—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds one of the codrug's components being an antibiotic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/554—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being a steroid plant sterol, glycyrrhetic acid, enoxolone or bile acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Botany (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361775161P | 2013-03-08 | 2013-03-08 | |
PCT/US2014/021062 WO2014138350A1 (fr) | 2013-03-08 | 2014-03-06 | Conjugués d'antibiotiques liés directement à des médicaments stéroïdiens |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201507244TA true SG11201507244TA (en) | 2015-10-29 |
Family
ID=50382684
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201507244TA SG11201507244TA (en) | 2013-03-08 | 2014-03-06 | Antibiotic conjugates directly linked with steroid drugs |
Country Status (15)
Country | Link |
---|---|
US (1) | US9402912B2 (fr) |
EP (1) | EP2964266A1 (fr) |
JP (1) | JP2016510750A (fr) |
KR (1) | KR20150126032A (fr) |
CN (1) | CN105073140A (fr) |
AR (1) | AR095071A1 (fr) |
AU (1) | AU2014225743A1 (fr) |
BR (1) | BR112015021836A2 (fr) |
CA (1) | CA2903435A1 (fr) |
IL (1) | IL240939A0 (fr) |
MX (1) | MX2015011948A (fr) |
RU (1) | RU2015138891A (fr) |
SG (1) | SG11201507244TA (fr) |
TW (1) | TW201505656A (fr) |
WO (1) | WO2014138350A1 (fr) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2015011948A (es) | 2013-03-08 | 2015-12-09 | Allergan Inc | Antibioticos conjugados directamente relacionados con farmacos esteroides. |
KR20150125663A (ko) | 2013-03-08 | 2015-11-09 | 알러간, 인코포레이티드 | 사이클로스포린 a 스테로이드 켤레물 |
MX2021002380A (es) * | 2018-08-31 | 2021-07-15 | Aerie Pharmaceuticals Inc | Conjugados de isoquinolina-esteroide y usos de los mismos. |
CN114173771A (zh) * | 2019-05-31 | 2022-03-11 | 普莱克斯医药公司 | 用于治疗眼部蛋白质聚集疾病的药理学试剂 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2999102A (en) | 1959-10-14 | 1961-09-05 | Thomae Gmbh Dr K | Bis-(steroid-21)-dicarboxylic acid esters |
US3147183A (en) | 1962-04-16 | 1964-09-01 | Boehringer Sohn Ingelheim | Bis-(steroid-21)-dicarboxylic acid esters |
US3916002A (en) | 1973-12-17 | 1975-10-28 | Taubert Hans Dieter | Oligomeric steroid esters, process for their production, and therapeutic compositions containing the same |
JPH089597B2 (ja) | 1986-01-21 | 1996-01-31 | 杏林製薬株式会社 | 選択毒性に優れた8‐アルコキシキノロンカルボン酸およびその塩並びにその製造方法 |
AU670674B2 (en) | 1993-01-06 | 1996-07-25 | Beckman Instruments, Inc. | Method for making a preconjugate |
US5688792A (en) | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
CA2136803A1 (fr) | 1993-12-22 | 1995-06-23 | Kazumi Ogata | Derives de steroides |
US6051576A (en) | 1994-01-28 | 2000-04-18 | University Of Kentucky Research Foundation | Means to achieve sustained release of synergistic drugs by conjugation |
DK0740650T3 (da) | 1994-01-28 | 2004-09-27 | Univ Kentucky Res Found | Codrugs som metode til styret transport af lægemiddel |
US5565568A (en) | 1995-04-06 | 1996-10-15 | Eli Lilly And Company | 2-acylaminopropanamides as tachykinin receptor antagonists |
WO2001005819A1 (fr) | 1999-07-15 | 2001-01-25 | Kuhnil Pharm. Co., Ltd. | Nouveaux composes conjugues a base de cyclosporine hydrosoluble |
US20010049366A1 (en) * | 2000-02-09 | 2001-12-06 | Alcon Universal Ltd. | Topical solution formulations containing an antibiotic and a corticosteroid |
US6306842B1 (en) | 2000-06-02 | 2001-10-23 | Medinox, Inc. | Protected forms of a combination of pharmacologically active agents and uses therefor |
AU2002259045B2 (en) | 2001-04-26 | 2008-05-22 | Psivida Us Inc. | Sustained release drug delivery system containing codrugs |
WO2003031441A1 (fr) | 2001-10-04 | 2003-04-17 | Morphochen Aktiengesellschaft Für Kombinatorische Chemie | Composes a actions multiples |
WO2003031443A1 (fr) | 2001-10-04 | 2003-04-17 | Morphochem Aktiengesellschaft für kombinatorische Chemie | Antibiotiques a action duale renfermant une oxazolidinone et une quinolone ou une fraction de naphthyridinone |
AUPR879601A0 (en) | 2001-11-09 | 2001-12-06 | Biota Scientific Management Pty Ltd | Novel chemical compounds and their use |
JP2005518354A (ja) | 2001-11-19 | 2005-06-23 | コントロール・デリバリー・システムズ・インコーポレイテッド | コドラッグを含有する医薬組成物 |
HRP20030324A2 (en) | 2003-04-24 | 2005-02-28 | Pliva-Istra�iva�ki institut d.o.o. | Compounds of antiinflammatory effect |
JP4805139B2 (ja) | 2003-04-30 | 2011-11-02 | モルホケム アクツィエンゲゼルシャフト フューア コンビナートリッシュ ヒェミー | 炭疽および他の感染を治療するためのオキサゾリジノン‐キノリンハイブリッド抗生物質の使用 |
WO2004112838A2 (fr) * | 2003-05-21 | 2004-12-29 | Control Delivery Systems, Inc. | Ameliorations apportees a des compositions et a des methodes destinees a l'administration d'un agent bioactif |
US20060105941A1 (en) | 2004-11-12 | 2006-05-18 | Allergan, Inc. | Mixed antibiotic codrugs |
WO2008094507A2 (fr) | 2007-01-26 | 2008-08-07 | Cellicon Biotechnologies, Inc. | Nouveaux composés de fusion |
ITMI20080382A1 (it) | 2008-03-07 | 2009-09-08 | Ctg Pharma S R L | Composizioni farmaceutiche oculari |
MX342183B (es) * | 2008-09-09 | 2016-09-20 | Allergan Inc | Suspension oftalmica para uso ocular. |
US20120046461A1 (en) * | 2009-01-23 | 2012-02-23 | Northeastern University | Steroidal anti-hormone hybrids |
EP2413974B1 (fr) | 2009-03-31 | 2016-03-23 | Technion Research & Development Foundation Ltd. | Agents antimicrobiens conjugués |
KR20140093661A (ko) | 2011-09-16 | 2014-07-28 | 데이비슨 로페즈, 엘엘씨 | 식물 스테로이드 및 그의 용도 |
EP2964267A1 (fr) | 2013-03-08 | 2016-01-13 | Allergan, Inc. | Conjugués antibiotiques liés à des médicaments stéroïdes |
MX2015011948A (es) | 2013-03-08 | 2015-12-09 | Allergan Inc | Antibioticos conjugados directamente relacionados con farmacos esteroides. |
KR20150125663A (ko) | 2013-03-08 | 2015-11-09 | 알러간, 인코포레이티드 | 사이클로스포린 a 스테로이드 켤레물 |
US20140256666A1 (en) | 2013-03-08 | 2014-09-11 | Allergan, Inc. | Antibiotic conjugates with nonsteroidal anti-inflammatory drugs |
-
2014
- 2014-03-06 MX MX2015011948A patent/MX2015011948A/es unknown
- 2014-03-06 EP EP14712944.9A patent/EP2964266A1/fr not_active Withdrawn
- 2014-03-06 CA CA2903435A patent/CA2903435A1/fr not_active Abandoned
- 2014-03-06 SG SG11201507244TA patent/SG11201507244TA/en unknown
- 2014-03-06 RU RU2015138891A patent/RU2015138891A/ru unknown
- 2014-03-06 JP JP2015561639A patent/JP2016510750A/ja active Pending
- 2014-03-06 KR KR1020157027830A patent/KR20150126032A/ko not_active Application Discontinuation
- 2014-03-06 US US14/198,939 patent/US9402912B2/en active Active
- 2014-03-06 WO PCT/US2014/021062 patent/WO2014138350A1/fr active Application Filing
- 2014-03-06 AU AU2014225743A patent/AU2014225743A1/en not_active Abandoned
- 2014-03-06 CN CN201480012688.3A patent/CN105073140A/zh active Pending
- 2014-03-06 BR BR112015021836A patent/BR112015021836A2/pt not_active IP Right Cessation
- 2014-03-07 AR ARP140100772A patent/AR095071A1/es unknown
- 2014-03-10 TW TW103108217A patent/TW201505656A/zh unknown
-
2015
- 2015-08-31 IL IL240939A patent/IL240939A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP2964266A1 (fr) | 2016-01-13 |
IL240939A0 (en) | 2015-11-30 |
US9402912B2 (en) | 2016-08-02 |
AR095071A1 (es) | 2015-09-16 |
MX2015011948A (es) | 2015-12-09 |
JP2016510750A (ja) | 2016-04-11 |
TW201505656A (zh) | 2015-02-16 |
CA2903435A1 (fr) | 2014-09-12 |
US20140256612A1 (en) | 2014-09-11 |
KR20150126032A (ko) | 2015-11-10 |
AU2014225743A1 (en) | 2015-09-24 |
WO2014138350A1 (fr) | 2014-09-12 |
CN105073140A (zh) | 2015-11-18 |
BR112015021836A2 (pt) | 2017-07-18 |
RU2015138891A (ru) | 2017-04-11 |
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