SG11201401268RA - Assays for identifying compounds that modulate bitter taste - Google Patents

Assays for identifying compounds that modulate bitter taste

Info

Publication number
SG11201401268RA
SG11201401268RA SG11201401268RA SG11201401268RA SG11201401268RA SG 11201401268R A SG11201401268R A SG 11201401268RA SG 11201401268R A SG11201401268R A SG 11201401268RA SG 11201401268R A SG11201401268R A SG 11201401268RA SG 11201401268R A SG11201401268R A SG 11201401268RA
Authority
SG
Singapore
Prior art keywords
assays
bitter taste
identifying compounds
modulate bitter
modulate
Prior art date
Application number
SG11201401268RA
Other languages
English (en)
Inventor
Kambiz Shekdar
Purvi Manoj Shah
Joseph Gunnet
Jane V Leland
Peter H Brown
Louise Slade
Original Assignee
Chromocell Corp
Kraft Foods Group Brands Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chromocell Corp, Kraft Foods Group Brands Llc filed Critical Chromocell Corp
Publication of SG11201401268RA publication Critical patent/SG11201401268RA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5041—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving analysis of members of signalling pathways
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Seasonings (AREA)
SG11201401268RA 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste SG11201401268RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161549693P 2011-10-20 2011-10-20
PCT/US2012/061400 WO2013059836A1 (fr) 2011-10-20 2012-10-22 Dosages pour l'identification de composés qui modulent le goût amer

Publications (1)

Publication Number Publication Date
SG11201401268RA true SG11201401268RA (en) 2014-05-29

Family

ID=48141484

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201401268RA SG11201401268RA (en) 2011-10-20 2012-10-22 Assays for identifying compounds that modulate bitter taste

Country Status (7)

Country Link
US (2) US9347934B2 (fr)
EP (1) EP2769216B1 (fr)
JP (1) JP6122858B2 (fr)
CN (1) CN103998933B (fr)
IN (1) IN2014MN00714A (fr)
SG (1) SG11201401268RA (fr)
WO (1) WO2013059836A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201508572UA (en) 2013-04-24 2015-11-27 Chromocell Corp Assays for identifying compounds that modulate bitter taste
US20180372721A1 (en) * 2015-07-28 2018-12-27 Mars, Incorporated Screening methods using canine t2r receptors and pet food products and compositions identified using the same
CN112442107B (zh) * 2020-11-18 2023-05-09 渤海大学 一种苦味抑制肽及其应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL118460A (en) * 1996-05-28 1999-09-22 Dead Sea Works Ltd Edible salt mixture
WO2000038536A2 (fr) 1998-12-23 2000-07-06 Mount Sinai School Of Medicine Of New York University Inhibiteurs de la reaction a la saveur amere
US6692965B1 (en) 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
CN1341632A (zh) * 2000-09-05 2002-03-27 上海博德基因开发有限公司 一种新的多肽——人味觉感受器蛋白t2r6－17.05和编码这种多肽的多核苷酸
US8030008B2 (en) * 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7883856B2 (en) 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
WO2004029087A2 (fr) 2002-09-25 2004-04-08 Deutsches Institut für Ernährungsforschung Recepteurs du gout amer
EP2270204B1 (fr) 2004-02-18 2014-05-28 Chromocell Corporation Méthodes et matières utilisant des sondes de signalisation
US7829299B2 (en) 2004-11-18 2010-11-09 Deutsches Institut fur Ernahrungforschung Potsdam-Rehbrucke Stiftung des Offentlichen Rechts Agonists of bitter taste receptors and uses thereof
AU2006262399A1 (en) 2005-06-22 2007-01-04 Senomyx, Inc. Identification of human T2R recepors that are activated by bitter molecules in coffee (chlorogenic lactones) and related assays for identifying human bitter taste modulators
US7923047B2 (en) * 2006-06-30 2011-04-12 Conagra Foods Rdm, Inc. Seasoning and method for seasoning a food product while reducing dietary sodium intake
US20080167286A1 (en) * 2006-12-12 2008-07-10 Abbott Laboratories Pharmaceutical compositions and their methods of use
WO2008119196A1 (fr) 2007-03-30 2008-10-09 Givaudan Sa Composés organiques bloquant les notes atypiques sensorielles
CN101652342B (zh) 2007-03-30 2014-01-29 奇华顿股份有限公司 遮蔽不适感感觉的有机化合物
EP2137322B1 (fr) * 2007-03-30 2013-02-27 Givaudan SA Procédé d'identification de modulateurs tas2r
EP1983342A1 (fr) 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antagonistes des récepteurs de l'amertume et leurs utilisations
WO2009015504A2 (fr) 2007-07-30 2009-02-05 Givaudan Sa Composés organiques
WO2009025793A2 (fr) * 2007-08-21 2009-02-26 Senomyx, Inc. Identification de récepteurs humains t2r sensibles aux composés amers qui provoquent le goût amer dans des compositions, et utilisation de ceux-ci dans des analyses d'identification de composés qui inhibent (bloquent) le goût amer dans des compositions et utilisation de celles-ci
US20110003711A1 (en) 2008-02-01 2011-01-06 Chromocell Corporation Cell lines expressing gaba receptor and methods using them
EP2300830B1 (fr) * 2008-06-13 2015-05-20 Givaudan SA Procédés d'identification de modulateurs du récepteur de goût amer tas2r44
EP2329263A1 (fr) * 2008-08-07 2011-06-08 Givaudan SA Procédés permettant d'identifier des modulateurs de l'interaction entre la dextrométhorphane et le récepteur du goût amer tas2r46
US20120015841A1 (en) 2009-02-02 2012-01-19 Chromocell Corporation Novel cell lines and methods
EP2404172A1 (fr) 2009-03-06 2012-01-11 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Procédés pour isoler des agonistes et des antagonistes de récepteurs de goût
EP2742349A1 (fr) 2011-08-08 2014-06-18 The Coca-Cola Company Lignées cellulaires comprenant des récepteurs endogènes du goût et leurs utilisations

Also Published As

Publication number Publication date
JP6122858B2 (ja) 2017-04-26
EP2769216A1 (fr) 2014-08-27
US20160299127A1 (en) 2016-10-13
EP2769216B1 (fr) 2017-01-04
CN103998933B (zh) 2016-12-14
EP2769216A4 (fr) 2015-05-13
JP2014530628A (ja) 2014-11-20
US20140248639A1 (en) 2014-09-04
US9347934B2 (en) 2016-05-24
WO2013059836A1 (fr) 2013-04-25
CN103998933A (zh) 2014-08-20
IN2014MN00714A (fr) 2015-07-03

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