SG10202112528QA - Nsg mice lacking mhc class i and class ii - Google Patents

Nsg mice lacking mhc class i and class ii

Info

Publication number
SG10202112528QA
SG10202112528QA SG10202112528QA SG10202112528QA SG10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA SG 10202112528Q A SG10202112528Q A SG 10202112528QA
Authority
SG
Singapore
Prior art keywords
class
nsg mice
mice lacking
lacking mhc
mhc class
Prior art date
Application number
SG10202112528QA
Other languages
English (en)
Inventor
Michael Brehm
Michael Wiles
Dale Greiner
Leonard Shultz
Original Assignee
Jackson Lab
Univ Massachusetts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jackson Lab, Univ Massachusetts filed Critical Jackson Lab
Publication of SG10202112528QA publication Critical patent/SG10202112528QA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
SG10202112528QA 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii SG10202112528QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762505264P 2017-05-12 2017-05-12
US201862649099P 2018-03-28 2018-03-28

Publications (1)

Publication Number Publication Date
SG10202112528QA true SG10202112528QA (en) 2021-12-30

Family

ID=62598038

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202112528QA SG10202112528QA (en) 2017-05-12 2018-05-14 Nsg mice lacking mhc class i and class ii

Country Status (10)

Country Link
US (1) US11778994B2 (fr)
EP (2) EP4144213A1 (fr)
JP (2) JP7129426B2 (fr)
KR (1) KR102652838B1 (fr)
CN (2) CN110868850B (fr)
AU (1) AU2018265887B2 (fr)
CA (1) CA3063368A1 (fr)
RU (1) RU2019140867A (fr)
SG (1) SG10202112528QA (fr)
WO (1) WO2018209344A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11712026B2 (en) * 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development
CN112094869A (zh) * 2020-08-06 2020-12-18 郑州大学 基于基因敲除叙利亚仓鼠的胰腺癌动物模型制备方法及其应用
WO2022066894A1 (fr) * 2020-09-24 2022-03-31 The Jackson Laboratory Modèles de souris humanisées pour évaluer une immunothérapie cellulaire
WO2024054904A1 (fr) * 2022-09-08 2024-03-14 The Jackson Laboratory Modèles murins immunodéficients humanisés

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9100481D0 (en) 1991-01-10 1991-02-20 Inst Nat Sante Rech Med Genetically engineered mice
US5356802A (en) 1992-04-03 1994-10-18 The Johns Hopkins University Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease
US5487994A (en) 1992-04-03 1996-01-30 The Johns Hopkins University Insertion and deletion mutants of FokI restriction endonuclease
US5436150A (en) 1992-04-03 1995-07-25 The Johns Hopkins University Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
EP1196600A1 (fr) 1999-07-21 2002-04-17 Albert Einstein College Of Medicine Of Yeshiva University Proteine associee a la recombinaison de drosophila et procedes d'utilisation
US6830910B1 (en) 1999-07-21 2004-12-14 Albert Einstein College Of Medicine Of Yeshiva University Drosophila recombination-associated protein and methods for use
FR2827302B1 (fr) 2001-07-13 2003-10-10 Genoway Cellule et animal transgenique modelisant la presentation antigenique humaine et leurs utilisations
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US8409861B2 (en) 2003-08-08 2013-04-02 Sangamo Biosciences, Inc. Targeted deletion of cellular DNA sequences
AU2005262319A1 (en) 2004-07-01 2006-01-19 Orthogen Ag Immunosuppressive exosomes
PT2767161T (pt) 2004-10-19 2018-04-20 Regeneron Pharma Método para gerar um animal homozigótico para uma modificação genética
EP1913149A4 (fr) 2005-07-26 2009-08-05 Sangamo Biosciences Inc Integration et expression ciblees de sequences d'acides nucleiques exogenes
JP2007244268A (ja) 2006-03-15 2007-09-27 Osaka Prefecture Univ イヌの造血前駆細胞を認識するモノクローナル抗体の製造方法
WO2007139898A2 (fr) 2006-05-25 2007-12-06 Sangamo Biosciences, Inc. Demi-domaines résultant de clivage par génie génétique
EP1878342A1 (fr) * 2006-07-13 2008-01-16 Institut Pasteur Souris immunodeficientes transgéniques pour la classe I et II de HLA, et leurs utilisations
JP2010525794A (ja) 2007-04-06 2010-07-29 インターナショナル ステム セル コーポレイション ヒト単為生殖性胚盤胞に由来する患者特異的幹細胞株
EP2206723A1 (fr) 2009-01-12 2010-07-14 Bonas, Ulla Domaines modulaires de liaison à l'ADN
AU2010327998B2 (en) 2009-12-10 2015-11-12 Iowa State University Research Foundation, Inc. TAL effector-mediated DNA modification
EP2558576B1 (fr) 2010-04-14 2016-10-19 Envigo RMS, Inc. Souris nod/scid glabres
CA2824997C (fr) 2011-01-18 2023-01-17 The Trustees Of The University Of Pennsylvania Compositions et procedes de traitement du cancer
US8450107B1 (en) 2011-11-30 2013-05-28 The Broad Institute Inc. Nucleotide-specific recognition sequences for designer TAL effectors
KR102268351B1 (ko) 2012-07-25 2021-06-22 셀덱스 쎄라퓨틱스, 인크. 항-kit 항체 및 그의 용도
RU2673156C2 (ru) 2012-11-05 2018-11-22 Ридженерон Фармасьютикалз, Инк. Генетически модифицированные не относящиеся к человеческому роду животные и способы их применения
CN110740641A (zh) 2016-11-30 2020-01-31 杰克逊实验室 具有改善的人先天免疫细胞发育的人源化小鼠模型
US11712026B2 (en) 2017-10-18 2023-08-01 The Jackson Laboratory Murine-MHC-deficient HLA-transgenic nod-mouse models for T1D therapy development

Also Published As

Publication number Publication date
KR20200006109A (ko) 2020-01-17
RU2019140867A (ru) 2021-06-15
WO2018209344A8 (fr) 2019-12-05
CA3063368A1 (fr) 2018-11-15
JP2022159551A (ja) 2022-10-17
EP3621433A1 (fr) 2020-03-18
CN110868850A (zh) 2020-03-06
AU2018265887A1 (en) 2019-11-28
AU2018265887B2 (en) 2024-05-09
JP7129426B2 (ja) 2022-09-01
CN115851834A (zh) 2023-03-28
WO2018209344A1 (fr) 2018-11-15
CN110868850B (zh) 2023-07-14
JP2020519282A (ja) 2020-07-02
US20200060245A1 (en) 2020-02-27
KR102652838B1 (ko) 2024-04-01
EP4144213A1 (fr) 2023-03-08
EP3621433B1 (fr) 2022-07-27
US11778994B2 (en) 2023-10-10

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