SG11201503221PA - 1 h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists - Google Patents

1 h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists

Info

Publication number
SG11201503221PA
SG11201503221PA SG11201503221PA SG11201503221PA SG11201503221PA SG 11201503221P A SG11201503221P A SG 11201503221PA SG 11201503221P A SG11201503221P A SG 11201503221PA SG 11201503221P A SG11201503221P A SG 11201503221PA SG 11201503221P A SG11201503221P A SG 11201503221PA
Authority
SG
Singapore
Prior art keywords
indole
antagonists
carboxamide derivatives
carboxamide
derivatives
Prior art date
Application number
SG11201503221PA
Other languages
English (en)
Inventor
Christophe Boldron
Alain Badorc
Angelina Besse
Valérie FOSSEY
Gernot Zech
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201503221PA publication Critical patent/SG11201503221PA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epidemiology (AREA)
  • Indole Compounds (AREA)
SG11201503221PA 2012-10-26 2013-10-24 1 h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists SG11201503221PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12306334.9A EP2725025A1 (fr) 2012-10-26 2012-10-26 Dérives de 1H-indole-3-carboxamide et leurs utilisation comme antagonistes du P2Y12
PCT/EP2013/072322 WO2014064219A1 (fr) 2012-10-26 2013-10-24 Derives de 1 h-indole-3-carboxamide et leurs utilisation comme antagonistes du p2y12

Publications (1)

Publication Number Publication Date
SG11201503221PA true SG11201503221PA (en) 2015-06-29

Family

ID=47146304

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201503221PA SG11201503221PA (en) 2012-10-26 2013-10-24 1 h-indole-3-carboxamide derivatives and use thereof as p2y12 antagonists

Country Status (14)

Country Link
US (1) US20150274703A1 (es)
EP (2) EP2725025A1 (es)
JP (1) JP6235029B2 (es)
KR (1) KR20150074131A (es)
CN (1) CN104936950B (es)
AU (1) AU2013336628A1 (es)
BR (1) BR112015009136A2 (es)
CA (1) CA2889538A1 (es)
ES (1) ES2608787T3 (es)
IL (1) IL238461A0 (es)
MX (1) MX2015005312A (es)
RU (1) RU2015119642A (es)
SG (1) SG11201503221PA (es)
WO (1) WO2014064219A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3125883B1 (en) 2014-04-04 2020-08-12 Iomet Pharma Ltd. Indole derivatives for use in medicine
US10858319B2 (en) 2016-10-03 2020-12-08 Iomet Pharma Ltd. Indole derivatives for use in medicine
KR102616949B1 (ko) 2017-09-14 2023-12-22 다이이찌 산쿄 가부시키가이샤 고리형 구조를 갖는 화합물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7470712B2 (en) * 2004-01-21 2008-12-30 Bristol-Myers Squibb Company Amino-benzazoles as P2Y1 receptor inhibitors
EP1899299B1 (en) * 2005-06-27 2010-10-20 Bristol-Myers Squibb Company C-linked cyclic antagonists of p2y1 receptor useful in the treatment of thrombotic conditions
KR20100015886A (ko) * 2007-04-23 2010-02-12 사노피-아벤티스 Ｐ2ｙ12 길항제로서의 퀴놀린-카복스아미드 유도체
WO2009080227A2 (en) * 2007-12-26 2009-07-02 Sanofi-Aventis Pyrazole-carboxamide derivatives as p2y12 antagonists
FR2974576B1 (fr) * 2011-04-29 2013-07-19 Sanofi Aventis Derives de n-[(1h-pyrazol-1-yl)aryl]-1h-indole ou 1h- indazole-3-carboxamide, leur preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
IL238461A0 (en) 2015-06-30
MX2015005312A (es) 2015-11-16
BR112015009136A2 (pt) 2017-07-04
WO2014064219A1 (fr) 2014-05-01
AU2013336628A1 (en) 2015-05-21
EP2917204B1 (fr) 2016-09-28
EP2917204A1 (fr) 2015-09-16
JP2015535230A (ja) 2015-12-10
KR20150074131A (ko) 2015-07-01
CA2889538A1 (en) 2014-05-01
CN104936950A (zh) 2015-09-23
JP6235029B2 (ja) 2017-11-22
RU2015119642A (ru) 2016-12-20
EP2725025A1 (fr) 2014-04-30
US20150274703A1 (en) 2015-10-01
ES2608787T3 (es) 2017-04-17
CN104936950B (zh) 2017-08-08

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