SG10202102997UA - Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus - Google Patents
Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locusInfo
- Publication number
- SG10202102997UA SG10202102997UA SG10202102997UA SG10202102997UA SG10202102997UA SG 10202102997U A SG10202102997U A SG 10202102997UA SG 10202102997U A SG10202102997U A SG 10202102997UA SG 10202102997U A SG10202102997U A SG 10202102997UA SG 10202102997U A SG10202102997U A SG 10202102997UA
- Authority
- SG
- Singapore
- Prior art keywords
- human animals
- repeat expansion
- hexanucleotide repeat
- c9orf72 locus
- c9orf72
- Prior art date
Links
- 241001465754 Metazoa Species 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Environmental Sciences (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Veterinary Medicine (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662402613P | 2016-09-30 | 2016-09-30 | |
US201762452795P | 2017-01-31 | 2017-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10202102997UA true SG10202102997UA (en) | 2021-04-29 |
Family
ID=60201654
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10202102997UA SG10202102997UA (en) | 2016-09-30 | 2017-09-29 | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
Country Status (12)
Country | Link |
---|---|
US (2) | US10781453B2 (fr) |
EP (1) | EP3518667A1 (fr) |
JP (2) | JP7026678B2 (fr) |
KR (2) | KR102294755B1 (fr) |
CN (1) | CN109862785B (fr) |
AU (1) | AU2017336100B2 (fr) |
CA (1) | CA3038548A1 (fr) |
IL (2) | IL265669B (fr) |
MX (2) | MX2019003745A (fr) |
RU (1) | RU2760877C2 (fr) |
SG (1) | SG10202102997UA (fr) |
WO (1) | WO2018064600A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014062691A2 (fr) | 2012-10-15 | 2014-04-24 | Isis Pharmaceuticals, Inc. | Compositions permettant de moduler l'expression de c90rf72 |
WO2014062736A1 (fr) | 2012-10-15 | 2014-04-24 | Isis Pharmaceuticals, Inc. | Procédés permettant de surveiller l'expression de c9orf72 |
WO2015054676A2 (fr) | 2013-10-11 | 2015-04-16 | Isis Pharmaceuticals, Inc. | Compositions pour moduler l'expression de c90rf72 |
WO2015143078A1 (fr) | 2014-03-18 | 2015-09-24 | University Of Massachusetts | Compositions à base de virus adéno-associé recombinant raav et méthodes de traitement de la sclérose latérale amyotrophique |
EP3302048B1 (fr) | 2015-05-29 | 2020-02-19 | Regeneron Pharmaceuticals, Inc. | Animaux non-humains comprenant une perturbation dans un locus c9orf72 |
WO2017079291A1 (fr) | 2015-11-02 | 2017-05-11 | Ionis Pharmaceuticals, Inc. | Composés et méthodes de modulation de c90rf72 |
CN109312339B (zh) * | 2015-12-23 | 2022-01-28 | 克里斯珀医疗股份公司 | 用于治疗肌萎缩侧索硬化症和/或额颞叶变性的材料和方法 |
SG10202102997UA (en) * | 2016-09-30 | 2021-04-29 | Regeneron Pharma | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
WO2018208972A1 (fr) * | 2017-05-09 | 2018-11-15 | University Of Massachusetts | Méthodes de traitement de la sclérose latérale amyotrophique (sla) |
JP7397488B2 (ja) | 2017-09-22 | 2023-12-13 | ユニバーシティ オブ マサチューセッツ | Sod1二重発現ベクターおよびその使用 |
CN111819281A (zh) * | 2017-10-23 | 2020-10-23 | 普利维尔治疗公司 | 用于神经变性疾病的基因疗法 |
WO2019222354A1 (fr) * | 2018-05-15 | 2019-11-21 | University Of Washington | Compositions et procédés pour réduire les anomalies d'épissage et traiter des troubles de dominance arn |
JP7449291B2 (ja) | 2018-12-20 | 2024-03-13 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ヌクレアーゼ媒介リピート伸長 |
EP3725536A1 (fr) * | 2019-04-18 | 2020-10-21 | Thales Dis France SA | Document de sécurité à double lentilles de vérification |
EP3966328A4 (fr) | 2019-05-06 | 2023-10-18 | University Of Massachusetts | Oligonucléotides anti-c9orf72 et procédés associés |
EP4073251A1 (fr) | 2019-12-13 | 2022-10-19 | Alnylam Pharmaceuticals, Inc. | Agents et compositions d'arni ciblant c9orf72 - cadre de lecture ouvert 72 sur le chromosome 9 - humain et procédés d'utilisation |
US20230040053A1 (en) * | 2019-12-23 | 2023-02-09 | Tsinghua University | DEVELOPMENT OF DUAL-gRNA APPROACH WITH UNDETECTABLE OFF-TARGET EFFECT TO CORRECT C9ORF72 REPEAT EXPANSION AND C9ORF72 PATHOLOGY |
AU2021253183A1 (en) * | 2020-04-09 | 2022-11-03 | Association Institut De Myologie | Antisense sequences for treating amyotrophic lateral sclerosis |
US20230381170A1 (en) * | 2020-10-20 | 2023-11-30 | University Of Florida Research Foundation, Incorporated | Method for treating als/ftd through degradation of rna repeat expansion |
IL308743A (en) | 2021-06-04 | 2024-01-01 | Alnylam Pharmaceuticals Inc | Compositions of human chromosome 9 open reading frame 72 iRNA factor (C9ORF72) and methods of using them |
WO2023077037A1 (fr) * | 2021-10-27 | 2023-05-04 | University Of Florida Research Foundation, Incorporated | Procédés de dégradation de petites molécules pour traiter d'als/ftd |
WO2024044493A2 (fr) * | 2022-08-22 | 2024-02-29 | The Johns Hopkins University | Traitement d'une maladie d'expansion de répétition |
Family Cites Families (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5514545A (en) * | 1992-06-11 | 1996-05-07 | Trustees Of The University Of Pennsylvania | Method for characterizing single cells based on RNA amplification for diagnostics and therapeutics |
US5523226A (en) | 1993-05-14 | 1996-06-04 | Biotechnology Research And Development Corp. | Transgenic swine compositions and methods |
US5670356A (en) | 1994-12-12 | 1997-09-23 | Promega Corporation | Modified luciferase |
US5874304A (en) | 1996-01-18 | 1999-02-23 | University Of Florida Research Foundation, Inc. | Humanized green fluorescent protein genes and methods |
WO1999005266A2 (fr) | 1997-07-26 | 1999-02-04 | Wisconsin Alumni Research Foundation | Transfert de noyau entre des especes differentes |
US20050144655A1 (en) | 2000-10-31 | 2005-06-30 | Economides Aris N. | Methods of modifying eukaryotic cells |
US7105348B2 (en) | 2000-10-31 | 2006-09-12 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US6586251B2 (en) | 2000-10-31 | 2003-07-01 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
AUPR451401A0 (en) | 2001-04-20 | 2001-05-24 | Monash University | A method of nuclear transfer |
US7612250B2 (en) | 2002-07-29 | 2009-11-03 | Trustees Of Tufts College | Nuclear transfer embryo formation method |
PT1802193E (pt) | 2004-10-19 | 2014-06-23 | Regeneron Pharma | Método para gerar um murganho homozigótico para uma modificação genética |
CN101117633B (zh) | 2006-08-03 | 2011-07-20 | 上海交通大学附属儿童医院 | 一种细胞核移植方法 |
EP3064599B1 (fr) | 2008-02-15 | 2018-12-12 | Synthetic Genomics, Inc. | Procédés de jonction in vitro et d'ensemble combinatoire de molécules d'acide nucléique |
RU2425880C2 (ru) * | 2009-07-30 | 2011-08-10 | Учреждение Российской академии наук Институт общей генетики им. Н.И. Вавилова РАН | Способ получения трансгенных мышей |
KR20180036810A (ko) * | 2009-08-14 | 2018-04-09 | 레비비코르 인코포레이션 | 당뇨병 치료를 위한 복수 형질전환 돼지 |
WO2011020014A1 (fr) | 2009-08-14 | 2011-02-17 | Regeneron Pharmaceuticals, Inc. | Cassette à auto-suppression dépendant de la différenciation régulée par un promoteur |
WO2013030588A1 (fr) | 2011-08-31 | 2013-03-07 | The University Of Manchester | Procédé de diagnostic d'une maladie neurodégénérative |
WO2013041577A1 (fr) | 2011-09-20 | 2013-03-28 | Vib Vzw | Procédés de diagnostic de la sclérose latérale amyotrophique et de la dégénérescence lobaire frontotemporale |
EP2847335B1 (fr) | 2012-04-25 | 2018-06-27 | Regeneron Pharmaceuticals, Inc. | Ciblage médié par nucléase avec de grands vecteurs de ciblage |
WO2014062736A1 (fr) | 2012-10-15 | 2014-04-24 | Isis Pharmaceuticals, Inc. | Procédés permettant de surveiller l'expression de c9orf72 |
WO2014062691A2 (fr) * | 2012-10-15 | 2014-04-24 | Isis Pharmaceuticals, Inc. | Compositions permettant de moduler l'expression de c90rf72 |
EP2906696B2 (fr) | 2012-10-15 | 2022-12-14 | Ionis Pharmaceuticals, Inc. | Procédés pour moduler l'expression de c90rf72 |
US8697359B1 (en) * | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
EP2948471A4 (fr) | 2013-01-24 | 2016-08-10 | Mayo Foundation | Procédés et matériaux de détection d'une dégénérescence du lobe frontotemporal positive aux expansions de répétitions hexanucléotidiques du gène c9orf72 ou d'une sclérose latérale amyotrophique positive aux expansions de répétitions hexanucléotidiques du gène c9orf72 |
ES2904803T3 (es) | 2013-02-20 | 2022-04-06 | Regeneron Pharma | Modificación genética de ratas |
AU2014241078B2 (en) * | 2013-03-14 | 2020-03-12 | University Of Florida Research Foundation, Inc. | Di-amino acid repeat-containing proteins associated with ALS |
PT3456831T (pt) | 2013-04-16 | 2021-09-10 | Regeneron Pharma | Modificação alvejada do genoma de rato |
US10508289B2 (en) | 2013-10-25 | 2019-12-17 | Cellectis | Rare-cutting endonucleases for efficient and specific targeting DNA sequences comprising highly repetitive motives |
JP6625055B2 (ja) | 2013-12-12 | 2020-01-08 | ザ・ブロード・インスティテュート・インコーポレイテッド | 組成物、及びヌクレオチドリピート障害におけるcrispr−cas系の使用方法 |
WO2015143078A1 (fr) * | 2014-03-18 | 2015-09-24 | University Of Massachusetts | Compositions à base de virus adéno-associé recombinant raav et méthodes de traitement de la sclérose latérale amyotrophique |
WO2015153760A2 (fr) | 2014-04-01 | 2015-10-08 | Sangamo Biosciences, Inc. | Procédés et compositions destinés à la prévention ou au traitement d'un trouble du système nerveux |
PT3155099T (pt) | 2014-06-23 | 2018-04-20 | Regeneron Pharma | Montagem de dna mediada por nuclease |
RU2771532C2 (ru) | 2014-06-26 | 2022-05-05 | Регенерон Фармасьютикалз, Инк. | Способы и композиции для нацеленных генетических модификаций и способы их применения |
WO2016025692A1 (fr) * | 2014-08-13 | 2016-02-18 | The Scripps Research Institute | Traitement de c9ftd/als par ciblage de séquences de répétition étendues d'arn |
WO2016024205A1 (fr) * | 2014-08-15 | 2016-02-18 | Pfizer Inc. | Oligomères ciblant l'expansion d'une répétition hexanucléotidique dans le gène c9orf72 humain |
US10538762B2 (en) * | 2014-10-14 | 2020-01-21 | The Board Of Regents Of The University Of Texas System | Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAS targeting the expanded hexanucleotide repeat |
KR20230070319A (ko) | 2014-11-21 | 2023-05-22 | 리제너론 파마슈티칼스 인코포레이티드 | 쌍 형성된 가이드 rna를 사용하는 표적화된 유전자 변형을 위한 방법 및 조성물 |
FI3850946T3 (fi) * | 2014-12-05 | 2023-12-28 | Regeneron Pharma | Ei-ihmiseläimiä, joilla on humanisoitu erilaistumisklusterin 47 geeni |
BR112017013104A2 (pt) | 2014-12-19 | 2018-05-15 | Regeneron Pharma | métodos para modificar um locus genômico alvo em uma célula, para intensificar a recombinação homóloga em um locus genômico alvo em uma célula e para produzir uma geração f0 de um animal não humano. |
WO2016112132A1 (fr) | 2015-01-06 | 2016-07-14 | Ionis Pharmaceuticals, Inc. | Compositions destinées à moduler l'expression du transcrit antisens c9orf72 |
CA2978096C (fr) * | 2015-03-16 | 2022-06-28 | Regeneron Pharmaceuticals, Inc. | Animal non humain presentant une baisse de la fonction des neurones moteurs superieurs et inferieurs et de la perception sensorielle |
WO2016174056A1 (fr) | 2015-04-27 | 2016-11-03 | Genethon | Compositions et méthodes pour le traitement de troubles dus à l'expansion de répétition des nucléotides |
DK3289076T3 (da) | 2015-05-01 | 2022-01-17 | Prec Biosciences Inc | Præcis sletning af kromosomale sekvenser in vivo |
EP3302048B1 (fr) | 2015-05-29 | 2020-02-19 | Regeneron Pharmaceuticals, Inc. | Animaux non-humains comprenant une perturbation dans un locus c9orf72 |
EP3344756A4 (fr) | 2015-09-02 | 2019-09-04 | University of Massachusetts | Détection de loci de gènes comprenant des répétitions matricielles de crispr et/ou des acides ribonucléiques mono-guides polychromatiques |
CN109312339B (zh) * | 2015-12-23 | 2022-01-28 | 克里斯珀医疗股份公司 | 用于治疗肌萎缩侧索硬化症和/或额颞叶变性的材料和方法 |
EP3442596A1 (fr) | 2016-04-14 | 2019-02-20 | Université de Lausanne | Traitement et/ou prévention de maladies ou de troubles de répétition de triplets d'adn |
US20190270980A1 (en) | 2016-07-25 | 2019-09-05 | Mayo Foundation For Medical Education And Research | Treating cancer |
SG10202102997UA (en) * | 2016-09-30 | 2021-04-29 | Regeneron Pharma | Non-human animals having a hexanucleotide repeat expansion in a c9orf72 locus |
JP7211940B2 (ja) | 2016-10-28 | 2023-01-24 | ジェネトン | 筋緊張性ジストロフィーの治療のための組成物および方法 |
US11427824B2 (en) | 2016-10-28 | 2022-08-30 | Genethon | Compositions and methods for the treatment of myotonic dystrophy |
WO2018165541A1 (fr) | 2017-03-10 | 2018-09-13 | The Board Of Regents Of The University Of Texas System | Traitement de la dystrophie cornéenne endothéliale de fuchs |
WO2018208972A1 (fr) | 2017-05-09 | 2018-11-15 | University Of Massachusetts | Méthodes de traitement de la sclérose latérale amyotrophique (sla) |
CA3079727A1 (fr) | 2017-10-24 | 2019-05-02 | Sangamo Therapeutics, Inc. | Methodes et compositions pour le traitement de maladies rares |
-
2017
- 2017-09-29 SG SG10202102997UA patent/SG10202102997UA/en unknown
- 2017-09-29 RU RU2019108888A patent/RU2760877C2/ru active
- 2017-09-29 KR KR1020197011950A patent/KR102294755B1/ko active IP Right Grant
- 2017-09-29 CA CA3038548A patent/CA3038548A1/fr active Pending
- 2017-09-29 WO PCT/US2017/054551 patent/WO2018064600A1/fr active Application Filing
- 2017-09-29 EP EP17792229.1A patent/EP3518667A1/fr active Pending
- 2017-09-29 CN CN201780060178.7A patent/CN109862785B/zh active Active
- 2017-09-29 US US15/721,517 patent/US10781453B2/en active Active
- 2017-09-29 MX MX2019003745A patent/MX2019003745A/es unknown
- 2017-09-29 KR KR1020217026697A patent/KR102527979B1/ko active IP Right Grant
- 2017-09-29 AU AU2017336100A patent/AU2017336100B2/en active Active
- 2017-09-29 JP JP2019517273A patent/JP7026678B2/ja active Active
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2019
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- 2019-03-29 MX MX2021003996A patent/MX2021003996A/es unknown
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2020
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- 2020-09-25 JP JP2020160492A patent/JP2020198894A/ja not_active Withdrawn
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2021
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Publication number | Publication date |
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JP2019530453A (ja) | 2019-10-24 |
RU2019108888A3 (fr) | 2021-01-18 |
CN109862785B (zh) | 2022-09-06 |
JP7026678B2 (ja) | 2022-02-28 |
US20200370054A1 (en) | 2020-11-26 |
CA3038548A1 (fr) | 2018-04-05 |
KR20190057104A (ko) | 2019-05-27 |
US10781453B2 (en) | 2020-09-22 |
IL265669A (en) | 2019-05-30 |
AU2017336100B2 (en) | 2023-11-30 |
AU2017336100A1 (en) | 2019-05-23 |
MX2021003996A (es) | 2021-06-23 |
RU2760877C2 (ru) | 2021-12-01 |
IL265669B (en) | 2021-08-31 |
KR102527979B1 (ko) | 2023-04-28 |
KR20210109649A (ko) | 2021-09-06 |
WO2018064600A1 (fr) | 2018-04-05 |
KR102294755B1 (ko) | 2021-08-31 |
MX2019003745A (es) | 2019-12-11 |
US20180094267A1 (en) | 2018-04-05 |
CN109862785A (zh) | 2019-06-07 |
JP2020198894A (ja) | 2020-12-17 |
RU2019108888A (ru) | 2020-10-30 |
IL285014A (en) | 2021-08-31 |
EP3518667A1 (fr) | 2019-08-07 |
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